References Where the ALZET^® Osmotic Pumps Were Used In Various Animal Models for Spinal Cord Injury Research

 

P8458 Byrnes,K.R., Stoica,B.A., Fricke,S., Di Giovanni,S., Faden,A.I. Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury. Brain 2007; 130(--):2977-2992. >>> Flavopiridol; Saline; DMSO; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 275-325g); contusion spinal cord injury; 1% DMSO.

P8136 Ishii,K., Nakamura,M., Dai,H.N., Finn,T.P., Okano,H., Toyama,Y., Bregman,B.S. Neutralization of ciliary neurotrophic factor reduces astrocyte production from transplanted neural stem cells and promotes regeneration of corticospinal tract fibers in spinal cord injury. Journal of Neuroscience Research 2006; 84(-8-):1669-1681. >>> Antibody, polyclonal goat anti-CNTF; immunoglobulin-G, goat; CSF/CNS (Intrathecal, subarachnoid space); Rat; 2002; 14 days; Controls received mp w/ IgG; brain tissue distribution; animal info (female, Sprague-Dawley, 250-300g. spinal cord lesioning, NSC transplant).

P8029 Dijkstra,S., Duis,S., Pans,I.M., Lankhorst,A.J., Hamers,F.P.T., Veldman,H., Baer,P.R., Gispen,W.H., Joosten,E.A.J., Geisert,EE Jr  Experimental Neurology 2006; 202(-1-):57-66. >>> Antibody, anti-CD81; immunoglobulin, G; PBS; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Post op. care (fluid therapy, 3.0 ml saline); animal info (adult, female, Wistar, 11 weeks old, 200-240 grams); spinal cord cannulation technique outlined (p. 58); PE tubing used; pump functionality measured incorrectly; x-ray image of pump/cannulation (p. 59); behavioral study.

P8019 Kaneko,S., Iwanami,A., Nakamura,M., Kishino,A., Kikuchi,K., Shibata,S., Okano,H.J., Ikegami,T., Moriya,A., Konishi,O. A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord. Nature Medicine 2006; 12(--):1380-1389. >>> SM-216289; CSF/CNS (intrathecal, spinal cord lesion); Rat; 2004; 4 weeks; Controls received mp w/ PBS; animal info (female, Sprague-Dawley, 200-250 grams, spinal cord transection); neuroscience.

P7994 Vavrek,R., Girgis,J., Tetzlaff,W., Hebert,G.W., Fouad,K. BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats. Brain 2006; 129(--):1534-1545. >>> Brain-derived neurotrophic factor; NT-3; Albumin, rat serum; CSF/CNS (left motor cortex, intrathecal, cisterna magna); Rat; 2002; 14 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; SCI (spinal cord injury); dental cement used to secure cannula; NT-3 delivered intrathecally; tissue perfusion (left motor cortex).

P7814 Hata,K., Fujitani,M., Yasuda,Y., Doya,H., Saito,T., Yamagishi,S., Mueller,B.K., Yamashita,T. RGMa inhibition promotes axonal growth and recovery after spinal cord injury. Journal of Cell Biology 2006; 173(-1-):47-58. >>> Antibody, anti-rat RGMA; immunoglobulin G, rabbit; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ rabbit IgG; animal info (female, Wistar, 200-250g., spinal cord hemisection); repulsive guidance molecule (RGM).

P7808 Karimi-Abdolrezaee,S., Eftekharpour,E., Wang,J., Morshead,C.M., Fehlings,M.G. Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. Journal of Neuroscience 2006; 26(-13-):3377-3389. >>> Fibroblast growth factor, basic; epidermal growth factor; platelet-derived growth factor-AA; CSF, artificial; gentamycin; BSA; CSF/CNS (intrathecal); Rat; 1007D; 7 days; Peptides; animal info (female, Wistar, 250g., spinal cord injury, neural precursor cells transplantation).

P7738 Hyatt,J.P.K., Roy,R.R., Baldwin,K.M., Wernig,A., Edgerton,V.R. Activity-unrelated neural control of myogenic factors in a slow muscle. Muscle&Nerve 2006; 33(-1-):49-60. >>> Uridine, bromodeoxy-; SC; Rat; 2ML2; 14 days; Animal info (female, Sprague-Dawley, 200-235g.; denervation or spinal cord isolation); labeling of satellite cells.

