References on the Use of ALZET^® Osmotic Pumps Where Post Operative Care Was Mentioned

 

P8601 Physiologica,A. Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure. ACTA PHYSIOLOGICA 2007; 190(-4-):339-350. >>> Losartan; IP; Rat; 2ML2; 14 days; Controls received no treatment; cardiovascular; post op. care (buprenorphine); ischemia (cardiac); animal info (male, Wistar, 250 grams, left anterior descending coronary artery ligation).

P8600 de Seigneux,S., Nielsen,J., Olesen,E.T.B., Dimke,H., Kwon,T.H., Frokiaer,J., Nielsen,S. Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney. American Journal of Physiology- Renal Physiology 2007; 293(-1-):F87-F99. >>> Aldosterone; vasopressin, 1-deamino-8-D-arginine; angiotensin II; Saline; DMSO; ringer's solution, lactated; SC; Rat; 2001; 2002; 6,7,8 days; Controls received mp w/ vehicle; cardiovascular; peptides; multiple pumps per animal (2); post op. care (Buprenorphine); animal info (male, Wistar-Hanover, 220-250 grams, male, Sprague-Dawley, 190-210 grams, male, Munich-Wistar, 220 grams); 30% and 25% DMSO used.

P8533 Morrey,J.D., Siddharthan,V., Olsen,A.L., Wang,H., Julander,J.G., Hall,J.O., Li,H., Nordstrom,J.L., Koenig,S., Johnson,S., Diamond,M.S. Defining limits of treatment with humanized neutralizing monoclonal antibody for West Nile virus neurological infection in a hamster model. Antimicrob.Agents Chemother. 2007/7; 51(-7-):2396-2402. >>> Antibody, monoclonal, hE16; CSF/CNS (pons); Hamster; 2001D; 24 hours; Controls received aCSF; functionality of mp verified by previous study with dye; comparison of IP injections vs. mp; post op. care (buprenorphine); animal info (female, Syrian golden, >7 weeks old); cannula placement confirmed with dye; E16 is anti-domain III of the West Nile Virus envelope protein.

P8516 Hong,L.Z., Hsieh,P.S. Hyperinsulinemia Instead of Insulin Resistance Induces Baroreflex Dysfunction in Chronic Insulin-Infused Rats. American Journal of Hypertension 2007; 20(-4-):451-458. >>> Insulin, porcine; Glycerin; ethanol; SC; Rat; 2002; 8 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced every 14 days; post op. care (penicillin); animal info (male, Sprague-Dawley, 200-250 grams); 50% ETOH used [manufacturer suggests 15% or less ETOH; for pump compatibility purposes].

P8513 Gomori,A., Ishihara,A., Ito,M., Matsushita,H., Ito,M., Mashiko,S., Iwaasa,H., Matsuda,M., Bednarek,M.A., Qian,S., MacNeil,D.J., Kanatani,A. Blockade of MCH1 receptor signalling ameliorates obesity and related hepatic steatosis in ovariectomized mice. Br.J.Pharmacol. 2007/7; 151(-6-):900-908. >>> Melanin-concentrating hormone 1, receptor antagonist; Propylene glycol; water, distilled; CSF/CNS; Mice; 2004; 8 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced after 4 weeks of vehicle delivery; ALZET brain infusion kit used; post op. care (cefamezin-a); animal info (female, C57BL/6J, 12 weeks old, female Mch1r KD, 14-16 weeks old, 22 g); cannula placement confirmed with Evans Blue dye; obesity.

P8494 Stoller,D.C., Sim-Selley,L.J., Smith,F.L. Role of kappa and delta opioid receptors in mediating morphine-induced antinociception in morphine-tolerant infant rats. Brain Research 2007; 1142(--):28-36. >>> Morphine; SC; Rat (neonate); 1003D; 72 hours; Controls received mp w/ vehicle; tolerance; post op. care (10% povidone iodine swab); animal info (P14, 30 g); Vetbond tissue adhesive used to close incision.

P8488 Smith,J.M., Lunga,P., Story,D., Harris,N., Le Belle,J., James,M.F., Pickard,J.D., Fawcett,J.W. Inosine promotes recovery of skilled motor function in a model of focal brain injury. Brain 2007; 130(--):915-925. >>> Inosine; CSF, artificial; CSF/CNS; Rat; 2004; 4 weeks; ALZET Brain Infusion Kit 2 used; multiple pumps per animal (2); post op. care (carprofen, IP); traumatic brain inujury; behavioral study; dental cement used; animal info (male, lister, hooded, 200-300 g).

P8435 Saade,N.E., Al Amin,H., Baki,S.A., Chalouhi,S., Jabbur,S.J., Atweh,S.F. Reversible attenuation of neuropathic-like manifestations in rats by lesions or local blocks of the intralaminar or the medial thalamic nuclei. Experimental Neurology 2007; 204(-1-):205-219. >>> Lidocaine; Dye, China ink; CSF/CNS (PVN of thalamus); CSF/CNS (rostral medial nuclei of thalamus); Rat; 2002; 14 days; Controls received sham treatment; comparison of lesions vs. mp; half-life (p. 216),<1hr; post op. care (dexamethasone, penicillin); animal info (male, female, Sprague-Dawley, 280-300 grams); "The effects of the microperfusion with lidocaine were more pronounced and durable than those of lesions." (p. 216).

P8402 Maruyama,J., Yamagata,T., Ulfendahl,M., Bredberg,G., Altschuler,R.A., Miller,J.M. Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs. NEUROBIOLOGY OF DISEASE 2007; 25(-2-):309-318. >>> Trolox; neomycin; ascorbic acid; Perilymph, artificial; sodium bicarbonate; Ear (cochlea); Guinea-Pig; 2002; 26 days; Controls received mp w/ vehicle; pumps replaced after 14 days; post op. care (doxycycline); animal info (male, pigmented, 250-400g., neomycin deafening); cannula primed with 10% neomycin solution followed by a small air bubble spacer to allow neomycin infusion for first 2 days; trolox, a vitamin F analogue, and ascorbic acid delivered together in 1 mp; tissue perfusion (cochlea).

P8390 Johnston,R.A., Theman,T.A., Terry,R.D., Williams,E.S., Shore,S.A. Pulmonary responses to acute ozone exposure in fasted mice: effect of leptin administration. Journal of Applied Physiology 2007; 102(-1-):149-156. >>> Leptin, recomb. mouse; PBS; HCR; NaOH; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; functionality of mp verified by serum leptin concentration; peptides; post op. care (buprenorphine hydrochloride); animal info (male, C57BL/6J, 8 wks old).

P8344 Bondi,C.O., Barrera,G., Lapiz,M.D.S., Bedard,T., Mahan,A., Morilak,D.A. Noradrenergic facilitation of shock-probe defensive burying in lateral septum of rats, and modulation by chronic treatment with desipramine. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY&BIOLOGICAL PSYCHIATRY 2007; 31(-2-):482-495. >>> Desipramine; Ethanol; IP; Rat; 2ML2; 2ML4; 7, 14, 21 days; Controls received mp w/ vehicle; functionality of mp verified by plasma DMI levels; comparison of IP injections vs. mp; post op. care (penicillin G); animal info (male, Sprague-Dawley, 200-250 grams); 10% ETOH.

P8329 Okada,T., Cyster,J.G. CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. Journal of Immunology 2007; 178(-5-):2973-2978. >>> TN14003, 4F-benzoyl; SC; Mice; 2001D; 1 day; Controls received no treatment; post op. care (buprenorphine); animal info (C57BL/6).

P8303 Zissen,M.H., Zhang,G., McKelvy,A., Propst,J.T., Kendig,J.J., Sweitzer,S.M. Tolerance, opioid-induced allodynia and withdrawal associated allodynia in infant and young rats. Neuroscience 2007; 144(-1-):247-262. >>> Morphine; Saline; SC; Rat (neonate); 1003D; 72 hours; Controls received mp w/ vehicle; dose-response (p. 250); comparison of acute or intermittently injections vs. mp; vs. pellet; good methods (p. 249); tolerance; post op. care (IP penicillin, fluid therapy); animal info (Sprague-Dawley); morphine withdrawal; behavioral testing.

P8300 Messina,M.M., Overton,J.M. Cardiovascular effects of melanin-concentrating hormone. REGULATORY PEPTIDES 2007; 139(-1-3-):23-30. >>> Melanin-concentrating hormone; PBS; BSA; CSF/CNS; Rat; 1002; 10 days; Controls received mp w/ vehicle; dose-response (fig. 1); comparison of acute icv infusion vs. mp; peptides; post op. care (Bupivacaine); animal info (male, Long-Evans, 330g.).

P8281 Lee,M.C., Bier,A.D., Nickisch,F., Eberson,C.P., Ehrlich,M.G., Chen,Q. Epiphysiodesis with infusion of stromal cell-derived factor-1 in rabbit growth plates. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME 2007; 89A(-1-):102-113. >>> Stromal cell-derived factor-1a, recomb. human; dye, methylene blue; PBS; hypaque; Bone (tibial physis); Rabbit; 2001D; 2004; 2,4 weeks; 24 hours; Controls received mp w/ vehicle and control leg w/ no treatment; functionality of mp verified by methylene blue study, hypaque; good methods (p. 103-105); peptides; post op. care (buprenorphine); animal info (New Zealand white, 6 weeks old, 2.5 kg); catheter with 16 fenestrations used; 30% hypaque, which "served as a radio-opaque marker of pump reservoir level."; "A continuous, implantable, direct delivery system offers a practical model for studying the local effects of various reagents on the physis and a therapeutic model by which agents for use in epiphysiodesis may be evaluated." (p. 110).

P8248 Nielsen,J., Kwon,T.H., Frokiaer,J., Knepper,M.A., Nielsen,S. Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade. American Journal of Physiology-Renal Physiology 2007; 292(-1-):F382-F394. >>> Aldosterone; Saline, sterile; DMSO; SC; Rat; 2002; 7, 10 days; Controls received mp w/ vehicle; functionality of mp verified by plasma aldosterone levels; dose-response (pg F383); no stress (see pg F384); post op. care (bupivacaine); animal info (male, Sprague-Dawley, 190-210g); 25% DMSO.

P8132 Haruta,M., Hata,Y. Experience-driven axon retraction without binocular imbalance in developing visual cortex. CURRENT BIOLOGY 2007; 17(-1-):37-42. >>> Muscimol; Saline; CSF/CNS (visual cortex, area 17); Cat (kitten); 2002; 2 weeks; Brain tissue distribution; post op. care (enrofloxacin); animal info (4 wks old, vision deprivation by eyelid suture); tissue perfusion (visual cortex).

P8103 Dickinson,H., Walker,D.W., Wintour,E.M., Moritz,K. Maternal dexamethasone treatment at midgestation reduces nephron number and alters renal gene expression in the fetal spiny mouse. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2007; 292(-1-):R453-R461. >>> Dexamethasone; SC; Mice (pregnant); 1003D; 60 hours; Controls received mp w/ saline; no stress (see p.R455); good methods p.R454; teratology; post op. care (xylocaine, betadine); animal info (female, gestation day 20); nephrology.

P7978 Engelhardt,M., Di Cristo,G., Berardi,N., Maffei,L., Wahle,P. Differential effects of NT-4, NGF and BDNF on development of neurochemical architecture and cell size regulation in rat visual cortex during the critical period. European Journal of Neuroscience 2007; 25(-2-):529-540. >>> Nerve growth factor, mouse; NT-4, human recomb.; brain-derived neurotrophic factor, recomb. human; CSF/CNS (visual cortex); Rat; 1007D; 8 days; Post op. care (antibiotics and local anesthetics); animal info (Long-Evans); dental cement used; 30 G cannula used; tissue perfusion (visual cortex).

P8377 Rasmussen,B.A., Perry,D.C. An autoradiographic analysis of [125I] alpha-bungarotoxin binding in rat brain after chronic nicotine exposure. Neuroscience Letters 2006; 404(-1-2-):9-14. >>> Nicotine hydrogen tartrate; Saline, sterile; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle; post op. care (buprenorphine); animal info (male, Sprague-Dawley, 225-275g.).

P8313 Shore,S.A., Terry,R.D., Flynt,L., Xu,A.M., Hug,C. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. Journal of Allergy and Clinical Immunology 2006; 118(-2-):389-395. >>> Adiponectin, recomb. mouse; Saline, Tris-buffered; SC; Mice; 1007D; 6 days; Controls received mp w/ vehicle; functionality of mp verified by serum adiponectin levels; no stress (see pg. 391); peptides; post op. care (Buprenorphine hydrochloride); animal info (male, female, BALB/cJ, 4 wks old).

P8297 Nitsos,I., Rees,S.M., Duncan,J., Kramer,B.W., Harding,R., Newnham,J.P., Moss,T.J.M. Chronic exposure to intra-amniotic lipopolysaccharide affects the ovine fetal brain. JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION 2006; 13(-4-):239-247. >>> Endotoxin, LPS; Intra-amniotic; Sheep (pregnant); 2ML4; 28 days; Controls received mp w/ saline; no stress (see pg. 240,242); teratology; post op. care (Penicillin); animal info (female, gestation days 80-108); mp attached to fetal forelimb using 3/0 braided silk ligature to ensure mp remained in amniotic fluid; "Intra-amniotic LPS infusion caused histological chorioamnionitis...but did not cause fetal death, preterm birth or abortion." (p. 242).

