References on the Administration of Vasopressin
Using ALZET^® Osmotic Pumps

P8600 de Seigneux,S., Nielsen,J., Olesen,E.T.B., Dimke,H., Kwon,T.H., Frokiaer,J., Nielsen,S. Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney. American Journal of Physiology- Renal Physiology 2007; 293(-1-):F87-F99. >>> Aldosterone; vasopressin, 1-deamino-8-D-arginine; angiotensin II; Saline; DMSO; ringer's solution, lactated; SC; Rat; 2001; 2002; 6,7,8 days; Controls received mp w/ vehicle; cardiovascular; peptides; multiple pumps per animal (2); post op. care (Buprenorphine); animal info (male, Wistar-Hanover, 220-250 grams, male, Sprague-Dawley, 190-210 grams, male, Munich-Wistar, 220 grams); 30% and 25% DMSO used.

P8417 Kazama,I., Arata,T., Michimata,M., Hatano,R., Suzuki,M., Miyama,N., Sanada,S., Sato,A., Satomi,S., Ejima,Y., Sasaki,S., Matsubara,M. Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats. NEPHROLOGY DIALYSIS TRANSPLANTATION 2007; 22(-1-):68-76. >>> Vasopressin, 1-deamino-8-D-arginine; Saline; SC; Rat; 2002; 14 days; No Stress (see pg. 71); animal info (male, Sprague-Dawley, 200g.); Nephrology.

P8375 Takefuji,S., Murase,T., Sugimura,Y., Takagishi,Y., Hayasaka,S., Oiso,Y., Murata,Y. Role of microglia in the pathogenesis of osmotic-induced demyelination. Experimental Neurology 2007; 204(-1-):88-94. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; 14 days; Animal Info (male, Sprague-Dawley, 7-8 wks old, 250-300g.); hyponatremia model.

P8333 Cristia,E., Amat,C., Naftalin,R.J., Moreto,M. Role of vasopressin in rat distal colon function. JOURNAL OF PHYSIOLOGY-LONDON 2007; 578(-2-):413-424. >>> Vasopressin; Saline; SC; Rat; 2002; 3, 7 days; Animal info (male, Sprague-Dawley, 200-250 grams).

P7989 Wada,K., Matsuyawa,U., Fujimori,A., Arai,Y., Sudoh,K., Sasamata,M., Miyata,K. A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH). BIOLOGICAL&PHARMACEUTICAL BULLETIN 2007; 30(-1-):91-95. >>> Vasopressin, arginine; Water, distilled; SC; Rat; 2001; ; Controls received mp w/ vehicle; animal info (male, Wistar, 244-313 grams).

P8439 Yue,C.M., Mutsuga,N., Verbalis,J., Gainer,H. Microarray analysis of gene expression in the supraoptic nucleus of normoosmotic and hypoosmotic rats. Cellular and Molecular Neurobiology 2006; 26(-4-6-):959-978. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; 7 days; Animal info (male, Sprague-Dawley, 260-320 g).

P8072 Mutsuga,N., Gainer,H. Molecular analysis of the magnocellular neuroendocrine phenotype: From the micropunch to laser microdissection. Neurochemical Research 2006; 31(-2-):189-199. >>> Vasopressin, 1-desamino-8-D-arginine; SC; Rat; 2002; 7 days; Animal info (male, Sprague-Dawley, 260-320g.); bioinformatics.

P7927 Tiwari,S., Packer,R.K., Hu,X.Q., Sugimura,Y., Verbalis,J.G., Ecelbarger,C.A. Increased renal alpha-ENaC and NCC abundance and elevated blood pressure are independent of hyperaldosteronism in vasopressin escape. American Journal of Physiology-Renal Physiology 2006; 291(-1-):F49-F57. >>> Vasopressin, 1-desamino-8-D-arginine; aldosterone; SC; Rat; 2002; ; Blood pressure taken; replacement therapy (adrenalectomy); multiple pumps per animal (2); animal info (male, Sprague-Dawley, 275 grams, ADX); dDAVP; one pump for each drug.

P7919 Sauter,D., Fernandes,S., Goncalves-Mendes,N., Boulkroun,S., Bankir,L., Loffing,J., Bouby,N. Long-term effects of vasopressin on the subcellular localization of ENaC in the renal collecting system. Kidney International 2006; 69(-6-):1024-1032. >>> Vasopressin, 1-desamino-8-D-arginine; Rat; 2002; 5 days; Animal info (Sprague-Dawley, male, 200 grams); dDAVP.

P7911 Pisitkun,T., Bieniek,J., Tchapyjnikov,D., Wang,G.H., Wu,W.W., Shen,R.F., Knepper,M.A. High-throughput identification of IMCD proteins using LC-MS/MS. PHYSIOLOGICAL GENOMICS 2006; 25(-2-):263-276. >>> Vasopressin, 1-desamino-8-D-arginine; Saline, isotonic; SC; Rat; 2001; 3 days; Controls received mp w/ vehicle; animal info (male, Brattleboro, 360-430 g.).

P7720 Zelena,D., Mergl,Z., Makara,G.B. The role of vasopressin in diabetes mellitus-induced hypothalamo-pituitary-adrenal axis activation: Studies in Brattleboro rats. Brain Research Bulletin 2006; 69(-1-):48-56. >>> Vasopressin, 1-desamino-8-D-arginine; SC; Rat; 2001; 18 days; Controls received sham surgery; pumps replaced after 10 days; animal info (male, brattleboro, di/di, di/+); v2 agonist; diabetes; A.K.A dDavp or Desmopressin or desmopresinum.

P7641 Silver,S.M., Schroeder,B.M., Sterns,R.H., Rojiani,A.M. Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. Journal of Neuropathology and Experimental Neurology 2006; 65(-1-):37-44. >>> Vasopressin, arginine; SC; Rat; 2001; 4-7 days; Controls received mp w/ agent and varied secondary treatment; animal info (male, Sprague-Dawley 275-350 g, hyponatremia).

P8237 Hoorn,E.J., Hoffert,J.D., Knepper,M.A. Combined proteomics and pathways analysis of collecting duct reveals a protein regulatory network activated in vasopressin escape. Journal of the American Society of Nephrology 2005; 16(-10-):2852-2863. >>> Vasopressin, 1-desamino-8-D-arginine; SC; Rat; 2001; 7 days; Animal info (male, Sprague-Dawley); bioinformatics.

P7578 Sun,R.J., Miller,R.L., Hemmert,A.C., Zhang,P., Shi,H.H., Nelson,R.D., Kishore,B.K. Chronic dDAVP infusion in rats decreases the expression of P2Y2 receptor in inner medulla and P2Y2 receptor-mediated PGE2 release by IMCD. American Journal of Physiology-Renal Physiology 2005; 289(-4-):F768-F776. >>> Vasopressin, l-deamino-8-D arginine; Saline, sterile; SC; Rat; 2002; 5, 6 days; Controls received mp w/ vehicle; dose-response (figs. 8, 9); animal info (male, Sprague-Dawley 309 g); agent also known as dDAVP or desmopressin.

P7464 Ge,Y.Q., Stricklett,P.K., Hughes,A.K., Yanagisawa,M., Kohan,D.E. Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure. American Journal of Physiology-Renal Physiology 2005; 289(-4-):F692-F698. >>> Vasopressin, I-deamino-8-D-arginine; SC; Mice (transgenic); 1002; 3-11 days.

P7364 Hassan,A., Tian,Y., Zheng,W., Ji,H., Sandberg,K., Verbalis,J.G. Small interfering RNA-mediated functional silencing of vasopressin V2 receptors in the mouse kidney. PHYSIOLOGICAL GENOMICS 2005; 21(-3-):382-388. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Mice; 1002; 14 days.

P7351 Sugimura,Y., Murase,T., Takefuji,S., Hayasaka,S., Takagishi,Y., Oiso,Y., Murata,Y. Protective effect of dexamethasone on osmotic-induced demyelination in rats. Experimental Neurology 2005; 192(-1-):178-183. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; 7 days; Peptides.

P7243 Miyazaki,T., Yamamura,Y., Onogawa,T., Nakamura,S., Kinoshita,S., Nakayama,S., Fujiki,H., Mori,T. Therapeutic effects of tolvaptan, a potent, selective nonpeptide vasopressin V2 receptor antagonist, in rats with acute and chronic severe hyponatremia. Endocrinology 2005; 146(-7-):3037-3043. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; 6, 14 days; Controls received mp w/ saline; peptides.