P7663 Kaplin,A.I., Deshpande,D.M., Scott,E., Krishnan,C., Carmen,J.S., Shats,I., Martinez,T., Drummond,J., Dike,S., Pletnikov,M., Keswani,S.C., Moran,T.H., Pardo,C.A., Calabresi,P.A., Kerr,D.A. IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis. Journal of Clinical Investigation 2005; 115(-10-):2731-2741. >>> Interleukin 6, recomb. rat; PBS; BSA; CSF/CNS (intrathecal, subarachnoid space); Rat; 1007D; 7 days; Controls received mp w/ vehicle; immunology; neurodegenerative (transverse myelitis, spinal cord injury); animal info (Sprague-Dawley, adult); SCI.

P7652 bdel-Karim,A.M., Barthlow,H.G., Bialecki,R.A., Elhilali,M.M. Effects of M274773 a neurokinin-2 receptor antagonist, on bladder function in chronically spinalized rats. Journal of Urology 2005; 174(-4-):1488-1492. >>> M274773; PEG 400; saline; SC; Rat; 2004; 1, 2 weeks; Animal info (female, Sprague-Dawley, 200-250 g); spinal cord injury (SCI).

P7563 Ikegami,T., Nakamura,M., Yamane,J., Katoh,H., Okada,S., Iwanami,A., Watanabe,K., Ishii,K., Kato,F., Fujita,H., Takahashi,T., Okano,H.J., Toyama,Y., Okano,H. Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43-positive fibers after rat spinal cord injury. European Journal of Neuroscience 2005; 22(-12-):3036-3046. >>> Chondroitinase ABC; Saline, physiological; CSF/CNS (intrathecal, subarachnoid space); Rat; 2001; 1 week; Controls received mp w/ heat inactivated agent; stability verified by ALZAID chemical compability test kit for 7 days; animal info (adult, female, Sprague-Dawley 230-250 g); mp primed overnight in 37 C saline; spinal cord injury.

P7556 Liebscher,T., Schnell,L., Schnell,D., Scholl,J., Schneider,R., Gullo,M., Fouad,K., Mir,A., Rausch,M., Kindler,D., Hamers,F.P.T., Schwab,M.E. Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Annals of Neurology 2005; 58(-5-):706-719. >>> Antibody, monoclonal mouse; anti-rat Nogo-A (623-640); antibody, monoclonal mouse; anti-Nogo-A (1-979); antibody, monoclonal mouse; anti- wheat auxin; PBS; CSF/CNS (intrathecal); Rat; 2ML2; 2 weeks; Controls received mp w/ monoclonal anti-wheat auxin Ab; functionality verified by Ab concentrations in CSF; post op. care (baytril, analgesic); animal info (female, Lewis, spinal cord lesion).

P7265 Ji,B.X., Li,M.W., Budel,S., Pepinsky,R.B., Walus,L., Engber,T.M., Strittmatter,S.M., Relton,J.K. Effect of combined treatment with methylprednisolone and soluble Nogo-66 receptor after rat spinal cord injury. European Journal of Neuroscience 2005; 22(-3-):587-594. >>> Nogo-66 receptor (27-310) ecto-Fc; immunoglobulin G, rat; PBS; CSF/CNS (intrathecal); Rat; 2004; 28 days; Controls received mp w/ vehicle rat IgG; functionality of mp verified by residual volume; stability verified by analysis of remaining mp contents; post op. care (buprenorphine/buprenex, ampicillin); spinal cord injury.

P6902 Fouad,K., Schnell,L., Bunge,M.B., Schwab,M.E., Liebscher,T., Pearse,D.D. Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. Journal of Neuroscience 2005; 25(-5-):1169-1178. >>> Chondroitinase ABC; antibody, immunoglobulin G, recomb. mouse; galactosidase; Saline; PBS; CSF/CNS (intrathecal, lumbar); Rat; 2002; 4 weeks; Comparison of IT injections vs. mp; pumps replaced at two weeks; post op. care (antibiotic); spinal cord injury; Recathco catheter used; behavioral study.

