References on the Administration of Norepinephrine Using
ALZET^® Osmotic Pumps

P8607 Ming,X.U., YanTing,Z., TianPao,H.A.O., Yao,S., ZhiZhen,L.U., QiDe,H.A.N., ShiQiang,W., YouYi,Z. Alpha 1-adrenergic receptors activate AMP-activated protein kinase in rat hearts. Acta Physiologica Sinica 2007; 59(-2-):175-182. >>> Norepinephrine; phenylephrine; Vitamin C; SC; Rat; 2002; 7 days; Controls received mp w/ vehicle; cardiovascular; animal info (male, Sprague-Dawley, 330-440 grams, 12 weeks old).

P8582 Garg,P., Martin,C.F., Elms,S.C., Gordon,F.J., Wall,S.M., Garland,C.J., Sutliff,R.L., O'Neill,W.C. Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone. American Journal of Physiology- Heart and Circulatory Physiology 2007; 292(-5-):H2100-H2105. >>> Norepinephrine; SC; Rat; 2001; 7 days; Functionality of mp verified by mean arterial blood pressure; cardiovascular; animal info (male, Sprague-Dawley, 360 grams).

P8523 Ko,E.A., Amiri,F., Pandey,N.R., Javeshghani,D., Leibovitz,E., Touyz,R.M., Schiffrin,E.L. Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice. American Journal of Physiology-Heart and Circulatory Physiology 2007; 292(-4-):H1789-H1795. >>> Norepinephrine; Mice; 2 weeks; Replacement therapy (nephrectomy); dose-response (fig 3); cardiovascular; animal info (3-4 months old, 20-35 g).

P8451 Ideura,H., Hiromura,K., Hiramatsu,N., Shigehara,T., Takeuchi,S., Tomioka,M., Sakairi,T., Yamashita,S., Maeshima,A., Kaneko,Y., Kuroiwa,T., Kopp,J.B., Nojima,Y. Angiotensin II provokes podocyte injury in murine model of HIV-associated nephropathy. American Journal of Physiology-Renal Physiology 2007; 293(-4-):F1214-F1221. >>> Angiotensin II; norepinephrine; SC; Mice (transgenic); 2004; 16 days; Functionality of mp verified by blood pressure; cardiovascular; peptides; animal info (FVB/N Podocin/rt TA tg, 7-8 wks old, 20-25g) nephrology.

P7990 Vongpatanasin,W., Thomas,G.D., Schwartz,R., Cassis,L.A., Osborne-Lawrence,S., Hahner,L., Gibson,L.L., Black,S., Samols,D., Shaul,P.W. C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice. Circulation 2007; 115(-8-):1020-1028. >>> Angiotensin II; norepinephrine; SC; Mice; 2002; 14 days; Blood pressure taken; cardiovascular; peptides; animal info (CF1-CRP).

P8395 Zhao,W.Y., Swanson,S.A., Ye,J.F., Li,X.L., Shelton,J.M., Zhang,W.G., Thomas,G.D. Reactive oxygen species impair sympathetic vasoregulation in skeletal muscle in angiotensin II-dependent hypertension. Hypertension 2006; 48(-4-):637-643. >>> Angiotensin II; norepinephrine; SC; Rat; 2002; 14 days; Controls received mp w/ vehicle, or sham surgery; cardiovascular; peptides; animal info (Sprague-Dawley, 200-300g., unilateral renal artery stenosis).

P8061 Wolf,G., Bohlender,J., Bondeva,T., Roger,T., Thaiss,F., Wenzell,U.O. Angiotensin II upregulates toll-like receptor 4 on mesangial cells. Journal of the American Society of Nephrology 2006; 17(-6-):1585-1593. >>> Angiotensin II; norepinephrine; IP; Rat; 2002; 7 days; Controls received mp w/ PBS; peptides; animal info (male, Wistar, 200g.); nephrology.

P8057 Eagleton,M.J., Ballard,N., Lynch,E., Srivastava,S.D., Upchurch,GR Jr, Stanley,J.C. Early increased MT1-MMP expression and late MMP-2 and MMP-9 activity during angiotensin II induced aneurysm formation. Journal of Surgical Research 2006; 135(-2-):345-351. >>> Angiotensin II; norepinephrine; Saline; SC; Mice; 2004; 7, 14, 21, 28 days; Controls received mp w/ vehicle; cardiovascular; peptides; animal info (c57BL/6J wt or ApoE -/-, male, 8-6 months old).

P7800 Palm,D., Lang,K., Niggemann,B., Drell,T.L., Masur,K., Zaenker,K.S., Entschladen,F. The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by betablockers. International Journal of Cancer 2006; 118(-11-):2744-2749. >>> Norepinephrine; propranolol; Saline, physiological; ascorbic acid; SC; Mice (nude); 1002; 4 weeks; Controls received mp w/ vehicle; pumps replaced after 2 weeks; half-life (pg. 2745) short, quickly metabolized; cancer (prostate carcinoma); animal info (female, BALB/C nude, athymic, 6 wk. old, 15g.).

P7440 Ayabe,N., Babaev,V.R., Tang,Y.W., Tanizawa,T., Fogo,A.B., Linton,M.F., Ichikawaa,I., Fazio,S., Kon,V. Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice. Atherosclerosis 2006; 184(-2-):312-321. >>> Angiotensin II; norepinephrine; SC; Mice; 1002; 2 weeks; Controls received mp w/ saline; dose-response (fig.1); stress/adverse reaction: (see pg. 313) 2 animals of 105 had mp extrusion; cardiovascular; peptides; animal info (female, C57BL/6, 8 weeks old).

P7739 Saito,K., Ishizaka,N., Aizawa,T., Sata,M., Iso-o,N, Noiri,E., Mori,I., Ohno,M., Nagai,R. Iron chelation and a free radical scavenger suppress angiotensin II- induced upregulation of TGF-beta 1 in the heart. American Journal of Physiology-Heart and Circulatory Physiology 2005; 288(-4-):H1836-H1843. >>> Angiotensin II, Val 5-; norepinephrine; SC; Rat; 7 days; Controls received no treatment; cardiovascular; animal info (male, Sprague-Dawley).

P7599 Ishizaka,N., Saito,K., Mori,I., Matsuzaki,G., Ohno,M., Nagai,R. Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II - Infused rats. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2005; 25(-11-):2282-2288. >>> Angiotensin II, val 5-; norepinephrine; SC; Rat; 2001; 4 weeks; 7 days; Controls received no treatment; dose-response (fig. 1); cardiovascular; peptides; animal info (male, Sprague-Dawley).

P7583 Chen,Y., Currie,R.W. Heat shock treatment suppresses angiotensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart. INFLAMMATION RESEARCH 2005; 54(-8-):338-343. >>> Angiotensin II; eprosartan; norepinephrine; Saline; SC; IP; IV (jugular); Rat; 2001; 2ML2; 3, 7 days; Controls received mp w/ vehicle or sham HS surgery; cardiovascular; peptides; animal info (male, Sprague-Dawley 280-310 g).

P7530 Saito,K., Ishizaka,N., Hara,M., Matsuzaki,G., Sata,M., Mori,I., Ohno,M., Nagai,R. Lipid accumulation and transforming growth factor-beta upregulation in the kidneys of rats administered angiotensin II. Hypertension 2005; 46(-5-):1180-1185. >>> Angiotensin II, val 5 -; norepinephrine; SC; Rat; 2001; 7 days; Controls received no treatment; functionality of mp verified by systolic blood pressure; cardiovascular; peptides; animal info (male, Sprague-Dawley, 250-300 g); lipotoxicity.