P7231 Hoffert,J.D., Chou,C.L., Fenton,R.A., Knepper,M.A. Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct. Journal of Biological Chemistry 2005; 280(-14-):13624-13630. >>> Vasopressin, 1-deamino-8-D-arginine; Saline; SC; Rat; 2002; 7 days; Controls received mp w/ vehicle.

P7187 Mutsuga,N., Shahar,T., Verbalis,J.G., Xiang,C.C., Brownstein,M.J., Gainer,H. Regulation of gene expression in magnocellular neurons in rat supraoptic nucleus during sustained hypoosmolality. Endocrinology 2005; 146(-3-):1254-1267. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; 7 days; Controls received mp w/ agent w/out water-loading diet; no stress (see pg. 1258); endocrinology.

P7153 Vagnes,O.B., Hansen,F.H., Feng,J.J., Iversen,B.M., Arendshorst,W.J. Enhanced Ca2+ response to AVP in preglomerular vessels from rats with genetic hypertension during different hydration states. American Journal of Physiology-Renal Physiology 2005; 288(-6-):F1249-F1256. >>> Vasopressin, arginine; Saline; SC; Rat; 2001; 6 days; Controls received mp w/ vehicle; cardiovascular; AVP.

P7128 Ge,Y.Q., Ahn,D., Stricklett,P.K., Hughes,A.K., Yanagisawa,M., Verbalis,J.G., Kohan,D.E. Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. American Journal of Physiology-Renal Physiology 2005; 288(-5-):F912-F920. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Mice (transgenic); 1002; 6-7 days.

P7127 Kwon,T.H., Nielsen,J., Knepper,M.A., Frokiaer,J., Nielsen,S. Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats. American Journal of Physiology-Renal Physiology 2005; 288(-4-):F673-F684. >>> Vasopressin, 1-deamino-8-D-arginine; candesartan; Saline, physiological; Na2CO3; SC; Rat; 2001; 7 days; Controls received mp w/ vehicle; multiple pumps per animal (2); mp primed 4 hours in 37 degrees celsius saline.

P6971 Kotnik,P., Nielsen,J., Kwon,T.H., Krzisnik,C., Frokiaer,J., Nielsen,S. Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus. American Journal of Physiology-Renal Physiology 2005; 288(-5-):F1053-F1068. >>> Vasopressin, 1-deamino-8-D-arginine; SC; Rat; 2002; 6 days; Controls received mp w/ vehicle.

P6693 van Balkom,B.W.M., Hoffert,J.D., Chou,C.L., Knepper,M.A. Proteomic analysis of long-term vasopressin action in the inner medullary collecting duct of the Brattleboro rat. American Journal of Physiology-Renal Physiology 2004; 286(-2-):F216-F224. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; Rat; 2001; 72 hours; Controls received mp w/ vehicle.

P6642 Lim,S.W., Li,C., Sun,B.K., Han,K.H., Kim,W.Y., Oh,Y.W., Lee,J.U., Kador,P.F., Knepper,M.A., Sands,J.M., Kim,J., Yang,C.W. Long-term treatment with cyclosporine decreases aquaporins and urea transporters in the rat kidney. American Journal of Physiology-Renal Physiology 2004; 287(-1-):F139-F151. >>> Vasopressin, 1-desamino-8-D arginine; Sodium Chloride; SC; Rat; 2ML1; 7 days.

P6561 Zhang,M.Z., Lopez,P.S., McKanna,J.A., Harris,R.C. Regulation of cyclooxygenase expression by vasopressin in rat renal medulla. Endocrinology 2004; 145(-3-):1402-1409. >>> Vasopressin, arginine-8-; Vasopressin, 1-desamino-8-D arginine; PV-OT; D3PVP; Water, distilled; SC; Rat; 2002; 6 days; Controls received mp w/ vehicle; replacement therapy (hypophysectomy); dose-response (table 1); comparison of IM or IP injections vs. mp; PV-OT is a V1a receptor agonist, D3PVP is a Vlb receptor agonist; dDVAP is a V2 receptor agonist.

P6467 Loyher,M.L., Mutin,M., Woo,S.K., Kwon,H.M., Tappaz,M.L. Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brain. Neuroscience 2004; 124(-1-):89-104. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; Rat; 2002; 7 days; Controls received sham treatment.

P6443 Massieu,L., Montiel,T., Robles,G., Quesada,O. Brain amino acids during hyponatremia in vivo: Clinical observations and experimental studies. Neurochemical Research 2004; 29(-1-):73-81. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 2001; 7 days; Vasopressin, 1-desamino-8-D arginine plasma levels taken.

P6383 Kim,D.G., Sands,J.M., Klein,J.D. Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats. American Journal of Physiology-Renal Physiology 2004; 286(-4-):F760-F766. >>> Vasopressin; Saline; SC; Rat; 2002; 5,12 days; Functionality of mp verified by urine osmolality; diabetes.

P6360 Windle,R.J., Kershaw,Y.M., Shanks,N., Wood,S.A., Lightman,S.L., Ingram,C.D. Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity. Journal of Neuroscience 2004; 24(-12-):2974-2982. >>> Oxytocin; vasopressin; Saline; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; ALZET brain infusion kit; peptides; dental cement used.

R0215 Ishikawa,S., Schrier,R.W. Pathophysiological roles of arginine vasopressin and aquaporin-2 in im paired water excretion. Clinical Endocrinology 2003; 58(-1-):1-17. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 14 days; Peptides; ALZET pumps mentioned on pg. 3 and 10.

P6704 Brooks,H.L., Ageloff,S., Kwon,T.H., Brandt,W., Terris,J.M., Seth,A., Michea,L., Nielsen,S., Fenton,R., Knepper,M.A. cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion. American Journal of Physiology-Renal Physiology 2003; 284(-1-):F218-F228. >>> Vasopressin, 1-desamino-8-D arginine; Saline, isotonic; SC; Rat; 2001; 7 days; 4, 72 hours; Controls received mp w/ vehicle.

P6587 Combet,S., Geffroy,N., Berthonaud,V., Dick,B., Teillet,L., Verbavatz,J.M., Corman,B., Trinh-Trang-Tan,M.M. Correction of age-related polyuria by Vasopressin, 1-desamino-8-D arginine: molecular analysis of aqu aporins and urea transporters. American Journal of Physiology-Renal Physiology 2003; 284(-1-):F199-F208. >>> Vasopressin, 1-desamino-8-D arginine; IP; Rat; 6 days; Controls received mp w/ saline; dose-response (p. F201); no stress (see pg.F201); peptides.

P6005 Michimata,M., Mizukami,K., Suzuki,M., Kazama,I., Nakamura,Y., Suzuki,K., Yanagisawa,T., Imai,Y., Sasaki,S., Matsubara,M. Vasopressin-independent renal urinary concentration: Increased rBSC1 and enhanced countercurrent multiplication. Kidney International 2003; 64(-3-):933-938. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 2002; 3 days; Vasopressin, 1-desamino-8-D arginine is desmopressin acetate.

P5994 Murase,T., Tian,Y., Fang,X.Y., Verbalis,J.G. Synergistic effects of nitric oxide and prostaglandins on renal escape from vasopressin-induced antidiuresis. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-2-):R354-R362. >>> Vasopressin, 1-desamino-8-D arginine; L-NAME; diclofenac; ranitidine; Saline; DMSO; SC; Rat; 2001; 2002; 5 days; Vasopressin, 1-desamino-8-D arginine was infused in the 2002 pump; L-NAME was dissolved in saline and diclofenac was dissolved in 50% DMSO; both were infused from a 2001 pump.

P5935 Zhang,Z., Ferraris,J.D., Brooks,H.L., Brisc,I., Burg,M.B. Expression of osmotic stress-related genes in tissues of normal and hyposmotic rats. American Journal of Physiology-Renal Physiology 2003; 285(-4-):F688-F693. >>> Vasopressin, 1-desamino-8-D arginine; SC; Rat; 2002; 4 days; Vasopressin, 1-desamino-8-D arginine is a V2 selective vasopressin agonist.