P6803 Colpaert,F.C., Wu,W.P., Hao,J.X., Royer,I., Sautel,F., Wiesenfeld-Hallin,Z., Xu,X.J. High-efficacy 5-HT1A receptor activation causes a curative-like action on allodynia in rats with spinal cord injury. European Journal of Pharmacology 2004; 497(-1-):29-33. >>> F13640; SC; Rat; 2ML4; 56 days; Controls received mp w/ saline; functionality of mp verified by plasma levels; long-term study; pumps replaced at day 28; 5-HT1A receptor agonist; spinal cord injury; pain.

P6801 Iannotti,C., Zhang,Y.P., Shields,C.B., Han,Y.C., Burke,D.A., Xu,X.M. A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury. Experimental Neurology 2004; 189(-2-):317-332. >>> Glial-derived neurotrophic factor, recomb. human; glial-derived neurotrophic factor, alexa S94 dye-conjugated; Saline; CSF/CNS (intrathecal); Rat; 2004; 3 weeks; 28 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume and cannula patency; good methods p. 318; brain tissue distribution; spinal cord injury.

P6538 Grimpe,B., Silver,J. A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord. Journal of Neuroscience 2004; 24(-6-):1393-1397. >>> Oligodeoxyribonucleotide, phosphorothioated; CSF/CNS (intrathecal, subarachnoid space); Mice; 1007D; 7 days; Controls received mp w/ control DNA enzyme; antisense (xylosyltransferase-1); spinal cord injury; PE-60 tubing connected to PE-10 tubing for IT delivery; DNA enzyme against xylosyltransferase-1 (XT-1).

P6451 Seki,S., Sasaki,K., Igawa,Y., Nishizawa,O., Chancellor,M.B., De Groat,W.C., Yoshimura,N. Suppression of detrusor-sphincter dyssynergia by immunoneutralization of nerve growth factor in lumbosacral spinal cord in spinal cord injured rats. Journal of Urology 2004; 171(-1-):478-482. >>> Antibody, anti-nerve growth factor; CSF, artificial; CSF/CNS (intrathecal); Rat; 2002; 14 days; Controls received mp w/ vehicle; spinal cord injury; PE-10 used for catheterization.

P6347 Kim,D.H., Jahng,T.A. Continuous brain-derived neurotrophic factor (BDNF) infusion after methylprednisolone treatment in severe spinal cord injury. Journal of Korean Medical Science 2004; 19(-1-):113-122. >>> Brain-derived neurotrophic factor; CSF, artificial; CSF/CNS (intrathecal); Rat; 2004; 6 weeks; ALZET brain infusion kit; spinal cord injury; behavorial study.

P5597 Fournier,A.E., Takizawa,B.T., Strittmatter,S.M. Rho kinase inhibition enhances axonal regeneration in the injured CNS. Journal of Neuroscience 2003; 23(-4-):1416-1423. >>> C3 Transferase; Glutathione S-transferase; Y-27632; PBS; CSF/CNS (intrathecal); Rat; 2002; 2-3 weeks; Enzyme inhibitor (protein kinase); peptides; spinal cord injury; Y-27632 is a Rho-associated kinase (ROCK) inhibitor.

P3678 Krenz,N.R., Meakin,S.O., Krassioukov,A.V., Weaver,L.C. Neutralizing intraspinal nerve growth factor blocks autonomic dysreflexia caused by spinal cord injury. J Neurosci 2003; 19(-17-):7405-7414. >>> Antibody, anti-nerve growth factor; Antibody, Immunoglobulin G; CSF, artificial; CSF/CNS (intrathecal); knee (articular cavity); Rat; 2ML2; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by residual volume; spinal cord injury; PE-10 intrathecal catheter tubing was perforated along its length and tip was sealed; PE-100 catheter used for knee joint infusion.

