“We administered nicotine to achieve a steady-state concentration, using subcutaneously implanted minipumps, a technique that avoids the episodic hypoxic-ischemic episodes that accompany nicotine injections, and that also sidesteps the inherent problems of repeated handling stress and episodic withdrawal between injections” Slotkin et al., Neurotoxicology and Teratology 2002; 24:369-384.

Downloads

 

ALZET Order Information and Forms

Order Form
Download this form to order ALZET products by fax (408.865.1406) or email (alzetcs@durect.com).

Payment Instructions for International Customers

 

Applications Fact Sheets

Mouse Infusion Fact Sheet
General information on the use of ALZET pumps in mice.

Mouse Infusion Fact Sheet Table

Recent citations highlighting various research applications, routes of administration and long-term delivery in mice, using ALZET Osmotic pumps.

Cancer Newsletter
Cancer research applications using ALZET pumps.

Neuroscience Newsletter NEW

Neuroscience research applications using ALZET pumps.

Neuroscience Fact Sheet

Neuroscience research applications using ALZET pumps

 

Technical Information

ALZET Technical Information Manual (2.5 MB)

 

Product Data Sheets

Neuroscience Products Fact Sheet
Specifications and general information about ALZET products related to neuroscience research, including ALZET pump models, ALZET brain infusion kits, and cyanoacrylate adhesive gel (Loctite 454). This fact sheet also contains useful neuroscience reference information, such as the composition of CSF in various species, and CSF volumes and production rates in various species.

Catheter Fact Sheet
Specifications and general information on sterile catheter tubing commercially available from DURECT Corp.

Colored Flow Moderator Fact Sheet

New flow moderators available for purchase.  These colored flow moderators are compatible with bio-luminescence imaging and allow for easier pump identification. 

 

Package Inserts

ALZET pump model 1003D insert

ALZET pump model 1007D insert

ALZET pump model 1002 insert

ALZET pump model 1004 insert

ALZET pump model 2001D insert

ALZET pump model 2001 insert

ALZET pump model 2002 insert

ALZET pump model 2004 insert

ALZET pump model 2006 insert

ALZET pump model 2ML1 insert

ALZET pump model 2ML2 insert

ALZET pump model 2ML4 insert

ALZET Brain Infusion Kit 1 insert

ALZET Brain Infusion Kit 2 insert

ALZET Brain Infusion Kit 3 insert

ALZAID Chemical Compatibility Test Kit Insert

 

Video Clips

View a short video clip (in QuickTime format) demonstrating the use of ALZET Osmotic Pumps and various surgical techniques.

DURECT Company Information

Advantages of Continuous Infusion Over Injections

ALZET Pump Models

Mechanism of Operation
How ALZET pumps work?

Pump Selection Criteria
Selecting the appropriate pump for your studies.

Filling ALZET Pumps
Brief explanation of what it is.

Catheter Use

Subcutaneous Implantation Procedure

Intraperitoneal Implantation Procedure

Intragastric Implantation Procedure

Intravenous Cannulation Procedure

ALZET Brain Infusion Kit Preparation

Intracerebral Cannulation Procedure

Intrathecal Cannulation Procedure

Lynch Coil Procedure
Adapting ALZET pumps for pulsatile, or discontinuous infusion of test agents.

 

Selected ALZET Scientific Publications

Theeuwes & Yum
Theeuwes F and Yum SI. Principles of the design and operation of generic osmotic pumps for the delivery of semisolid or liquid drug formulations. Ann Biomed Eng 1976;4(4):343-353.

Fara & Urquhart
Fara J, and Urquhart J. The Value of Infusion and Injection Regimens in Assessing Efficacy and Toxicity of Drugs.   Trends Pharmacol Sci 1984;5(1):21-25.

Urquhart, Fara & Willis
Urquhart J, Fara J, and Willis KL. Rate-controlled Delivery Systems in Drug and Hormone Research. Ann Rev Pharmacol Toxicol 1984;24:199-236.

Sendelbeck & Urquhart
Sendelbeck SL and Urquhart J. Spatial distribution of dopamine, methotrexate, and antipyrine during continuous intracerebral microperfusion. Brain Res 1985;328:251-258.

Book Chapter on Continuous Infusion Studies with ALZET Pumps

Pre-Clinical Continuous Intravenous Infusion. (Smith & Healing, editors, Taylor and Francis, London): Chapter 21. Perkins L, Peer C, and Murphy-Hackley P. The use of mini-osmotic pumps in continuous infusion studies.

 

Speaker's Presentation Materials

Speaker's PowerPoint Presentation

ALZET Pump Cross Section Graphic

ALZET Pump Models Chart

Theeuwes & Yum
Theeuwes F and Yum SI. Principles of the design and operation of generic osmotic pumps for the delivery of semisolid or liquid drug formulations. Ann Biomed Eng 1976;4(4):343-353.

Book Chapter on Continuous Infusion Studies with ALZET Pumps

Pre-Clinical Continuous Intravenous Infusion. (Smith & Healing, editors, Taylor and Francis, London): Chapter 21. Perkins L, Peer C, and Murphy-Hackley P. The use of mini-osmotic pumps in continuous infusion studies.

 

Programs

Adobe Acrobat Reader
The majority of the documents that are available for download in the ALZET website require Adobe Acrobat Reader. If you do not have this program installed on your computer, you may download a free version directly from the link provided above.

QuickTime Video Viewer
The videoclips found in this website require QuickTime. If you do not have this program installed on your computer, you may download a free version directly from the link provided above.

 

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ALZET pumps and ancillary products can be ordered by calling 877-922-5938 or on-line.

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