P7080 Li,Z.P., Oben,J.A., Yang,S.Q., Lin,H.Z., Stafford,E.A., Soloski,M.J., Thomas,S.A., Diehl,A.M. Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. Hepatology 2004; 40(-2-):434-441. >>> Norepinephrine; Saline, pyrogen-free; Mice; 3,4 weeks; Controls received mp w/ vehicle.

P6492 Chen,Y., Ross,B.M., Currie,R.W. Heat shock treatment protects against angiotensin II-induced hypertension and inflammation in aorta. CELL STRESS&CHAPERONES 2004; 9(-1-):99-107. >>> Angiotensin II; eprosartan; norepinephrine; Saline; SC; IP; IV (vena cava); Rat; 2001; 2002; 2ML2; 1,3,5,7,11,14 days; Controls received empty mp for 7 days; functionality of mp verified by SBP; cardiovascular; peptides.

P6465 Oben,J.A., Roskams,T., Yang,S., Lin,H., Sinelli,N., Torbenson,M., Smedh,U., Moran,T.H., Li,Z., Huang,J., Thomas,S.A., Diehl,A.M. Hepatic fibrogenesis requires sympathetic neurotransmitters. Gut 2004; 53(-3-):438-445. >>> Isoprenaline; norepinephrine; SC; Mice; 4 weeks; Controls received mp w/ vehicle.

P6408 Van Landeghem,F.K.H., Schreiber,S., Unterberg,A.W., Von Deimling,A., Stover,J.F. Differential concentration-dependent effects of prolonged norepinephrine infusion on intraparenchymal hemorrhage and cortical contusion in brain-injured rats. Journal of Neurotrauma 2003; 20(-12-):1327-1337. >>> Norepinephrine; Saline; IV; Rat; 2001; 44 hours; Controls received mp w/ vehicle; blood pressure taken; dose-response (p. 1329); brain injury.

P6087 Saito,K., Ishizaka,N., Mitani,H., Ohno,M., Nagai,R. Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat. FEBS Letters 2003; 551(-1-3-):58-62. >>> Angiotensin II; Norepinephrine; SC; Rat; 2001; 1 week; Peptides.

P6079 Li,P., Li,J., Feng,X., Li,Z., Hou,R., Han,C., Zhang,Y. Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. CELLULAR AND MOLECULAR LIFE SCIENCES 2003; 60(-10-):2200-2209. >>> Norepinephrine; Ascorbic acid; IV (jugular); Rat; 2002; 7 days; Functionality of mp verified by liquid chromatography; cardiovascular.

P6051 Mardon,K., Montague,O., Elbaz,N., Malek,Z., Syrota,A., Dubois-Rande,J.L., Meignan,M., Merlet,P. Uptake-1 carrier downregulates in parallel with theβ-adrenergic receptor desensitization in rat hearts chronically exposed to high levels of circulating norepinephrine: Implications for cardiac neuroimaging in human cardiomyopathies. Journal of Nuclear Medicine 2003; 44(-9-):1459-1466. >>> Norepinephrine; Saline; IV (jugular); Rat; 2001; 5 days; Controls received mp w/ vehicle; cardiovascular; silastic catheter used.

P5834 Caprile,T., Hein,S., Rodriguez,S., Montecinos,H., Rodriguez,E. Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid. MOLECULAR BRAIN RESEARCH 2003; 110(-2-):177-192. >>> Serotonin, binoxaiate; Norepinephrine; serotonin trifluoroacetate; Serotonin creatinin sulfate; L-DOPA; CSF, artificial; radio-isotopes; 3H tracer; CSF/CNS; Rat; 2001; 7 days.

P5728 Briest,W., Holzl,A., Rassler,B., Deten,A., Baba,H.A., Zimmer,H.G. Significance of matrix metalloproteinases in norepinephrine-induced remodelling of rat hearts. Cardiovascular Research 2003; 57(-2-):379-387. >>> Norepinephrine; Saline; Ascorbic Acid; IV (jugular); Rat; 14 days; Controls received mp w/ vehicle; cardiovascular; Norepinephrine is also called Noradrenalin; ascorbic acid added to vehicle solution to prevent oxidation.

P5663 Festuccia,W.T.L., Guerra-Sa,R., Kawashita,N.H., Garofalo,M.A.R., Evangelista,E.A., Rodrigues,V., Kettelhut,I.C., Migliorini,R.H. Expression of glycerokinase in brown adipose tissue is stimulated by the sympathetic nervous system. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2003; 284(-6-):R1536-R1541. >>> Norepinephrine; dobutamine; isoproterenol; Saline; sodium metabisulfite; SC; Rat; 2002; 3 days; 6, 12, 24, 72 hours; Controls received mp w/ vehicle; the norepinephrine vehicle solution contained sodium metabisulfite as an antioxidant; the b-adrenergic agonists (isoproterenol, dobutamine, and CL316243) were dissolved in saline and infused over 3 days..

P5574 Golden,K.L., Ren,J., Dean,A., Marsh,J.D. Norepinephrine regulates the in vivo expression of the L-type calcium channel. MOLECULAR AND CELLULAR BIOCHEMISTRY 2002; 236(-1-2-):107-114. >>> Isoproterenol; Norepinephrine; Phenylephrine; HCl; SC; rat; 3, 7 days; controls received mp with vehicle; alpha&beta adrenergic agonist.

P5473 Erami,C., Zhang,H., Ho,J.G., French,D.M., Faber,J.E. Alpha 1-adrenoceptor stimulation directly induces growth of vascular wall in vivo. American Journal of Physiology-Heart and Circulatory Physiology 2002; 283(-4-):H1577-H1587. >>> Norepinephrine; benoxathian; prazosin; KMD-3213; AH11110A; BMY-7378; propranolol; RX-821002; Ringer's, lactated; ascorbate; Perivascular; Rat; 2ML2; 14, 28 days; Tissue perfusion (left carotid wall); pumps replaced after 14 days for prazosin; catheter constructed from thin walled vinyl tubing and fenestrated at end placed near vessel; norepinephrine is a catecholamine; propranolol is a beta adrenoceptor antagonist; all other agents are antagonists alpha antagonists.

P5447 Ishizaka,N., Saito,K., Mitani,H., Yamazaki,I., Sata,M., Usui,S., Mori,I., Ohno,M., Nagai,R. Iron overload augments angiotensin II-induced cardiac fibrosis and promotes neointima formation. Circulation 2002; 106(-14-):1840-1846. >>> Angiotensin II; hydralazine; losartan; norepinephrine; SC; Rat; 2001; 7 days; Antihypertensive.

P5396 Bonnefont-Rousselot,D., Mahmoudi,A., Mougenot,N., Varoquaux,O., Le Nahour,G., Fouret,P., Lechat,P. Catecholamine effects on cardiac remodelling, oxidative stress and fibrosis in experimental heart failure. REDOX REPORT 2002; 7(-3-):145-151. >>> Norepinephrine; Saline; SC; Rat; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by norepinephrine plasma levels (p.148); cardiovascular; also called noradrenalin (a catecholamine).