P8279 Lin,E.J.D., Lee,N.J., Slack,K., Karl,T., Duffy,L., O'Brien,E., Matsumoto,I., Dedova,I., Herzog,H., Sainsbury,A. Distinct endocrine effects of chronic haloperidol or risperidone administration in male rats. Neuropharmacology 2006; 51(-7-8-):1129-1136. >>> Haloperidol; risperidone; Acetic acid; SC; Rat; 2ML4; 28 days; Controls received mp w/ vehicle; no stress (see pg. 1131); half-life (p. 1131) 4-6 times shorter in rodents than in humans; post op. care (bupivicaine); animal info (male, Sprague-Dawley, 9-10 weeks old, 280-430 grams); "This dosing regimen also takes into consideration the reported 4-6 times shorter half-life of antipsychotic drugs in rodents than humans and highlights the advantage of using minipumps in the present study for continuous drug administration to achieve receptor occupancies comparable to clinical use in humans." (p. 1131).

P8113 Kanehisa,M., Akiyoshi,J., Kitaichi,T., Matsushita,H., Tanaka,E., Kodama,K., Hanada,H., Isogawa,K. Administration of antisense DNA for ghrelin causes an antidepressant and anxiolytic response in rats. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY&BIOLOGICAL PSYCHIATRY 2006; 30(-8-):1403-1407. >>> Oligodeoxynucleotide, antisense; oligodeoxynucleotide, missense; Saline; CSF/CNS; Rat; 1003D; 1007D; 3 days; Controls received mp w/ vehicle, or missense oligo; antisense (ghrelin); post op. care (ceftriaxone sodium); animal info (male, Wistar, 7-9 wks old, 300-330g.).

P8112 Ji,B., Li,M., Wu,W.T., Yick,L.W., Lee,X., Shao,Z., Wang,J., So,K.F., Mccoy,J.M., Pepinsky,R.B., Mi,S., Relton,J.K. LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury. MOLECULAR AND CELLULAR NEUROSCIENCE 2006; 33(-3-):311-320. >>> Immunoglobulin G1, human; LINGO-1-Fc, recomb. human; PBS; CSF/CNS (intrathecal, subarachnoid space); Rat; 2004; 4 weeks; Controls received mp w/ vehicle, or IgG1; replacement therapy (dorsal hemisection); peptides; post op. care (Buprenorphine/Buprenex, Ampicillin); animal info (female, Long Evans, 7 wk old).

P8069 Mitchell,H.A., Ahern,T.H., Liles,L.C., Javors,M.A., Weinshenker,D. The effects of norepinephrine transporter inactivation on locomotor activity in mice. Biological Psychiatry 2006; 60(-10-):1046-1052. >>> Reboxetine; bupropion; imipramine; desipramine; venlafaxine; Saline; ethanol; IP; Mice; 2004; 18-20 days; Controls received mp w/ vehicle; comparison of IP injections vs. mp; no stress (see p.1049); post op. care (Buprenorphine); animal info (male, female, C57BL6/J, 3-7 months old); 50% ETOH vehicle for desipramine; mp primed 1 day in 37 celsius saline.

P8038 Wilson-Gerwing,T.D., Verge,V.M.K. Neurotrophin-3 attenuates galanin expression in the chronic constriction injury model of neuropathic pain. Neuroscience 2006; 141(-4-):2075-2085. >>> NT-3; PBS; albumin, rat serum; streptomycin; penicillin; CSF/CNS (intrathecal, lumbar); Rat; 2001; 7 days; Post op. care (buprenorphine); animal info (adult, male, wistar, 250-300 grams).

P8029 Dijkstra,S., Duis,S., Pans,I.M., Lankhorst,A.J., Hamers,F.P.T., Veldman,H., Baer,P.R., Gispen,W.H., Joosten,E.A.J., Geisert,EE Jr  Experimental Neurology 2006; 202(-1-):57-66. >>> Antibody, anti-CD81; immunoglobulin, G; PBS; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Post op. care (fluid therapy, 3.0 ml saline); animal info (adult, female, Wistar, 11 weeks old, 200-240 grams); spinal cord cannulation technique outlined (p. 58); PE tubing used; pump functionality measured incorrectly; x-ray image of pump/cannulation (p. 59); behavioral study.

P8025 O'Dell,L.E., Bruijnzeel,A.W., Smith,R.T., Parsons,L.H., Merves,M.L., Goldberger,B.A., Richardson,H.N., Koob,G.F., Markou,A. Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction. Psychopharmacology 2006; 186(-4-):612-619. >>> Nicotine; Saline; SC; Rat; 2ML2; 7-8 days; Controls received mp w/ vehicle; nicotine plasma levels taken; dependence; post op. care (Bacitracin ointment); animal info (male, Wistar).

P8023 Niewiadomska,G., Baksalerska-Pazera,M., Gasiorowska,A., Mietelska,A. Nerve growth factor differentially affects spatial and recognition memory in aged rats. Neurochemical Research 2006; 31(-12-):1481-1490. >>> Nerve growth factor, beta; CSF, artificial; CSF/CNS; Rat; 2004; 1 month; ALZET brain infusion kit used; post op. care (antibiotic and analgesic to scalp + fluid therapy); silastic tubing used; 28 G cannula.

P8020 Ma,T., Nelson,E.R., Mawatari,T., Oh,K.J., Larsen,D.M., Smith,R.L., Goodman,S.B. Effects of local infusion of OP-1 on particle-induced and NSAID-induced inhibition of bone ingrowth in vivo. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 2006; 79A(-3-):740-746. >>> OP-1, recomb. human; Acetate buffer; Bone (tibia); Rabbit; 2004; 6, 24 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced every 4-6 weeks; stress/adverse reaction (see pg. 742) implant (DTC and mp) infection in one animal [manufacturer note: pumps are provided sterile]; peptides; post op. care (cephalosporin); animal info (male, New Zealand white, 6-12 months old, 3.5-4.2 kg); agent also know as bone morphogenic protein-7; mp implanted with a titanium drug test chamber (DTC).

P7942 Berni,R., Cacciani,F., Zaniboni,M., Savi,M., Bocchi,L., Lapucci,S., Razzetti,R., Pastore,F., Musso,E., Stilli,D. Effects of the alpha 2-adrenergic/DA2-dopaminergic agonist CHF-1024 in preventing ventricular arrhythmogenesis and myocyte electrical remodeling, in a rat model of pressure-overload cardiac hypertrophy. Journal of Cardiovascular Pharmacology 2006; 47(-2-):295-302. >>> CHF-1024; Saline; ascorbic acid; SC; Rat; 2ML4; 1 month; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; dose-response (table 1); stability verified for at least 1 month (pg. 296); cardiovascular; post op. care (gentamicin); animal info (male, Wistar, 6 months old); "a clear dose dependency was found in CHF-1024 plasma levels, indicating a good performance of the osmotic pumps in drug release." (p. 299).

P7934 Zissen,M.H., Zhang,G.H., Kendig,J.J., Sweitzer,S.M. Acute and chronic morphine alters formalin pain in neonatal rats. Neuroscience Letters 2006; 400(-1-2-):154-157. >>> Morphine; Saline; Rat (neonate); 1003D; 72 hours; Controls received mp w/ vehicle; post op. care (penicillin, ringer's solution); animal info (male and female Sprague-Dawley); Vetbond tissue used.

P7932 Zeinoaldini,S., Swarts,H.J.M., Van de Heijning,B.J.M. Effects of central infusion and immunoneutralization of growth hormone on the timing of puberty and plasma leptin levels in the female rat. REGULATORY PEPTIDES 2006; 134(-2-3-):158-163. >>> Growth hormone, recomb. human; immunoglobulin G, goat; growth hormone, anti-rat; Saline, sterile; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; peptides; post op. care (analgesia, ibuprofen); animal info (female, Wistar, 45 grams).

P7901 Ahern,T.H., Javors,M.A., Eagles,D.A., Martillotti,J., Mitchell,H.A., Liles,L.C., Weinshenker,D. The effects of chronic norepinephrine transporter inactivation on seizure susceptibility in mice. Neuropsychopharmacology 2006; 31(-4-):730-738. >>> Reboxetine; sertraline; desipramine; bupropion; imipramine; venlafaxine; Saline; ethanol; IP; Mice; 2004; 21 days; Controls received mp w/ vehicle; functionality of mp verified by serum drug levels; dose-response (fig. 4); comparison of IP injections vs. mp; stress/adverse reaction: (see pg. 731) Dbh -/- mice did not tolerate mp surgery well and showed signs of general malaise. All other mice strains showed no stress.; post op. care (buprenorphine); animal info (female, male, 3-7 month old; C57BL/6J NET -/- or wt; 257BL/6J 129SvEv Dbh -/-, +/-) 50% ethanol; mp primed 2 days in 37 celsius saline; "we achieved serum levels that fell within or very close to human therapeutic range for each drug with the exception of sertraline." (pg. 732).

P7900 Thompson,E.L., Murphy,K.G., Patterson,M., Bewick,G.A., Stamp,G.W.H., Curtis,A.E., Cooke,J.H., Jethwa,P.H., Todd,J.F., Ghatei,M.A., Bloom,S.R. Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2006; 291(-5-):E1074-E1082. >>> Kisspeptin-54; Saline; SC; Rat; 2001D; 2001; 2002; 1, 2, 3, 13 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; comparison of SC injection vs. mp; no stress (see pg. E1078); stability verified by 14 days in mp in 37 celsius saline (see fig. 2); good methods pg. E1075; peptides; post op. care (flucloxacillin, amoxicillin); animal info (male, Wistar, 275-325g.); mp primed for 3hrs. (2001D) or overnight (2001, 2002) in 37 celsius saine; "animals were healthy throughout the study period. No adverse behaviors were observed in any of the treatment groups at any point during the study." (pg. E1078).

P7870 Nakai,S., Matsunaga,W., Ishida,Y., Isobe,K., Shirokawa,T. Effects of BDNF infusion on the axon terminals of locus coeruleus neurons of aging rats. NEUROSCIENCE RESEARCH 2006; 54(-3-):213-219. >>> Brain-derived neurotrophic factor; antibody, anti-BDNF; brain-derived neurotrophic factor, biotin-labeled; immunoglobulin G; PBS; BSA; CSF/CNS (frontal cortex); Rat; 2002; 14 days; Controls received mp w/ vehicle, or IgG; dose-response (fig. 3); ALZET brain infusion kit used; brain tissue distribution; peptides; post op. care (enrofloxacin); animal info (male, F344/N, 13 month old, 19 month old); mp primed 3-6 hours in 37 celsius saline.

P7868 Marengo,S.R., Chen,D.H.C., Evan,A.P., Sommer,A.J., Stowe,N.T., Ferguson,D.G., Resnick,M.I., MacLennan,G.T. Continuous infusion of oxalate by minipumps induces calcium oxalate nephrocalcinosis. UROLOGICAL RESEARCH 2006; 34(-3-):200-210. >>> Potassium oxalate; oxalic acid, 14c-; PBS; SC; Rat; 2ML1; 13 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume and in vitro 14c-oxalic acid mp into PBS, scintillation counting; dose-response (fig. 2); pumps replaced after 6 days; no stress (see pg. 203); good methods pg. 201-203; post op. care (bupivacaine); animal info (male, Sprague-Dawley, 200-250g.); mp primed 24 hours in 25 celsius PBS; "The osmotic minipump makes possible an oxalate direct in vivo model for the study of CaOx nephrocalcinosis and interactions between oxalate and the kidney." (pg. 209).

P7824 Moriya,R., Sano,H., Umeda,T., Ito,M., Takahashi,Y., Matsuda,M., Ishihara,A., Kanatani,A., Iwaasa,H. RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice. Endocrinology 2006; 147(-6-):2916-2922. >>> Peptide, RFamide QREFP43; PBS; BSA; CSF/CNS; Mice; 2004; 4 weeks; 24 days; Controls received mp w/ vehicle; dose-response (fig. 3); pumps replaced after 2 weeks of vehicle alone; ALZET brain infusion kit used; peptides; post op. care (cefamedin alpha); animal info (male, C57BL/6J, 27-30g., 15-wk old); endocrinology.

P7812 Ma,Q.L., Lim,G.P., Harris-White,M.E., Yang,F.S., Ambegaokar,S.S., Glabe,C.G., Teter,B., Frautschy,S.A., Cole,G.M. Antibodies against beta-amyloid reduce A beta oligomers, glycogen synthase kinase-3 beta activation and tau phosphorylation in vivo and in vitro. Journal of Neuroscience Research 2006; 83(-3-):374-384. >>> Antibody, monoclonal, anti-amyloid protein, beta (1-15); immunoglobulin, IgG2b, mouse; PBS; CSF/CNS; Mice (transgenic); 1002; 14 days; Controls received mp w/ mouse IgG2b; post op. care (marcaine); neurodegenerative (Alzheimer's disease); animal info (male, female, 11-12 month old).

P7795 Peleg-Raibstein,D., Sydekum,E., Russig,H., Feldon,J. Withdrawal from continuous amphetamine administration abolishes latent inhibition but leaves prepulse inhibition intact. Psychopharmacology 2006; 185(-2-):226-239. >>> Amphetamine; SC; Rat; 2001; 2ML1; 7 days; Controls received mp w/ vehicle or saline; dose-response (fig. 4); comparison of escalating SC dose injections vs. mp; dependence; post op. care (PVP-iodine); animal info (male, wistar, 300-350 g).

P7747 Schwenke,D.O., Pearson,J.T., Kangawa,K., Shirai,M. Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats?. ACTA PHYSIOLOGICA 2006; 186(-4-):309-318. >>> L-NAME; sydnonimine-hydrochloride, 3-[4-morpholinyl]-; CSF, artificial; CSF/CNS; Rat; 2004; 3 weeks; Controls received mp w/ vehicle; no stress (see pg. 312); enzyme inhibitor (no synthase); post op. care (viccillin); animal info (male, Sprague-Dawley, 8 wk. old, 200-320g.); correct catheter positioning confirmed post mortem w/ Evans blue dye.

