References on Toxicology Research Using
ALZET^® Osmotic Pumps

P8437 Henke,E., Perk,J., Vider,J., de Candia,P., Chin,Y., Solit,D.B., Ponomarev,V., Cartegni,L., Manova,K., Rosen,N., Benezra,R. Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo. NATURE BIOTECHNOLOGY 2008; 26(-1-):91-100. >>> Oligonucleotide, antisense, peptide conjugated; oligonucleotide, phosphorothioate antisense; peptide, F3; TBS; SC; Mice (nude); mice; 1007D; 1002; 14, 21 days; Controls received mp w/ vehicle or control peptide and oligo in non-conjugated form, or rcId1-PCAO; comparison of IV injections vs. mp; pumps replaced after 14 days; no stress (see pg. 95, 97); stability verified after 24 hours in 37 C, plasma up to 28 days in 37 C saline; antisense (Id1, rcId1); cancer (breast, lung carcinoma); peptides; toxicology; animal info (female, nude NCR; male, C57J/B6); antisense oligos covalently coupled to address peptide that targets tumor endothelial cells; "no adverse effects on treated mice have been observed." (p. 97).

P8480 Levy,A., Cohen,G., Gilat,E., Kapon,J., Dachir,S., Abraham,S., Herskovitz,M., Teitelbaum,Z., Raveh,L. Extrapolating from animal studies to the efficacy in humans of a pretreatment combination against organophosphate poisoning. Archives of Toxicology 2007; 81(-5-):353-359. >>> Caramiphen; SC; Dog; 2001; 2ML1; 48 hours; Functionality of mp verified by plasma levels; toxicology; pharmacokinetics.

P8406 Zeevalk,G.D., Manzino,L., Sonsalla,P.K., Bernard,L.P. Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: Relevance to Parkinson's disease. Experimental Neurology 2007; 203(-2-):512-520. >>> Glutathione, monoethyl ester; MPP+; Saline; SC; CSF/CNS; Rat; 2ML4; 28 days; Controls received mp w/ vehicle; dose-response (fig. 6); stability verified by incubation for 0-28 days at 37 celsius, assessed by HPLC; half-life (pg. 515) 10-14 hours in culture; brain tissue distribution; toxicology; animal info (Sprague-Dawley, 300g.); neurodegenerative (Parkinson's disease).

P8308 Price,R.J., Walters,D.G., Finch,J.M., Gabriel,K.L., Capen,C.C., Osimitz,T.G., Lake,B.G. A mode of action for induction of liver tumors by Pyrethrins in the rat. TOXICOLOGY AND APPLIED PHARMACOLOGY 2007; 218(-2-):186-195. >>> Uridine, bromodeoxy; Rat; 2ML1; 7 days; Cancer (liver); toxicology; animal info (male, female, Sprague-Dawley CD, 10-11 wks old); labeling of hepatocytes.

P8276 Rustamzadeh,E., Hall,W.A., Todhunter,D.A., Vallera,V.D., Low,W.C., Liu,H.Y., Panoskaltsis-Mortari,A., Vallera,D.A. Intracranial therapy of glioblastoma with the fusion protein DTAT in immunodeficient mice. International Journal of Cancer 2007; 120(-2-):411-419. >>> DTAT; Saline; CSF/CNS; Mice; 1007D; ; Controls received mp w/ vehicle; dose-response (table 1); comparison of bolus ICV injections vs. mp; cancer (glioblastoma); toxicology; peptides; animal info (C57BL/6, female, 12 weeks old); diptheria toxin; "delivery of DTAT resulted in about a 16 fold increase in maximum tolerated dose." (p. 411); "The results of this experiment indicate that the toxicity of uPAR can be reduced by CED (mp) delivery." (p. 416).

P8016 Fridman,J.S., Caulder,E., Hansbury,M., Liu,X.D., Yang,G.J., Wang,Q., Lo,Y., Zhou,B.B., Pan,M., Thomas,S.M., Grandis,J.R., Zhuo,J.C., Yao,W.Q., Newton,R.C., Friedman,S.M., Scherle,P.A., Vaddi,K. Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer. Clinical Cancer Research 2007; 13(-6-):1892-1902. >>> Marimastat; INCB3619; SC; Mice; mice (nude); 7, 14 days; Controls received mp w/ vehicle; enzyme inhibitor (metalloprotease); cancer (squamous cell carcinoma, breast, lung carcinoma); toxicology; animal info (BALB/c, CD-1 nu/nu); ErbB ligand shedding inhibitor.

P8386 Serralta,A., Barcia,J.A., Ortiz,P., Duran,C., Hernandez,M.E., Alos,M. Effect of intracerebroventricular continuous infusion of valproic acid versus single i.p. and i.c.v. injections in the amygdala kindling epilepsy model. Epilepsy Research 2006; 70(-1-):15-26. >>> Valproic acid; Saline; CSF/CNS; Rat; 2001; 2002; 7 days; Controls received no treatment; dose-response (fig. 1); comparison of icv, IP injections vs. mp; no stress (see pg. 22); toxicology; multiple pumps per animal (2); animal info (male, Wistar, amygdala-kindled epilepsy, 380-420g.); mp primed 1 hr. in 37.5 celsius saline; evans blue dye used to confirm cannula placement, "chronic i.c.v. VPA infusion affords protection against kindled seizures accompanied by less ataxia and sedation" (pg. 24).

P8332 Prevost,G.P., Lonchampt,M.O., Holbeck,S., Attoub,S., Zaharevitz,D., Alley,M., Wright,J., Brezak,M.C., Coulomb,H., Savola,A., Huchet,M., Chaumeron,S., Nguyen,Q.D., Forgez,P., Bruyneel,E., Bracke,M., Ferrandis,E., Roubert,P., Demarquay,D., Gespach,C., Kasprzyk,P.G. Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric G alpha /G beta gamma protein complex. Cancer Research 2006; 66(-18-):9227-9234. >>> BIM-46174; Rat; 6 days; No stress (see pg. 9231); cancer (lung); toxicology.

P8272 Benson,J.M., Gomez,A.P., Statom,G.L., Tibbetts,B.M., Fleming,L.E., Backer,L.C., Reich,A., Baden,D.G. Placental transport of brevetoxin-3 in CD-1 mice. Toxicon 2006; 48(-8-):1018-1026. >>> Brevetoxin-3; Radio-isotopes; 3H; PBS; tween 80; Mice (pregnant); 72 hours; Controls received mp w/ vehicle; comparison of intratracheal instillation; half-life (p. 1023) 39 hours in blood, 1.7 hours in brain tissue; teratology; toxicology; animal info (female, CD-1, 10-11 weeks old, GD15-16 to 18-19); "Continuous compound release by the pump was intended to simulate slow continuous absorption as may occur following inhalation over a prolonged period." (p. 1020).