P5230 Mitani,H., Ishizaka,N., Aizawa,T., Ohno,M., Usui,S., Suzuki,T., Amaki,T., Mori,I., Nakamura,Y., Sato,M., Nangaku,M., Hirata,Y., Nagai,R. In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 2002/4; 39(-4-):838-843. >>> Angiotensin II, [Val 5]; Norepinephrine; Rat; 7 and 14 days; Peptides.

P5223 Ishizaka,N., Aizawa,T., Ohno,M., Usui,Si S., Mori,I., Tang,S.S., Ingelfinger,J.R., Kimura,S., Nagai,R. Regulation and localization of HSP70 and HSP25 in the kidney of rats undergoing long-term administration of angiotensin II. Hypertension 2002/1; 39(-1-):122-128. >>> Angiotensin II; Norepinephrine; SC; Rat; 2001; 7 days; Peptides.

P5221 Aizawa,T., Ishizaka,N., Usui,S., Ohashi,N., Ohno,M., Nagai,R. Angiotensin II and catecholamines increase plasma levels of 8-epi- prostaglandin F(2alpha) with different pressor dependencies in rats. Hypertension 2002; 39(-1-):149-154. >>> Angiotensin II, [Val 5]; Norepinephrine; Rat; 2001; up to 7 days; Dose-response (p. 151); cardiovascular; peptides.

P5159 Moser,L., Faulhaber,J., Wiesner,R.J., Ehmke,H. Predominant activation of endothelin-dependent cardiac hypertrophy by norepinephrine in rat left ventricle. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2002; 282(--):R1389-R1394. >>> Angiotensin II; Norepinephrine; SC; rat; 2001; 7 days; cardiovascular.

P5068 Wenzel,U.O., Thaiss,F., Helmchen,U., Stahl,R.A.K., Wolf,G. Angiotensin II infusion ameliorates the early phase of a mesangioproliferative glomerulonephritis. Kidney International 2002; 61(--):1020-1029. >>> Angiotensin II; Norepinephrine; SC; rat; 2002; 6-10 days; peptides; all animals received either Ang II or NE.

P5067 Vecchione,C., Fratta,L., Rizzoni,D., Notte,A., Poulet,R., Porteri,E., Frati,G., Guelfi,D., Trimarco,V., Mulvany,M.J., Agabiti-Rosei,E., Trimarco,B., Cotecchia,S., Lembo,G. Cardiovascular influences of alpha 1b-adrenergic receptor defect in mice. Circulation 2002/4/9; 105(-14-):1700-1707. >>> Angiotensin II; Norepinephrine; Phenylephrine; Saline; Ascorbic acid; SC; mice (transgenic); 2004; 18 days; controls received mp w/ vehicle; cardiovascular; peptides; Ang II infused in saline, NE and PHE in 0.2% ascorbic acid.

P8593 Dao,H.H., Martens,F.M., Lariviere,R., Yamaguchi,N., Cernacek,P., De Champlain,J., Moreau,P. Transient involvement of endothelin in hypertrophic remodeling of small arteries. J Hypertens 2001; 19(-10-):1801-1812. >>> Norepinephrine; angiotensin II; SC; Rat; 2002; 2004; 3,7,14,28 days; Functionality of mp verified by plasma NE levels and blood pressure; cardiovascular; peptides; animal info (Sprague-Dawley, 175-200 grams).

P5192 Briest,W., Holzl,A., Rassler,B., Deten,A., Leicht,M., Baba,H.A., Zimmer,H.G. Cardiac remodeling after long term norepinephrine treatment in rats. Cardiovascular Research 2001; 52(--):265-273. >>> Norepinephrine; nisoldipin; Saline; ascorbic acid; ethanol; IP; IV (jugular); Rat; 3 or 14 days; Controls received mp w/ vehicle; comparison of infusion pump vs. mp; cardiovascular; Norepinephrine was infused IV for 14 days in saline w/ 0.01% ascorbic acid; nisoldipin, a calcium channel blocker, was delivered IP for 3 days in absolute ethanol.

P4832 Cervenka,L., Maly,J., Karasova,L., Simova,M., Vitko,S., Hellerova,S., Heller,J., El Dahr,S.S. Angiotensin II-induced hypertension in bradykinin B-2 receptor knockout mice. Hypertension 2001; 37(--):967-973. >>> Angiotensin II; Norepinephrine;; Saline;; IP;; mice;; 1002;; 13 days;; Controls received mp w/ vehicle; dose-response (p. 970); cardiovascular; angiotensin II and norepinephrine were infused into separate groups of animals..

P4775 Weiss,D., Kools,J.J., Taylor,W.R. Angiotensin II-induced hypertension accelerates the development of atherosclerosis in ApoE-deficient mice. Circulation 2001; 103(--):448-454. >>> Angiotensin II; Norepinephrine;; Water; Sodium chloride; Acetic acid;; SC;; mice;; 1002;; 4 or 8 weeks; Functionality of mp verified by plasma angiotensin levels; long-term study, pumps replaced 4 to 8 week study; vehicle solution was 0.15 M NaCl, .01 N acetic acid;.

P4702 Ishizaka,N., Aizawa,T, Mori,I., Taguchi,J.-I, Yazaki,Y, Nagai,R, Ohno,M  Am.J.Physiol.Heart Circ.Physiol. 2000; 279(--):H672-H678. >>> Angiotensin II; Norepinephrine;; SC; IV (jugular vein);; rat;; 2001;; 7 days;; Controls received mp w/ vehicle; cardiovascular; antihypertensive; Angiotensin II infused SC; Norepinephrine infused IV;.

P3870 Wang,P., Tait,S.T., Chaudry,I.H. Sustained elevation of norepinephrine depresses hepatocellular function. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2000; 1535(--):36-44. >>> Norepinephrine bitartrate; Saline; IP; rat; 2ML1; 24 hours; controls received mp w/ vehicle; functionality of mp verified by plasma norepinephrine levels..

P5113 Fukai,T, Siegfried,M.R., Ushio-Fukai,M, Griendling,K.K., Harrison,D.G. Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension. Circulation Research 1999; 85(--):23-28. >>> Angiotensin II, [Val 5]; Norepinephrine; Losartan; SC; mice; 2002; 7 days; controls received empty pump or sham surgery; cardiovascular; peptides; antihypertensive; some animals received 2 pumps for treatment with both Ang II and Losartan simultaneously; losartan is an AT1 receptor antagonist.

P4071 Sun,X., Ng,Y.-C. Effects of norepinephrine on expression of IGF-1/IGF-1R and SERCA2 in rat heart. Cardiovasc.Res. 1998; 37(--):202-209. >>> Norepinephrine bitartrate; Saline; Ascorbic acid; SC; rat; 2002; 3,6,14 days; controls received mp w/vehicle; cardiovascular; antihypertensive.

P4068 Zhou,Y.-G., Wang,Z.-G., Zhu,P.-F., Xiong,R.-P. Role of G proteins in the cardiovascular adrenergic desensitization of rats. Chinese J.Pharmacol.Toxicol. 1998; 12(-2-):117-122. >>> Norepinephrine; SC; rat; 2001; 3,6 days; article written in Chinese with English abstract; cardiovascular.