P5786 Bardoux,P., Bichet,D.G., Martin,H., Gallois,Y., Marre,M., Arthus,M.F., Lonergan,M., Ruel,N., Bouby,N., Bankir,L. Vasopressin increases urinary albumin excretion in rats and humans: involvement of V-2 receptors and the renin-angiotensin system. NEPHROLOGY DIALYSIS TRANSPLANTATION 2003; 18(-3-):497-506. >>> Vasopressin, 1-desamino-8-D arginine; IP; Rat; 2001; 1 week; Comparison of acute IP injections chronic vs. mp.

P5748 Christensen,B.M., Wang,W.D., Frokiaer,J., Nielsen,S. Axial heterogeneity in basolateral AQP2 localization in rat kidney: effect of vasopressin. American Journal of Physiology-Renal Physiology 2003; 284(-4-):F701-F717. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; Rat; 6 days; Controls received mp w/ vehicle; peptides; Vasopressin, 1-desamino-8-D arginine (1-deamino-(8-D-arginine)-vasopressin) is a V2 selective vasopressin agonist.

P5636 Somponpun,S.J., Sladek,C.D. Osmotic regulation of estrogen receptor-beta in rat vasopressin and oxytocin neurons. Journal of Neuroscience 2003; 23(-10-):4261-4269. >>> Vasopressin, 1-desamino-8-D arginine; Saline, isotonic; IP; Rat; ; Controls received mp w/ vehicle; synthetic selective V2 Vasopressin Agonist.

P5404 Martin,P.Y., Bianchi,M., Roger,F., Niksic,L., Feraille,E. Arginine vasopressin modulates expression of neuronal NOS in rat renal medulla. American Journal of Physiology-Renal Physiology 2002; 283(-3-):F559-F568. >>> Vasopressin, arginine; Saline; IP; Rat; 1 week; Controls received mp w/ vehicle.

P5082 Soupart,A., Silver,S., Schroeder,B., Sterns,R., Decaux,G. Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia. Journal of the American Society of Nephrology 2002; 13(--):1433-1441. >>> Vasopressin, arginine-8-; SC; rat; 2001; 3 days; Vasopressin induced hyponatremia; serum sodium levels checked.

P5079 Silver,S.M., Schroeder,B.M., Sterns,R.H. Brain uptake of myoinositol after exogenous administration. Journal of the American Society of Nephrology 2002; 13(--):1255-1260. >>> Vasopressin; SC; rat; 3 days; controls received mp w/ vehicle; peptides; synthetic vasopressin; chronic vasopressin induced hyponatremia; plasma sodium levels checked..

P5026 Leng,G., Brown,C.H., Bull,P.M., Brown,D., Scullion,S., Currie,J., Blackburn-Munro,R.E., Feng,J.F., Onaka,T., Verbalis,J.G., Russell,J.A., Ludwig,M. Responses of magnocellular neurons to osmotic stimulation involves coactivation of excitatory and inhibitory input: An experimental and theoretical analysis. Journal of Neuroscience 2001; 21(-17-):6967-6977. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 2001; 2002; 5-14 days; peptides; Vasopressin, 1-desamino-8-D arginine is a V2 selective vasopressin agonist;.

P4697 Ecelbarger,C.A, Kim,G.-H, Knepper,M.A, Liu,J, Tate,M, Welling,P.A, Wade,J.B  J.Am.Soc.Nephrol. 2001; 12(--):10-18. >>> Vasopressin, 1-desamino-8-D arginine;; Saline;; rat;; 2001;; 7 days;; Controls received mp w/ vehicle; peptides; Barttner's Disease; d-DAVP is 1-deamino-(8-D-arginine)-vasopressin;.

P4879 Baker,E.A., Tian,Y., Adler,S., Verbalis,J.G. Blood-brain barrier disruption and complement activation in the brain following rapid correction of chronic hyponatremia. Experimental Neurology 2000; 165(--):221-230. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 2001; 7 days; functionality of mp verified by plasma sodium levels; peptides; Vasopressin, 1-desamino-8-D arginine is an arginine vasopressin V2-receptor agonist that causes hyponatremia..

P4860 Glasgow,E., Murase,T., Zhang,B.J., Verbalis,J.G., Gainer,H. Gene expression in the rat supraoptic nucleus induced by chronic hyperosmolality versus hyposmolality. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2000; 279(--):R1239-R1250. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 2002; 7 days; functionality of mp verified by plasma sodium levels; dose response (table 1 p. R1240); peptides; Vasopressin, 1-desamino-8-D arginine induced hyponatremia.

P4443 Wade,J.B, Lee,A.J, Liu,J, Ecelbarger,C.A, Mitchell,C, Bradford,A.D, Terris,J, Kim,G.-H, Knepper,M.A  Am.J.Physiological.Renal Physiol. 2000; 278(--):F52-F62. >>> Vasopressin, 1-desamino-8-D arginine; Saline;; SC;; rat;; 2002;; 7 days;; controls received mp w/vehicle; peptides;.

P4449 Kim,G.H, Ecelbarger,C.A, Mitchell,C, Packer,R.K, Wade,J.B, Knepper,M.A  Am.J.Physiol.(Renal Physiol.45) 1999; 276(--):F96-F103. >>> Vasopressin, 1-desamino-8-D arginine;; Saline;; SC;; rat;; 2002;; 7 days;; controls received mp w/vehicle; peptides;.

P4431 Kwon,T-H, Frokiaer,J, Fernandez-Llama,P, Maunsbach,A.B, Knepper,M.A, Nielsen,S  Am.J.Physiol.(Renal Physiol.46) 1999; 277(--):F257-F270. >>> Vasopressin, 1-desamino-8-D arginine;; NaCl; Dextrose; Acetic acid;; SC;; rat;; 2002;; 7days;; controls received mp w/saline; functionality of mp verified by plasma levels; peptides;.

P4521 Terris,J, Ecelbarger,C.A, Sands,J.M, Knepper,M.A  Journal of the American Society of Nephrology 1998/5; 9(--):729-736. >>> Vasopressin, arginine; Furosemide;; Dextrose; Acetic acid; Sodium Chloride;; rat;; 2002;; 5 days;; controls received mp w/vehicle; functionality of mp verified by plasma levels; peptides;.

P4500 Ecelbarger,C.A, Chou,C-L, Lee,A.J, DiGiovanni,S.R., Verbalis,G.J., Knepper,M.A  Am.J.Physiol.(Renal Physiol.43) 1998; 274(--):F1161-F1166. >>> Vasopressin, 1-desamino-8-D arginine; SC;; rat;; 2002;; 4 days;; peptides;.

P4464 Kwon,T.H, Frokiaer,J, Knepper,M.A, Nielsen,S  Am.J.Physiol.(Renal Physiol.44) 1998; 275(--):F724-F741. >>> Vasopressin, 1-desamino-8-D arginine; Saline; Dextrose; acetic acid;; SC;; rat;; 2002;; 7 days;; controls received mp w/saline + sham surgery;.

P4156 McBroom,M.J., Qureshi,A., Davidson,N. Antidiuretic hormone infusion reduces taurine and NaCl-induced hypernatremia in the rat. Amino Acids 1998; 15(--):89-97. >>> Vasopressin, arginine; Water, distilled; SC; rat; 2001; 8 days; controls received mp w/vehicle; peptides.

P4076 Kjoer,A., Knigge,U., Jorgensen,H., Warberg,J. Selective inhibition of magnocellular vasopressin neurons by hypoosmolality: effect on histamine- and stress-induced secretion of adrenocorticotropin and prolactin. Neuroendocrinology 1998; 67(--):330-335. >>> Vasopressin, 1-desamino-8-D arginine; Acetic acid; SC; rat; 2002; 9 days; controls received mp w/vehicle; functionality of mp verified by measuring residual reservoir volume; vasopressin 2 receptor antagonist.

P4072 Harada,K., Ogura,T., Yamauchi,T., Otsuka,F., Mimura,Y., Hashimoto,M., Oishi,T., Makino,H. Effect of continuous infusion of vasopressin on glomerular growth response in spontaneously hypertensive rats. Regul.Pept. 1998; 74(--):11-18. >>> Vasopressin, arginine; Ringer's solution, lactated; SC; rat; 15 days; controls received mp w/vehicle; cardiovascular; peptides.

P4069 Cordoba,J., Gottstein,J., Blei,A.T. Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis. J.Hepatol. 1998; 29(--):589-594. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; rat; 2002; 7 days; controls received mp w/vehicle; no stress (see p. 591); peptides.

