References on the Administration of Agents to Nerves Using
ALZET^® Osmotic Pumps

P7968 Wang,Y.L., Wang,D.Z., Nie,X., Lei,D.L., Liu,Y.P., Zhang,Y.J., Suwa,F., Tamada,Y., Fang,Y.R., Jin,Y. The role of bone morphogenetic protein-2 in vivo in regeneration of peripheral nerves. BRITISH JOURNAL OF ORAL&MAXILLOFACIAL SURGERY 2007; 45(-3-):197-202. >>> Bone morphogenetic protein-2; Saline; CSF/CNS (facial nerve); Rabbit; 2ML4; 10 days; Controls received mp w/ vehicle; animal info (New Zealand, 1.6-2.3 kg); total daily infused volume incorrect.

P7988 Wang,X.Y., Engisch,K.L., Teichert,R.W., Olivera,B.M., Pinter,M.J., Rich,M.M. Prolongation of evoked and spontaneous synaptic currents at the neuromuscular junction after activity blockade is caused by the upregulation of fetal acetylcholine receptors. Journal of Neuroscience 2006; 26(-35-):8983-8987. >>> Tetrodotoxin; Saline; CSF/CNS (sciatic nerve); Mice; 1002; ; Controls received mp w/ vehicle; animal info (2-4 months old); silastic nerve cuff.

P7928 Toth,C., Brussee,V., Martinez,J.A., McDonald,D., Zochodne,D.W. Rescue and regeneration of injured peripheral nerve axons by intrathecal insulin. Neuroscience 2006; 139(-2-):429-449. >>> Insulin; Saline; CSF/CNS (intrathecal, lumbar, peroneal nerve); Rat; 2002; 2 weeks; Controls received mp w/ vehicle; peptides; animal info (adult male, Sprague-Dawley, 250-300 grams); silicone catheters (0.012" x 0.025") used between L6-S1 vertebrae; nerve perfusion chamber used for nerve infusion; nerve injury; India Ink in pumps to verify delivery; behavioral testing.

P7606 Kadoya,T., Oyanagi,K., Kawakami,E., Hasegawa,M., Inagaki,Y., Sohma,Y., Horie,H. Oxidized galectin-1 advances the functional recovery after peripheral nerve injury. Neuroscience Letters 2005; 380(-3-):284-288. >>> Galectin-1, recomb. human oxidized; CSF/CNS (sciatic nerve); Rat; 2ML4; 12 weeks; Controls received mp w/ PBS; dose-response (fig. 1); long-term study; no stress (see pg. 285); peptides; animal info (male, adult, Sprague-Dawley); "No rats showed any toxic effects or reaction to the administration of rh GAL-1/Ox." (p. 285).

P7453 Domercq,M., Etxebarria,E., Perez-Samartin,A., Matute,C. Excitotoxic oligodendrocyte death and axonal damage induced by glutamate transporter inhibition. Glia 2005; 52(-1-):36-46. >>> Oligonucleotide, antisense; oligonucleotide sense; kainate, dihydro-; aspartic acid, DL-threo-B-benzyloxy-; Saline, sterile; CSF/CNS (optic nerve); Rabbit; 1003D; 3 days; Controls received mp w/ vehicle, or contralateral nerves; antisense (glutamate transporters GLAST + GLT-1); animal info (adult, male, white New Zealand).

P7416 Xie,W.R., Strong,J.A., Meij,J.T.A., Zhang,J.M., Yu,L. Neuropathic pain: Early spontaneous afferent activity is the trigger. Pain 2005; 116(-3-):243-256. >>> Tetrodotoxin; Saline; CSF/CNS (sciatic nerve); Rat; 1003D; 2001; 7 days; Controls received mp w/ vehicle; animal info (male, wistar, 200-250 g); nerve injury; silicone tubing (0.64 mm I.D., 1.19 mm O.D.); "implanting a silicone cuff on injured sciatic nerve was extremely difficult to do without further damaging the nerve." "hence instead of a cuff we surrounded the nerve with two soft pieces of silicone formed by cutting a slit in the end of silicone tubing." P. 245; behavioral study.

P7412 Vassias,I., Lecolle,S., Vidal,P.P., de Waele,C. Modulation of GABA receptor subunits in rat facial motoneurons after axotomy. MOLECULAR BRAIN RESEARCH 2005; 135(-1-2-):260-275. >>> Colchicine; tetrodotoxin; PBS; CSF/CNS (facial nerve); Rat; 2002; 8 days; Controls received mp w/ vehicle; animal info (male, Long-Evans, 200 g); silastic tubing cuff.