P7592 Imamura,K., Morii,H., Nakadate,K., Yamada,T., Mataga,N., Watanabe,Y., Mori,N. Brain-derived neurotrophic factor enhances expression of superior cervical ganglia clone 10 in lateral geniculate nucleus and visual cortex of developing kittens. European Journal of Neuroscience 2006; 23(-3-):637-648. >>> Brain-derived neurotrophic factor, recomb. human; PBS; BSA; CSF/CNS (visual cortex); Cat (kitten); cat; 2002; 14 days; Controls received mp w/ vehicle; brain tissue distribution; peptides; multiple pumps per animal (2); post op. care (ampicillin sodium).

P7585 Day,M., Langston,R.F. Post-training N-methyl-D-aspartate receptor blockade offers protection from retrograde interference but does not affect consolidation of weak or strong memory traces in the water maze. Neuroscience 2006; 137(-1-):19-28. >>> Ap5, D-; CSF, artificial; CSF/CNS; Rat; 1007D; 7, 14 days; Controls received mp w/ vehicle; pumps replaced after 7 days; post op. care (carpofen); animal info (male, Lister-hooded 230-280 g); electrophysiology.

P7582 Cardoso,A., Paula-Barbosa,M.M., Lukoyanov,N.V. Reduced density of neuropeptide Y neurons in the somatosensory cortex of old male and female rats: Relation to cholinergic depletion and recovery after nerve growth factor treatment. Neuroscience 2006; 137(-3-):937-948. >>> Dye, methylene blue; nerve growth factor; CSF, artificial; BSA; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle or sham surgery; functionality of mp verified by pretesting; Alzet brain infusion kit used; post op. care (antiseptic); animal info (male, female, Wistar 6 month old, 24 month old); Lynch coil filled with NGF, air-oil spacer between mp and catheter, mp filled with dye.

P7569 Saade,N.E., Al Amin,H., Baki,S.A., Safieh-Garabedian,B., Atweh,S.F., Jabbur,S.J. Transient attenuation of neuropathic manifestations in rats following lesion or reversible block of the lateral thalamic somatosensory nuclei. Experimental Neurology 2006; 197(-1-):157-166. >>> Lidocaine; CSF/CNS (ventrobasal complex); Rat; 2002; 14 days; Controls received no treatment or contralateral intact paw; post op. care (dexamethasone, penicillin; animal info (male, female, Sprague-Dawley, 290 g; spared nerve injury mononeuropathy; cannula placement confirmed by.

P7558 Kelleher,M.O., Myles,L.M., Al-Abri,R.K., Glasby,M.A. The use of ciliary neurotrophic factor to promote recovery after peripheral nerve injury by delivering it at the site of the cell body. Acta Neurochirurgica 2006; 148(-1-):55-61. >>> Ciliary neurotrophic factor; CSF/CNS (intrathecal, subarachnoid space); Sheep; 2ML4; 28 days; Controls received mp w/ physiological saline; no stress (see pg. 57); half-life (pg. 59) 3 minutes in serum; peptides; post op. care (cefuroxime); median nerve transected and repaired; "The adverse cytokine-like side-effects associated with systemic administration of CNTF, namely cough, asthenia, nausea, anorexia and weight loss, aphthous stomatitis and fever were not observed in any of our animals". (pg. 57).

P7451 Fekete,C., Singru,P.S., Sanchez,E., Sarkar,S., Christoffolete,M.A., Riberio,R.S., Rand,W.M., Emerson,C.H., Bianco,A.C., Lechan,R.M. Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus. Endocrinology 2006; 147(-1-):520-529. >>> Leptin, recomb. mouse; insulin; glucose; CSF, artificial; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; functionality of mp verified by agent levels in CSF+ serum; peptides; post op. care (bacitracin ointment); animal info (male Sprague-Dawley, 200-250 g); cannula placement confirmed by light microscope.

P8606 Hagg,T., Baker,K.A., Emsley,J.G., Tetzlaff,W. Prolonged local neurotrophin-3 infusion reduces ipsilateral collateral sprouting of spared corticospinal axons in adult rats. Neuroscience 2005; 130(-4-):875-887. >>> Neurotrophin-3, recomb. human; PBS; gentamicin; albumin, rat serum; CSF/CNS (intrathecal); Rat; 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; dose-response (fig. 4); stability verified by activity assay of residual mp content after 14 days in vivo; ALZET brain infusion kit used; peptides; post op. care (Penicillin G, buprenorphine); animal info (Sprague-Dawley, 3 months old, 200-220 grams, partial resection of corticospinal tract); schematic of mp p. 877 fig 2.

P8193 Ye,T., Liu,Z.Q., Sun,C.F., Zheng,Y., Ma,A.Q., Fang,Y. Altered expression of renal bumetanide-sensitive sodium-potassium-2 chloride cotransporter and Cl- channel -K2 gene on angiotensin II-infused hypertensive rats. Chinese Medical Journal 2005; 118(-23-):1945-1951. >>> Angiotensin II; Saline; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle; no stress (see pg. 1947); cardiovascular; peptides; post op. care (Penicillin G); animal info (male, Sprague-Dawley, 260-320 grams); nephrology.

P8187 Welch,M.G., Welch-Horan,T.B., Anwar,M., Anwar,N., Ludwig,R.J., Ruggiero,D.A. Brain effects of chronic IBD in areas abnormal in autism and treatment by single neuropeptides secretin and oxytocin. Journal of Molecular Neuroscience 2005; 25(-3-):259-273. >>> Secretin; oxytocin; Saline; IV (femoral); Rat; 2002; 20 days; Controls received mp w/ vehicle; post op. care (Bacitracin); animal info (male, Sprague-Dawley, 250-450 grams); autism.

P8059 Hara,H., Takeno,K., Shimogori,H., Yamashita,H. CGRP expression in the vestibular periphery after transient blockage of bilateral vestibular input. ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES 2005; 67(-5-):259-265. >>> Tetrodotoxin; Ear (cochlea perilymphatic space); Guinea-pig; 2002; 7 days; Controls received mp w/ sterile saline; post op. care (piperacillin sodium); animal info (male, Hartley, 600g.); tissue perfusion (cochlea).

P8058 Wahl,E.C., Perrien,D.S., Aronson,J., Liu,Z.D., Fletcher,T.W., Skinner,R.A., Feige,U., Suva,L.J., Badger,T.M., Lumpkin,CK Jr  ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 2005; 29(-8-):1466-1472. >>> Interleukin-1 receptor antagonist; tumor necrosis factor-a, recomb. rat; interleukin-1, recomb. rat; PBS; BSA; SC; bone (tibia); Rat; 2002; 14 days; Controls received mp w/ vehicle; dose-response (fig 3); no stress (see p. 1467, 1468, 1469); peptides; post op. care (buprenex); animal info (male, Sprague-Dawley).

P7740 Sekhon,H.S., Song,P.F., Jia,Y.B., Lindstrom,J., Spindel,E.R. Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure. Cell and Tissue Research 2005; 320(-2-):287-297. >>> Nicotine tartrate; Water, bacteriostatic; SC; Monkey (pregnant); 2ML4; 19 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced every 3 weeks; post op. care (cefazolin); animal info (female, Rhesus, gestation day 26-160); amniocentesis.

P7715 Fukada,K., Koyanagi,M., Arimura,Y., Ogiuchi,H., Uchiyama,T., Yagi,J. CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4+ T cells in vivo. Cellular Immunology 2005; 238(-2-):103-112. >>> Staphylococcal enterotoxin A; SC; Mice; 2001; 7 days; Immunology; post op. care (penicillin G); animal info (C57BL/6, female, B-12 wk. old, CD28 -/- or B6 wt).

P7688 Abraham,U., Prior,J.L., Granados-Fuentes,D., Piwnica-Worms,D.R., Herzog,E.D. Independent circadian oscillations of Period1 in specific brain areas in vivo and in vitro. Journal of Neuroscience 2005; 25(-38-):8620-8626. >>> Luciferin, beetle-D-; IP; Rat (transgenic); 2ML1; 7 days; Post op. care (Baytril); animal info (male, transgenic, Wistar); (BLI), bioilluminescence; IVIS; olfactory bulb imaging; circadian rythym; image levels were 10 fold lower than cannula delivered luciferin; "...pump-implantation procedure yielded a higher success rate." (than luciferin injected rats.) (p. 8623); peptides.

P7669 Lindblom,N., de Villiers,S.H.L., Semenova,S., Kalayanov,G., Gordon,S., Schilstroem,B., Johansson,A.M., Markou,A., Svensson,T.H. Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 2005; 372(-3-):182-194. >>> Nicotine hydrogen tartrate; SC; Rat; 2ML4; 28 days; Controls received mp w/ saline; half-life (pg. 192); dependence; post op. care (bacitracin); animal info (male, Wistar 250-300 g, 450-650 g).

P7662 Li,L., Rema,V., Ebner,F.F. Chronic suppression of activity in barrel field cortex downregulates sensory responses in contralateral barrel field cortex. Journal of Neurophysiology 2005; 94(-5-):3342-3356. >>> Muscimol; Saline, sterile; CSF/CNS (barrel field cortex); CSF/CNS (visual cortex); Rat; 2001; 7 days; Controls received mp w/ vehicle or agent delivered to visual cortex; comparison of acute ICV injection vs. mp; brain tissue distribution; cyanoacrylate adhesive; post op. care (neuropracin); animal info (male, Long-Evans 250-350 g, 2-3 mo old).

P7651 Shore,S.A., Schwartzman,I.N., Mellema,M.S., Flynt,L., Imrich,A., Johnston,R.A., Shore,S.A. Effect of leptin on allergic airway responses in mice. Journal of Allergy and Clinical Immunology 2005; 115(--):103-109. >>> Leptin; Saline; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; leptin plasma levels taken; peptides; post op. care (buprenorphine analgesic); animal info (BALB/cj).

P7624 Tanaka,S., Fan,L.W., Tien,L.T., Park,Y., Liu-Chen,L.Y., Rockhold,R.W., Ho,I.K. Butorphanol dependence increases hippocampal kappa-opioid receptor gene expression. Journal of Neuroscience Research 2005; 82(-2-):255-263. >>> Butorphanol tartrate; Saline, physiological; CSF/CNS; Rat; 2001; 3 days; Controls received mp w/ vehicle; dependence; post op. care (procaine penicillin G; animal info (male, Sprague-Dawley, 250-275 g).

P7570 Philippens,I.H.C.H., Joosen,M.J.A., Vanwersch,R.A.P. Stress adversely affects efficacy of physostigmine-scopolamine pretreatment against soman in guinea pigs. Pharmacology Biochemistry and Behavior 2005; 82(-1-):125-132. >>> Physostigmine; scopolamine bromide; Water, distilled; propylene glycol; acetic acid, glacial; ethanol; SC; Guinea-pig; 2002; 2 weeks; Controls received mp w/ vehicle; post op. care (nobecutane); animal info (male, dunkin-hartley albino, 400-450 g); 10% ETOH.

P7562 Hillebrand,J.J.G., van Elburg,A.A., Kas,M.J.H., van Engeland,H., Adan,R.A.H. Olanzapine reduces physical activity in rats exposed to activity-based anorexia: Possible implications for treatment of anorexia nervosa?. Biological Psychiatry 2005; 58(-8-):651-657. >>> Olanzapine; Saline, sterile isotonic; acetic acid; NaOH; SC; Rat; 2001; 1 week; Controls received mp w/ vehicle; half-life (pg. 655) 2.5 hours in rats, 21-53 hours in humans; post op. care (buprenorphin, saline fluid treatment); animal info (female, Wistar, 160 g); mp primed overnight at 37 C.

P7556 Liebscher,T., Schnell,L., Schnell,D., Scholl,J., Schneider,R., Gullo,M., Fouad,K., Mir,A., Rausch,M., Kindler,D., Hamers,F.P.T., Schwab,M.E. Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Annals of Neurology 2005; 58(-5-):706-719. >>> Antibody, monoclonal mouse; anti-rat Nogo-A (623-640); antibody, monoclonal mouse; anti-Nogo-A (1-979); antibody, monoclonal mouse; anti- wheat auxin; PBS; CSF/CNS (intrathecal); Rat; 2ML2; 2 weeks; Controls received mp w/ monoclonal anti-wheat auxin Ab; functionality verified by Ab concentrations in CSF; post op. care (baytril, analgesic); animal info (female, Lewis, spinal cord lesion).

P7543 Cryan,J.F., Page,M.E., Lucki,I. Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment. Psychopharmacology 2005; 182(-3-):335-344. >>> Reboxetine hydrobromide; fluoxetine hydrobromide; moclobemide; Ethanol; saline; SC; Rat; 2ML1; 2ML2; 3, 14 days; Controls received mp w/ vehicle or saline; functionality of mp verified by residual volume; dose-response (fig. 1); post op. care (providone-iodine antiseptic ointment); animal info (male, Sprague-Dawley, 350-500 g); 50% ethanol.

P7540 Babu,M., Purhonen,A.K., Bansiewicz,T., Maekelae,K., Walkowiak,J., Miettinen,P., Herzig,K.H. Effect of total colectomy and PYY infusion on food intake and body weight in rats. REGULATORY PEPTIDES 2005; 131(-1-3-):29-33. >>> Peptide YY (3-36); PBS; IV (jugular); Rat; 2ML2; 14 days; Controls received mp w/ vehicle; replacement therapy (proctocolectomy); no stress (see pg. 31-32) "no signs of stress... were found at any time during our studies"; peptides; post op. care (buprenorphine); animal info (male, Wistar 300-395 g); "we chose continuous infusion from subcutaneous implanted mini pumps to mimic physiological conditions and minimize stress caused by interperitoneal injections of the peptide." (p. 32).