P3813 Everts,H.G.J., Koolhaas,J.M. Lateral septal vasopressin in rats: role in social and object recognition?. Brain Research 1997; 760(--):1-7. >>> Vasopressin antagonist; CSN/CNS (lateral septum); rat; 2002; 2 weeks; controls received mp w/saline; 2 pumps and 2 brain cannulae implanted per animal; cannulae placed in animals 6 days before pumps to allow for recovery.

P4073 Stoynev,A.G., Nagai,K. Lack of effect of suprachiasmatic infusion of a vasopressin antagonist on the circadian rhythm of wheel-running activity in rats. Acta Physiol.Pharmacol.Bulg. 1996; 22(--):39-43. >>> Vasopressin, (Pmp1, Tyr (Me)2)-Arg8; CSF/CNS (suprachiasmatic nucleus); rat; 2001; 8 days; vasopressin antagonist; peptides.

P4049 Kishore,B.K., Terris,J.M., Knepper,M.A. Quantitation of aquaporin-2 abundance in microdissected collecting ducts: axial distribution and control by AVP. Am.J.Physiol.(Renal Fluid Electrolyte Physiol.40) 1996; 271(--):F62-F70. >>> Vasopressin; Arginine; Dextrose solution; Water; Acetic acid; SC; rat; 2002; 1, 3, 5, 14 days; peptides.

P3565 Bouby,N., Ahloulay,M., Nsegbe,E., Deschaux,M., Schmitt,F., Bankir,L. Vasopressin increases glomerular filtration rate in conscious rats through its antidiuretic action. J.Am.Soc.Nephrol. 1996; 7(--):842-851. >>> Vasopressin, 1-desamino-8-D arginine; Inulin; 14C tracer; Radio-isotopes; IP; rat; 2001; 7 days; no comment posted.

P3358 Makara,G.B., Kiss,A., Lolait,S.J., Aguilera,G. Hypothalamic-pituitary corticotroph function after shunting of magnocellular vasopressin and oxytocin to the hypophyseal portal circulation. Endocrinology 1996; 137(-2-):580-586. >>> Vasopressin, desamino- [D-Arg8]-; SC; rat; 2001; 5 days; controls received silastic tubing.

P2967 Adler,S., Verbalis,G.J., Williams,D. Effect of rapid correction of hyponatremia on the blood-brain barrier of rats. Brain Research 1995; 679(--):135-143. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 1,2,7&14 days; controls received mp with isotonic NaCI.

P8223 DiGiovanni,S.R., Nielsen,S., Christensen,E.I., Knepper,M.A. Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat. Proc.Natl.Acad.Sci.U.S.A 1994/9/13; 91(-19-):8984-8988. >>> Vasopressin, arginine 8; Water; dextrose; acetic acid; SC; Rat; 5-6 days; Controls received mp w/ vehicle; animal info (male, Brattleboro di/di, 6-10 weeks old).

P3110 Tsuboi,Y., Ishikawa,S., Fujisawa,G., Okada,K., Saito,T. In vivo diuretic effect of a new non-peptide arginine vasopressin antagonist, OPC-31260, in conscious rats. J.Endocrinol. 1994; 143(--):227-234. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; rat; 2001; no duration posted; controls received mp with vehicle.

P2984 Evans,D.A.P., Van Der Kleij,A.A.M., Sonnemans,M.A.F., Burbach,J.P.H., Van Leeuwen,F.W. Frameshift mutations at two hotspots in vasopressin transcripts in post-mitotic neurons. Proc.Natl.Acad.Sci.USA 1994; 91(--):6059-6063. >>> Vasopressin; SC; rat; 2ML4; 40 weeks; controls received a tube similar in size to mp and were sham operated every 28 days; replacement therapy (genetic -- homozygous(di/di) -- inability to produce vasopressin); long-term study, pumps replaced every 28 days.

P8043 Winslow,J.T., Hastings,N., Carter,C.S., Harbaugh,C.R., Insel,T.R. A role for central vasopressin in pair bonding in monogamous prairie voles. Nature 1993/10/7; 365(-6446-):545-548. >>> Vasopressin, arginine; oxytocin; CSF; CSF/CNS; Prairie vole; 48 hours; Controls received mp w/ vehicle; cannula secured w/ dental cement.

P3197 Hauger,R.L., Aguilera,G. Regulation of pituitary corticotropin releasing hormone (CRH) receptors by CRH: interaction with vasopressin. Endocrinology 1993; 133(--):1708-1714. >>> Corticotropin-rel. factor; Vasopressin; Vasopressin antagonist; SC; rat; 2001; 48 hours; controls received inactive mp or silastic tubing; peptides; the vasopressin antagonist was (mercapto cyclopenta-methylene propionic acid)-[methyl-tyrosine]arginine VP; agents given singly or together.

P3108 Tsuchihashi,T., Takata,Y., Nakao,Y., Tominaga,M., Takishita,S., Kobayashi,K., Abe,I., Fujishima,M. Haemodynamic and humoral consequences of chronic infusion of vasopressin in conscious rats. Clin.Exp.Pharmacol.Physiol. 1993; 20(--):489-495. >>> Vasopressin, arginine; Saline; IV (jugular); rat; 2001; 7 days; controls received mp with vehicle; peptides.

P2608 Allen,D.E., Gellai,M. a2-Adrenoceptor antagonism attenuates the diuretic response to acute cold exposure. Am.J.Physiol. 1993; 265(-34-):R689-R696. >>> Vasopressin, arginine; Acetic acid; Ringer's solution, lactated; SC; rat; 2002; no duration posted; peptides.

P2600 Allen,D.E., Gellai,M. Mechanisms for the diuresis of acute cold exposure: role for vasopressin?. Am.J.Physiol. 1993; 264(-33-):R524-R532. >>> Vasopressin, arginine; Acetic acid; Ringer's solution, lactated; SC; rat; 2002; 14 days; peptides.

P2518 Verbalis,J.G., Gullans,S.R. Rapid correction of hyponatremia produces differential effects on brain osmolyte and electrolyte reaccumulation in rats. Brain Research 1993; 606(--):19-27. >>> Vasopressin, 1-deamino-8-D-arginine; SC; rat; 2002; 14 days; functionality of mp verified by plasma Na levels; dose-response (pg. 20 plasma).

P2205 Fujisawa,G., Ishikawa,S.-E., Tsuboi,Y., Okada,K., Saito,T. Therapeutic efficacy of non-peptide ADH antagonist OPC-31260 in SIADH rats. Kidney Int. 1993; 44(--):19-23. >>> Vasopressin, 1-deamino-8-D-arginine; Sodium chloride; SC; rat; 2002; 14 days; controls received vehicle in mp; OPC-31260 was given orally.

P3122 Tizabi,Y., Aguilera,G. Desensitization of the hypothalamic-pituitary-adrenal axis following prolonged administration of corticotropin-releasing hormone or vasopressin. Neuroendocrinology 1992; 56(--):611-618. >>> Corticotropin-rel. factor; Vasopressin; SC; rat; 48-50 hours; controls received silastic tubing; peptides; animals given CRF or CRF + vasopressin.

P3109 Tsuchihashi,T., Takata,Y., Tomita,Y., Takishita,S., Nakao,Y., Kobayashi,K., Fujishima,M. Chronic cardiovascular effects of central vasopressin in conscious rats. Clin.Exp.Hypertens.-Theory Pract. 1992; A14(-4-):699-716. >>> Vasopressin, arginine; Saline; IV (jugular); CSF/CNS; rat; 7 days; controls received mp with saline; functionality of mp verified by residual volume; stability verified by bioactivity after 7 days at 37 degrees; peptides.

P2235 Cridland,R.A., Kasting,N.W. A critical role for central vasopressin in regulation of fever during bacterial infection. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.32) 1992; 263(-32-):R1235-R1240. >>> [d(CH2)5Tyr(Me)] arginine vasopressin; Saline; CSF/CNS (ventral septal area); rat; 2001; no duration posted; functionality of mp verified by measuring residual volume; bilateral brain cannulae used; [d(CH2)5Tyr(Me)]AVP is a V1 antagonist; telemetry used to monitor body temperature.

P2130 Burgess,W.J., Balment,R.J. Plasma atrial natriuretic peptide in vasopressin deficiency: the effects of acute water deprivation in rats. J.Endocrinol. 1992; 135(--):431-438. >>> Vasopressin, arginine; Saline; SC; rat; 2001; 7 days; controls received mp with vehicle; replacement therapy (genetic deficiency); peptides.