P7228 Eleore,L., Vassias,I., Vidal,P.P., Triller,A., de Waele,C. Modulation of glycine receptor subunits and gephyrin expression in the rat facial nucleus after axotomy. European Journal of Neuroscience 2005; 21(-3-):669-678. >>> Colchicine; tetrodotoxin; PBS; CSF/CNS (facial nerve); Rat; 2002; 1,3,8,30,60 days; Controls received mp w/ vehicle; facial palsy.

P7201 Perrin,F.E., Lacroix,S., viles-Trigueros,M., David,S. Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration. Brain 2005; 128(--):854-866. >>> Antibody, anti-MCP-1/MIA-1a; antibody, anti-IL-1B; immunoglobulin G; CSF/CNS (sciatic nerve); Mice; 1007D; 7 days; Controls received mp w/ IgG; animal info (adult female, BALB/c).

P6904 Qiu,J., Cafferty,W.B.J., McMahon,S.B., Thompson,S.W.N. Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation. Journal of Neuroscience 2005; 25(-7-):1645-1653. >>> AG-490; Saline; CSF/CNS (sciatic nerve); Rat; 2004; ; Controls received mp w/ vehicle; enzyme inhibitor (JAK2); silastic tubing and a gortex nerve cuff used.

P7025 Wang,X.Y., Engisch,K.L., Li,Y.J., Pinter,M.J., Cope,T.C., Rich,M.M. Decreased synaptic activity shifts the calcium dependence of release at the mammalian neuromuscular junction in vivo. Journal of Neuroscience 2004; 24(-47-):10687-10692. >>> Tetrodotoxin; Sodium chloride; penicillin; streptomycin; CSF/CNS (sciatic nerve); Mice; 1002; 8-10 days; Controls received mp w/ vehicle; ; TTX cuff made from silastic tubing, was placed around sciatic nerve and connected to mp.

P6944 Motoyoshi,K., Hyodo,M., Yamagata,T., Gyo,K. Restoring vocal fold movement after transection and immediate suturing of the recurrent laryngeal nerve with local application of basic fibroblast growth factor: An experimental study in the rat. Laryngoscope 2004; 114(-7-):1247-1252. >>> Fibroblast growth factor, basic; PBS; BSA; CSF/CNS (recurrent laryngeal nerve); Rat; 2002; 14 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; good methods (p. 1248); nerve infusion schematic (p. 1248).

P6761 McCallister,W.V., McCallister,E.L., Dubois,B., Trumble,T.E. Regeneration along intact nerves using nerve growth factor and ciliary neurotrophic factor. Journal of Reconstructive Microsurgery 2004; 20(-6-):473-481. >>> Nerve growth factor; ciliary neurotrophic factor; CSF/CNS (peroneal nerve); Rat; 2ML4; 28 days; Controls received mp w/ isotonic saline; peptides; mp primed 24 hours in 37 degrees Celsius saline.

P6610 Buffelli,M., Busetto,G., Bidoia,C., Favero,M., Cangiano,A. Activity-dependent synaptic competition at mammalian neuromuscular junctions. NEWS IN PHYSIOLOGICAL SCIENCES 2004; 19(--):85-91. >>> Tetrodotoxin; CSF/CNS (soleus nerve); Rat; ; Controls received mp on contralateral side.

P6550 Chauhan,B.C., LeVatte,T.L., Jollimore,C.A., Yu,P.K., Reitsamer,H.A., Kelly,M.E.M., Yu,D.Y., Tremblay,F., Archibald,M.L. Model of endothelin-1 - Induced chronic optic neuropathy in rat. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2004; 45(-1-):144-152. >>> Endothelin-1; Balanced salt solution; Eye (retrobulbar optic nerve); Rat; 2004; 21,42,84 days; Controls received mp w/ vehicle and fellow eye w/ no treatment; dose-response (fig.5); long-term study; pumps replaced every 28 days; peptides; post op. care (rentamicin, buprenex).

P6541 Brooks,D.E., Kaellberg,M.E., Cannon,R.L., Komaromy,A.M., Ollivier,F.J., Malakhova,O.E., Dawson,W.W., Sherwood,M.B., Kuekuerichkina,E.E., Lambrou,G.X. Functional and structural analysis of the visual system in the rhesus monkey model of optic nerve head ischemia. INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE 2004; 45(-6-):1830-1840. >>> Endothelin; Saline; acetic acid; CSF/CNS (optic nerve); Monkey; 18 months; Controls received mp w/ vehicle; long-term study; pumps replaced every 6 weeks; no stress (see pg. 1833); peptides; "The osmotic minipumps were well tolerated by the monkeys for the length (1.5 years) of the experiment." The long exposure time was used to "mimic more closely the prolonged human glaucomatous condition." p. 1838; pump model not listed; ischemia.