P7529 Tanaka,K., Takemoto,T., Sugahara,K., Okuda,T., Mikuriya,T., Takeno,K., Hashimoto,M., Shimogori,H., Yamashita,H. Post-exposure administration of edaravone attenuates noise-induced hearing loss. European Journal of Pharmacology 2005; 522(-1-3-):116-121. >>> Edaravone; saline; Water; NaOH; Ear (cochlea); Guinea-pig; 2002; 12 hours; Controls received no treatment to left ear; pumps replaced, mp w/ saline used then replaced with mp with agent; stability verified for 24 hours; post op. care (antibiotic ointment); animal info (male, Hartley, 300-450 g); tissue perfusion (cochlea).

P7522 Paterson,N.E., Bruijnzeel,A.W., Kenny,P.J., Wright,C.D., Froestl,W., Markou,A. Prolonged nicotine exposure does not alter GABAB receptor-mediated regulation of brain reward function. Neuropharmacology 2005; 49(-7-):953-962. >>> Nicotine, free base; Saline, physiological; SC; Rat; 2ML2; 2ML4; 28 days; Controls received mp w/ vehicle; pumps replaced at day 14; post op. care (antibacterial ointment); animal info (male, Wistar, 300-350g).

P7465 Lenard,N.R., Roerig,S.C. Development of antinociceptive tolerance and physical dependence following morphine i.c.v. infusion in mice. European Journal of Pharmacology 2005; 527(-1-3-):71-76. >>> Morphine sulfate; Saline, sterile; CSF/CNS; Mice; 1003D; 3 days; Controls received mp w/ vehicle; comparison of sc pellets vs. mp; no stress (see pg. 73); tolerance; dependence; cyanoacrylate adhesive; post op. care (antibacterial ointment); animal info (male, 28-45 g); mp primed in sterile saline 37C overnight.

P7462 Sakai,M., Kudoh,M. Characteristics of sound discrimination enhancement after sound exposure in adult rats. Behavioral Neuroscience 2005; 119(-4-):961-973. >>> Ap5, D-; Saline; CSF/CNS (auditory cortex); Rat; 1003D; 60 hours; Controls received mp w/ vehicle; no stress (see pg. 970); post op. care (ampicillin, fradiomycin); animal info (male, Wistar); cannula placement verified via fast blue dye; mp installed to externalization device.

P7449 Li,S.L., Saragovi,H.U., Nedev,H., Zhao,C.N., Racine,R.J., Fahnestock,M. Differential actions of nerve growth factor receptors TrkA and p75(NTR) in a rat model of epileptogenesis. MOLECULAR AND CELLULAR NEUROSCIENCE 2005; 29(-2-):162-172. >>> Peptides, NGF mimics; antibody, anti-NGF monoclonal, NGF30; immunoglobulin G; PBS; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle or control peptide or IgG; peptides; post op. care (penicillin, apo-sulfatrim); animal info (male Long-Evans, hooded); cannula placement verified with cresyl violet staining; peptides: c25-35, c30-35, c92-92, ss51 (control).

P7439 Jorgensen,N.R., Teilmann,S.C., Henriksen,Z., Meier,E., Hansen,S.S., Jensen,J.E.B., Sorensen,O.H., Petersen,J.S. The antiarrhythmic peptide analog rotigaptide (ZP123) stimulates gap junction intercellular communication in human osteoblasts and prevents decrease in femoral trabecular bone strength in ovariectomized rats. Endocrinology 2005; 146(-11-):4745-4754. >>> Rotigaptide; IP; Rat; 2ML4; 30 days; Controls received mp w/ vehicle; functionality of mp verified by plasma agent levels; replacement therapy (ovariectomy); comparison of SC injections vs. mp; half-life (p. 4746) 14 days in human plasma; peptides; post op. care (temgesic, metacam); animal info (female, Wistar, 8 months old, 264 g); agent also known as ZP123.

P7432 Ellis,S., Mouihate,A., Pittman,Q.J. Early life immune challenge alters innate immune responses to lipopolysaccharide: implications for host defense as adults. FASEB Journal 2005; 19(-8-):U826-U842. >>> Corticosterone; PEG; IP; Rat; 2001; 1 week; Replacement therapy (adrenalectomy); no stress (see pg. 4); immunology; post op. care (derapen); "the survival rate of this procedure (ADX + mp) was 100% with animals having normal body temperature within 24 hours after the surgery.".

P7423 Sorge,R.E., Rajabi,H., Stewart,J. Rats maintained chronically on buprenorphine show reduced heroin and cocaine seeking in tests of extinction and drug-induced reinstatement. Neuropsychopharmacology 2005; 30(-9-):1681-1692. >>> Buprenorphine; CSF/CNS (nucleus accumbens); Rat; 2ML2; ; Controls received incision and pocket, no pump; dependence; post op. care (antibiotic injection); animal info (male, long-evans, 350-375 g); Plastics One 20G cannula used.

P7406 Hillebrand,J.J.G., Koeners,M.P., de Rijke,C.E., Kas,M.J.H., Adan,R.A.H. Leptin treatment in activity-based anorexia. Biological Psychiatry 2005; 58(-2-):165-171. >>> Leptin; Saline, sterile; CSF/CNS; Rat; 1007D; 5 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; post op. care (buprenorphin); telemetry implants in IP cavity.

P7372 Gliddon,C.M., Darlington,C.L., Smith,P.F. Effects of chronic infusion of a GABAA receptor agonist or antagonist into the vestibular nuclear complex on vestibular compensation in the guinea pig. Journal of Pharmacology and Experimental Therapeutics 2005; 313(-3-):1126-1135. >>> Muscimol; gabazine; Water, deionized; NaOH; CSF, modified artificial; CSF/CNS (vestibular nucleus complex); Guinea-Pig; 1003D; 30 hours; Controls received mp w/ vehicle; functionality of mp verified by agent placed in catheter, dyed sterile PBS placed in mp; dose-response (Fig. 2); post op. care (lidocaine, Bactroban); mp primed overnight in 37 degrees celsius sterile saline; cannula tip placement confirmed by Alcian blue injection; "The advantage of using mini-osmotic pumps is that, unlike injections, they are not associated with frequent handling of the animal, which can lead to stress modify the animal's vestibular, proprioceptive&visual information." (p. 1127).

P7350 Slagter,B.J., Kittilson,J., Sheridan,M.A. Expression of somatostatin receptor mRNAs is regulated in vivo by growth hormone, insulin, and insulin-like growth factor-I in rainbow trout (Oncorhynchus mykiss). REGULATORY PEPTIDES 2005; 128(-1-):27-32. >>> Growth hormone, recomb. bovine; insulin, recomb. bovine; insulin-like growth factor. recomb. human; NaCl; IP; Fish (rainbow trout); 1007D; 21 days; Controls received mp w/ vehicle; peptides; post op. care (topical antibiotic ointment); at 14 degrees celsius, the 1007D infuses at 0.14 ul/hr for approximately 21 days.

P7349 Soppa,G.K.R., Smolenski,R.T., Latif,N., Yuen,A.H.Y., Malik,A., Karbowska,J., Kochan,Z., Terracciano,C.M.N., Yacoub,M.H. Effects of chronic administration of clenbuterol on function and metabolism of adult rat cardiac muscle. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-3-):H1468-H1476. >>> Clenbuterol; Saline; SC; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; cardiovascular; post op. care (antibiotic).

P7334 Turrone,P., Remington,G., Kapur,S., Nobrega,J.N. Continuous but not intermittent olanzapine infusion induces vacuous chewing movements in rats. Biological Psychiatry 2005; 57(-4-):406-411. >>> Haloperidol; olanzapine; SC; Rat; 2ML4; 8 weeks; Controls received mp w/ vehicle; comparison of injections vs. mp; long-term study; pumps replaced every four weeks in a new incision; post op. care (placed in heated plexiglass cage); wound clips and vetbond were used to close incision.

P7306 Shepherd,R.K., Coco,A., Epp,S.B., Crook,J.M. Chronic depolarization enhances the trophic effects of brain-derived neurotrophic factor in rescuing auditory neurons following a sensorineural hearing loss. Journal of Comparative Neurology 2005; 486(-2-):145-158. >>> Brain-derived neurotrophic factor, recomb. human; perilymph, artificial; Ringer's solution; albumin, recomb. guinea-pig; Ear (scala tympani); Guinea-Pig; 2004; 28 days; Controls received mp w/ artificial perilymph or untreated contralateral cochlea; functionality of mp verified by residual fluid, cannula connection and patency; no stress (see pg. 155); good methods; peptides; post op. care (carprofen, Baytril); mp primed 36-48 hours in 37 degrees celsius Ringer's solution; Electrode array also inserted into scala tympani; "We observed no evidence of mechanical trauma to cochlea following long-term implantation and AP or BDNF delivery." (p. 155); tissue perfusion (scala tympani).

P7303 Riley,L.G., Fox,B.K., Kaiya,H., Hirano,T., Grau,E.G. Long-term treatment of ghrelin stimulates feeding, fat deposition, and alters the GH/IGF-I axis in the tilapia, Oreochromis mossambicus. General and Comparative Endocrinology 2005; 142(-1-2-):234-240. >>> Ghrelin-C8, tilapia; ghrelin-C10, tilapia; Saline, sterile; IP; Fish (tilapia); 1002; 21 days; Controls received mp w/ vehicle; no stress (see pg. 235); peptides; post op. care (maracyn); fish temperature of 25 degrees celsius gives a 28 day predicted duration for mp 1002; endocrinology.

P7297 Cairns,M.J., Burns,P., Di Nicolantonio,R., McKinley,M.J., Mathai,M.L. Influence of brain angiotensin on thermoregulation and hydromineral balance during pregnancy in rats. Journal of Applied Physiology 2005; 98(-5-):1813-1819. >>> Candesartan; CSF, artificial; CSF/CNS; Rat (pregnant); 2004; 4 weeks; Controls received mp w/ vehicle, or no treatment; no stress (see pg. 1815); post op. care (aspirin, sucrose water); mp primed; AT1 receptor antagonist.

P7289 Pereira,P.A., Cardoso,A., Paula-Barbosa,M.M. Nerve growth factor restores the expression of vasopressin and vasoactive intestinal polypeptide in the suprachiasmatic nucleus of aged rats. Brain Research 2005; 1048(-1-2-):123-130. >>> Nerve growth factor; dye, methylene blue; CSF/CNS; Rat; 2002; 14 days; Functionality of mp verified by pretesting delivery rate; ALZET brain infusion kit used; peptides; post op. care (SC saline, local antiseptic); mp filled with Methylene blue, air-oil spacer at tubing connection, tubing filled with NGF; Lynch coil; "Because there is evidence that the surgical procedure does not interfere with the structure of SCN, vehicle - treated rats were not included in this study." (p. 124).

P7286 Balatsouka,D., Gotfredsen,K., Lindh,C.H., Berglundh,T. The impact of nicotine on osseointegration - An experimental study in the femur and tibia of rabbits. CLINICAL ORAL IMPLANTS RESEARCH 2005; 16(-4-):389-395. >>> Nicotine hydrogen tartrate salt; water, sterile; SC; Rabbit; 2ML4; 2 months; Controls received mp w/ saline; functionality of mp verified by plasma cotinine levels; long-term study; pumps replaced at 4 weeks; multiple pumps per animal (2); post op. care (streptocillin, temgesic); titanium implants in femur and tibia.

P7280 Lodge,D.J., Grace,A.A. Acute and chronic corticotropin-releasing factor 1 receptor blockade inhibits cocaine-induced dopamine release: Correlation with dopamine neuron activity. Journal of Pharmacology and Experimental Therapeutics 2005; 314(-1-):201-206. >>> CRA-0450; Water, deionized; Tween 80; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; comparison of acute icv injections vs. mp; ALZET brain infusion kit 1 used; tolerance; post op. care (pramoxine HcL/Neomycin, Tylenol); CRF1 receptor antagonist.

P7270 Jonkman,S., Henry,B., Semenova,S., Markou,A. Mild anxiogenic effects of nicotine withdrawal in mice. European Journal of Pharmacology 2005; 516(-1-):40-45. >>> Nicotine tartrate; nicotine free base; Saline; SC; Mice; 2002; 14 days; Controls received mp w/ vehicle; dose-response (fig. 2); stress/adverse reaction: (see pg. 42) 5 of the mice receiving the highest dose of nicotine showed damage to the outer skin, most likely due to the high acidity of the nicotine; dependence; post op. care (Bacitracin zinc ointment).

P7265 Ji,B.X., Li,M.W., Budel,S., Pepinsky,R.B., Walus,L., Engber,T.M., Strittmatter,S.M., Relton,J.K. Effect of combined treatment with methylprednisolone and soluble Nogo-66 receptor after rat spinal cord injury. European Journal of Neuroscience 2005; 22(-3-):587-594. >>> Nogo-66 receptor (27-310) ecto-Fc; immunoglobulin G, rat; PBS; CSF/CNS (intrathecal); Rat; 2004; 28 days; Controls received mp w/ vehicle rat IgG; functionality of mp verified by residual volume; stability verified by analysis of remaining mp contents; post op. care (buprenorphine/buprenex, ampicillin); spinal cord injury.

P7256 Kenny,P.J., Markou,A. Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems. Journal of Neuroscience 2005; 25(-26-):6208-6212. >>> Nicotine hydrogen tartrate salt; Saline, sterile; SC; Rat; 2ML2; 2 weeks; Controls received mp w/ vehicle; dependence; post op. care (Bacitracin ointment).