P6662 Capers,Q, Alexander,W, Lou,P., de Leon,H., Wilcox,J.N., Ishizaka,N, Howard,A.B, Taylor,W.R. Monocyte Chemoattractant Protein-1 Expression in Aortic Tissues of Hypertensive Rats. Hypertension 1997; 30(--):1397-1402. >>> Angiotensin II; norepinephrine; Sodium chloride; acetic acid; SC; IV (jugular); Rat; 2002; 7 days; Controls received mp w/ vehicle or sham operation; functionality of mp verified by blood pressure measurements.

P6324 Ishizaka,N, de Leon,H., Laursen,J.B., Fukui,T., Wilcox,J.N., De Keulenaer,G., Griendling,K.K., Alexander,W. Angiotensin II-Induced Hypertension Increases Heme Oxygenase-1 Expression in Rat Aorta. Circulation 1997; 96(--):1923-1929. >>> Angiotensin II; norepinephrine; Sodium chloride; acetic acid; SC; IV (vena cava); Rat; 2001; 1,3,5,7, days; Cardiovascular; Ang II via SC, NE via IV administration.

P4612 Lantelme,P, Lo,M, Luttenauer,L, Sassard,J. Pivotal role of the renin-angiotensin system in Lyon hyertensive rats.. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.42) 1997; 273(--):R1793-R1799. >>> Angiotensin II; Norepinephrine; IV (jugular); Rat; 2ML4; 4 weeks; Stability of norepinephrine verified at the end of the experiment by testing the pressure effect of the residual solution; peptides; cardiovascular;.

P4611 Du,Y, Qiu,J, Nelson,S.H, Wang,D.H. Regulation of type 1 ANG II receptor in vascular tissue: role of a1-adrenoreceptor.. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.42) 1997; 273(--):R1224-R1229. >>> Norepinephrine; Prazosin;; Saline, physiological; DMSO;; SC;; rat;; 2002; 2ML2;; 2 weeks;; controls received mp w/vehicle; antihypertensive; cardiovascular;.

P4124 Al-Arabi,A., Andrews,J.F. Synergistic action by neuropeptide y (NPY) and norepinephrine (NE) on food intake, metabolic rate, and brown adipose tissue (bat) causes remarkable weight loss in the obese (fa/fa) Zucker rat. Biomed.Sci.Instrum. 1997; 33(--):216-225. >>> Neuropeptide Y; Norepinephrine; SC; rat; 2002; 14 days; controls received mp w/vehicle; agents infused alone or in combination; peptides.

P3864 Seasholtz,T.M., Gurdal,H., Wang,H.-Y., Johnson,M.D., Friedman,E. Desensitization of norepinephrine receptor function is associated with G protein uncoupling in the rat aorta. Am.J.Physiol. 1997; 273(-42-):H279-H285. >>> Norepinephrine; Ascorbic acid; NaCl; SC; rat; 2001; 6 days; cardiovascular.

P3824 Chi,M.S., Vander Tuig,J.G., Chi,C.H., Norman,A., Chapman,L., Blanks,T. Effects of norepinephrine infusion and exercise on blood pressure in rats. P.S.E.B.M. 1997; 215(--):174-178. >>> Norepinephrine bitartrate; Saline; SC; rat; 14 days; controls received mp w/saline; cardiovascular.

P3796 Hamada,H., Hakamata,N., Ohsuzu,F., Nakamura,H. Age-related effects of norepinephrine on rat ventricular hypertrophy. Jpn.Heart J. 1997; 38(-3-):433-443. >>> Norepinephrine HCl; Norepinephrine bitartrate; Bunazosin; Bisoprolol; SC; rat; 2002; 7, 14 days; controls received mp w/saline or norepinephrine; dose-response; antihypertensive; cardiovascular; 2 pumps implanted in each animal.

P4199 Kaddoura,S., Firth,J.D., Boheler,K.R., Sugden,P.H., Poole-Wilson,P.A. Endothelin-1 is involved in norepinephrine-induced ventricular hypertrophy in vivo. Circulation 1996; 93(--):2068-2079. >>> Norepinephrine bitartrate; Saline; Ascorbate; SC; rat; 2001; 1,2,3,5,7 days; controls received mp w/vehicle; cardiovascular.

P3647 Laycock,S.K., Kane,K.A., McMurray,J., Parratt,J.R. Captopril and norepinephrine-induced hypertrophy and haemodynamics in rats. J.Cardiovasc.Pharmacol. 1996; 27(--):667-672. >>> Norepinephrine; Captopril; Ascorbic acid; Saline; SC; rat; 2ML4; 28 days; controls received vehicle infusion; antihypertensive; multiple pumps per animal (1 or 2).

P3584 De Blois,D., Schwartz,S.M., van Kleef,E.M., Su,J.E., Griffin,K.A., Bidani,A.K., Daemen,M.J.A.P., Lombardi,M.J.A.P. Chronic a(1)-adrenoreceptor stimulation increases DNA synthesis in rat arterial wall. Arterioscler.Thromb.Vasc.Biol. 1996; 16(--):1122-1129. >>> Phenylephrine; Norepinephrine; Uridine, bromodeoxy-;; Ringer's solution, lactated; Ascorbate;; SC;; rat;; 2002;; 2 weeks;; 2 pumps implanted simultaneously; cell proliferation;.

P4063 Harris,T.J., Waltman,T.J., Carter,S.M., Maisel,A.S. Effect of prolonged catecholamine infusion on immunoregulatory function: implications in congestive heart failure. J.Am.Coll.Cardiol. 1995; 26(-1-):102-109. >>> Epinephrine; Norepinephrine; Propranolol; HCl; Ascorbic acid; SC; rat; 4 weeks; controls received mp w/vehicle; immunology, antihypertensive; cardiovascular.

P3303 Laycock,S.K., McMurray,J., Kane,K.A., Parratt,J.R. Effects of chronic norepinephrine administration on cardiac function in rats. J.Cardiovasc.Pharmacol. 1995; 26(--):584-589. >>> Norepinephrine; Saline; Ascorbic acid; SC; rat; 2ML4; 10-28 days; controls received mp w/acid saline.

P3079 Zhou,Y., Friedman,E., Roberts,J., Johnson,M.D. Modulation of aortic and cardiac G protein alpha subunits and their mRNAs during norepinephrine infusion in rats. J.Vasc.Res. 1995; 32(--):16-23. >>> Norepinephrine; Saline; Ascorbic acid; SC; rat; 2001; 3, 6 days; controls received mp with vehicle.

P2844 Tsukazaki,K., Nikami,H., Shimizu,Y., Kawada,T., Yoshida,T., Saito,M. Chronic administration of B-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue. J.Biochem 1995; 117(--):96-100. >>> Norepinephrine; Isoproterenol; Phenylephrine HCl; Ascorbic acid; SC; rat; 10 days; controls received mp with vehicles; agents are adrenergic agonists.

P2822 Granneman,J.G  Endocrinology 1995; 136(-5-):2007-2012. >>> Norepinephrine; Isoproterenol; Phenylephrine; Ascorbic acid; rat; 2001; 4 days; controls received mp with vehicle; isoproterenol and phenylephrine infused separately and together.

P2813 Nishino,K., Kikuchi,K., Ohyu,H., Kowada,M. Chronic intraventricular norepinephrine and delayed neuronal death in the hippocampus. J.Clin.Neuroscience 1995; 2(-2-):152-155. >>> Norepinephrine; Ascorbic acid; CSF/CNS; gerbil; 2001; 14 days; brain tissue distribution; pump placed intraperitoneally.