R0227 Gordon,T., Sulaiman,O., Boyd,J.G. Experimental strategies to promote functional recovery after peripheral nerve injuries. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 2003; 8(-4-):236-250. >>> Brain-derived neurotrophic factor; glial-derived neurotrophic factor; CSF/CNS (peripheral nerve); Mice; 1 month; dose-response.

P6438 Trigueros,S.D.A., Kalyvas,A., David,S. Phospholipase A2 plays an important role in myelin breakdown and phagocytosis during Wallerian degeneration. MOLECULAR AND CELLULAR NEUROSCIENCE 2003; 24(-3-):753-765. >>> AACOCF3; PBS; DMSO; CSF/CNS (sciatic nerve); Mice; ; Controls received mp w/ vehicle; enzyme inhibitor (cytosolic phospolipase); tygon tubing used; AACOCF3 was dissolved in PBS and 1% DMSO; AACOCF3 is an arachidonic acid analogue/cPLA2 inhibitor or (arachidonyl trifluoromethyl ketone); pump model not listed.

P6190 Dobretsov,M., Hastings,S.L., Romanovsky,D., Stimers,J.R., Zhang,J.M. Mechanical hyperalgesia in rat models of systemic and local hyperglycemia. Brain Research 2003; 960(-1-2-):174-183. >>> Glucose; sorbinil; HEPES, buffered saline; CSF/CNS (sciatic nerve); Rat; 2002; 14 days; Enzyme inhibitor (aldose reductase); post op. care (amoxicillin/clavulanate potassium 3 days).

P5981 Dupont,A.C., Richmond,F.J.R., Loeb,G.E. Prevention of muscle disuse atrophy by low-frequency electrical stimulation in rats. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING 2003; 11(-3-):218-226. >>> Tetrodotoxin; Saline; CSF/CNS (sciatic nerve); Rat; 1007D; 7 days; Post Op. care (topical lidocaine cream applied); schematic of pump and nerve cuff p. 220; "all devices were checked at necropsy, and no evidence was found that devices moved from their sites of implantation." p.221.

P5980 Dupont,A.C., Richmond,F.J.R., Loeb,G.E. Effects of muscle immobilization at different lengths on tetrodotoxin-induced disuse atrophy. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING 2003; 11(-3-):209-217. >>> Tetrodotoxin; Saline; CSF/CNS (sciatic nerve); Rat; 1007D; 7 days; Post Op. Care (Topical Lidocaine cream over sutures); schematic of pump and nerve cuff p. 210; nerve cuff consisted of silastic tubing&a custom cuff; cuff was closed by looping four sutures (3-0 silk) around it.

P5967 Boyd,J.G., Gordon,T. Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor sustain the axonal regeneration of chronically axotomized motoneurons in vivo. Experimental Neurology 2003; 183(-2-):610-619. >>> Glial-derived neurotrophic factor; brain-derived neurotrophic factor; Saline; CSF/CNS (tibial nerve); Rat; 2001; 2ML4; 7,28 days; Controls received mp w/ vehicle; tissue perfusion (nerve repair site); good methods (p. 611,612); silastic cuff used; pumps used for a 1 week and 4 week study.

P5747 Rogers,S.D., Peters,C.M., Pomonis,J.D., Hagiwara,H., Ghilardi,J.R., Mantyh,P.W. Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS. Glia 2003; 41(-2-):180-190. >>> Endothelin-1; Bosentan; Dye, Evans blue; CSF, artificial; CSF/CNS (optic nerve); Rabbit; 2ML2; 14 days; Controls received mp w/ vehicle; functionality of mp verified by Evans Blue Dye; good methods p.182, 181; antihypertensive; Bosentan (commercial drug name is tracleer) is an endothelin receptor antagonist (ERA); Vialon catheter with holes used; pump/catheter schematic (p.182); pump is described as advantageous for optic nerve infusion (p.182).

P5712 Fukaya,K., Hasegawa,M., Mashitani,T., Kadoya,T., Horie,H., Hayashi,Y., Fujisawa,H., Tachibana,O., Kida,S., Yamashita,J. Oxidized galectin-1 stimulates the migration of Schwann cells from both proximal and distal stumps of transected nerves and promotes axonal regeneration after peripheral nerve injury. Journal of Neuropathology and Experimental Neurology 2003; 62(-2-):162-172. >>> Insulin-like growth factor-I; Dulbecco's mem; CSF/CNS (sciatic nerve); Rat; 2004; 14 days; Controls received mp w/ vehicle; no stress (see pg. 89); animal info (female, wistar, 250-300 g).