P2172 Bachmann,S., Dawnay,A.B.S.J., Bouby,N., Bankir,L. Tamm-horsfall protein excretion during chronic alterations in urinary concentration and protein intake in the rat. Renal Physiol.Biochem. 1991; 14(--):236-245. >>> Furosemide; Vasopressin, 1-deamino-8-D-arginine; IP; rat; 2002; 2ML1; 10, 11, 12 days; controls received sham operation; antihypertensive; DDAVP.

P1986 Inaba,M., Katayama,S., Itabashi,A., Maruno,Y., Ishii,J. Effects of arginine vasopressin on blood pressure and renal prostaglandin E2 in rabbits. Endocrinol.Japan 1991; 38(-5-):505-509. >>> Vasopressin, arginine; Acetic acid; SC; rabbit; 1 week; functionality of mp verified by plasma levels of AVP; peptides.

P1970 Wang,Y.-X., Franco,R., Gavras,I., Gavras,H. Effects of chronic administration of a vasopressin antagonist with combined antivasopressor and antidiuretic activities in rats with left ventricular dysfunction. J.Lab.Clin.Med. 1991; 117(--):313-318. >>> Vasopressin antagonist; Dextrose; Water; IV (jugular); rat; 2002; no duration posted; no comment posted.

P1942 Caltabiano,S., Kinter,L.B. Up-regulation of renal adenylate cyclase-coupled vasopressin receptors after chronic administration of vasopressin antagonists to rats. J.Pharmacol.Exp.Ther. 1991; 258(-3-):1046-1054. >>> SKF-100273; SKF-101485; SKF-101926; Vasopressin; Saline; SC; rat; 2001; 5 days; peptides; vasopressin antagonists.

P1760 Verbalis,J.G., Mangione,M.P., Stricker,E.M. Oxytocin produces natriuresis in rats at physiological plasma concentrations. Endocrinology 1991; 128(-3-):1317-1322. >>> Oxytocin antagonist; Oxytocin; Vasopressin antagonist; SC; rat; 2001; no duration posted; 4 doses of oxytocin infused, some animals received 2 pumps.

P3267 Malendowicz,L.K., Miskowiak,B. Effects of prolonged administration of neurotensin, arginine-vasopressin, NPY, and bombesin on blood TSH, T3, and T4 levels in the rat. In Vivo 1990; 4(--):259-262. >>> Neurotensin; Vasopressin, arginine; Bombesin; Saline; IP; rat; 7,8 days; controls received mp w/saline; peptides.

P2040 Yasujima,M., Abe,K., Tanno,M., Kohzuki,M., Kanazawa,M., Yoshida,K., Omata,K., Sato,M., Takeuchi,K., Hiwatari,M., Sato,T., Yoshinaga,K. Effects of digoxin on blood pressure responses to norepinephrine, angiotensin II and vasopressin in conscious rats. Tohoku J.Exp.Med. 1990; 162(--):203-212. >>> Angiotensin II; Norepinephrine bitartrate; Vasopressin; Acetic acid; Ascorbic acid; Glutathione; IP; rat; 2001; 6 days; peptides.

P1746 Kim,J.K., Soubrier,F., Michel,J.-B., Bankir,L., Corvol,P., Schrier,R.W. Arginine vasopressin gene regulation in the homozygous brattleboro rat. J.Clin.Invest. 1990; 86(--):14-16. >>> Vasopressin, arginine; SC; rat; 2 weeks; replacement therapy (hereditary AVP deficiency).

P1661 Robinson,A.G., Roberts,M.M., Evron,W.A., Verbalis,J.G., Sherman,T.G. Hyponatremia in rats induces downregulation of vasopressin synthesis. J.Clin.Invest. 1990; 86(--):1023-1029. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; rat; 2002; 14 days; no comment posted.

P1636 Cowley,Jr.,B.D., Ferraris,J.D., Carper,D., Burg,M.B. In vivo osmoregulation of aldose reductase mRNA, protein, and sorbitol in renal medulla. Am.J.Physiol. 1990; 27(-1-):F154-F161. >>> Vasopressin, arginine; SC; 2002; 7 days; peptides.

P1592 Brooks,D.P., Solleveld,H.A., Contino,L.C. Vasopressin and the pathogenesis of chronic renal failure. Br.J.Pharmacol. 1990; 100(--):79-82. >>> Vasopressin antagonist; Saline; IP; rat; 2002; no duration posted; pumps replaced after 2 weeks; agent is [1-(B-mercapto-B, B-cyclopentamethylene propionic acid), 1-(0-methyl tyrosine), 8-arginine vasopressin.

P1788 Cornett,L.E., Breckinridge,S.M., Koike,T.I. Induction of V2 receptors in renal medulla of homozygous brattleboro rats by arginine vasopressin. Peptides 1989; 10(--):985-991. >>> Vasopressin, arginine; SC; rat; 2002; 14 days; controls received pumps with saline only; peptides; 4 doses infused.

P1681 McDaniel,W.F., Waters,P.E., Davall,E.J. Arginine vasopressin 4-9 retards spatial alternation learning. Neuropeptides 1989; 14(--):219-224. >>> Vasopressin, arginine; Saline; SC; rat; 2002; no duration posted; no comment posted.

P1556 van Tol,H.H., Kiss,J.Z., Burbach,J.P. Differential responses in vasopressin and oxytocin gene expression in distinct hypothalamic nuclei after hypothalamoneurohypophyseal disconnection and vasopressin substitution. Neuroendocrinology 1989; 49(--):337-343. >>> Vasopressin, arginine; SC; rat; 2002; 1 week; dose-response; stability of agent verified; peptides.

P1530 Arnauld,E., Bibene,V., Meynard,J., Rodriguez,F., Vincent,J.-D. Effects of chronic ICV infusion of vasopressin on sleep-waking cycle of rats. Am.J.Physiol. 1989; 256(--):R674-R684. >>> Antibody, anti-oxytocin; Antibody, anti-vasopressin, arginine; Oxytocin, 2-phenylalanine,8-ornithine; Serum, rabbit; Oxytocin; Vasopressin, 1-desamino-8-D arginine; Vasopressin, arginine; CSF, artificial; CSF/CNS; rat; 2002; 9, 10 days; dose-response; functionality of mp verified by plasma levels; peptides.

P1518 Hyde,J.F., North,W.G., Ben-Jonathan,N. The vasopressin-associated glycopeptide is not a prolactin-releasing factor: studies with lactating Brattleboro rats. Endocrinology 1989; 125(-1-):35-40. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat (pregnant); 2002; 2 weeks; vasopressin analog; peptides.

P1450 Sterns,R.H., Thomas,D.J., Herndon,R.M. Brain dehydration and neurologic deterioration after rapid correction of hyponatremia. Kidney Int. 1989; 35(--):69-75. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 2001; 2002; 5 days; no comment posted.

P1534 Kaissling,B., Stanton,B.A. Adaptation of distal tubule and collecting duct to increased sodium delivery I; ultrastructure. Am.J.Physiol. 1988; 255(--):F1256-F1268. >>> Aldosterone; Dexamethasone; Furosemide; Vasopressin, arginine; Saline; SC; Rat; 2002; 2ML1; 6 days; Dose-response; multiple pumps per animal (2); functionality of mp verified by plasma levels; replacement therapy (adrenalectomy); antihypertensive.

P1503 Gavras,I., Mulinari,R., Gavras,H. Renin-angiotensin and vasopressin in the development of salt-induced hypertension. J.Hypertens. 1988; 6(--):999-1002. >>> Vasopressin antagonist; IV (jugular); rat; 10 days; dose-response.

P1388 Sladek,C.D., Blair,M.L., Sterling,C., Mangiapane,M.L. Attenuation of spontaneous hypertension in rats by a vasopressin antagonist. Hypertension 1988; 12(--):506-512. >>> Vasopressin antagonist; Vasopressin, arginine; Saline; SC; rat; 2002; 8, 14 weeks; pump replaced at 2 week intervals; long-term study.

P1366 Regunathan,S., Sourkes,T.L. Effect of vasopressin on the induction of adrenal tyrosine hydroxylase and phenylethanolamine n-methyltransferase. Regul.Pept. 1988; 23(--):217-226. >>> Vasopressin, arginine; Acetic acid; Saline; Water; SC; rat; 6 days; peptides.