P3243 Liu,X., Perusse,F., Bukowiecki,L.J. Chronic norepinephrine infusion stimulates glucose uptake in white and brown adipose tissues. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.35) 1994; 266(--):R914-R920. >>> Norepinephrine; Water, distilled; Sodium metabisulfite; SC; rat; 1007D; 4 days; controls received mp with vehicle.

P4074 Butterfield,M.C., Chess-Williams,R. Potentiation of a-adrenoceptor-mediated responses following chronic b-adrenoceptor stimulation in the rat heart. Br.J.Pharmacol. 1993; 108(--):658-662. >>> Norepinephrine; Isoproterenol; Saline; Ascorbic acid; SC; rat; 2001; 3 days; controls received mp w/vehicle.

P3192 Himura,Y., Felten,S.Y., Kashiki,M., Lewandowski,T.J., Delahanty,J.M., Liang,C.-S. Cardiac noradrenergic nerve terminal abnormalities in dogs with experimental congestive heart failure. Circulation 1993; 88(--):1299-1309. >>> Norepinephrine; SC; dog; 2ML4; 8 weeks; controls received mp with saline; long-term study, pumps replaced after 3-4 weeks.

P2687 Carpene,C., Galitzky,J., Collon,P., Esclapez,F., Dauzats,M., Lafontan,M. Desensitization of beta-1 and beta-2, but not beta-3, adrenoceptor-mediated lipolytic responses of adipocytes after long-term norepinephrine infusion. J.Pharmacol.Exp.Ther. 1993; 265(-1-):237-247. >>> Norepinephrine; SC; hamster; guinea-pig; 2001; no duration posted; controls received sham operations; comparison of ip injections.

P2612 McCorkle,F.M., Taylor Jr,R.L. Biogenic amines regulate avian immunity. Poult.Sci. 1993; 72(--):1285-1288. >>> Epinephrine; Norepinephrine;; Saline; SC; bird (chicken); 2001; 24,48 or 72 hours; controls received mp w/ vehicle; immunology.

P2451 Yoshida,K., Yasujima,M., Kohzuki,M., Kanazawa,M., Yoshinaga,K., Abe,K. Endothelin-l augments pressor response to angiotensin ll infusion in rats. Hypertension 1992; 20(-3-):292-297. >>> Norepinephrine; Angiotensin II; Endothelin; Acetic acid; Saline; IP; IV (jugular); rat; 6 days; controls received mp w/ vehicle; functionality of mp verified upon removal; peptides.

P2103 Brown,L., Sernia,C., Newling,R., Fletcher,C. Cardiac responses after norepinephrine-induced ventricular hypertrophy in rats. J.Cardiovasc.Pharmacol. 1992; 20(--):316-323. >>> Norepinephrine HCl; Ascorbic acid; Saline; SC; rat; 2002; 14 days; no comment posted.

P2049 Brown,L.A., Harding,S.E. The effect of pertussis toxin on B-adrenoceptor responses in isolated cardiac myocytes from noradrenaline-treated guinea-pigs and patients with cardiac failure. Br.J.Pharmacol. 1992; 106(--):115-122. >>> Norepinephrine HCl; Ascorbate; Saline; SC; guinea-pig; 2002; 7 days; toxicology.

P2035 Stewart,J.M., Patel,M.B., Wang,J., Ochoa,M., Gewitz,M., Loud,A.V., Anversa,P., Hintze,T.H. Chronic elevation of norepinephrine in conscious dogs produces hypertrophy with no loss of LV reserve. Am.J.Physiol. 1992; 262(-31-):H331-H339. >>> Norepinephrine; SC; dog; 2ML4; 28 days; an additional pump was implanted sc on day 10 to maintain plasma levels of norepinephrine p. 332.

P2409 Patel,M.B., Stewart,J.M., Loud,A.V., Anversa,P., Wang,J., Fiegel,L., Hintze,T.H. Altered function and structure of the heart in dogs with chronic elevation in plasma norepinephrine. Circulation 1991; 84(-5-):2091-2100. >>> Norepinephrine; SC; dog; 2ML4; 28 days; no comment posted.

P2150 Fujimura,A., Ohashi,K.-I., Ebihara,A. Chronopharmacological study of furosemide; (IX) influence of continuous norepinephrine infusion. Life Sci. 1991; 50(--):449-455. >>> Norepinephrine; Ascorbic acid; Saline; SC; rat; 2ML2; 11 days; controls received mp with vehicle.

P2038 Kuroshima,A., Ohno,T. Cold- and noradrenaline-induced changes in ganglioside GM3 levels of rat brown adipose tissue. J.Therm.Biol. 1991; 16(-1-):37-39. >>> Norepinephrine bitartrate; Ascorbic acid; Tiron; rat; 2002; 2 weeks; no comment posted.

P2004 Johnson,M.D., Wang,H.-Y., Ciechanowski,D., Friedman,E. Reduced G protein function in desensitized rat aorta. J.Pharmacol.Exp.Ther. 1991; 259(-1-):255-259. >>> Norepinephrine; Ascorbic acid; Saline; SC; rat; 2001; 6 days; no comment posted.

P3202 Jones,S.M., Hunt,N.A., Del Monte,F., Harding,S.E. Contraction of cardiac myocytes from noradrenaline-treated rats response to isoprenaline, forskolin and dibutyryl cAMP. Eur.J.Pharmacol. 1990; 191(--):129-140. >>> Norepinephrine bitartrate; Ascorbate; SC; rat; 2001; 2002; 7-14 days; controls received sham operation.

P2040 Yasujima,M., Abe,K., Tanno,M., Kohzuki,M., Kanazawa,M., Yoshida,K., Omata,K., Sato,M., Takeuchi,K., Hiwatari,M., Sato,T., Yoshinaga,K. Effects of digoxin on blood pressure responses to norepinephrine, angiotensin II and vasopressin in conscious rats. Tohoku J.Exp.Med. 1990; 162(--):203-212. >>> Angiotensin II; Norepinephrine bitartrate; Vasopressin; Acetic acid; Ascorbic acid; Glutathione; IP; rat; 2001; 6 days; peptides.

P1801 Eickenburg,D.C. Effects of chronic norepinephrine administration on sympathetic neurotransmission in the isolated perfused rat kidney. J.Pharmacol.Exp.Ther. 1990; 255(-3-):1053-1059. >>> Epinephrine; Norepinephrine; Ascorbic acid; Saline; SC; rat; 6 days; no comment posted.

P1727 Albino-Teixeira,A., Azevedo,I., Branco,D., Osswald,W. Purine agonists prevent trophic changes caused by sympathetic denervation. Eur.J.Pharmacol. 1990; 179(--):141-149. >>> Adenosine; Adenosine, N-ethylcarboxamido-; Inosine; Norepinephrine; IV (saphenous); dog; 2ML1; no duration posted; functionality of mp verified by inspecting catheter for clots, observing collapsed pump reservoir, and measuring residual drug solution.

P1577 Yakubu,M.A., Deighton,N.M., Hamilton,C.A., Reid,J.L. Differences in the regulation of [3H]idazoxan and [3H]yohimbine binding sites in the rabbit. Eur.J.Pharmacol. 1990; 176(--):305-311. >>> Amitriptyline; Idazoxan; Norepinephrine; Saline; IP; IV (femoral); rabbit; 5, 10, 21 days; not clear that amitriptyline delivered by pumps.