P7245 Mashiko,S., Ishihara,A., Gomori,A., Moriya,R., Ito,M., Iwaasa,H., Matsuda,M., Feng,Y., Shen,Z., Marsh,D.J., Bednarek,M.A., MacNeil,D.J., Kanatani,A. Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice. Endocrinology 2005; 146(-7-):3080-3086. >>> Melanin-concentrating hormone 1 receptor antagonist; Propylene glycol; CSF, artificial; CSF/CNS; CSF/CNS (third ventricle); Mice; 1007D; 2002; 2004; 3, 8 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced after 1 or 4 weeks of vehicle; ALZET brain infusion kit used; peptides; cyanoacrylate adhesive; post op. care (cefamedin); DEXA; cannula placement confirmed by Evans blue dye injection; animal info (C57BL/6); pumps used in lateral ventricle for one group of animals, and third ventricle for others. Third ventricle group used Plastics One cannulae.

P7219 Friel,K.M., Martin,J.H. Role of sensory-motor cortex activity in postnatal development of corticospinal axon terminals in the cat. Journal of Comparative Neurology 2005; 485(-1-):43-56. >>> Muscimol; Saline; CSF/CNS (motor cortex); Cat; 2002; 2, 4 weeks; Controls received no treatment; pumps replaced after 14 days; no stress (see pg. 54); ALZET brain infusion kit used; post op. care (broad spectrum antibiotic); GABA-A agonist; "muscimol infusion at the rate used does not have untoward toxic or damaging effects on the developing motor cortex." (p. 54).

P7198 Machaalani,R., Waters,K.A., Tinworth,K.D. Effects of postnatal nicotine exposure on apoptotic markers in the developing piglet brain. Neuroscience 2005; 132(-2-):325-333. >>> Nicotine hydrogen tartrate salt; water, sterile; IP; Pig (neonate); 2ML2; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by cotinine levels in serum and urine; no stress (see pg. 326); post op. care (cephalexin).

P7197 MacKay,J.A., Deen,D.F., Szoka,FC Jr  Brain Research 2005; 1035(-2-):139-153. >>> Liposomes; FITC-dextran-lysine; Saline; tris buffer; CSF/CNS (caudate putamen); CSF/CNS (intratumoral); Rat; 2001D; 24 hours; Tissue perfusion (intratumoral); comparison of acute CSF/CNS injection vs. mp; half-life (p. 151) 9.9 hours; cancer (glioblastoma); ALZET brian infusion kit 2 used; brain tissue distribution; post op. care (buprenophine).

P7185 Kim,S.Y., Chudapongse,N., Lee,S.M., Levin,M.C., Oh,J.T., Park,H.J., Ho,I.K. Proteomic analysis of phosphotyrosyl proteins in morphine-dependent rat brains. MOLECULAR BRAIN RESEARCH 2005; 133(-1-):58-70. >>> Morphine sulfate; Saline, sterile physiological; CSF/CNS; Rat; 2001; 72 hours; Controls received mp w/ vehicle; functionality of mp verified by residual volume; good methods p. 60; dependence; post op. care (sensorcaine, procaine penicillin G); mp primed overnight in 35 degrees celsius saline.

P7150 Proskocil,B.J., Sekhon,H.S., Clark,J.A., Lupo,S.L., Jia,Y.B., Hull,W.M., Whitsett,J.A., Starcher,B.C., Spindel,E.R. Vitamin c prevents the effects of prenatal nicotine on pulmonary function in newborn monkeys. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2005; 171(-9-):1032-1039. >>> Nicotine; Water; SC; Monkey (pregnant); 2ML4; 134 days; Controls received mp w/ vehicle; long-term study; pumps replaced every three weeks; teratology; post op. care (antiobiotic, twice a day for 3 days).

P7099 Benn,S.C., Ay,I., Bastia,E., Chian,R.J., Celia,S.A., Pepinsky,R.B., Fishman,P.S., Brown,RH Jr, Francis,J.W. Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice. Journal of Neurochemistry 2005; 95(-4-):1118-1131. >>> Toxin, tetanus fragment C; tempol, toxin tetanus fragment C; CSF/CNS; Mice; 2001; 7 days; Stability verified by incubation at 37C for 7 days; brain tissue distribution; post op. care (bupivicaine and betadine in wound); animal info (C57BL/6, male, 25-30 g); dental cement used for cannula adhesion, agent also know as TTC; compounds were also distributed to further brain sites such as the hypothalamus and the thalamus.

P7047 Biswas,P., Roy,A., Gong,R.J., Yango,A., Tolbert,E., Centracchio,J., Dworkin,L.D. Hepatocyte growth factor induces an endothelin-mediated decline in glomerular filtration rate. American Journal of Physiology-Renal Physiology 2005; 288(-1-):F8-F15. >>> Hepatocyte growth factor; Saline; IV (jugular); Rat; 1 week; Controls received mp w/ vehicle; functionality of mp verified by plasma and urine HGF levels; comparison of acute IV infusions vs. mp; no stress (see pg. F12); post op. care (atipamezole).

P6911 Rasmussen,K., Benvenga,M.J., Bymaster,F.P., Calligaro,D.O., Cohen,I.R., Falcone,J.F., Hemrick-Luecke,S.K., Martin,F.M., Moore,N.A., Nisenbaum,L.K., Schaus,J.M., Sundquist,S.J., Tupper,D.E., Wiernicki,T.R., Nelson,D.L. Preclinical pharmacology of FMPD [6- fluoro-10-[ 3-( 2-methoxyethyl)- 4- methyl-piperazin-1-yl]-2-methyl-4H-3- thia-4,9-diaza-benzo[f]azulene]: A potential novel antipsychotic with lower histamine H1 receptor affinity than olanzapine. Journal of Pharmacology and Experimental Therapeutics 2005; 315(-3-):1265-1277. >>> FMPD; olanzapine, HCl; Water; SC; Rat; 2ML1; 2ML2; 14 days; Controls received mp w/ vehicle; post op. care (antibiotic ointment); animal info (male, Sprague-Dawley, 280-330 g); potential novel antipsychotic.

P6902 Fouad,K., Schnell,L., Bunge,M.B., Schwab,M.E., Liebscher,T., Pearse,D.D. Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. Journal of Neuroscience 2005; 25(-5-):1169-1178. >>> Chondroitinase ABC; antibody, immunoglobulin G, recomb. mouse; galactosidase; Saline; PBS; CSF/CNS (intrathecal, lumbar); Rat; 2002; 4 weeks; Comparison of IT injections vs. mp; pumps replaced at two weeks; post op. care (antibiotic); spinal cord injury; Recathco catheter used; behavioral study.

P8471 Fewlass,D.C., Noboa,K., Pi-Sunyer,F.X., Johnston,J.M., Yan,S.D., Tezapsidis,N. Obesity-related leptin regulates Alzheimer's A beta. FASEB J. 2004/12; 18(-15-):1870-1878. >>> Leptin, recomb. mouse; PBS; SC; Mice (transgenic); 2004; 4,8; Controls received mp w/ vehicle; long-term study; pumps replaced after 4 weeks; peptides; post op. care (lidocaine); neurodegenerative(Alzheimer's disease); animal info (male, female, Tg2576 APPswe, C57BL/6 wt, 10 wks old, 32 wks old); obesity.

P7121 Beaudry,G., Zekki,H., Rouillard,C., Levesque,D. Clozapine and dopamine D3 receptor antisense reduce cocaine-and amphetamine-regulated transcript expression in the rat nucleus accumbens shell. Synapse 2004; 51(-4-):233-240. >>> Oligodeoxynucleotide, phosphorothioate antisense; oligodeoxynucleotide, missense; CSF, artificial; CSF/CNS; Rat; 2001; 5 days; Controls received mp w/vehicle, or missense ODN; antisense (dopamine receptors D2, D3); ALZET brain infusion kit 2 used; post op. care (ampicillin).

P7103 Perrien,D.S., Wahl,E.C., Hogue,W.R., Feige,U., Aronson,J., Ronis,M.J.J., Badger,T.M., Lumpkin,CK Jr  TOXICOLOGICAL SCIENCES 2004; 82(-2-):656-660. >>> Interleukin-1, receptor antagonist; SC; Rat; 2ML2; 14-21 days; Controls received mp w/ vehicle; post op. care (buprenex); left tibia fracture.

P7064 Luo,Z., Costy-Bennett,S., Fregosi,R.E. Prenatal nicotine exposure increases the strength of GABAA receptor-mediated inhibition of respiratory rhythm in neonatal rats. JOURNAL OF PHYSIOLOGY-LONDON 2004; 561(-2-):387-393. >>> Nicotine; SC; Rat (pregnant); 2ML4; 4 weeks; Controls received mp w/ physiological saline; no stress (see pg. 389); teratology; post op. care (buprenorphine, penicillin).

P7059 Kim,S.Y., Chudapongse,N., Lee,S.M., Levin,M.C., Oh,J.T., Park,H.J., Ho,I.K. Proteomic analysis of phosphotyrosyl proteins in the rat brain: Effect of butorphanol dependence. Journal of Neuroscience Research 2004; 77(-6-):867-877. >>> Butorphanol tartrate; CSF/CNS; Rat; 2001; 72 hours; Controls received mp w/ saline; functionality of mp verified by residual drug volume; dependence; post op. care (procaine penicillin G); stadol; mp primed overnight at 35 degree C in sterile saline.

P7044 Auchtung,T.L., Dahl,G.E. Prolactin mediates photoperiodic immune enhancement: Effects of administration of exogenous prolactin on circulating concentrations, receptor expression, and immune function in steers. Biology of Reproduction 2004; 71(-6-):1913-1918. >>> Prolactin, recomb. bovine; Saline; SC; Cattle; 2ML2; 10 days; Comparison of IV injections vs mp; no stress ( see pg. 1914); immunology; peptides; post op. care (prodine, excenel); each animal received 4 rounds of 10 day prolactin treatment (2 w/ mp, 2 IV injection) with 11 days of non treatment between each round.

P7034 Lal,A., Veinot,J.P., Leenen,F.H.H. Critical role of CNS effects of aldosterone in cardiac remodeling post-myocardial infarction in rats. Cardiovascular Research 2004; 64(-3-):437-447. >>> Spironolactone; Ethanol; water, sterile; CSF/CNS; Rat; 2002; 2004; 6 weeks; Controls received mp w/ vehicle; comparison of oral dosing vs. mp; pumps replaced after 4 weeks; cardiovascular; post op. care (buprenorphine); 0.2% ethanol; "The beneficial effects of icv spironolactone (by mp) at low doses on LV function and remodeling were equal or better to those achieved with oral administration at high dose" (pg. 446); ischemia (cardiac).

P6981 Hawkins,B.T., Abbruscato,T.J., Egleton,R.D., Brown,R.C., Huber,J.D., Campos,C.R., Davis,T.P. Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution. Brain Research 2004; 1027(-1-2-):48-58. >>> Nicotine hydrogen tartrate; Saline; SC; Rat; 2ML4; 1,7 days; Controls received mp w/ vehicle; functionality of mp verified by nicotine and cotinine plasma levels; post op. care (gentamycin).

P6979 Sams-Dodd,F. (+) MK-801 and phencyclidine induced neurotoxicity do not cause enduring behaviours resembling the positive and negative symptoms of schizophrenia in the rat. BASIC&CLINICAL PHARMACOLOGY&TOXICOLOGY 2004; 95(-5-):241-246. >>> MK-801; phencyclidine hydrochloride; Sodium chloride; SC; Rat; 2ML2; 6 days; Controls received mp w/ vehicle; dose-response; comparison of SC injections vs. mp; post op. care (wound plast); NMDA antagonists.

P6977 Hayes,E.S., Curnow,E.C., Trounson,A.O., Danielson,L.A., Unemori,E.N. Implantation and pregnancy following in vitro fertilization and the effect of recombinant human relaxin administration in Macaca fascicularis. Biology of Reproduction 2004; 71(-5-):1591-1597. >>> Relaxin, recomb. human; Acetate; SC; Monkey (cynomolgus); monkey (pregnant); 2004; 21 days; Controls received mp w/ vehicle; functionality of mp verified by serum rhRLX levels; no stress (see pg. 1593); good methods p. 1592; peptides; post op. care (ketoprofen, butorphanol).

P6920 Aronson,J. The Nicolas Andry Award - Modulation of distraction osteogenesis in the aged rat by fibroblast growth factor. Clinical Orthopaedics and Related Research 2004; (-425-):264-283. >>> Fibroblast growth factor, recomb. human; dihydrotestosterone; Sodium citrate; SC; bone (tibia); Rat; 1007D; 1002; 2002; 7, 14 days; Functionality of mp verified by residual volume; comparison of injections vs. mp; post op. care (heated cage/analgesics); pumps used for systemic or targeted delivery; silastic tubing used; "The pumps were well tolerated without inflammatory reaction, infection, or pain." (p. 273); picture of pump and catheter (radiograph image) p. 277, fig 10A-B; animal info (Sprague-Dawley).

P6889 Shahar,T., House,S.B., Gainer,H. Neural activity protects hypothalamic magnocellular neurons against axotomy-induced programmed cell death. Journal of Neuroscience 2004; 24(-29-):6553-6562. >>> Tetrodotoxin; PBS, sterile; CSF/CNS (supraoptic nucleus); Rat; 2002; 2 weeks; Controls received mp w/ vehicle to contralateral side; good methods (p. 6554); multiple pumps per animal (2); post op. care (ketoprofen); diagram shows placement of mp (fig. 1); mp filled >12 hours before surgery and primed in PBS at 37 degrees Celsius.