P6311 Coumans,J.V., Lin,T.T-S., Dai,H.N., Macarthur,L., McAtee,M., Nash,C., Bregman,B.S. Axonal Regeneration and Functional Recovery after Complete Spinal Cord Transection in Rats by Delayed Treatment with Transplants and Neurotropins. The Journal of Neuroscience 2001; 21(-23-):9334-9344. >>> Brain-derived neurotrophic factor, human recomb.; NT-3, human recomb.; CSF/CNS (spinal cord, intrathecal); Rat; 2002; 14 days; Controls received mp w/ saline; tissue perfusion (fetal spinal cord transplant tissue); good methods p.9335; post op. care (sulfamethoxazole-trimethoprim).

P4984 Nesic,O., Xu,G.Y., McAdoo,D., High,K.W., Hulsebosch,C., Perez-Polo,R. IL-1 receptor antagonist prevents apoptosis and caspase-3 activation after spinal cord injury. Journal of Neurotrauma 2001; 18(-9-):947-956. >>> Interleukin-1 receptor antagonist, recombinant mouse; CSF, artificial; CSF/CNS (spinal cord, intrathecal); rat; 1003D; ; controls received mp w/ vehicle; tissue perfusion (spinal cord T8 injury site); functionality of mp verified by ELISA IL-1 detection assay, IL-1 mRNA levels; dose response (fig 1. p. 951); peptides; PE-60 catheter tubing used.

P4940 Jones,L.L., Tuszynski,M.H. Chronic intrathecal infusions after spinal cord injury cause scarring and compression. MICROSCOPY RESEARCH AND TECHNIQUE 2001; 54(--):317-324. >>> Dye, Evans Blue; Saline; CSF/CNS (intrathecal); Rat; 2002; 5 or 12 days; controls received mp w/ saline; functionality of mp verified by infusion of dye; pumps replaced after 5 of 12 days of infusion with fresh pumps filled with Evans Blue dye; dye infusion was for 2 days; catheter patency verified by infusion of Evans Blue dye; spinal cord injury; PE-10 was connected to PE-60 tubing..

P5231 Oudega,M., Hagg,T. Neurotrophins promote regeneration of sensory axons in the adult rat spinal cord. Brain Res 1999/2/13; 818(-2-):431-438. >>> Nerve growth factor; NT-3; Brain-derived neurotrophic factor; PBS; Albumin, rat serum; Gentamicin; CSF/CNS (dorsal spinal cord, intrathecal); Rat; 2002; 14 days; Controls received mp w/ vehicle; peptides; Schematic representation of spinal cord infusion model (p.432); agents infused separatedly or concomitantly in the same pump;.

P3405 Gelderd,J.B., Hall,N.R.S., O'Grady,M.P., Oliver,J., Ferrer,C., Anderson,J.A. The effects of interleukin-1 receptor antagonist protein (IRAP) infusion following spinal cord transection in rats. Mol.and Chem.Neuropathy 1996; 27(--):167-183. >>> Interleukin-1 receptor antagonist; PBS; CSF/CNS (spinal cord, intrathecal); rat; 2001; 7 days; controls received mp w/ vehicle; tissue perfusion (spinal cord transection site); peptides; pump placed in flank..

P2887 Malmberg,A.B., Yaksh,T.L. Effect of continuous intrathecal infusion of w-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hot-plate tests in rats. Pain 1995; 60(--):83-90. >>> SNX-III; SNX-239; Morphine sulfate; Saline, physiological; CSF/CNS (spinal cord, intrathecal); rat; 2001; 2 or 7 days; controls received mp with saline; peptides; tolerance; PE-10 tubing into spinal cord fused with PE-60 tubing on pump; catheter filled with saline to delay drug infusion 18 hours; SNX-III and SNX-239 are w-conopeptides and calcium channel blockers.

P2630 Stevens,C.W., Yaksh,T.L. Studies of morphine and D-ala2-D-leu5-enkephalin (DADLE) cross-tolerance after continuous intrathecal infusion in the rat. Anesthesiology 1992; 76(-4-):596-603. >>> Morphine sulfate; Enkephalin analog DADLE; Saline; CSF/CNS (spinal cord, intrathecal); rat; 2001; 7 days; controls received mp w/ vehicle; dose-response (pg.600); stability of morphine in spinal cord assessed; tolerance; "cont. spinal infusion, in contrast to . . .avoids the peak and trough or exponentially decreasing concentration of tolerogen and the receptor during exposure period"; y-catheter used for intrathecal infusion.

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