P8164 Barchiesi,F., Jackson,E.K., Fingerle,J., Gillespie,D.G., Odermatt,B., Dubey,R.K. 2-methoxyestradiol, an estradiol metabolite, inhibits neointima formation and smooth muscle cell growth via double blockade of the cell cycle. Circulation Research 2006; 99(-3-):266-274. >>> Estradiol, 2-methoxy-; IV; Rat; 7, 8, 14, days; Controls received mp w/ vehicle; no stress (see pg. 269); cardiovascular; toxicology; animal info (male, Wistar Kyoto, 350-400 grams); balloon carotid artery injury, "treatment with 2-ME was not associated with any toxic adverse effects." (p. 269); estradiol metabolite.

P8126 Lin,C.R., Amaya,F., Barrett,L., Wang,H.B., Takada,J., Samad,T.A., Woolf,C.J. Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity. Journal of Pharmacology and Experimental Therapeutics 2006; 319(-3-):1096-1103. >>> RNA, short hairpin; RNA, short hairpin, mismatched; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle, or mismatched shRNA; dose-response (p.1100); antisense (Ep4); brain tissue distribution; toxicology; animal info (male, Sprague-Dawley, 200g., peripheral hind paw inflammation).

P8099 Bernstein,D.M., Rogers,R., Smith,P., Chevalier,J. The toxicological response of Brazilian chrysotile asbestos: A multidose subchronic 90-day inhalation toxicology study with 92-day recovery to assess cellular and pathological response. INHALATION TOXICOLOGY 2006; 18(-5-):313-332. >>> Uridine, bromodeoxy, 5-; SC; Rat; 2001; 3 days; Toxicology; animal info (male, Wistar Han-Ibm, 9 wk old).

P7930 Voss,K.A., Riley,R., Dunn,C., Corton,J.C. The role of tumor necrosis factor alpha and the peroxisome proliferator-activated receptor alpha in modulating the effects of fumonisin in mouse liver. Toxicology 2006; 222(-3-):165-174. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 7 days; Toxicology; animal info (male, 1.5 weeks old); labeling of hepatocytes.

P7892 Burniston,J.G., Clark,W.A., Tan,L.B., Goldspink,D.F. Dose-dependent separation of the hypertrophic and myotoxic effects of the beta 2-adrenergic receptor agonist clenbuterol in rat striated muscles. Muscle&Nerve 2006; 33(-5-):655-663. >>> Clenbuterol; Saline; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle, or no treatment; dose-response (table 1); good methods pg.656; half-life (pg.659) "long plasma half-life"; cardiovascular; toxicology; animal info (male, Wistar, 285grams); "Administration of clenbuterol via the animal's drinking water...or via food in other sutdies, introduces uncertainty regarding the actual dose received by each animal...clenbuterol solutions are sensitive to light and oxidation may occur...The administration of clenbuterol by subcutaneously implanted osmotic pumps ensures that the dose received by each animal is consistent." (pg.661).

P7830 Welshons,W.V., Nagel,S.C., vom Saal,F.S. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology 2006; 147(-6-):S56-S69. >>> Bisphenol A; Mice (pregnant); mice; ; Toxicology; animal info (female, CD-1, pregnant, lactating); endocrinology; "An approach to administering BPA that may best mimic what appears to be tonic exposure by humans is by administration via SILASTIC brand silicon tubing or osmotic pumps." (pg. 564).

P7780 Gu,L.Z., Hu,W.Y., Antic,N., Mehta,R., Turner,J.R., de Lanerolle,P. Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells. European Journal of Cancer 2006; 42(-7-):948-957. >>> ML-7; DMSO; SC; Mice; 2004; 4 weeks; Controls received mp w/ vehicle; no stress (see pg. 952, 955); enzyme inhibitor (myosin light chain kinase); cancer (mammary adenocarcinoma); toxicology; animal info (female, 14-20 wk. old, MMTV-free, C3H/Hen); 50% DMSO.

P7511 vom Saal,F.S., Welshons,W.V. Large effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol A. Environmental Research 2006; 100(-1-):50-76. >>> Bisphenol A; SC; Rat; mice (pregnant); ; Dose-response (table 1); teratology; toxicology; animal info (CD-1, female&male).

R0232 Brouillet,E., Jacquard,C., Bizat,N., Blum,D. 3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease. Journal of Neurochemistry 2005; 95(-6-):1521-1540. >>> Nitropropionic acid, 3-; SC; IP; Rat; mice; 2002; 2ML1; 2ML4; 4 weeks; 5,14 days; Neurodegenerative (Huntington's disease); dose-response (table 1); toxicology; animal info (C57BL/6, Sprague-Dawley, Lewis); "an improved 3NP model using osmotic minipumps in Lewis rats." (p. 1526).

P8234 Keenan,K.P., Hoe,C.M., Mixson,L., McCoy,C.L., Coleman,J.B., Mattson,B.A., Ballam,G.A., Gumprecht,L.A., Soper,K.A. Diabesity: A polygenic model of dietary-induced obesity from ad libitum overfeeding of Sprague-Dawley rats and its modulation by moderate and marked dietary restriction. Toxicologic Pathology 2005; 33(-6-):650-674. >>> Uridine, bromodeoxy; Sodium bicarbonate; SC; Rat; 2ML1; 7 days; Toxicology; animal info (male, female, Sprague-Dawley, 12, 25, or 52 weeks old).

P8098 Newcomb,J.D., Brown,W.D., Rodriguez,A.I., Garbuzova-Davis,S., Saporta,S., Sanberg,P.R., Willing,A.E. Behavioral alterations in Lewis rats following two-day continuous 3-nitropropionic acid administration. NEUROTOXICITY RESEARCH 2005; 8(-3-4-):259-265. >>> Nitropropionic acid, 3-; Saline; SC; Rat; 2ML4; 2 days; Controls received mp w/ vehicle; toxicology; animal info (male, Lewis, 12 wks old, 250-300g.).

P8051 Wang,J.R., Zheng,H., Qiu,X.H., Kulkarni,A., Fink,L.M., Hauer-Jensen,M. Modulation of the intestinal response to ionizing radiation by anticoagulant and non-anticoagulant heparins. THROMBOSIS AND HAEMOSTASIS 2005; 94(-5-):1054-1059. >>> Nadroparin; sr-80258a; Saline, physiological; SC; Rat; 2002; 17 days; Controls received mp w/ vehicle; half-life (p.1055) 3.5 hrs. (nadroparin); cancer (radiation therapy); cardiovascular; toxicology; animal info (male,Sprague-Dawley, 43-49 days old, 175-200 grams, small bowel irradiation).