P1657 Granneman,J.G., Bannon,M.J. Neural control of the a-subunit of Gs messenger ribonucleic acid in rat brown adipose tissue. Endocrinology 1989; 125(-5-):2328-2334. >>> Isoproterenol; Norepinephrine; Phenylephrine; Ascorbic acid; SC; rat; 2001; no duration posted; no comment posted.

P1606 Li,P., Jackson,E.K. Enhanced slow-pressor response to angiotensin II in spontaneously hypertensive rats. J.Pharmacol.Exp.Ther. 1989; 251(-3-):909-921. >>> Angiotensin II; Norepinephrine; Water; IA (renal); IP; IV (jugular); rat; 2002; 1, 2 weeks; dose-response (graph); tissue perfusion; peptides.

P1476 Teixeira,A.A., Azevedo,I., Branco,D., Rodrigues-Pereira,E., Osswald,W. Sympathetic denervation caused by long-term noradrenaline infusions; prevention by desipramine and superoxide dismutase. Br.J.Pharmacol. 1989; 97(--):95-102. >>> Desipramine HCl; Norepinephrine; tempol; EDTA; Heparin; Saline; IV (saphenous); dog; 2ML1; 5 days; dose-response; implanted sc above the knee; functionality of mp verified by visual inspection of sectioned pump and by serum levels; tissue perfusion; animal info (m, 9-15 kg); 5000 Units of heparin.

P1357 Deighton,N.M., Brown,A.D., Hamilton,C.A., Reid,J.L. Regulation of adrenergic receptor number following chronic noradrenaline infusion in the rabbit. Naunyn-Schmiedeberg's Arch.Pharmacol. 1988; 338(--):517-522. >>> Norepinephrine; Ascorbic acid; Water; IV (femoral); rabbit; 2002; 10 days; dose-response; functionality of mp verified by plasma levels.

P1334 Desautels,M., Dulos,R.A. Is adrenergic innervation essential for maintenance of UCP in hamster BAT mitochondria?. Am.J.Physiol. 1988; 254(--):R1035-R1042. >>> Norepinephrine HCl; Ascorbic acid; Saline; SC; rat; 2001; 7 days; no comment posted.

P1309 Elfellah,M.S., Deighton,N., Reid,J.L. Regulation of B-adrenoceptors by catecholamines in the rabbit skeletal muscle. Eur.J.Pharmacol. 1988; 157(--):215-220. >>> Epinephrine; Norepinephrine; Ascorbic acid; Water; IV (femoral); rabbit; 2002; 10 days; functionality of mp verified by plasma levels.

P1276 Granneman,J.G. Norepinephrine infusions increase adenylate cyclase responsiveness in brown adipose tissue. J.Pharmacol.Exp.Ther. 1988; 245(-3-):1075-1080. >>> Clonidine HCl; Isoproterenol HCl; Norepinephrine bitartrate; Phenylephrine HCl; Ascorbic acid; SC; rat; 3 days; solubility limitations; antihypertensive.

P1210 Geloen,A., Collet,A.J., Guay,G., Bukowiecki,J. Beta-adrenergic stimulation of brown adipocyte proliferation. Am.J.Physiol. 1988; 254(--):C175-C182. >>> Isoproterenol; Norepinephrine; Phenylephrine; Sodium metabisulfate; Water; SC; rat; 2002; 4 days; controls received mp w/ vehicle; agents infused separately; comparison of 4 day cold exposure vs. 4 day mp infusion of adrenergic agonists.

P1064 Battista,P.J., Poff,J.P., Deaver,D.R., Condon,W.A. Biogenic amine regulation of bovine luteal progesterone production in vivo. J.Reprod.Fertil. 1987; 80(-2-):517-522. >>> Epinephrine, l-; Norepinephrine, l-; Serotonin; Saline; SC; cattle; 72 hours; Pump model not stated; concomitant infusion of agents; comparison of agents effects.

P1056 King,B.D., Sack,D., Kichuk,M.R., Hintze,T.H. Absence of hypertension despite chronic marked elevations in plasma norepinephrine in conscious dogs. Hypertension 1987; 9(--):582-590. >>> Norepinephrine; SC; dog; 2ML4; 28 days; dose-response; functionality of mp verified.

P1026 Forest,C., Doglio,A., Casteilla,L., Ricquier,D., Ailhaud,G. Expression of the mitochondrial uncoupling protein in brown adipocytes. Exp.Eye Res. 1987; 168(-1-):233-246. >>> Norepinephrine; mice; no duration posted; vague mention of mp only.

P1022 Loomis,C.W., Milne,B., Cervenko,F.W. Determination of cross tolerance in rat spinal cord using intrathecal infusion via sequential mini-osmotic pumps. Pharmacol.Biochem.Behav. 1987; 26(-1-):131-139. >>> Dye, Methylene blue; Morphine sulfate; Norepinephrine HCl; Ascorbic acid; Saline; CSF/CNS (spinal cord, intrathecal); rat; 2001; no duration posted; NE pumps replaced after 4 days w/morphine sulfate; 2 mp infused agents separately and simultaneously in same animal; mp connected to cath..

P1011 Johnson,R.D., Iuvone,P.M., Minneman,K.P. Regulation of Alpha-1 adrenergic receptor density and functional responsiveness in rat brain. J.Pharmacol.Exp.Ther. 1987; 242(-3-):842-849. >>> Norepinephrine; Prazosin; DMSO; Water; CSF/CNS; rat; 2002; 2ML2; 14 days; controls received mp w/ appropriate vehicle; mp connected to cannula in ventricle; DMSO used as vehicle for Prazosin; agents infused separately; antihypertensive.

P0950 Yamori,Y., Mano,M., Nara,Y., Horie,R. Catecholamine-induced polyploidization in vascular smooth muscle cells. Circulation 1987; (-1-):1-92. >>> Epinephrine; Norepinephrine; IV (jugular); rat; 1701; 12 days; pumps replaced after 6 days; mp connected to rubber tube in jugular vein; functionality of mp verified.

R0067 Struyker-Boudier,H.A.J., Kleinjans,J.C.S., le Noble,L.M.L., Nievelstein,H.M.N., Smits,J.F.M. Rate-controlled cardiovascular drug administration and action. In 'Rate-Controlled Drug Administration and Action,' H.A.J.Struyker-Boudier (ed.), CRC Press 1986; (-Ch. 7-):171-203. >>> Clonidine; Endralazine; Norepinephrine; Propranolol; no duration posted; cardiovascular drug delivery; many mp refs. injection vs. mp infusion; half-lives; hypertension; antihypertensive.

P1016 Yasujima,M., Abe,K., Tanno,M., Kohzuki,M., Kasai,Y., Sato,M., Omata,K., Takeuchi,K., Yoshinaga,K., Masugi,F., Ogihara,T. Effects of ouabain on blood pressure regulation in rats. J.Hypertens. 1986; 4(-5-):597-601. >>> Norepinephrine bitartrate; Ouabain; Glutathione; Saline; IP; IV (jugular); rat; 2001; 3, 6 days; controls received mp w/vehicle; mp connected to cath. in jug. vein; agents inf. sep. and simult. w/appropriate vehicle; 2 mp used in same animal.