P6879 Nanci,A., Wazen,R.M., Zalzal,S.F., Fortin,M., Goldberg,H.A., Hunter,G.K., Ghitescu,D.L. A tracer study with systemically and locally administered dinitrophenylated osteopontin. JOURNAL OF HISTOCHEMISTRY&CYTOCHEMISTRY 2004; 52(-12-):1591-1600. >>> Osteopontin, rat dinitrophenol; Bone (hemimandible); Rat; 1003D; 2001D; 1,3 days; Controls received mp w/ saline; or dinitrophenylated rat albumin; dose-response (table 1); comparison of IV injections vs. mp; post op. care (buprenorphine HCL).

P6872 Dolev,I., Michaelson,D.M. A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004; 101(-38-):13909-13914. >>> Thiorphan; CSF, artificial; ascorbic acid; CSF/CNS; Mice; mice (transgenic); 2004; 1 month; 2,4 weeks; Controls received mp w/ vehicle; enzyme inhibitor (neprilysin); ALZET brain infusion kit used; cyanoacrylate adhesive (Loctite 454); post op. care (oxytetracycline); neurodegenerative disease (Alzheimer's).

P6831 Mphahlele,N.R., Fuller,A., Roth,J., Kamerman,P.R. Body temperature, behavior, and plasma cortisol changes induced by chronic infusion of Staphylococcus aureus in goats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2004; 287(-4-):R863-R869. >>> Bacteria, staphylococcus aureus; IV (jugular); Goat; 2ML1; ; Controls received mp w/ sterile saline; functionality of mp verified by examining contents of internal reservoir; comparison of IV injections vs. mp; no stress (see pg. R864); post op. care (enrofloxacin); catheter filled with heparinized saline (100 units/ml); to delay infusion of pump contents until 24 hours after mp implantation; "no signs of secondary infection or pathology...were found." (p. R864)..

P6788 Wiksten,M., Vaeaenaenen,A.J., Liebkind,R., Liesi,P. Regeneration of adult rat spinal cord is promoted by the soluble KDI domain of gamma 1 laminin. Journal of Neuroscience Research 2004; 78(-3-):403-410. >>> Laminin, gamma 1-KDI domain; Saline; serum, human; CSF/CNS (intrathecal, spinal cord); Rat; 2ML4; 28 days; Controls received mp w/ vehicle; brain tissue distribution; peptides; post op. care (morphine, ketoprofen).

P6753 Nguyen,H.N., Rasmussen,B.A., Perry,D.C. Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long-term but not short-term nicotine treatment. Journal of Neurochemistry 2004; 90(-1-):40-49. >>> Nicotine, free base; Saline, sterile; SC; Rat; 2002; 2 weeks; 16 hours; Controls received mp w/ vehicle; functionality of mp verified by plasma nicotine levels; post op. care (topical antibiotics).

P6673 Lambert,A.J., Merry,B.J. Effect of caloric restriction on mitochondrial reactive oxygen species production and bioenergetics: reversal by insulin. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2004; 286(-1-):R71-R79. >>> Insulin; Saline; acetic acid; SC; Rat; 2002; 2 weeks; Insulin plasma levels; peptides; post op. care (buprenorphin injection); aging.

P6550 Chauhan,B.C., LeVatte,T.L., Jollimore,C.A., Yu,P.K., Reitsamer,H.A., Kelly,M.E.M., Yu,D.Y., Tremblay,F., Archibald,M.L. Model of endothelin-1 - Induced chronic optic neuropathy in rat. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2004; 45(-1-):144-152. >>> Endothelin-1; Balanced salt solution; Eye (retrobulbar optic nerve); Rat; 2004; 21,42,84 days; Controls received mp w/ vehicle and fellow eye w/ no treatment; dose-response (fig.5); long-term study; pumps replaced every 28 days; peptides; post op. care (rentamicin, buprenex).

P6536 Sugahara,K., Shimogori,H., Okuda,T., Takemoto,T., Hashimoto,M., Yamashita,H. Cochlear administration of adenosine triphosphate facilitates recovery from acoustic trauma (temporary threshold shift). ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES 2004; 66(-2-):80-84. >>> Adenosine triphosphate; PPADS; Ear (cochlea); Guinea-pig; 2002; ; Post op. care (antibiotic ointment applied); PE-10 used to target the inner ear and fixed with dental cement; for recover period, pumps and catheters were filled with saline, then pumps replaced with reagent filled pumps; infusion of agents was 12 hours post pump replacement to allow for saline in catheter to be infused; PPADS is pyridoxal-phosphate-6-azophenyl-2',4'-disulfonic acid solution; tissue perfusion (cochlea).

P6526 Francis,J., Chu,Y., Johnson,A.K., Weiss,R.M., Felder,R.B. Acute myocardial infarction induces hypothalamic cytokine synthesis. American Journal of Physiology-Heart and Circulatory Physiology 2004; 286(-6-):H2264-H2271. >>> Pentoxifylline; Water, sterile; IP; Rat; 4 weeks; Controls received mp w/ vehicle; cardiovascular; post op. care (benzathine penicillin I.M injection); pump model not listed.

P6462 Takemoto,T., Sugahara,K., Okuda,T., Shimogori,H., Yamashita,H. The clinical free radical scavenger, edaravone, protects cochlear hair cells from acoustic trauma. European Journal of Pharmacology 2004; 487(-1-3-):113-116. >>> Edaravone; saline; NaOH; water; HCL; Ear (cochlea); Guinea-pig; 2002; 17 days; Controls received no treatment to contralateral ear; animals received mp w/saline for 3 days; then pumps replaced for mp w/edaravone; no stress (see pg. 115); post op. care (antibiotic ointment); edaravone is a free radical scavenger; tissue perfusion (cochlea).

P6458 Olivius,P., Alexandrov,L., Miller,J.M., Ulfendahl,M., Bagger-Sjoebaeck,D., Kozlova,E.N. A model for implanting neuronal tissue into the cochlea. BRAIN RESEARCH PROTOCOLS 2004; 12(-3-):152-156. >>> Brain-derived neurotrophic factor; ciliary neurotrophic factor Ax1, human; Ear (scala tympani); Guinea-pig; 2002; 21-22 days; Pump replaced on days 11-12; post op. care (cyclosporine, doxycycline); tissue perfusion (scala tympani).

P6440 Matsunaga,W., Shirokawa,T., Isobe,K. BDNF is necessary for maintenance of noradrenergic innervations in the aged rat brain. NEUROBIOLOGY OF AGING 2004; 25(-3-):341-348. >>> Brain-derived neurotrophic factor; BDNF antibody-; immunoglobulin G; PBS; CSF/CNS (frontal cortex); Rat; 2002; 13-15 days; Controls received mp w/ vehicle; post op. care (antibiotic for 5 days after operation); cannula secured by dental cementl; BDNF dissolved in PBS (pH 7.4); brain tissue distribution was measured by biotin-labeled BDNF.

P6436 Porro,C.A., Cavazzuti,M., Giuliani,D., Vellani,V., Lui,F., Baraldi,P. Effects of ketamine anesthesia on central nociceptive processing in the rat: A 2-deoxyglucose study. Neuroscience 2004; 125(-2-):485-494. >>> Heparin; Saline; IA (carotid); IV (jugular); Rat; 2001; 7 days; Controls received mp w/ vehicle; post op. care (wounds treated with local anesthetics, lidocaine cream); PE-50 tubing was filled with rat serum and heparin and plugged with nylon fishing line until the pumps were attached; pumps were used only as a means of keeping vessel catheters patent..

P6399 Rosenberger,T.A., Villacreses,N.E., Hovda,J.T., Bosetti,F., Weerasinghe,G., Wine,R.N., Harry,G.J., Rapoport,S.I. Rat brain arachidonic acid metabolism is increased by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide. Journal of Neurochemistry 2004; 88(-5-):1168-1178. >>> Endotoxin, E. coli; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 2002; 6 days; Controls received mp w/ vehicle; post op. care (1% lidocaine); Plastics One cannula used.

P6280 Anderson,M.F., Nilsson,M., Eriksson,P.S., Sims,N.R. Glutathione monoethyl ester provides neuroprotection in a rat model of stroke. Neuroscience Letters 2004; 354(-2-):163-165. >>> Glutathione monoethyl ester; Saline; CSF/CNS; Rat; 2001; ; Controls received mp w/ vehicle; ALZET brain infusion kit 2 used; dental cement used; post op. care (xylocaine/adrenaline injected into site of wound); neuroprotection; ischemia (cerebral); antioxidant.

P6256 Paterson,N.E., Markou,A. Prolonged nicotine dependence associated with extended access to nicotine self-administration in rats. Psychopharmacology 2004; 173(-1-2-):64-72. >>> Nicotine; Saline; SC; Rat; 2ML1; 1 week; Dependence; post op. care (topical iodine); lists nicotine dependence dose for infusion.

P7706 Mashiko,S., Ishihara,A., Iwaasa,H., Sano,H., Oda,Z., Ito,J., Yumoto,M., Okawa,M., Suzuki,J., Fukuroda,T., Jitsuoka,M., Morin,N.R., MacNeil,D.J., Van der Ploeg,L.H., Ihara,M., Fukami,T., Kanatani,A. Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp34NPY. Endocrinology 2003/5; 144(-5-):1793-1801. >>> Neuropeptide Y, D-Trp34; PBS; BSA; CSF/CNS; Mice; 2001; 2002; 13-21 days; Controls received mp w/ vehicle; dose-response (fig. 1); pumps replaced after 7-14 days; ALZET Brain Infusion kit used; peptides; post op. care (cefamedin); animal info (C57BL/6J, 9-12 weeks old, male); cannula placement confirmed by Evans blue dye injection.

P6708 Huddleston,G.G., Michael,R.P., Zumpe,D., Clancy,A.N. Estradiol in the male rat amygdala facilitates mounting but not ejaculation. PHYSIOLOGY&BEHAVIOR 2003; 79(-2-):239-246. >>> Fadrozole; Saline; SC; Rat; 2004; 8 weeks; Functionality of mp verified by residual volume; long-term study; pumps replaced after 26 days; enzyme inhibitor (aromatase); post op. care (penicillin, banamine); fadrozole is also termed CGS-15949A.

P6706 Paula-Barbosa,M.M., Pereira,P.A., Cadete-Leite,A., Madeira,M.D. NGF and NT-3 exert differential effects on the expression of neuropeptides in the suprachiasmatic nucleus of rats withdrawn from ethanol treatment. Brain Research 2003; 983(-1-2-):64-73. >>> Nerve growth factor; NT-3; CSF, artificial; BSA; CSF/CNS; Rat; 2002; 10 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; dependence; post op. care (local antiseptic); agent was placed in catheter, tubing had an air-oil spacer at pump end, mp contained methylene blue (p.66).

P6701 Rhodes,K.E., Moon,L.D.F., Fawcett,J.W. Inhibiting cell proliferation during formation of the glial scar: Effects on axon regeneration in the CNS. Neuroscience 2003; 120(-1-):41-56. >>> Ara-C; Saline, sterile; CSF/CNS (medial forebrain); CSF/CNS (intrathecal, subarachnoid space); Rat; 1007D; 7 days; Controls received mp w/ vehicle; good methods (P.42); ALZET brain infusion kit used; post op. care (heated recovery box; paracetamol).

P6698 Hortobagyi,T., Goerlach,C., Benyo,Z., Lacza,Z., Hortobagyi,S., Wahl,M., Harkany,T. Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: Neuroprotection by 3-aminobenzamide. Neuroscience 2003; 121(-4-):983-990. >>> Aminobenzamide, 3-; Saline, physiological; DMSO; IP; Rat; 2001D; 16, 25 hours; Controls received vehicle; enzyme inhibitor (poly (ADP-ribose) polymerase); post op. care (xylocaine spray); 33.3% DMSO; "AB reached the target neurons only at sub-optimal concentrations likely due to its limited blood-brain barrier permeability." (p. 989); neuroprotection.

P6652 Eisch,A.J., Bolanos,C.A., de Wit,J., Simonak,R.D., Pudiak,C.M., Barrot,M., Verhaagen,J., Nestler,E.J. Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: A role in depression. Biological Psychiatry 2003; 54(-10-):994-1005. >>> Brain-derived neurotrophic factor, human recomb.; CSF/CNS (ventral tegmentum); Rat; 1007D; 1 week; Controls received mp w/ saline; no stress (see pg. 1001); post op. care (penicillin [IM], topical antibiotic); cannula placement and gross morphology verified at end of infusion period.

P6588 Min,K., Munarriz,R., Kim,N.N., Choi,S., O'Connell,L., Goldstein,I., Traish,A.M. Effects of ovariectomy and estrogen replacement on basal and pelvic nerve stimulated vaginal lubrication in an animal model. JOURNAL OF SEX&MARITAL THERAPY 2003; 29(-1-):77-84. >>> Estradiol; PEG 300; SC; Rabbit; 2002; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by plasma levels; replacement therapy (ovariectomy); post op. care (butorphanol tartrate, cephazolin).

P6542 Isogawa,K., Akiyoshi,J., Tsutsumi,T., Kodama,K., Horinouti,Y., Nagayama,H. Anxiogenic-like effect of corticotropin-releasing factor receptor 2 antisense oligonucleotides infused into rat brain. JOURNAL OF PSYCHOPHARMACOLOGY 2003; 17(-4-):409-413. >>> Oligonucleotide, antisense; oligonucleotide, scrambled; CSF/CNS; Rat; 1003D; 1007D; ; Antisense (CRF-R2); ALZET brain infusion kit 1 used; post op. care (IP injection of ceftriaxone sodium to minimize infection); behavioral testing.

P6506 Nagano,M., Sakai,A., Takahashi,N., Umino,M., Yoshioka,K., Suzuki,H. Decreased expression of glial cell line-derived neurotrophic factor signaling in rat models of neuropathic pain. British Journal of Pharmacology 2003; 140(-7-):1252-1260. >>> Glial-derived neurotrophic factor, recomb. human; Saline; CSF/CNS (intrathecal); Rat; 9 days; Controls received mp w/ vehicle; replacement therapy (spinal nerve ligation axotomy); post op. care (IP kanamycin sulfate).