P7593 Kaufmann,W., Mellert,W., van Ravenzwaay,B., Landsiedel,R., Poole,A. Effects of styrene and its metabolites on different lung compartments of the mouse - cell proliferation and histomorphology. Regulatory Toxicology and Pharmacology 2005; 42(-1-):24-36. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 2001; ; Cancer; toxicology; animal info (female, CD1, 49 days old); labeling of lung cells.

P7572 Saghir,S.A., Lebofsky,M., Pinson,D.M., Rozman,K.K. Validation of Haber's Rule (dose x time = constant) in rats and mice for monochloroacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin under conditions of kinetic steady state. Toxicology 2005; 215(-1-2-):48-56. >>> Monochloroacetic acid; monochloroacetic acid; Saline, physiological; radio-isotopes; 14C tracer; SC; Rat; 2001D; 2-10 hours; Functionality of mp verified by radioactivity in plasma; dose-response (table 2); comparison of IV injections vs. mp; half-life (pg. 49) 2-3 hours; toxicology; animal info (male, Sprague-Dawley, 171 g); PE-60 tubing filled with saline attached to mp to.

P7475 Qiao,D., Seidler,F.J., Slotkin,T.A. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. TOXICOLOGY AND APPLIED PHARMACOLOGY 2005; 206(-1-):17-26. >>> Nicotine bitartrate; sodium bitartrate; Water, bacteriostatic; SC; Rat; 1007D; 1002; 7, 15 days; Controls received mp w/ vehicle and sodium bitartrate; dose-response (fig. 5); toxicology; animal info (Sprague-Dawley, 30 days old, male and female).

P7472 Nakagawa,Y., Kawashima,T., Yamada,T., Harano,M., Monji,A., Yuzuriha,T., Iwaki,T. Aluminum chloride does not facilitate deposition of human synthetic amyloid beta1-42 peptide in the rat ventricular system of a short-term infusion model. NEUROPATHOLOGY 2005; 25(-3-):195-200. >>> Amyloid protein, beta (1-42), human; PBS; CSF/CNS; Rat; 1 hour; Controls received vehicle, or Tris; no stress (see pg. 197); ALZET brain infusion kit used; toxicology; peptides; neurodegenerative (Alzheimer's disease); animal info (male, Wistar); no mp used, 60 minute infusion of 100ul by pumping a disposable syringe; co-infused with Alcl3.

P7461 Garcia,R.A.G., Liu,L.S., Hu,Z.Y., Gonzalez,A., von Borstel,R.W., Saydoff,J.A. Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency; neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine. Brain Research 2005; 1066(-1-2-):164-171. >>> Azide, sodium; SC; Mice; 2, 14 days; Controls received mp w/ vehicle; dose-response (table 1); enzyme inhibitor (cytochrome c oxidase); toxicology; neurodegenerative (mitochondrial dysfunction); animal info (male, C57/BL6J, 10-12 weeks old).

P7444 Green,T., Toghill,A., Lee,R., Waechter,F., Weber,E., Noakes,J. Thiamethoxam induced mouse liver tumors and their relevance to humans - Part 1: Mode of action studies in the mouse. TOXICOLOGICAL SCIENCES 2005; 86(-1-):36-47. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Mice; 1003D; 3 days; Cancer (hepatic); toxicology; animal info (male, 30-43 g); labeling of hepatocytes.

P7441 Green,T., Toghill,A., Lee,R., Waechter,F., Weber,E., Peffer,R., Noakes,J., Robinson,M. Thiamethoxam induced mouse liver tumors and their relevance to humans - Part 2: Species differences in response. TOXICOLOGICAL SCIENCES 2005; 86(-1-):48-55. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Rat; 2ML1; 3 days; Cancer (hepatic); toxicology; animal info (female, 140-160 g).

P7322 Dings,R.P.M., Williams,B.W., Song,C.W., Griffioen,A.W., Mayo,K.H., Griffin,R.J. Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells. International Journal of Cancer 2005; 115(-2-):312-319. >>> Anginex; PBS; SC; Mice (nude); 2002; 2004; 2, 4 weeks; Controls received mp w/ vehicle; comparison of IP injections vs. mp; no stress (see pg. 315); half-life (p. 318) 50-90 min. in mice; cancer (ovarian, mammary carcinoma); toxicology; peptides; irradiation 5 Gy once per week or 25 Gy one time tumo-bearing legs; angiogenesis inhibitor; "continuous infusion of anginex in combination with weekly irradiation resulted in tumor regression and impalpable tumors by the end of treatment." P317.

P7283 Ozawa,T., Afzal,J., Lamborn,K.R., Bollen,A.W., Bauer,W.F., Koo,M.S., Kahl,S.B., Deen,D.F. Toxicity, biodistribution, and convection-enhanced delivery of the boronated porphyrin BOPP in the 9L intracerebral rat glioma model. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2005; 63(-1-):247-252. >>> Porphyrin, boronated; PBS; CSF/CNS (intratumoral); Rat; 2001D; 24 hours; Controls received no treatment; dose-response; comparison of IV injections vs. mp; cancer (brain glioma); toxicology.

P7278 Lobo,E.D., Balthasar,J.P. Application of anti-methotrexate Fab fragments for the optimization of intraperitoneal methotrexate therapy in a murine model of peritoneal cancer. Journal of Pharmaceutical Sciences 2005; 94(-9-):1957-1964. >>> Methotrexate; IP; Mice; 1003D; 72 hours; Controls received ip bolus saline injection; dose-response (fig. 3); cancer (peritoneal sarcoma); toxicology; mp primed overnight in 37 degrees saline.

P7238 Abdel-Rahman,A., Dechkovskaia,A.M., Sutton,J.M., Chen,W.C., Guan,X.R., Khan,W.A., bou-Donia,M.B. Maternal exposure of rats to nicotine via infusion during gestation produces neurobehavioral deficits and elevated expression of glial fibrillary acidic protein in the cerebellum and CA1 subfield in the offspring at puberty. Toxicology 2005; 209(-3-):245-261. >>> Nicotine bitartrate; Water, bacteriostatic; SC; Rat (pregnant); 2ML2; 16 days; Controls received mp w/ vehicle; no stress (see 249); teratology; toxicology; "No sign of overt toxicity was observed in any group of mothers or offspring throughout the experimental period." (p. 249); "Nicotine delivery via osmotic minipump offers an alternative approach, whereby the episodic peak of plasma nicotine levels and resultant hypoxic episodes and stress of repeated injection can be avoided." (p. 246).