P0812 Shimazu,T., Noma,M., Saito,M. Chronic infusion of norepinephrine into the ventromedial hypothalmus induces obesity in rats. Brain Research 1986; 369(-1/2-):215-223. >>> Acetylcholine chloride; Cefalotin; Cholecystokinin tetrapeptide; Epinephrine HCl; Bombesin; Endorphin, B-; Enkephalin, methionine-; Norepinephrine HCl; Saline; Sodium bisulfite; CSF/CNS (hypothalamus); rat; 2002; 5-20 weeks; Cholinergic agent; pumps replaced periodically; mp connected to perm. steel cannula in hypothalamus; cannula fitted w/removable protector; (see p.217); agents infused sep. (cefalotin infused w/each agent); long-term study; peptides.

P0775 Racotta,R., Ramirez-Altamirano,L., Velasco-Delgado,E. Metabolic effects of chronic infusions of epinephrine and norepinephrine in rats. Am.J.Physiol. 1986; 250(-13-):E518-E522. >>> Epinephrine; Norepinephrine; Ascorbic acid; HCl; Saline; SC; rat; 2001; 7 days; mps left in animal for 5 days after 7 day infusion; controls received mp w/vehicle.

P0732 Seeber,A.M., Vila,S.B., Catanzaro,O.L. Effect of norepinephrine and vasopressin on renal kallikrein excretion in rats. Arch.Int.Physiol.Biochim. 1985; 93(--):83-88. >>> Norepinephrine; Vasopressin; Ascorbic acid; Water; abdomen; rat; 2001; 1 week; comparison of acute iv infusion vs. chronic mp infusion; peptides.

P0719 Yasujima,M., Abe,K., Kohzuki,M., Tanno,M., Kasai,Y., Sato,M., Omata,K., Kudo,K., Tsunoda,K., Takeuchi,K., Yoshinaga,K., Inagami,T. Atrial natriuretic factor inhibits the hypertension induced by chronic infusion of norepinephrine in conscious rats. Circ.Res. 1985; 57(-3-):470-474. >>> Atrial natriuretic factor; Norepinephrine bitartrate; Saline; IP; IV (jugular); rat; 2001; 3 days; Multiple pumps per animal (2); ANF administered iv via catheter from mp to jugular; mp implanted sc in interscapular region; NE administered orally or via ip mp to induce hypertension; peptides.

P0710 Mills,D.E., Woods,R.B. Interaction of prolactin with adrenal hormones in blood pressure regulation in rats. Am.J.Physiol. 1985; 249(--):E614-E618. >>> Corticosterone; Epinephrine; Norepinephrine; Prolactin, ovine; Ethanol; Sodium chloride; Water; IP; rat; 2001; 7 days; replacement therapy (adrenalectomy); separate and simultaneous infusion of agents; multiple pumps per animal (2) for CORT; hypertension; controls received mp w/NaCl; peptides.

P0685 Snavely,M.D., Ziegler,M.G., Insel,P.A. Subtype-selective down-regulation of rat renal cortical a- and B-adrenergic receptors by catecholamines. Endocrinology 1985; 117(-5-):2182-2189. >>> Epinephrine; Norepinephrine; Isoproterenol;; HCl; SC; rat; 1-11 days; mp model not stated; comparison of agents effects.

P0632 Milne,B., Cervenko,F., Jhamandas,K., Loomis,C., Sutak,M. Analgesia and tolerance to intrathecal morphine and norepinephrine infusion via implanted mini-osmotic pumps in the rat. Pain 1985; 22(-2-):165-172. >>> Morphine; Norepinephrine; Ascorbic acid; Saline; CSF/CNS (spinal cord, intrathecal); rat; 2001; 2002; 7 or 14 days; comparison of agents effects singly or in sequence; no stress/weight loss p. 167, 169; stability of residual NE determ. by spectrofluorometer; saline/ascorbate used w/NE, vehicle for MOR not stated.

P0624 Stone,E.A., Slucky,A.V., Platt,J.E., Trullas,R. Reduction of the cyclic adenosine 3',5'-monophosphate response to catecholamines in rat brain slices after repeated restraint stress. J.Pharmacol.Exp.Ther. 1985; 233(-2-):382-388. >>> ACTH(1-24); Epinephrine bitartrate; Norepinephrine bitartrate; Acetic acid; Ascorbic acid; SC; rat; 12 days; mp model not stated; comparison of ACTH sc inject vs. mp infusion; comparison of agents effects; mp functionality pp. 386, 388; acetic acid was vehicle w/ACTH, ascorbic acid was w/NE and EPI; peptides.

P0613 Siri,F.M. Chronic norepinephrine infusion and adrenergic function of hypertrophied hearts. Am.J.Physiol. 1985; 248(-4-):H485-H492. >>> Norepinephrine; Water; IV (jugular); rat; 2001; 1 week; the NE used was l-arterenol bitartrate.

P0537 Kleinjans,J.C.S., Smits,J.F.M., van Essen,H., Kasbergen,C.M., Struyker Boudier,H.A.J. Hemodynamic characterization of hypertension induced by chronic intrarenal or intravenous infusion of norepinephrine in conscious rats. Hypertension 1984; 6(-5-):689-699. >>> Norepinephrine; Saline; IA (renal); IV (jugular); rat; 2001; 5 days; comparison of acute infusion by Percidor pump vs. iv or ia mp infusion; dose-response data; 2 doses NE - 4 and 36 ug/kg/hr; tissue perfusion.

P0468 Kleinjans,J.C.S., Smits,J.F.M., Kasbergen,C.M., van Essen,H., Struyker-Boudier,H.A.J. Evaluation of renal function during intrarenal norepinephrine infusion in conscious rats. Renal Physiol. 1984; 7(--):243-250. >>> Norepinephrine; Ascorbic acid; Saline; IA (renal); IV (jugular); rat; 5 days; comparison of iv vs. ia mp infusion; dose-response data; tissue perfusion.

P0462 Kuppermann,B.D., Kasamatsu,T. Enhanced binocular interaction in the visual cortex of normal kittens subjected to intracortical norepinephrine perfusion. Brain Research 1984; 302(--):91-99. >>> Norepinephrine HCl, l-; Ascorbate; Saline; CSF/CNS (visual cortex); cat (kitten); 2001; 7&8 days; no comment posted.

P0439 Costall,B., Domeney,A.M., Naylor,R.J. Locomotor hyperactivity caused by dopamine infusion into the nucleus accumbens of rat brain: specificity of action. Psychopharmacology 1984; 82(--):174-180. >>> Acetylcholine HCl; Aminobutyric acid, Y-; Serotonin bimaleinate; Dopamine HCl; Norepinephrine bitartrate; Nitrogen; Sodium metabisulfite; CSF/CNS (nucleus accumbens); rat; 2002; 13 days; Cholinergic agent; comparison of agents effects; no stress p. 175; stability of substances remaining in pump after 13 days was verified.

P0437 Mory,G., Bouillaud,F., Combes-George,M., Ricquier,D. Noradrenaline controls the concentration of the uncoupling protein in brown adipose tissue. FEBS Lett. 1984; 166(-2-):393-396. >>> Norepinephrine; Ascorbic acid; Benzene disulfonic acid, dihydroxy-; SC; rat; 2002; 9 days; comparison of chronic cold exposure vs mp NE infusion.