P1364 Mah,S.C., Opperman,J.R., Baum,H.P., Hofbauer,K.G. Biologic response to chronic blockade of vasopressin receptors in Sprague-Dawley rats. J.Pharmacol.Exp.Ther. 1988; 245(-3-):1021-1027. >>> Vasopressin antagonist; Water; IV (femoral); rat; 2001; 2002; 7, 14 days; comparison of sc injections vs. mp infusion.

P1354 Bohman,S.-O., Sundelin,B., Forsum,U., Tribukait,B. Experimental depletion of different renal interstitial cell populations. Am.J.Med.Sci. 1988; 295(-4-):252-257. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 21 days; pump model not stated; comparision of sc injections vs. mp infusion.

P1351 Bankir,L., Fischer,C., Fischer,S., Jukkala,K., Specht,H.C., Kriz,W. Adaptation of the rat kidney to altered water intake and urine concentration. Pflugers Arch. 1988; 412(--):42-53. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 2002; 6 weeks; replacement therapy (hereditary ADH deficiency); long-term study; pump replaced every 2 weeks; peptides.

P1283 Weyer,P., Brown,D., Orci,L. Lectin-gold labeling of glycoconjugates in normal and Brattleboro rat papilla: effect of vasopressin. Am.J.Physiol. 1988; 254(--):C450-C458. >>> Vasopressin, lysine; Saline; SC; rat; 2002; 5 weeks and 14, 21 days; replacement therapy (genetic vasopressin defect); pump replaced every 2 weeks.

P1275 Mah,S.C., Hofbauer,K.G. Evaluation of the pharmacologic properties of a vasopressin antagonist in brattleboro rats. J.Pharmacol.Exp.Ther. 1988; 245(-3-):1028-1032. >>> Vasopressin antagonist; Vasopressin, arginine; Saline; IV (femoral); rat; 2001; 2002; 1, 2 weeks; controls received mp w/saline; replacement therapy (hereditary AVP deficit.); peptides.

P1182 Verbalis,J.G., Baldwin,E.F., Neish,P.N., Robinson,A.G. Effect of protein intake and urea on sodium excretion during inappropriate antidiuresis in rats. Metabolism 1988; 37(-1-):46-54. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 4 days; Pump model not stated; hyponatremia induced by d DAVP infusion; peptides.

P1195 Herman,J.P., Marciano,F.F., Wiegand,S.J., Gash,D.M. Selective cell death of magnocellular vasopressin neurons in neurohypophysectomized rats following chronic administration of vasopressin. J.Neurosci. 1987; 7(-8-):2564-2575. >>> Vasopressin, arginine; Saline, bacteriostatic; SC; rat; 2002; 2 weeks; controls received mp w/ saline; replacement therapy (hypophysectomy); peptides.

P1162 Holmes,M.C., Catt,K.J., Aguilera,G. Involvement of vasopressin in the down-regulation of pituitary corticotropin-releasing factor receptors after adrenalectomy. Endocrinology 1987; 121(-6-):2093-2098. >>> Dye, Trypan blue; Corticotropin-rel. factor; Vasopressin; Saline; SC; rat; 48 hours; Pump model not stated; concomitant and simultaneous infusion of agents; functionality of mp verified; replacement therapy (vasopressin deficiency); peptides.

P1045 Vilhardt,H., Lundin,S. Antidiuretic antagonism and agonism of 1-deamino-pentamethylene-2-D-phenylalanine-4-isoleucine-arginine vasopressin in rats with diabetes insipidus. J.Endocrinol. 1987; 112(--):439-442. >>> Oxytocin; Vasopressin antagonist; Vasopressin, arginine; Saline; IP; rat; 2001; 7 days; controls received mp w/vehicle; peptides; concomitant infusion of AVP w/antagonist and oxytocin w/antagonist; functionality of mp verified.

P1038 Tinius,T.P., Beckwith,B.E., Preussler,D.W. Prenatal administration of arginine vasopressin impairs memory retrieval in adult rats. Peptides 1987; 8(-3-):493-499. >>> Vasopressin, arginine; Saline; SC; rat (pregnant); 2001; 6 days; controls received mp w/vehicle; peptides.

P0929 Mokry,H., Rao,B., George,J.M., Sriram,M.G. Effect of two-week infusion of deamino D-arginine vasopressin in rats. Horm.Res. 1987; 25(--):60-64. >>> Vasopressin, 1-desamino-8-D arginine; Sodium chloride; SC; rat; 2001; 2 weeks; pumps replaced after 1 week; half-life data; peptides.

P1032 Yasujima,M., Abe,K., Kohzuki,M., Tanno,M., Kasai,Y., Sato,M., Omata,K., Kudo,K., Takeuchi,K., Yoshinaga,K. Antihypertensive effect of synthetic atrial natriuretic factor in vasopressin-infused rats. Jpn.Circ.J. 1986; 50(--):1185-1190. >>> Atrial natriuretic factor; Vasopressin, arginine; Acetic acid; Saline; IP; IV (jugular); rat; 6/3 days; controls received mp w/vehicle; mp connected to catheter in jugular; peptides; 2 pumps/animal; agents inf. simult. for 3 days; ANF pump removed after 3 days; ANF infused iv; vp infused ip; stability of ANF verified.

P1020 Aperia,A., Sahlgren,B., Eklof,A.-C., Lundin,S., Melin,P. Role of arginine-vasopressin for the development of hypertension following aortic constriction. Acta Physiol.Scand. 1986; 128(--):495-499. >>> Vasopressin, 1-desamino-8-D arginine; Vasopressin, arginine; IP; rat; 2002; 2 weeks; controls received mp w/vehicle; peptides; animals rec'd either sham-operation or constriction of renal arteries; vehicle mentioned but not identified.

P1001 Sladek,C.D., Blair,M.L., Mangiapane,M. Evidence against a pressor role for vasopressin in spontaneous hypertension. Hypertension 1986; 9(--):332-338. >>> Vasopressin, arginine; Saline; SC; rat; 2002; 8-10 weeks; controls received mp w/vehicle; pumps replaced every 2 wks; peptides; rats were spontaneously hypertensive; comparison of iv injections vs. mp infusion; long-term study.

P0936 Cheng,S.W.T., North,W.G. Exogenous vasopressin modulates activity of oxytocin neurons in homozygous Brattleboro rats. Am.J.Physiol. 1986; 251(--):E556-E562. >>> Vasopressin, 1-desamino-8-D arginine; Vasopressin, arginine; SC; rat; 2002; 12 days; comparison of ip injections vs. mp infusion; peptides.

P0922 Craven,P.A., Verbalis,J.G., DeRubertis,F.R. Increased urinary excretion of PGE2 during inappropriate antidiuresis induced by Vasopressin, 1-desamino-8-D arginine. Kidney Int. 1986; 29(--):1110-1115. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; rat; 2001; 24 hours; controls were sham operated; mps primed in saline prior to implant; peptides.

P0883 Besseghir,K., Trimble,M.E., Stoner,L. Action of ADH on isolated medullary thick ascending limb of the Brattleboro rat. Am.Physiol.Soc. 1986; (--):271-277. >>> Vasopressin, arginine; SC; rat; 2002; 10-21 days; functionality of mp verified by urine osmolality; peptides; mp replaced.

P0864 Hinojosa,C., Haywood,J.R. Development of high sodium renal hypertension during chronic blockade of the vascular effects of vasopressin. J.Pharmacol.Exp.Ther. 1986; 238(-2-):492-496. >>> Vasopressin antagonist; Albumin; Saline; SC; rat; 2ML1; 5 days; controls received mp w/ vehicle and sham surgery; hypertension; pumps primed in saline for 4 hours; peptides.

P0844 Williams,J.L., Johnson,M.D. Sympathetic nervous system and blood pressure maintenance in the Brattleboro DI rat. Am.J.Physiol. 1986; 250(--):R770-R775. >>> Vasopressin, arginine; Saline; SC; rat; 2001; 7 days; controls received mp w/saline; mp used in 2 of four experiments; peptides.

P0832 Berecek,K.H., Mitchum,T.N. Role of vasopressin in the cardiovascular response to stimulation of the locus coeruleus. Endocrinology 1986; 118(-5-):1829-1934. >>> Vasopressin; CSF/CNS; rat; 2001; 10-14 days; mp connected to catheter in the lateral cerebroventricle; peptides.