P7182 Osuchowski,M.F., Edwards,G.L., Sharma,R.P. Fumonisin B1-induced neurodegeneration in mice after intracerebroventricular infusion is concurrent with disruption of sphingolipid metabolism and activation of proinflammatory signaling. Neurotoxicology 2005; 26(-2-):211-221. >>> Fumonisin B1; Saline; SC; CSF/CNS; Mice; 1007D; 7 days; Controls received mp w/ vehicle; dose-response (fig 3); no stress (see pg. 214); enzyme inhibitor (ceramide synthase); toxicology; mp primed overnight; animal info (female, 7-8 weeks old, BALB/C).

P7955 Nakagawa,Y., Yuzuriha,T., Iwaki,T. Active clearance of human amyloid beta 1-42 peptide aggregates from the rat ventricular system. NEUROPATHOLOGY 2004; 24(-3-):194-200. >>> Amyloid protein, beta (1-42), human synthetic; PBS; CSF/CNS; Rat; ; Controls received mp w/ vehicle; ALZET brain infusion kit used; brain tissue distribution; toxicology; peptides; neurodegenerative (Alzheimer's disease); animal info (male, Wistar, 200-250 grams); 60 minute infusion by syringe; no ALZET pump used, only brain infusion kit.

P7210 Bermudez,E., Mangum,J.B., Wong,B.A., Asgharian,B., Hext,P.M., Warheit,D.B., Everitt,J.I. Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. TOXICOLOGICAL SCIENCES 2004; 77(-2-):347-357. >>> Uridine, bromodeoxy-; SC; Rat; mice; hamster; 2001; 2ML1; 5 days; Toxicology; labeling of the lung.

P7090 Armstrong,B.D., Noguchi,K.K. The neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine on serotonin, dopamine, and GABA-ergic terminals: An in-vitro autoradiographic study in rats. Neurotoxicology 2004; 25(-6-):905-914. >>> Methamphetamine hcl; Methamphetamine hcl, 3,4-methylenedioxy-; Water, distilled; SC; Rat; 2ML1; 5 days; Controls received mp w/ vehicle; toxicology.

P7087 Andratschke,N.H., Nieder,C., Price,R.E., Rivera,B., Tucker,S.L., Ang,K.K. Modulation of rodent spinal cord radiation tolerance by administration of platelet-derived growth factor. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2004; 60(-4-):1257-1263. >>> Platelet-derived growth factor-BB; SC; CSF/CNS (cisterna magna, intrathecal); Rat; 2ML1; 4 days; Controls received mp w/ saline; functionality of mp cannulas and catheters verified before implantation and after removal; dose-response (table 2); no stress (see pg. 1261); cancer; toxicology.

P7041 Lock,T., Cottrell,L., Soames,T., Jacobsen,M., Williams,R. Formic acid excretion in rats and mice exposed to bromodichloromethane: a possible link to renal tubule cell proliferation in long-term studies. Archives of Toxicology 2004; 78(-7-):410-417. >>> Uridine, bromodeoxy-; Saline, isotonic; SC; Rat; mice; 2001; 2ML1; 5 days; Functionality of mp verified by BrdU staining of duodenum; toxicology.

P7028 Harrington,K.J., Syrigos,K.N., Uster,P.S., Zetter,A., Lewanski,C.R., Gullick,W.J., Vile,R.G., Stewart,J.S.W. Targeted radiosensitisation by pegylated liposome-encapsulated 3', 5'-O-dipalmitoyl 5-iodo-2'-deoxyuridine in a head and neck cancer xenograft model. British Journal of Cancer 2004; 91(-2-):366-373. >>> Uridine, iododeoxy-; DMSO; water distilled; SC; Mice (nude); 2002; 7 days; Controls received PBS injections; comparison of pegylated liposomes vs. IV bolus injections vs. mp; no stress (pg. 370); cancer (head and neck); toxicology; 20% DMSO; therapeutic irradiation with 137Cs source after day 7.

P6992 Wolfe,D., Niranjan,A., Trichel,A., Wiley,C., Ozuer,A., Kanal,E., Kondziolka,D., Krisky,D., Goss,J., DeLuca,N., Murphey-Corb,M., Glorioso,J.C. Safety and biodistribution studies of an HSV multigene vector following intracranial delivery to non-human primates. Gene Therapy 2004; 11(-23-):1675-1684. >>> Ganciclovir; SC; Monkey (Rhesus); 2ML1; 2ML2; 4,5,34,35 days; Pumps replaced after 2 weeks; no stress (see pg. 1677); cancer (glioblastoma); toxicology; MRI; multiple pumps per animal (2); gene therapy.

P6854 Ling,Z.D., Chang,Q.A., Tong,C.W., Leurgans,S.E., Lipton,J.W., Carvey,P.M. Rotenone potentiates dopamine neuron loss in animals exposed to lipopolysaccharide prenatally. Experimental Neurology 2004; 190(-2-):373-383. >>> Rotenone; DMSO; PEG; IV (jugular); Rat; 2ML2; 14 days; Controls received mp w/ vehicle; stress/adverse reaction: (see pg. 376) One agent and one veh. animal became sick immediately after surgery, 2 more became sick at 10 days, the remaining 24 animals survived the protocol with no adverse effects; toxicology; 50% DMSO; animals received prenatal LPS.

P6815 Wang,J., Zheng,H., Ou,X., Albertson,C.M., Fink,L.M., Herbert,J.M., Hauer-Jensen,M. Hirudin ameliorates intestinal radiation toxicity in the rat: support for thrombin inhibition as strategy to minimize side-effects after radiation therapy and as countermeasure against radiation exposure. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 2004; 2(-11-):2027-2035. >>> Hirudin; Saline; IP; Rat; 2ML2; 16 days; Controls received mp w/ vehicle; enzyme inhibitor thrombin; cancer (abdominal, pelvic); toxicology; scrotal hernia created via orchiectomy w/ a loop of ileum sutured to inside of scrotum.

P6745 Gourdeau,H., Leblond,L., Hamelin,B., Dong,K., Ouellet,F., Boudreau,C., Custeau,D., Richard,A., Gilbert,M.J., Jolivet,J. Species differences in troxacitabine pharmacokinetics and pharmacodynamics: Implications for clinical development. Clinical Cancer Research 2004; 10(-22-):7692-7702. >>> Troxacitabine; Saline; SC; Mice; 2001; 1,3,5,6 days; Controls received mp w/ vehicle; functionality of mp verified by plasma concentrations; dose-response (fig 3); comparison of IV injections vs. mp; cancer (colon); toxicology; agent also known as Troxatyl BCH-4556; Athymic.