T0004 Kleinjans,J.C.S. Stimulation of renal adrenergic mechanisms as a model for the development of hypertension. Dissertation, State University of Limburg, Netherlands 1983; (--):-. >>> Captopril; Norepinephrine; Radio-isotopes; 3H tracer; Ascorbic acid; Saline; IA (renal); IP; IV (jugular); rat; 5 days; 6 diff. exp. done; exp in ch. 5 used captopril in ip pump, sc pump delivered saline or NE w/ ascorbic acid via ia catheters; stability of NE in pump verified; tissue perfusion; antihypertensive.

P0496 Kleinjans,J.C.S., Smits,J.F.M., Kasbergen,C.M., Struyker-Boudier,H.A.J. Body fluid and salt homeostasis during hypertension caused by chronic intrarenal norepinephrine infusion in conscious rats. J.Hypertens. 1983; 1(-2-):207-209. >>> Norepinephrine; Ascorbic acid; Saline; IA (renal); rat; 5 days; dose-response data; tissue perfusion.

P0376 Johnson,M.D., Smith,P.G., Mills,E., Schanberg,S.M. Paradoxical elevation of sympathetic activity during catecholamine infusion in rats. J.Pharmacol.Exp.Ther. 1983; 227(-1-):254-259. >>> Normetanephrine; Epinephrine; Norepinephrine; Radio-isotopes; 3H tracer; Ascorbic acid; Saline; SC; rat; 2001; 6 and 7 days; comparison of agents effects; 3H tracer used w/ normetanephrine and NE together; NE and E also used separately with just ascorbic acid.

P0348 Kleinjans,J.C.S., Smits,J.F.M., Kasbergen,C.M., Vervoort-Peters,H.T.M., Struyker-Boudier,H.A.J. Blood pressure response to chronic low-dose intrarenal noradrenaline infusion in conscious rats. Clin.Sci. 1983; 65(--):111-116. >>> Norepinephrine; Ascorbic acid; Saline; IA (renal); IV (jugular); rat; 2001; 5 days; comparison of i.v. vs. i.a. infusion; tissue perfusion.

P0342 Johnson,M.D., Grignolo,A., Kuhn,C.M., Schanberg,S.M. Hypertension and cardiovascular hypertrophy during chronic catecholamine infusion in rats. Life Sci. 1983; 33(--):169-180. >>> Epinephrine; Norepinephrine; Ascorbic acid; SC; rat; 2001; 1-4 weeks; pumps replaced weekly.

P0232 Majewski,H., Tung,L.-H., Rand,M.J. Adrenaline activation of prejunctional B-adrenoceptors and hypertension. J.Cardiovasc.Pharmacol. 1982; 4(-1-):99-106. >>> Epinephrine bitartrate; Norepinephrine HCl; Radio-isotopes; 3H tracer; Ascorbic acid; Saline; IP; rat; 2001; 6 days; no comment posted.

P0224 Chang,H.Y., Klein,R.M., Kunos,G. Selective desensitization of cardiac beta adrenoreceptors by prolonged in vivo infusion of catecholamines in rats. J.Pharmacol.Exp.Ther. 1982; 221(-3-):784-789. >>> Isoproterenol HCl, l-; Norepinephrine HCl, l-; Saline; SC; rat; 2001; 2-7 days; no comment posted.

P0198 Tung,L.-H., Rand,M.J., Majewski,H. Adrenaline-induced hypertension in rats. Clin.Sci. 1981; 61(--):191S-193S. >>> Epinephrine bitartrate; Norepinephrine bitartrate; Ascorbic acid; Saline; IP; rat; 2001; 6 days; intermittent iv vs. mp ip infusion.

P0176 Diz,D.I., Baer,P.G., Nasjletti,A. Effect of norepinephrine and renal denervation on renal PGE2 and kallikrein in rats. Am.J.Physiol. 1981; 241(-5-):F477-F481. >>> Norepinephrine; Ascorbic acid; Glutathione; IP; rat; 1702; 7 days; comparison of renal denervation vs. infusion.

P0156 Kasamatsu,T., Pettigrew,J.D., Ary,M. Cortical recovery from effects of monocular deprivation: acceleration with norepinephrine and suppression with 6-hydroxydopamine. J.Neurophysiol. 1981; 45(-2-):254-266. >>> Dopamine HBr, 6-hydroxy-; Norepinephrine HCl, l-; Saline; CSF/CNS (visual cortex); cat (kitten); no duration posted; no comment posted.

P0152 Kleinjans,J., Kasbergen,C., Vervoort-Peters,L., Smits,J., Struyker-Boudier,H.A.J. Chronic intravenous infusion of noradrenaline produces labile hypertension in conscious rats. Life Sci. 1981; 29(-5-):509-514. >>> Norepinephrine; Ascorbic acid; Saline; IV (jugular); rat; 2001; 5 days; stability of NE in pump verified.

P0138 Kasamatsu,T., Itakura,T., Jonsson,G. Intracortical spread of exogenous catecholamines: effective concentration for modifying cortical plasticity. J.Pharmacol.Exp.Ther. 1981; 217(-3-):841-850. >>> Dopamine HBr, 6-hydroxy-; Norepinephrine HCl; Radio-isotopes; 3H tracer; Ascorbate; Saline; CSF/CNS (visual cortex); cat; cat (kitten); 1701; 1, 3,&7 days; no comment posted.

P0103 Biswas,B., Jonsson,G. Reversal of noradrenaline denervation-induced increase of B-adrenoreceptor binding in rat neocortex by noradrenaline infusion. Eur.J.Pharmacol. 1981; 69(-3-):341-346. >>> Norepinephrine; Ascorbic acid; Saline; CSF/CNS; rat; 9 days; no comment posted.

P0111 Yamori,Y., Tarazi,R.C., Ooshima,A. Effect of B-receptor-blocking agents on cardiovascular structural changes in spontaneous and noradrenaline-induced hypertension in rats. Clin.Sci. 1980; 59(--):457S-460S. >>> Phentolamine; Norepinephrine; IV (vena cava); rat; 1702; 7 days; comparison of agents; separate&simultaneous infusion of agents; antihypertensive.

P0072 Yamori,Y., Kihara,M., Ikeda,K., Ooshima,A., Tarazi,R.C. Effects of continuous catecholamine infusion on hypertension, lipidemia and cardiac hypertrophy in rats. Jpn.Heart J. 1980; 21(-4-):566-. >>> Norepinephrine HCl, dl-; Isoproterenol HCl, dl-; IV (jugular); rat; 1701; 7 days; no comment posted.

P0033 Kasamatsu,T., Pettigrew,J.D., Ary,M. Restoration of visual cortical plasticity by local microperfusion of norepinephrine. J.Comp.Neurol. 1979; 185(-1-):163-181. >>> Dopamine, 6-hydroxy-; Norepinephrine; Radio-isotopes; 3H tracer; Ascorbate; Saline; CSF/CNS (visual cortex); cat (kitten); no duration posted; pumps replaced after 1 week.

P0007 Pettigrew,J.D., Kasamatsu,T. Local perfusion of noradrenaline maintains visual cortical plasticity. Nature 1978; 271(-5647-):761-763. >>> Norepinephrine; dopamine, 6-hydroxy-; saline; ascorbate; CSF/CNS (visual cortex); cat (kitten); 1701; 7 days; controls received mp with vehicle in other visual cortex; multiple pumps per animal (2); pump/cannula schematic P. 762, Fig. 1.

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