P6416 Shimegi,S., Fischer,Q.S., Yang,Y.P., Sato,H., Daw,N.W. Blockade of cyclic AMP-dependent protein kinase does not prevent the reverse ocular dominance shift in kitten visual cortex. Journal of Neurophysiology 2003; 90(-6-):4027-4032. >>> Rp-8-cl-cAMPS; muscimol; PBS; CSF/CNS (visual cortex); Cat (kitten); 2001; ; Post op. care (antibiotic Baytril and analgesic Buprenex).

P6348 Marshall,J.W.B., Ridley,R.M. Assessment of cognitive and motor deficits in a marmoset model of stroke. ILAR JOURNAL 2003; 44(-2-):153-160. >>> Clomethiazole; AR-R15896AR; NXY-059; Saline; SC; Monkey (marmoset); 2001D; 48 hours; Controls received mp w/ vehicle; pumps replaced every 24 hours; ischemia (cerebral); neuroprotective; post op. care (incubator); behavioral study.

P6342 Li,S., Saragovi,H.U., Racine,J.R., Fahnestock,M. A ligand of the p65/p95 receptor suppresses perforant path kindling, kindling-induced mossy fiber sprouting, and hilar area changes in adult rats. Neuroscience 2003; 119(-4-):1147-1156. >>> Reo 3Y; ReoL; PBS; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; no stress (see pg. 1149); peptides; post op. care (Penicllin, Apo-sulfatrim).

P6233 Shearman,L.P., Camacho,R.E., Stribling,D.S., Zhou,D., Bednarek,M.A., Hreniuk,D.L., Feighner,S.D., Tan,C.P., Howard,A.D., Van der Ploeg,L.H.T., MacIntyre,D.E., Hickey,G.J., Strack,A.M. Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats. European Journal of Pharmacology 2003; 475(-1-3-):37-47. >>> Neuropeptide Y, rat; melanin-concentrating hormone-1, receptor agonist; melanin-concentrating hormone-1, receptor antagonist; Saline; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; dose-response (fig. 5); peptides; post op. care (antisedan); pump model incorrectly given as 2001 (p. 39); based on flow rate (.5 ul/hr) and duration (14 days) is actually model 2002 (p. 39).

P6217 Leamey,C.A., Ho-Pao,C.L., Sur,M. Role of calcineurin in activity-dependent pattern formation in the dorsal lateral geniculate nucleus of the ferret. Journal of Neurobiology 2003; 56(-2-):153-162. >>> FK-506; DMSO; saline; CSF/CNS (dorsal lateral geniculate nucleus); Ferret (kit); 2002; 12 days; Controls received mp w/ vehicle; teratology; post op. care (prophylactically treated with amoxycillin); 50% DMSO used; 14-15 day told ferret kits received pumps.

P6214 Francis,J., Weiss,R.M., Johnson,A.K., Felder,R.B. Central mineralocorticoid receptor blockade decreases plasma TNF-alpha after coronary artery ligation in rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-2-):R328-R335. >>> Spironolactone; Ethanol; CSF/CNS (third ventricle); Rat; 2004; 21 days; Controls received mp w/ vehicle; functionality of mp verified by checking residual drug volume at end of study and cannula location; comparison of IP injections vs. CNS mp; cardiovascular; post op. care (buprenorphine 2 times); cannula fixed to skull with dental cement; silastic tubing used.

P6190 Dobretsov,M., Hastings,S.L., Romanovsky,D., Stimers,J.R., Zhang,J.M. Mechanical hyperalgesia in rat models of systemic and local hyperglycemia. Brain Research 2003; 960(-1-2-):174-183. >>> Glucose; sorbinil; HEPES, buffered saline; CSF/CNS (sciatic nerve); Rat; 2002; 14 days; Enzyme inhibitor (aldose reductase); post op. care (amoxicillin/clavulanate potassium 3 days).

P6150 Marshall,J.W.B., Cummings,R.M., Bowes,L.J., Ridley,R.M., Green,A.R. Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion. Stroke 2003; 34(-9-):2228-2233. >>> NXY-059; Saline; IV; Monkey (marmoset); 2001D; 48 hours; Controls received mp w/ vehicle; NXY-059 plasma levels taken; pumps replaced every 24 hours; post op. care (flunixin meglumine); behavior study; neuroprotective; ischemia (cerebral).

P6080 Wenk,G.L., McGann,K., Hauss-Wegrzyniak,B., Rosi,S. The toxicity of tumor necrosis factor-alpha; upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: Implications for Alzheimer's disease. Neuroscience 2003; 121(-3-):719-729. >>> Tumor necrosis factor, alpha; CSF, artificial; CSF/CNS (basal forebrain); Mice; 1002; 14 days; Controls received mp w/ vehicle; tissue perfusion (basal forebrain); Plastics One cannula used; "A volume overload to the brain tissue is minimal using this procedure because the 0.25 ul/hr administered contributes only about 0.2% of the total CSF volume produced by the mouse each hour..." p. 720; post op. care (1.0 ml of sterile saline (S.C) injected to prevent dehydration); neurodegenerative (Alzheimer's disease).

P6065 DeCouto,S.A., Jones,E.E., Kudwa,A.E., Shoemaker,S.E., Shafer,A.J., Brieschke,M.A., James,R., Vaughn,J.C., Isaacson,L.G. The effects of deafferentation and exogenous NGF on neurotrophins and neurotrophin receptor mRNA expression in the adult superior cervical ganglion. MOLECULAR BRAIN RESEARCH 2003; 119(-1-):73-82. >>> Cytochrome C; nerve growth factor; Acetic acid; bisbenzimide; CSF/CNS; Rat; 2002; 2 weeks; Functionality of mp verified by labeling of the ependymyl lining of the lateral and 3rd ventricles with 0.1% bisbenzimide; post op. care (acetaminophen suspension drops (80mg/day) in a cheese puff); 0.05 acetic acid used for vehicle.

P6009 Srivastava,S., Terjung,R.L., Yang,H.T. Basic fibroblast growth factor increases collateral blood flow in spontaneously hypertensive rats. American Journal of Physiology-Heart and Circulatory Physiology 2003; 285(-3-):H1190-H1197. >>> Fibroblast growth factor, basic; Sodium citrate; glycerol; PBS; IA (iliac); Rat; 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume p. H1192; antihypertensive; post op. care (topical antibiotic powder); "The pump was housed in a tunnel under the skin in the left groin area; this placement did not hamper hindlimb movement while rats were walking on the treadmill." p. H1191; behavioral study; "There were no signs of ischemia or necrosis and no presence of infection or complications from the osmotic pumps..." p. H1192.

P5992 Semenova,S., Bespalov,A., Markou,A. Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mic e is reversed by nicotine self-administration. European Journal of Pharmacology 2003; 472(-1-2-):99-110. >>> Nicotine tartrate; Saline, sterile; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; wound closed with wound clips; post op. care (antibacterial bacitracin zink ointment applied to incision area).

P5981 Dupont,A.C., Richmond,F.J.R., Loeb,G.E. Prevention of muscle disuse atrophy by low-frequency electrical stimulation in rats. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING 2003; 11(-3-):218-226. >>> Tetrodotoxin; Saline; CSF/CNS (sciatic nerve); Rat; 1007D; 7 days; Post Op. care (topical lidocaine cream applied); schematic of pump and nerve cuff p. 220; "all devices were checked at necropsy, and no evidence was found that devices moved from their sites of implantation." p.221.

P5980 Dupont,A.C., Richmond,F.J.R., Loeb,G.E. Effects of muscle immobilization at different lengths on tetrodotoxin-induced disuse atrophy. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING 2003; 11(-3-):209-217. >>> Tetrodotoxin; Saline; CSF/CNS (sciatic nerve); Rat; 1007D; 7 days; Post Op. Care (Topical Lidocaine cream over sutures); schematic of pump and nerve cuff p. 210; nerve cuff consisted of silastic tubing&a custom cuff; cuff was closed by looping four sutures (3-0 silk) around it.

P5965 Cadete-Leite,A., Pereira,P.A., Madeira,M.D., Paula-Barbosa,M.M. Nerve growth factor prevents cell death and induces hypertrophy of basil forebrain cholinergic neurons in rats withdrawn from prolonged ethanol intake. Neuroscience 2003; 119(-4-):1055-1069. >>> Nerve growth factor; dye, methylene blue; CSF; BSA; CSF/CNS; Rat; 2004; 28 days; good methods p. 1057; ALZET brain infusion kit 1 used; peptides; post op. care (sc injection of saline and cortrimoxazol); lynch coil used; air bubble used to separate vehicle and agent/vehicle; pump contained dye.

P5962 Fan,L.W., Tien,L.T., Tanaka,S., Ma,T., Chudapongse,N., Sinchaisuk,S., Rockhold,R.W., Ho,I.K. Changes in the brain kappa-opioid receptor levels of rats in withdrawal from physical dependence upon butorphanol. Neuroscience 2003; 121(-4-):1063-1074. >>> Butorphanol; morphine; Saline, sterile; CSF/CNS; Rat; 2001; 72 hours; Controls received mp w/ vehicle; dependence; post op. care (penicillin, 0.5% sensorcaine in wound site); guide cannula with stylet was used; dental cement used to adhere cannula to skull; protective aluminuim cap was placed around the cannula; tygon tubing was used; solutions were filter sterilized during filling of the pumps; brain diagram (p. 1066).

P5961 Edgley,A.J., Kett,M.M., Anderson,W.P. Evidence for renal vascular remodeling in angiotensin II-induced hyper tension. Journal of Hypertension 2003; 21(-7-):1401-1406. >>> Angiotensin II; Saline; heparin; IV (vena cava); Rat; 2ML4; 10 days; controls received mp w/ vehicle; post op. care (sc, buprenorphine); pumps implanted IP; catheter targeted the vena cava via the lumbar vein; 10 IU/ml of heparin.

P5926 Cryan,J.F., Bruijnzeel,A.W., Skjei,K.L., Markou,A. Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat. Psychopharmacology 2003; 168(-3-):347-358. >>> Nicotine; Saline; SC; Rat; 2ML1; 7 days; Dependence; post op. care (povidone-iodine ointment).

P5925 Skjei,K.L., Markou,A. Effects of repeated withdrawal episodes, nicotine dose, and duration of nicotine exposure on the severity and duration of nicotine withdrawal in rats. Psychopharmacology 2003; 168(-3-):280-292. >>> Nicotine tartrate; Saline; SC; Rat; 2ML1; 2ML4; 4 weeks; 7 days; Controls received mp w/ vehicle; two doses used; dependence; post op. care (wound covered w/ povidone-iodine ointment); pumps contained varied doses.

P5902 Deseure,K., Koek,W., Adriaensen,H., Colpaert,F.C. Continuous administration of the 5-hydroxytryptamine 1A agonist (3-ch loro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]-methadone (F 13640) attenuates allodynia-like behavior in a rat model of trigeminal neuropathic pain. Journal of Pharmacology and Experimental Therapeutics 2003; 306(-2-):505-514. >>> F13640; F13714; morphine; bacioten; Saline; SC; Rat; 2ML2; 14 days; Controls received mp w/ vehicle; Post Op. Care (aerosol bandage applied to protect against bacterial contamination); F13640 is a novel analgesic&5-HT1A receptor agonist; behavorial study; F13640, F13714&morphine were infused in one pump; bacioten infused in two pumps due to limited solubility; contro.

P5881 Hauss-Wegrzyniak,B., Willard,L.B., Del Soldato,P., Pepeu,G., Wenk,G.L. Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS. Brain Res 2003; 815(-1-):36-43. >>> Endotoxin, LPS; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 2004; 30 days; Controls received mp w/ vehicle; post op. care (chloramphenicol lidocaine) p.38.

P5716 Slot,L.A.B., Koek,W., Tarayre,J.P., Colpaert,F.C. Tolerance and inverse tolerance to the hyperalgesic and analgesic actions, respectively, of the novel analgesic, F 13640. European Journal of Pharmacology 2003; 466(-3-):271-279. >>> F13640; Water, distilled; SC; Rat; 2ML2; 5 weeks; Controls received mp w/ saline; dose-response (Fig.2; p.275); pumps replaced every week, F13640 is a novel analgesic; serotonin receptor agonist; post op. care (the site of pump emplacement was massaged daily to avoid tissue adherence).

P5520 Melton,L.M., Keith,A.B., Davis,S., Oakley,A.E., Edwardson,J.A., Morris,C.M. Chronic glial activation, neurodegeneration, and APP immunoreactive deposits following acute administration of double-stranded RNA. Glia 2003; 44(-1-):1-12. >>> RNA, double stranded; statolon dsRNA; polyinosinic acid ds RNA; polycytidilic acid dsRNA; Tris/borate/EDTA buffer; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; gene therapy; post op. care (buprenorphine); statolon is a naturally occuring dsRNA from a mycophage; neurodegenerative (Parkinson's disease, Alzheimer's); "we have found that intracerebral administration of dsRNA from an.

P8154 Girling,J.E., Bennett,E.J., Cockrem,J.F. Administration of pregnant mare serum gonadotropin to Japanese quail (Coturnix coturnix japonica): dose response over seven days and comparison of delivery by daily injection or osmotic pump. NZ Vet J 2002; 50(-3-):115-121. >>> Gonadotropin, pregnant mare serum; Saline; SC; Bird (quail); 2001; 7 days; Controls received mp w/ vehicle; dose-response (fig. 1); comparison of daily SC injections vs. mp; peptides; post op. care (Bactroban); animal info (Japanese, 6 weeks old, female); 41 C body temperature, endocrinology.