P6741 Van Helden,H.P.M., Vanwersch,R.A.P., Kuijpers,W.C., Trap,H.C., Philippens,I.H.C., Benschop,H.P. Low levels of Sarin affect the EEG in marmoset monkeys: a pilot study. Journal of Applied Toxicology 2004; 24(-6-):475-483. >>> Pyridostigmine bromide; Propylene glycol: ethanol; acidic acid, glacial; water, distilled; SC; Marmoset; 2002; ; Controls received mp w/ vehicle; toxicology; sarin vapor.

P6685 Crunkhorn,S.E., Plant,K.E., Gibson,G.G., Kramer,K., Lyon,J., Lord,P.G., Plant,N.J. Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth. Biochemical Pharmacology 2004; 67(-1-):107-118. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; 48,72 hours; Labeling of hepatocytes; toxicology.

P6622 Cheung,C., Akiyama,T.E., Ward,J.M., Nicol,C.J., Feigenbaum,L., Vinson,C., Gonzalez,F.J. Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha. Cancer Research 2004; 64(-11-):3849-3854. >>> Uridine, bromodeoxy-; SC; Mice; 2001; 1 week; Labeling of hepatocytes; toxicology.

P6571 Weglarz,T.C., Sandgren,E.P. Cell cross-talk mediates PPARalpha; null hepatocyte proliferation after peroxisome proliferator exposure. Carcinogenesis 2004; 25(-1-):107-112. >>> Uridine, bromodeoxy-; Mice (transgenic); 2001; 7 days; hepatocyte labeling; toxicology.

P6570 Zimmerman,L.J., Valentine,H.L., Valentine,W.M. Characterization of S-(N,N-dialkylaminocarbonyl)cysteine adducts and enzyme inhibition produced by thiocarbamate herbicides in the rat. Chemical Research In Toxicology 2004; 17(-2-):258-267. >>> Molinate; PEG 200; SC; IP; Rat; 2ML2; 46,59 days; Controls received mp w/ vehicle; long-term study; pumps replaced every 2 weeks; toxicology; molinate is an herbicide.

P6551 Van Helden,H.P.M., Trap,H.C., Kuijpers,W.C., Oostdijk,J.P., Benschop,H.P., Langenberg,J.P. Low-level exposure of guinea pigs and marmosets to sarin vapour in air: Lowest-observable-adverse-effect level (LOAEL) for miosis. Journal of Applied Toxicology 2004; 24(-1-):59-68. >>> Pyridostigmine bromide; Propylene glycol; ethanol; water; acetic acid, glacial; SC; Guinea-pig; marmoset; 2002; 4 days; Controls received mp w/ vehicle; toxicology.

P6482 Mellert,W., Kaufmann,W., Rossbacher,R., van Ravenzwaay,B. Investigations on cell proliferation in B6C3F1 mouse liver by diethanolamine. Food and Chemical Toxicology 2004; 42(-1-):127-134. >>> Uridine, 5-bromo-2'deoxy-; Saline; SC; Mice; 2001; 7 days; Cancer (liver); toxicology.

P6350 Burkhardt,S., Bahnemann,R., Failing,K., Reinacher,M. Zonal distribution of cell proliferation in the liver of untreated B6C3F1 and C57BL mice. Toxicologic Pathology 2004; 32(-1-):100-105. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 3, 7 days; Comparison of IP injections vs. mp; labeling of hepatocytes; toxicology.

R0216 Kita,T., Wagner,G.C., Nakashima,T. Current research on methamphetamine-induced neurotoxicity: Animal model of monoamine disruption. JOURNAL OF PHARMACOLOGICAL SCIENCES 2003; 92(-3-):178-195. >>> Amphetamine; SC; Mice; 1 week; Toxicology; ALZET pumps mentioned on pg. 181, ref. 36; "These pumps have a continuous uniform rate assuring a constant drug concentration." (p. 181).

P7700 Murata,M., Nishimura,N., Zhang,B  Journal of Vet.Med.Sci. 2003; 65(-4-):511-513. >>> Interleukin-6, recomb. human; PBS; serum, mouse; SC; Mice; 1007D; 6 days; Controls received mp w/ vehicle; functionality of mp verified by serum rhIL-6 levels; dose-response (table 1); toxicology; peptides; animal info (female, 20 wks old).

P6656 Liu,J., Li,C.X., Waalkes,M.P., Clark,J., Myers,P., Saavedra,J.E., Keefer,L.K. The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-ind uced hepatotoxicity in mice. Hepatology 2003; 37(-2-):324-333. >>> V-PYRRO/NO; Mice; 2001D; 18-26 hours; Controls received mp w/ saline; dose-response (fig.1); no stress (see pg. 327); toxicology; "Osmotic pumps were used to ensure a constant rate of NO release to the liver. " (p. 325); "V-PYRRO/NO delivered via osmotic pump alone did not produce any toxicity." (p. 327).

P6499 Zhao,L.L., Ching,L.M., Kestell,P., Baguley,B.C. Improvement of the antitumor activity of intraperitoneally and orally administered 5,6-dimethylxanthenone-4-acetic acid by optimal scheduling. Clinical Cancer Research 2003; 9(-17-):6545-6550. >>> Acetic acid, 5, 6-dimethylxanthenone-4-; SC; Mice; 1003D; 3 days; Controls received mp w/ saline; functionality of mp verified by measuring residual volume via HPLC; Dose-response (table1); comparison of oral gavage vs. IP injections vs. mp; no stress (see pg.6547); cancer (colon); toxicology; agent also referred to as DMXAA.

P6105 Lobo,E.D., Balthasar,J.P. Pharmacokinetic-pharmacodynamic modeling of methotrexate-induced toxicity in mice. Journal of Pharmaceutical Sciences 2003; 92(-8-):1654-1664. >>> Methotrexate; Saline; IP; Mice; 1003D; 2001D; 2001; 1,3,7 days; Controls received mp w/ vehicle; mtx plasma levels taken; dose-response (p. 1659); comparison of bolus injections vs. IP mp; toxicology; IP catheter used.

P6023 McCormick,J.K., Tripp,T.J., Llera,A.S., Sundberg,E.J., Dinges,M.M., Mariuzza,R.A., Schlievert,P.M. Functional analysis of the TCR binding domain of toxic shock syndrome toxin-1 predicts further diversity in MHC class II/superantigen/TCR te rnary complexes. Journal of Immunology 2003; 171(-3-):1385-1392. >>> Toxin-1, TSS; PBS; SC; Rabbit; 2001; 7 days; Toxicology.