P0806 Kline,R.L., Patel,K.P., Mercer,P.F. Enhanced noradrenergic activity in kidney of brattleboro rats with diabetes insipidus. Am.J.Physiol. 1986; 250(--):R567-R572. >>> Vasopressin, 1-desamino-8-D arginine; SC; rat; 2001; 7 days; vasopressin tannate given by sc injection in one group, mp infusion of Vasopressin, 1-desamino-8-D arginine in other group; diabetes; peptides.

P0746 Rigter,H., Crabbe,J.C. Vasopressin and ethanol preference. I. Effects of vasopressin and the fragment DGAVP on altered ethanol preference in Brattleboro diabetes insipidus rats. Peptides 1985; 6(-4-):669-676. >>> Vasopressin, desglycinamide-arginine; Vasopressin, lysine; Saline; SC; rat; 1701; 7-9 days; replacement therapy (vasopressin deficiency); states mps actually released for 9 days and estimated rate of release was lowered accordingly; controls received mp w/vehicle; 2 seperate exp. using mps; peptides.

P0744 Bouby,N., Bankir,L., Trinh-Trang-Tan,M.M., Minuth,W.W., Kriz,W. Selective ADH-induced hypertrophy of the medullary thick ascending limb in Brattleboro rats. Kidney Int. 1985; 28(--):456-466. >>> Vasopressin, 1-desamino-8-D arginine; IP; rat; 1701; 5-6 weeks; mp replaced every 2nd week; peptides.

P0732 Seeber,A.M., Vila,S.B., Catanzaro,O.L. Effect of norepinephrine and vasopressin on renal kallikrein excretion in rats. Arch.Int.Physiol.Biochim. 1985; 93(--):83-88. >>> Norepinephrine; Vasopressin; Ascorbic acid; Water; abdomen; rat; 2001; 1 week; comparison of acute iv infusion vs. chronic mp infusion; peptides.

P0706 Trinh-Trang-Tan,M.M., Bankir,L., Doucet,A., El Mernissi,G., Imbert-Teboul,M., Montegut,M., Siaume,S., Morel,F. Influence of chronic ADH treatment on adenylate cyclase and ATPase activity in distal nephron segments of diabetes insipidus Brattleboro rats. Pflugers Arch. 1985; 405(-3-):216-222. >>> Vasopressin; IP; rat; 2002; 8-10 weeks; mp replaced every 2 weeks; long-term study; peptides; replacement therapy (genetically deprived of ADH).

P0668 Lundin,S., Melin,P., Vilhardt,H. Use of three specific radioimmunoassays in measuring neurohypophysial hormone content and plasma concentrations of vasopressin, oxytocin and Vasopressin, 1-desamino-8-D arginine in rats after prolonged infusion of Vasopressin, 1-desamino-8-D arginine. Experientia 1985; 41(-7-):933-935. >>> Vasopressin, 1-desamino-8-D arginine; Saline, bacteriostatic; IP; rat; 2001; 3 days; stability of Vasopressin, 1-desamino-8-D arginine in pump implied by RIA determination in plasma; peptides.

P0570 Koch,B., Lutz-Bucher,B. Specific receptors for vasopressin in the pituitary gland: evidence for down-regulation and desensitization to adrenocorticotropin-releasing factors. Endocrinology 1985; 116(-2-):671-676. >>> Vasopressin, arginine; Vasopressin, lysine; SC; rat; 1 week; comparison of 3x daily sc injec vs. mp infusion; comparison of agents effects; peptides.

P0622 Kruisbrink,J., Boer,G.J. Controlled long-term release of small peptide hormones using a new microporous polypropylene polymer: its application for vasopressin in the Brattleboro rat and potential perinatal use. J.Pharm.Sci. 1984; 73(-12-):1713-1718. >>> Vasopressin; Saline; SC; rat; 2002; 20 days; replacement therapy (vasopressin deficiency) comparison of mp vs. a Vaso-loaded microporous polymer implant, an agar-collodion preparation,&daily sc injections; peptides.

P0594 Bouby,N., Trinh-Trang-Tan,M.M., Bankir,L. Stimulation of tubular reabsorption of magnesium and calcium by antidiuretic hormone in conscious rats: study in Brattleboro rats with hereditary hypothalamic diabetes insipidus. Pflugers Arch. 1984; 402(--):458-464. >>> Vasopressin, 1-desamino-8-D arginine; Saline; IP; rat (neonate); 2002; more than 2 weeks; no stress p. 463 - refers to value of exp. with non-stressed animals; prior to implant w/ mp, neonate rats received daily sc admin. of Vasopressin, 1-desamino-8-D arginine; peptides; teratology.

P0541 Krukoff,T.L., Calaresu,F.R. Exogenous vasopressin reverses hyperactivity in the hypothalamus of Brattleboro rats. Am.J.Physiol. 1984; 247(-5-):R932-R935. >>> Vasopressin, arginine; Saline; SC; rat; 2001; 1 week; peptides.

P0532 Verbalis,J.G. An experimental model of syndrome of inappropriate antidiuretic hormone secretion in the rat. Am.J.Physiol. 1984; 247(--):E540-E553. >>> Vasopressin, 1-desamino-8-D arginine; Vasopressin, arginine; Saline; SC; rat; 2001; 1-5 days; comparison of agents effects; advantage of mp use p548; peptides.

P0492 Hofbauer,K.G., Mah,S.C., Baum,H.-P., Hanni,H., Wood,J.M., Kraetz,J. Endocrine control of salt and water excretion: the role of vasopressin in DOCA-salt hypertension. J.Cardiovasc.Pharmacol. 1984; 6(-1-):S184-S191. >>> Vasopressin antagonist; Saline; IV (femoral); rat; 2001; 2002; 1&6 weeks; pumps replaced after 2nd and 4th week; long-term study; concomitant ADOCA pellets used; peptides.

P0486 Trinh-Trang-Tan,M.-M., Bouby,N., Doute,M., Bankir,L. Effect of long- and short-term antidiuretic hormone availability on internephron heterogeneity in the adult rat. Am.J.Physiol. 1984; 246(--):F879-F888. >>> Vasopressin, 1-desamino-8-D arginine; Saline; IP; rat; 1702; 2002; 4&6 weeks; pumps replaced every 2 weeks; long-term study; comparison of daily sc inject. vs. acute infusion vs. ip mp infusion; intermittent inject. vs. mp infusion; peptides.

P0485 Gellai,M., Silverstein,J.H., Hwang,J.-C., LaRochelle Jr,F.T., Valtin,H. Influence of vasopressin on renal hemodynamics in conscious Brattleboro rats. Am.J.Physiol. 1984; 246(--):F819-F827. >>> Vasopressin, arginine; SC; rat; 10 days; mp model not stated; comparison of injection vs. infusion vs. prolonged mp infusion; dose-response data; peptides.

P0471 Bouby,N., Trinh-Trang-Tan,M.M., Doute,M., Bankir,L. Effects of osmolality and antidiuretic hormone on prostaglandin synthesis by renal papilla: study in Brattleboro rats with diabetes insipidus. Pflugers Arch. 1984; 400(-1-):96-99. >>> Vasopressin, 1-desamino-8-D arginine; IP; rat; 1701; 1 day; peptides.

P0399 Beasley,D., Malvin,R.L., Mouw,D.R. CNS-induced natriuresis and renal hemodynamics in conscious rats. Am.J.Physiol. 1983; 245(--):F763-F771. >>> Vasopressin, arginine; SC; rat; 2002; at least 1 week; comparison of acute iv infusion vs. mp infusion; peptides.

P0386 Woods,R.L., Johnston,C.I. Contribution of vasopressin to the maintenance of blood pressure during dehydration. Am.J.Physiol. 1983; 245(--):F615-F621. >>> Vasopressin, 1-desamino-8-D arginine; Vasopressin, arginine; SC; rat; 6 days; comparison of agents effects; peptides.

P0369 Russell,W.E., Bucher,L.R. Vasopressin modulates liver regeneration in the Brattleboro rat. Am.J.Physiol. 1983; 245(--):G321-G324. >>> Vasopressin, arginine; Saline; IP; rat; 2001; 5 days; peptides.