P6310 Barclay,J., Patel,S., Dorn,G., Wotherspoon,G., Moffatt,S., Eunson,L., Abdel'al,S., Natt,F., Hall,J., Winter,J., Bevan,S., Wishart,W., Fox,A., Ganju,P. Functional Downregulation of P2X3 Receptor Subunit in Rat Sensory Neurons Reveals a Significant Role in Chronic Neuropathic and Inflammatory Pain. The Journal of Neuroscience 2002; 22(-18-):8139-8147. >>> Oligonucleotide, antisense; oligonucleotide, missense; CSF/CNS (intrathecal); Rat; 2001; 7 days; Controls received mp w/ saline; functionality of mp verified by fluorescently labeled antisense oligonucleotide; no stress (see pg. 8140, 8144); antisense (P2X3 receptor); post op. care (antibiotic powder); P2X is an ATP-gated cation channel.

P6224 Seye,C.I., Kong,Q.M., Erb,L., Garrad,R.C., Krugh,B., Wang,M.F., Turner,J.T., Sturek,M., Gonzalez,F.A., Weisman,G.A. Functional P2Y2 nucleotide receptors mediate uridine 5 '-triphosphate-induced intimal hyperplasia in collared rabbit carotid arteries. Circulation 2002; 106(-21-):2720-2726. >>> Uridine 5-triphosphate; IA (carotid); Rabbit; 2ML2; 3,14 days; Controls received mp w/ PBS; cardiovascular; post op. care (buprenorphine).

P6208 Fan,L.W., Tanaka,S., Tien,L.T., Ma,T.G., Rockhold,R.W., Ho,I.K. Withdrawal from dependence upon butorphanol uniquely increases kappa1-opioid receptor binding in the rat brain. Brain Research Bulletin 2002; 58(-2-):149-160. >>> Butorphanol tartrate; morphine; Saline, sterile physiological; CSF/CNS; Rat; 2001; 72 hours; Controls received mp w/ vehicle; functionality of mp verified by residual drug volume; good methods (p. 150); dependence; post op. care (sensorcaine, procaine penicillin G); guide cannula&stylet used; dental cement secured cannula.

P6207 Fan,L.W., Tanaka,S., Park,Y., Sasaki,K., Ma,T.G., Tien,L.T., Rockhold,R.W., Ho,I.K. Butorphanol dependence and withdrawal decrease hippocampal K-2-opioid receptor binding. Brain Research 2002; 958(-2-):277-290. >>> Butorphanol tartrate; Saline, sterile physiological; CSF/CNS; Rat; 2001; 72 hours; Controls received mp w/ vehicle; functionality of mp verified by residual volume; good methods (p. 279); dependence; post op. care (sensorcaine, procaine penicillin).

P6162 Levine,A.S., Grace,M.K., Cleary,J.P., Billington,C.J. Naltrexone infusion inhibits the development of preference for a high- sucrose diet. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2002; 283(-5-):R1149-R1154. >>> Naltrexone; Saline; SC; Rat; 2001; 20 days; Pumps replaced once; post op. care (topical antibiotic).

P6161 Marsh,D.R., Wong,S.T., Meakin,S.O., MacDonald,J.I.S., Hamilton,E.F., Weaver,L.C. Neutralizing intraspinal nerve growth factor with a trkA-IgG fusion protein blocks the development of autonomic dysreflexia in a clip-compression model of spinal cord injury. Journal of Neurotrauma 2002; 19(-12-):1531-1541. >>> Immunoglobulin G,trka; Imunoglobulin G, human; CSF, artificial; CSF/CNS (intrathecal); Rat; 2ML2; 14 days; Controls received mp w/ Igg, human; post op. care (antibiotics and analgesics); catheter was perforated with a sealed end.

P6139 Lee,J.M., Zipfel,G.J., Park,K.H., He,Y.Y., Hsu,C.Y., Choi,D.W. Zinc translocation accelerates infarction after mild transient focal ischemia. Neuroscience 2002; 115(-3-):871-878. >>> EDTA, calcium; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ saline; post op. care (antibiotics given); custom cannula secured with Durelon Cement; ischemia (cerebral).

P7426 Beaver,C.J., Ji,Q., Fischer,Q.S., Daw,N.W. Cyclic AMP-dependent protein kinase mediates ocular dominance shifts in cat visual cortex. Nat.Neurosci. 2001/2; 4(-2-):159-163. >>> Rp-8-CL-cAMPS; Phosphate buffer; CSF/CNS (visual cortex); Cat (kitten); 6,14 days; Controls received mp w/ vehicle; enzyme inhibitor (protein kinase); ALZET brain infusion kit 3; post op. care (antibiotic/analgesic); animal info (25-31 days old, 15 weeks old); cannula was beveled.

P6311 Coumans,J.V., Lin,T.T-S., Dai,H.N., Macarthur,L., McAtee,M., Nash,C., Bregman,B.S. Axonal Regeneration and Functional Recovery after Complete Spinal Cord Transection in Rats by Delayed Treatment with Transplants and Neurotropins. The Journal of Neuroscience 2001; 21(-23-):9334-9344. >>> Brain-derived neurotrophic factor, human recomb.; NT-3, human recomb.; CSF/CNS (spinal cord, intrathecal); Rat; 2002; 14 days; Controls received mp w/ saline; tissue perfusion (fetal spinal cord transplant tissue); good methods p.9335; post op. care (sulfamethoxazole-trimethoprim).

P6713 Al-Barazanji,K.A., Arch,J.R.S., Buckingham,R.E, Tadayyon,M. Central Exendin-4 Infusion Reduces Body Weight without Altering Plasma Leptin in fa/fa Zucker Rats. Obesity Research 2000; 8(-4-):317-323. >>> Exendin-4; Saline, sterile; CSF/CNS; Rat; 2001; 15 days; Controls received mp w/ vehicle; pumps replaced after 7 days; ALZET brain infusion kit used; peptides; post op. care (antibiotic); mp primed 4 hours in sterile saline at 37 degrees Celsius; 1st mp contained vehicle for 7 days, 2nd mp contained vehicle or agent for 8 days..

P7960 Porro,C.A., Cavazzuti,M., Baraldi,P., Giuliani,D., Panerai,A.E., Corazza,R. CNS pattern of metabolic activity during tonic pain: evidence for modulation by beta-endorphin. European Journal of Neuroscience 1999; 11(-3-):874-888. >>> Heparin, calcium; SC; Rat; 2001; ; Post op. care (lidocaine cream); animal info (male, Sprague-Dawley, 320-340 grams).

P6326 Jakeman,L.B., Wei,P., Guan,Z., Stokes,B.T. Brain-Derived Neurotrophic Factor Stimulates Hindlimb Stepping and Sprouting of Cholinergic Fibers after Spinal Cord Injury. Experimental Neurology 1998; 154(--):170-184. >>> Brain-derived neurotrophic factor, recomb. human; PBS; serum, rat; CSF/CNS (intrathecal); Rat; 2002; 28 days; Controls received mp w/ vehicle, or injury only; pumps replaced at day 14; good methods p.171; post op. care (gentamycin); mp replaced at day 14 to ensure biological efficacy of BDNF at body temp..

P6320 Parker,S.B., Wade,S.S., Prewitt,R.L. Pressure Mediates Angiotensin II-Induced Arterial Hypertrophy and PDGF-A Expression. Hypertension 1998; 32(--):452-458. >>> Angiotensin II; uridine, bromodeoxy; Saline, physiological; SC; Rat; 2001; 2002; 2 weeks; 7 days; Controls received mp w/ vehicle; functionality of mp verified by postive BrdU staining (p. 454); cardiovascular; multiple pumps per animal (2); post op. care (penicillin G); minoxidil administered concomitantly via drinking water.

P6313 Wang,D.H., Qiu,J, Hu,Z. Differential Regulation of Angiotensin II Receptor Subtypes in the Adrenal Gland. Hypertension 1998; 32(--):65-70. >>> Aldosterone; Saline; ethanol; SC; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by plasma aldosterone levels; no stress (see pg. 66); cardiovascular; post op. care (penicillin G).

P6290 Rodgers,K.E., Girgis,W., Amand,K.St., S.diZerega,G. Reduction of adhesion formation in rabbits by intraperitoneal administration of lazaroid formulations. Human Reproduction 1998; 13(-9-):2443-2451. >>> PNU83,836E; Citric acid; sodium citrate; sodium chloride; citrate buffer; Injury site; Rabbit; 2ML1; 1,2,3,7, days; Controls received mp w/ vehicle; dose-response (tables III&IV, p. 2446); comparison of bolus administration; good methods p. 2444; post op. care (morphine, bupronex); PNU83,836E is a non-steroidal 2-methylaminochriman derivative.

P4631 Fung,Y.K., Mendlik,M.G, Haven,M.C, Akhter,M.P, Kimmel,D.B  Pharmacology and Toxicology 1998; 82(--):243-249. >>> Nicotine tartrate;; Saline, sterile;; SC;; rat;; 2004;; 2 months;; controls received mp w/ saline; long-term study, pumps replaced after 30 days; toxicology; post op. care (incision covered w/ mycitracin antibiotic and lidocaine).

P6329 Hong,M.K., Kent,K.M., Mehran,R., Mintz,G.S., Tio,F.O., Foegh,M., Wong,S.C., Cathapermal,S.S., Leon,M.B. Continuous Subcutaneous Angiopeptin Treatment Significantly Reduces Neointimal Hyperplasia in a Porcine Coronary In-Stent Restenosis Model. Circulation 1997; 95(-2-):449-454. >>> Angiopeptin; SC; Pig; 2ML1; 1 week; Controls received saline via catheter; comparison of dispatch catheter (30 min.); stability verified by plasma levels; good methods p.450; cardiovascular; post op. care (aspirin, ticlopidine); "continuous subcutaneous angiopeptin treatment was the optimal mode of angiopeptin therapy + resulted in maximal reduction in neointimal hyperplasia after stent implantation" (p.452).

P6328 Cabelli,R.J., Shelton,D.L., Segal,R.A., Shatz,C.J. Blockade of Endogenous Ligands of TrkB Inhibits Formation of Ocular Dominance Columns. Neuron 1997; 19(--):63-76. >>> Immunoglobulin G, TrkA; immunoglobulin, TrkB; immunoglobulin G, TrkC; NT-4/5; NT-3; BSA; PBS, sterile; CSF/CNS (visual cortex); Cat; ferret; 2002; 2,3 weeks; 2 days; Controls received mp w/ vehicle, or IgG protein fusions unrelated to Trk; comparison of CSF/CNS injections vs. mp; stability verified by Ab immunostaining of brain sections; peptides; post op. care (7 days oral amoxicillin); 3 week infusions had a flow rate of approx. 0.33 ul/hr, "the reduced flow rate (~0.33 ul/hr) was achieved by coating ~1/3 of the surface area of the minipump with hot paraffin prior to filling") p. 74).

P6314 Takizawa,H., DelliPizzi,A., Nasjletti,A. Prostaglandin I2 Contributes to the Vasodespressor Effect of Baicalein in Hypertensive Rats. Hypertension 1997; 31(--):866-871. >>> Angiotensin II; Acetic acid; IP; Rat; 2002; 12-14 days; Controls received mp w/ vehicle; functionality of mp verified by blood pressure; cardiovascular; post op. care (ampicillin).

P6307 Rayn,C.K., Miller,J.H., Seydel,A.S., Jensen,K., Sax,H.C. Epidermal Growth Factor and Neurotensin Induce Microvillus Hypertrophy Following Massive Enterectomy. JOURNAL OF GASTROINTESTINAL SURGERY 1996; 1(-5-):467-473. >>> Epidermal growth factor; neurotensin; Saline; SC; Rabbit; 1 week; Controls received mp w/ vehicle; replacement therapy (enterectomy); good methods p.468; peptides; post op. care (IM gentamycin; IV banamine).

R0077 Ray,N., Theeuwes,F. Implantable osmotically powered drug delivery systems. In 'Drug Delivery Systems: Fundamentals and Techniques,' P.Johnson and J.G.Lloyd-Jones (eds.), Ellis Horwood Ltd., Chichester, England and VCH Verlasgesellschaft mbH, Weinheim, Federal Republic of Germany 1987; (-Ch. 7-):120-138. >>> Antipyrine; bleomycin; dopamine HCl; melatonin; methotrexate, sodium; nicotine; prednisolone; radio-isotopes; valproic acid; 14C tracer; 3H tracer; IA; IP; SC; Mice, rabbit, rat; no duration posted; ALZA-authored; synoptic review of mp; post op. care (antibiotic); comparison of sc injections vs. mp infusion; pulsed delivery.

P8160 Baskin,D.S., Hosobuchi,Y., Loh,H.H., Lee,N.M. Dynorphin (1-13) improves survival in cats with focal cerebral ischaemia. Nature 1984; 312(-5994-):551-552. >>> Enkephalin, Leu-; dynorphin; dynorphin (3-13); Saline; SC; Cat; 2ML1; 7 days; Controls received mp w/ vehicle; peptides; post op. care (penicillin E, lactated ringer's solution); ischemia (cerebral); animal info (adult, male, MCAO).

P0021 Gronan,R.J., York,D.H. Effects of chronic intraventricular administration of angiotensin II on drinking behavior and blood pressure. Pharmacol.Biochem.Behav. 1979; 10(-1-):121-126. >>> Angiotensin II; Saline; CSF/CNS; SC; Rat; 1701; 7 days; Peptides; blood pressure taken; post op. care (prophylactic dose of penicillin G); guide cannula and stylete used; trypan blue dye used to verify cannula placement some animals had SC pumps.

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