P5960 Valles,E.G., Laughter,A.R., Dunn,C.S., Cannelle,S., Swanson,C.L., Cattley,R.C., Corton,J.C. Role of the peroxisome proliferator-activated receptorα in responses to dilsononyl phthalate. Toxicology 2003; 191(-2-3-):211-225. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 7 days; Toxicology; labeling of hepatocytes.

P5959 Rios-Blanco,M.N., Yamaguchi,S., Dhawan-Robl,M., Kessler,W., Schoonhoven,R., Filser,J.G., Swenberg,J.A. Effects of propylene oxide exposure on rat nasal respiratory cell proliferation. TOXICOLOGICAL SCIENCES 2003; 75(-2-):279-288. >>> Uridine, bromodeoxy-; PBS; SC; Rat; 2ML1; 3 days; Toxicology; labeling of the hepatocytes and anterior face.

P5955 Tharappel,J.C., Nalca,A., Owens,A.B., Ghabrial,L., Konz,E.C., Glauert,H.P., Spear,B.T. Cell proliferation and apoptosis are altered in mice deficient in the NF-κB p50 subunit after treatment with the peroxisome proliferator ciprofibrate. TOXICOLOGICAL SCIENCES 2003; 75(-2-):300-308. >>> Uridine, bromodeoxy-; SC; Mice (knockout); 1003D; 3 days; Toxicology; labeling of hepatocytes.

P5804 Kondoh,M., Imada,N., Kamada,K., Tsukahara,R., Higashimoto,M., Takiguchi,M., Watanabe,Y., Sato,M. Property of metallothionein as a Zn pool differs depending on the induced condition of metallothionein. TOXICOLOGY LETTERS 2003; 142(-1-2-):11-18. >>> Cadmium acetate; Saline; SC; Mice; 14 days; Controls received mp w/ vehicle; no stress (see pg. 12) "None of the animals displayed any evidence of infection or other adverse effects from the procedure."; toxicology.

P5785 Ou,Y.C., Conolly,R.B., Thomas,R.S., Gustafson,D.L., Long,M.E., Dobrev,I.D., Chubb,L.S., Xu,Y.H., Lapidot,S.A., Andersen,M.E., Yang,R.S.H. Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. TOXICOLOGICAL SCIENCES 2003; 73(-2-):301-314. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 3 days; Labeling of hepatocytes; toxicology.

P5707 Muggleton,N.G., Bowditch,A.P., Crofts,H.S., Scott,E.A.M., Pearce,P.C. Assessment of a combination of physostigmine and scopolamine as pretreatment against the behavioral effects of organophosphates in the common marmoset (Callithrix jacchus). Psychopharmacology 2003; 166(-3-):212-220. >>> Physostigmine salicylate; scopolamine hydrobromide; Saline; SC; Monkey (marmoset); 2002; 14 days; Controls received mp w/ vehicle; behavioral testing; agents infused via same pumps; toxicology.

P5699 Kenyon,N.J., Ward,R.W., Last,J.A. Airway fibrosis in a mouse model of airway inflammation. TOXICOLOGY AND APPLIED PHARMACOLOGY 2003; 186(-2-):90-100. >>> Relaxin; Sodium acetate; SC; Mice (transgenic); 2001; 12 days; Controls received mp w/ vehicle; pumps replaced after 1 week; peptides; toxicology.

P5691 Sarasin,A., Schlumpf,M., Muller,M., Fleischmann,L., Lauber,M.E., Lichtensteiger,W. Adrenal-mediated rather than direct effects of nicotine as a basis of altered sex steroid synthesis in fetal and neonatal rat. REPRODUCTIVE TOXICOLOGY 2003; 17(-2-):153-162. >>> Nicotine hydrogen tartrate; Tartaric acid; SC; Rat (pregnant); 2001; 1 week; Controls received mp w/ vehicle; teratology; toxicology.

P7702 Guarnieri,M., Biser-Rohrbaugh,A., Tyler,B.M., Gabikian,P., Bunton,T.E., Wu,Q.Z., Weingart,J., Carson Sr,B.S. Toxicity of intracranial and intraperitoneal O6-benzyl guanine in combination with BCNU delivered locally in a mouse model. Cancer Chemother.Pharmacol. 2002/11; 50(-5-):392-396. >>> Benzylguanine, 06-; Propylene glycol; ethanol; IP; CSF/CNS (parietal lobe); Mice; 2001; 7 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; dose-response (table 2); comparison of IP injection vs. mp; stability verified by 14 days at 37 C, UV spectra analysis; good methods (p. 393); cancer (glioma brain); toxicology; animal info (female, BALB/C, 6-12 weeks old); 10% ETOH.

P6146 Kilgour,J.D., Rattray,N.J., Foster,J., Soames,A., Hext,P.M. Pulmonary responses and recovery following single and repeated inhalat ion exposure of rats to polymeric methylene diphenyl diisocyanate aero sols. Journal of Applied Toxicology 2002; 22(-6-):371-385. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 7 days; Toxicology; BrdU used for labeling lung and small intestine.

P5742 Balakrishnan,S., Payawal,J., Schuler,M.J., Hasegawa,L., Eastmond,D.A. Enhancing the in vitro and in vivo detection of aneuploidy by fluorescence in situ hybridization with the use of bromodeoxyuridine as a proliferation marker. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 2002; 521(-1-2-):81-89. >>> Uridine, bromodeoxy-; SC; Rat; 2001; 3 days; Toxicology; lymphocytes and hepatocytes were labelled.

P5576 Gamer,A.O., Jaeckh,R., Leibold,E., Kaufmann,W., Gembardt,C., Bahnemann,R., van Ravenzwaay,B. Investigations on cell proliferation and enzyme induction in male rat kidney and female mouse liver caused by tetrahydrofuran. TOXICOLOGICAL SCIENCES 2002; 70(-1-):140-149. >>> Uridine, bromodeoxy-; saline; SC; rat; mice; 2001; 2ML1; 3, 7 days; toxicology.

P5547 Bermudez,E., Mangum,J.B., Asgharian,B., Wong,B.A., Reverdy,E.E., Janszen,D.B., Hext,P.M., Warheit,D.B., Everitt,J.I. Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles. TOXICOLOGICAL SCIENCES 2002; 70(-1-):86-97. >>> Uridine, bromodeoxy-; SC; Rat; mice; hamster; 2001; 2ML1; 5 days; Rats and hamsters received model 2ML1; mice received model 2001; toxicology.