P0356 Berecek,K.H., Webb,R.L., Brody,M.J. Evidence for a central role for vasopressin in cardiovascular regulation. Am.J.Physiol. 1983; 244(-6-):H852-H859. >>> Vasopressin, arginine; Acetic acid, glacial; Saline; CSF/CNS; rat; 2001; 5-7 days; comparison of injec. vs. mp infusion; peptides.

P0295 Jerome,M.L., Barbella,Y.R., Wurpel,J., Keil,L.C., Severs,W.B. Eating, drinking and urine output after prolonged cerebroventricular vasopressin infusions in rats. Pharmacology 1983; 26(--):79-84. >>> Vasopressin, arginine; Saline; CSF/CNS; rat; 2001; 5 days; peptides.

P0394 Bayle,F., Eloy,L., Trinh-Trang-Tan,M.-M., Grunfeld,J.-P., Bankir,L. Papillary plasma flow in rats. I. Relation to urine osmolality in normal and Brattleboro rats with hereditary diabetes insipidus. Pflugers Arch. 1982; 394(--):211-216. >>> Vasopressin, 1-desamino-8-D arginine; IP; rat; 1701; 5 days; comparison of acute infusion vs. continuous mp infusion; peptides.

P0263 Gash,D.M., Warren,P.H., Dick,L.B., Sladek,J.R., Ison,J.R. Behavioral modification in Brattleboro rats due to vasopressin administration and neural transplantation. Ann.N.Y.Acad.Sci. 1982; 394(--):672-688. >>> Vasopressin, arginine; Saline; SC; rat; 2001; 10 days; replacement therapy (vasopressin deficiency); peptides.

P0262 Rigter,H., Crabbe,J. Ethanol preference in homozygous diabetes insipidus (Brattleboro) rats: effect of vasopressin fragments. Ann.N.Y.Acad.Sci. 1982; 394(--):663-671. >>> Vasopressin, desglycinamide-arginine; Vasopressin, lysine; Saline; SC; rat; 1701; 8-9 days; peptides.

P0261 Fujimoto,S., Hedge,G.A. Alterations in pituitary function in rats with hypothalamic diabetes insipidus (Brattleboro strain). Ann.N.Y.Acad.Sci. 1982; 394(--):614-618. >>> Vasopressin, 1-desamino-8-D arginine; Vasopressin, arginine; Saline; SC; rat; 1 week; peptides.

P0260 Fujimoto,S., Hedge,G.A. Abnormalities in thyrotropin and thyroxine secretion in Brattleboro rats. Ann.N.Y.Acad.Sci. 1982; 395(--):549-559. >>> Vasopressin, 1-desamino-8-D arginine; Vasopressin, arginine; Saline; SC; rat; 1 week; peptides.

P0259 Cheng,S.W.T., North,W.G., Gellai,M. Replacement therapy with arginine vasopressin in homozygous Brattleboro rats. Ann.N.Y.Acad.Sci. 1982; 394(--):473-480. >>> Vasopressin, arginine; Acetic acid; Saline; IP; SC; rat; 2002; 7-10 days; replacement therapy (vasopressin deficiency); no stress - p. 474, 479; peptides.

P0258 Kinter,L.B. Water balance in the Brattleboro rat: considerations for hormone replacement therapy. Ann.N.Y.Acad.Sci. 1982; 394(--):448-463. >>> Vasopressin tannate; Vasopressin, 1-desamino-8-D arginine; Vasopressin, arginine; Vasopressin, lysine; IP; rat; 1701; 1 week; comparison of bolus inject., gavage, oral self-admin., and mp infusion; comparison of agents effects; replacement therapy (vasopressin deficiency) ; peptides.

P0257 Sundelin,B., Bohman,S.-O. Interstitial cells in the renal medulla of Brattleboro rats: effects of long term vasopressin treatment. Ann.N.Y.Acad.Sci. 1982; 394(--):435-447. >>> Vasopressin, arginine; Peanut oil; Saline; SC; rat; 19 days; comparison of inject. vs. mp infusion; peptides.

P0256 Gellai,M. The role of vasopressin in the control of renal hemodynamics. The Brattleboro rat as an experimental model. Ann.N.Y.Acad.Sci. 1982; 394(--):343-349. >>> Oxytocin; Vasopressin, arginine; SC; rat; 10 days; peptides.

P0255 Saito,T., Yajima,Y. Development of DOCA-salt hypertension in the Brattleboro rat. Ann.N.Y.Acad.Sci. 1982; 394(--):309-318. >>> Vasopressin, 1-desamino-8-D arginine; Vasopressin, arginine; SC; rat; 10 weeks; peptides; pumps replaced; long-term study.

P0250 Kinter,L.B., Beeuwkes III,R. Oral antidiuretic therapy: studies in the diabetes insipidus rat. Am.J.Physiol. 1982; 243(--):R491-R499. >>> Vasopressin, 1-desamino-8-D arginine; Vasopressin, arginine; Water; IP; rat; 1 week; comparison of oral admin. vs. ip infusion; replacement therapy (vasopressin deficiency); peptides.

P0231 Christensen,S., Agner,T. Effects of lithium on circadian cycles in food and water intake, urinary concentration and body weight in rats. Physiol.Behav. 1982; 28(--):635-640. >>> Vasopressin, arginine; Saline; IV (atrium); rat; 1701; 1 week; peptides.

P0207 Beck,T.R., Hassid,A., Dunn,M.J. Desamino-D-arginine vasopressin induces fatty acid cyclooxygenase activity in the renal medulla of diabetes insipidus rats. J.Pharmacol.Exp.Ther. 1982; 221(-2-):269-274. >>> Vasopressin, 1-desamino-8-D arginine; Saline; IP; rat; 5 days; peptides.

P0204 Fujimoto,S., Hedge,G.A. Altered pituitary-thyroid function in the brattleboro rat with diabetes insipidus. Endocrinology 1982; 110(-5-):1628-1633. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; rat; 7 days; replacement therapy (vasopressin deficiency); peptides.

P0168 Mills,D.E., Buckman,M.T., Peake,G.T. Effects of prolactin administration and suppression on blood pressure and body fluid compartments in the rat. Endocrinology 1981; 109(-5-):1590-1596. >>> Lergotrile mesylate; Prolactin, ovine; Vasopressin, 1-desamino-8-D arginine; Saline; IP; rat; no duration posted; Exp. 1-3, 1701, 7 days: 1)saline, oPRL,&LM&oPRL simultaneously; 2&3)saline, oPRL, Vasopressin, 1-desamino-8-D arginine; 4) 2001, 7 days, saline, oPRL; peptides.

P0123 Walker,L.A., Frolich,J.C. Dose-dependent stimulation of renal prostaglandin synthesis by deamino-8-D-arginine vasopressin in rats with hereditary diabetes insipidus. J.Pharmacol.Exp.Ther. 1981; 217(-1-):87-91. >>> Vasopressin, 1-desamino-8-D arginine; Saline; SC; rat; 7 days; pumps replaced 3-4 days after removal of previous pump for dose-response studies; long-term study; peptides.

P0087 Melin,P., Lundin,S., Vilhardt,H., Lindeberg,G., Larsson,L.-E., Pliska,V. Antidiuretic agonism and antagonism of some O-alkylated analogues of vasopressin containing 2-O-alkylated tyrosine. Eur.J.Pharmacol. 1980; 67(-2/3-):173-177. >>> Vasopressin, d-ethyl-lysine; Vasopressin, lysine; Saline; SC; rat; 4 days; simultaneous&separate infusion of agents; peptides.

P0076 Christensen,S. Failure of infusion of prostaglandin A2 to restore the response to antidiuretic hormone in rats with polyuria induced by lithium. J.Endocrinol. 1980; 84(-3-):459-465. >>> Prostaglandin A2; Vasopressin, arginine; Methanol; Propylene glycol; Saline; IV (atrium); rat; 1701; 7 days; comparison of bolus injection vs. infusion; separate&simultaneous infusion of agents; pumps replaced 1-2 times; peptides.

P0063 Christensen,S. Vasopressin, 1-desamino-8-D arginine(1-desamino-8-D-arginine-vasopressin) treatment of lithium-induced polyuria in the rat. Scand.J.Clin.Lab.Invest. 1980; 40(--):151-157. >>> Vasopressin, 1-desamino-8-D arginine; Vasopressin, arginine; Saline; IV (atrium); SC; rat; 1701; 7 days; comparison of sc vs. iv infusion; replaced 1-2 times; long-term study; peptides.

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