P5532 Chen,C.M., Stott,N.S., Smith,H.K. Effects of botulinum toxin A injection and exercise on the growth of juvenile rat gastrocnemius muscle. Journal of Applied Physiology 2002; 93(-4-):1437-1447. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 7 days; Functionality of mp verified by measurement of residual volume; toxicology.

P5528 Lallement,G., Demoncheaux,J.P., Foquin,A., Baubichon,D., Galonnier,M., Clarencon,D., Dorandeu,F. Subchronic administration of pyridostigmine or huperzine to primates: Compared efficacy against soman toxicity. Drug and Chemical Toxicology 2002; 25(-3-):309-320. >>> Pyridostigmine; huperzine; SC; Monkey; 2ML1; 6 days; Enzyme inhibitor (acetylcholinesterase); toxicology.

P5527 Lake,B.G., Rumsby,P.C., Cunninghame,M.E., Price,R.J. Dose-related effects of the peroxisome proliferator methylclofenapate in rat liver. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 2002; 11(-3-4-):233-242. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 1 week; Pumps implanted on study weeks 0, 3, and 12; toxicology.

P5424 Wyde,M.E., Cambre,T., Lebetkin,M., Eldridge,S.R., Walker,N.J. Promotion of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-diox in and 17 beta-estradiol in male Sprague-Dawley rats. TOXICOLOGICAL SCIENCES 2002; 68(-2-):295-303. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; 7 days; Toxicology; hepatocyte proliferation.

P5352 Wetherell,J., Hall,T., Passingham,S. Physostigmine and hyoscine improves protection against the lethal and incapacitating effects of nerve agent poisoning in the guinea-pig. Neurotoxicology 2002; 23(-3-):341-349. >>> Physostigmine salicylate; Hyoscine hydrobromide; Pyridostigmine; Saline; SC; Guinea-pig; 2001; 7 days; Physostigmine and hyoscine infused together; toxicology.

P5343 Spencer,P.J., Crissman,J.W., Stott,W.T., Corley,R.A., Cieszlak,F.S., Schumann,A.M., Hardisty,J.F. Propylene glycol monomethyl ether (PGME): Inhalation toxicity and carcinogenicity in Fischer 344 rats and B6C3F1 mice. Toxicologic Pathology 2002; 30(-5-):570-579. >>> Uridine, bromodeoxy-;; SC; Rat; mice; ; Toxicology; liver, kidney and duodenum cell proliferation labeling.

P5341 Stoller,D.C., Thornton,S.R., Smith,F.L. Loss of antinociceptive efficacy in rat pups infused with morphine from osmotic minipumps. Pharmacology 2002; 66(-1-):11-18. >>> Morphine sulfate; Saline, isotonic; SC; Rat (neonate); 1003D; 72 hours; Controls received mp w/ saline; toxicology; teratology; tolerance; dependence; 6-day and 14-day old rat pups implanted; incision closed w/ vetbond tissue adhesive.

P5206 Goldsworthy,T.L., Fransson-Steen,R. Quantitation of the cancer process in C57BL/6J, B6C3F1 and C3H/HeJ mice. Toxicol.Pathol. 2002/1; 30(-1-):97-105. >>> Uridine, bromodeoxy-; PBS; Mice; 2001; 3,5-7 days; Cancer; toxicology; hepatocyte proliferation.

P5189 Hahn,F.F., Avila,K.J., Hahn,F.F., Kubatko,J.E., Nikula,K.J. A double-label immunohistochemical method for assessment of epithelial cell replication in paraffin sections of toxicant-damaged lungs. JOURNAL OF HISTOTECHNOLOGY 2002; 25(-1-):15-20. >>> Uridine, bromodeoxy-; Saline; Rat; 2ML1; 7 days; Toxicology.

P5187 Filliat,P., Foquin,A., Lallement,G. Effects of chronic administration of huperzine A on memory in guinea pigs. Drug and Chemical Toxicology 2002; 25(-1-):9-24. >>> Huperzine A; Saline; HCl; SC; Guinea-pig; 2001; 6 days; Toxicology; enzyme inhibitor; huperzine is an alkaloid, reversible Acetylcholinesterase (AChE) inhibitor; neurodegenerative (Alzheimer's disease).

P5152 Constan,A.A., Wong,B.A., Everitt,J.I., Butterworth,B.E. Chloroform inhalation exposure conditions necessary to initiate liver toxicity in female B6C3F1 mice. TOXICOLOGICAL SCIENCES 2002; 66(--):201-208. >>> Uridine, bromodeoxy-; PBS; SC; mice; 2001; 3.5 days; toxicology; liver&duodenum cell proliferation.

P5144 Pronko,P.S., Jarvelainen,H.A., Lindros,K.O. Acinar distribution of rat liver arylamine N-acetyltransferase: Effect of chronic ethanol and endotoxin exposure. PHARMACOLOGY&TOXICOLOGY 2002; 90(--):150-154. >>> Endotoxin, LPS; IV; rat; 4 weeks; toxicology.

P5099 Tharappel,J.C., Lee,E.Y., Robertson,L.W., Spear,B.T., Glauert,H.P. Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by polychlorinated biphenyls. Toxicol.Appl.Pharmacol 2002/3/15; 179(--):172-184. >>> Uridine, bromodeoxy-; SC; rat; 2ML1; 3 days; toxicology; hepatocyte proliferation.

P5075 Elcombe,C.R., Elcombe,C.R., Odum,J., Foster,J.R., Stone,S., Hasmall,S., Soames,A.R., Kimber,I., Ashby,J. Prediction of rodent nongenotoxic carcinogenesis: Evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens. Environmental Health Perspectives 2002; 110(-4-):363-375. >>> Uridine, bromodeoxy-; PBS; SC; rat; mice; 2001; 2ML1; 7 days; toxicology; rats received 2ML1 pumps, mice received 2001 pumps..

P5205 Molon-Noblot,S., Keenan,K.P., Coleman,J.B., Hoe,C.M., Laroque,P. The effects of ad libitum overfeeding and moderate and marked dietary restriction on age-related spontaneous pancreatic islet pathology in Sprague-Dawley rats. Toxicol.Pathol. 2001/5; 29(-3-):353-362. >>> Uridine, bromodeoxy; Sodium bicarbonate; SC; Rat; 2ML1; 7 days; Toxicology; islet cell proliferation labeling.

P5145 Meshulam,Y., Cohen,G., Chapman,S., Alkalai,D., Levy,A. Prophylaxis against organophosphate poisoning by sustained release of scopolamine and physostigmine. Journal of Applied Toxicology 2001; 21(--):S75-S78. >>> Scopolamine; Physostigmine; Propylene glycol; Ethanol; Water; Acetic acid, glacial; SC; Dog; 2001; 24 or 48 hours; functionality of mp verified by plasma scopolamine&physostigmine levels; dose-response (table, p. S77); toxicology; vehicle was 10% ethanol, 20% PG, 70% water, 0.0035% AA; mentions benefits of infusion via pump (p. S77).

P5008 Robinson,S.E., Wallace,M.J. Effect of perinatal buprenorphine exposure on development in the rat. Journal of Pharmacology and Experimental Therapeutics 2001; 298(--):797-804. >>> Buprenorphine; Methadone; Water; SC; rat (pregnant); rat (neonate); 14, 28 days; controls received mp w/ vehicle; dose-response (graphs p. 802); teratology; toxicology; dependence; 28-day pumps implanted in pregnant rats; 14-day pumps implanted in 10-day old rat pups..

P4817 Griffiths,G.D., Hornby,R.J., Stevens,D.J., Scott,L.A.M., Upshall,D.G. Biological consequences of multiple vaccine and pyridostigmine pretreatment in the guinea pig.. Journal of Applied Toxicology 2001; 21(--):59-68. >>> Pyridostigmine bromide;; Saline;; SC;; guinea-pig;; 28 days;; Controls received mp w/ vehicle; functionality of mp verified by AChE levels via assay p. 60; immunology; enzyme inhibitor; PB is an acetylcholinesterase inhibitor; toxicology.

P4806 Lallement,G., Foquin,A., Dorandeu,F., Baubichon,D., Carpentier,P. Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity. Drug and Chemical Toxicology 2001; 24(-2-):165-180. >>> Pyridostigmine; Huperzine; Physostigmine; Scopolamine;; SC;; guinea-pig;; 6 days;; Controls received sham operation; enzyme inhibitor; these are poisons known to be acetylcholinesterase inhibitors; doses inhibited 30% of AChE activity; Physostigmine was infused alone or together with Scopolamine; toxicology.

P4651 Bahnemann,R  Toxicology Methods 2001; 10(--):81-97. >>> Uridine, bromodeoxy-;; Saline;; SC;; rat;; 2ML1;; 3, 7 days;; Comparison of IP injections vs. mp; cancer; toxicology; liver cell proliferation;.

P8474 Klement,G., Baruchel,S., Rak,J., Man,S., Clark,K., Hicklin,D.J., Bohlen,P., Kerbel,R.S. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. Journal of Clinical Investigation 2000; 105(-8-):15-24. >>> Vinblastine sulfate; Saline; SC; Mice (SCID); 3 weeks; Controls received IP injections; comparison of IP injections vs. mp; no stress (see pg. R19); cancer (neuroblastoma); toxicology; animal info (SCID, 4-6 weeks old, 15-20 grams); IP bolus given at start of mp treatment.

P5236 Tabata,H. Peripheral neuropathy in B6C3F1 mice and SD rats induced by chronic intermittent insulin hypoglycemia. Drug Chem.Toxicol. 2000/8; 23(-3-):485-496. >>> Insulin, bovine; Water; HCl; SC; Rat; Mice; 1007D, 2002; 2 weeks; Controls received mp w/ vehicle; functionality veryfied by blood glucose levels; dose-response (p.490); pumps replaced at intervals of 5 to 7 days; peptides; 1007D pumps used in mice; 2002 pumps used in rats; toxicology.

P4819 Babin,M.C., Ricketts,K., Skvorak,J.P., Gazaway,M., Mitcheltree,L.W., Casillas,R.P. Systemic administration of candidate antivesicants to protect against topically applied suitor mustard in the mouse ear vesicant model (MEVM ).. Journal of Applied Toxicology 2000; 20(--):S141-S144. >>> Hydrocortisone; indomethacin; olvanil; PEG 200; SC; mice; 2 days; Controls received mp w/ vehicle; toxicology.

P4814 Van Horssen,P.J., Preijers,F.W.M.B., Van Oosterhout,Y.V.J.M., Eling,W.M.C., De Witte,T. Relationship of the CD22 immunotoxin dose and the tumour establishment in a SCID mice model. Leuk.Lymphoma 2000; 39(-5-6-):591-599. >>> Chloroquine; PBS; IP; Mice (scid); 2001; 7 days; Controls received mp w/ vehicle; dose-response (p. 595 graph); comparison of oral delivery vs. mp (p. 594); cancer; immunology; toxicology.

P4756 Leventhal,L, Sortwell,C.E, Hanbury,R, Collier,T.J., Korkower,J.H, Palfi,S. Cyclosporin A protects striatal neurons in vitro and in vivo from 3-nitropropionic acid toxicity.. The Journal of Comparative Neurology 2000; 425(--):471-478. >>> Nitropropionic acid, 3-; PBS;; SC;; rat;; 2004;; 7 days;; Controls received mp w/ vehicle; toxicology; 3-nitro-propionate also called 3-nitropropionic acid (3NP); 3NP is a mitochondrial toxin; neurodegenerative (Huntington's disease).

P4705 Adler,M., Capacio,B, Deshpande,S.S. Antagonism of botulinum toxin A-mediated muscle paralysis by 3,4-diaminopyridine delivered via osmotic minipumps.. Toxicon 2000; 38(--):1381-1388. >>> Pyridine, 3,4-diamino-;; Saline;; SC;; rat;; 2ML1;; 7 days;; functionality of mp verified by plasma levels; toxicology; multiple pumps per animal (2); 3,4-DAP is a potassium channel blocker;.

P4684 Wolf,D.C., Goldsworthy,T.L., Janszen,D.B, Harden,R, Donner,E.M, David,C.S, Everitt,J.I. Promotion by sodium barbital induces early development but does not increase the multiplicity of hereditary renal tumors in Eker rats.. Carcinogenesis 2000; 21(-8-):1553-1558. >>> Uridine, bromodeoxy-;; Saline;; rat;; 3 days;; Functionality of mp verified by postmortem examination of kidney staining; cancer; toxicology;.

P4682 George,M.H, Moore,T, Kilburn,S, Olson,G.R, DeAngelo,A.B. Carcinogenicity of chloral hydrate administered in drinking water to the male F344/N rat and male B6C3F1 mouse.. Toxicologic Pathology 2000; 28(-4-):610-618. >>> Uridine, bromodeoxy-;; SC;; rat; mice;; 2001;; 5 days;; Cancer; toxicology; hepatocyte proliferation;.

P4681 Hasmall,S.C, Roberts,R.A  Toxicologic Pathology 2000; 28(-4-):503-509. >>> Uridine, bromodeoxy-;; Saline;; SC;; rat;; 7 days;; Controls received mp w/ vehicle; cancer; toxicology;.

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