P6665 Miana-Mena,F.J, Roux,S, Benichou,J.C, Osta,R, Brulet,P  PNAS 2002; 99(-5-):3234-3239. >>> Tetrodotoxin; CSF/CNS (sciatic nerve); Mice; 1007D; 4 days; Controls received mp w/ sterile saline.

P5571 Germinario,E., Esposito,A., Midrio,M., Betto,R., Danieli-Betto,D. Expression of sarco(endo)plasmic reticulum Ca2+-ATPase slow (SERCA2) i soform in regenerating rat Soleus skeletal muscle depends on nerve impulses. Experimental Physiology 2002; 87(-5-):575-583. >>> Tetrodotoxin; CSF/CNS (sciatic nerve); rat; 2002; 14 days; tissue perfusion (nerve cuff); PE catheter connected to a silicon nerve cuff.

P5372 Tam,S.L., Archibald,V., Tyreman,N., Gordon,T. Tetrodotoxin prevents motor unit enlargement after partial denervation in rat hindlimb muscles. JOURNAL OF PHYSIOLOGY-LONDON 2002; 543(-2-):655-663. >>> Tetrodotoxin; CSF/CNS (sciatic nerve); Rat; 2ML1; 1 month; Functionality of mp verified by blockage of the sciatic nerve action potential.

P5248 Wongtrakul,S., Bishop,A.T., Friedrich,P.F. Vascular endothelial growth factor promotion of neoangiogenesis in conventional nerve grafts. J Hand Surg.[Am.] 2002/3; 27(-2-):277-285. >>> Vascular endothelial growth factor; PBS; Albumin, rabbit serum; CSF/CNS (sciatic nerve); Rabbit; 1003D; 3 days; Controls received mp w/ vehicle; tissue perfusion (sciatic nerve graft); peptides; human recomb. VEGF used; transplantation;.

P5186 Gordon,T., Boyd,J.G., Gordon,T. A dose-dependent facilitation and inhibition of peripheral nerve regeneration by brain-derived neurotrophic factor. European Journal of Neuroscience 2002; 15(--):613-626. >>> Brain-derived neurotropic factor; PBS; Tween 20; CSF/CNS (tibial nerve); Rat; 2ML4; 28 days; Controls received gelfoam or mp w/ saline; tissue perfusion (tibial nerve); stability verified by in vitro assay on embryonic chick neurons (p. 614); good methods (p. 614-5); peptides; silastic tubing used; graphic showing nerve perfusion (p. 615); "pump, nerve cuff and drug delivery catheter did not interfere with regeneration of the TIB motor axons" (p. 617).

R0204 Mendell,L.M., Munson,J.B., Arvanian,V.L. Neurotrophins and synaptic plasticity in the mammalian spinal cord. Journal of Physiology 2001; 533.1(--):91-97. >>> NT-3; CSF/CNS (nerve); Cat; 5 weeks.

P5190 Young,C., Miller,E., Nicklous,D.M., Hoffman,J.R. Nerve growth factor and neurotrophin-3 affect functional recovery foll owing peripheral nerve injury differently. RESTORATIVE NEUROLOGY AND NEUROSCIENCE 2001; 18(--):167-175. >>> Nerve growth factor; NT-3; Saline; acetate; CSF/CNS (Sciatic nerve); Rat; 2004; 28 days; Controls received mp w/ vehicle; tissue perfusion (sciatic nerve); peptides;.

P4986 Tiangco,D.A., Papakonstantinou,K.C., Mullinax,K.A., Terzis,J.K. IGF-I and end-to-side nerve repair: A dose-response study. Journal of Reconstructive Microsurgery 2001; 17(--):247-256. >>> Insulin-like growth factor I; Acetic acid; BSA; CSF/CNS (musculocutaneous nerve); rat; 2004; 28 days; controls received mp w/ vehicle; tissue perfusion (musculocutaneous nerve coaption site); dose-response (text p. 254 paragraph 3); no stress (see pg. 251); good methods p. 249; vehicle was a 10mM acetic acid solution, with 0.1% BSA; nerve regeneration.

P4802 Kryger,G.S., Kryger,Z., Zhang,F., Shelton,D.L., Lineaweaver,W.C., Buncke,H.J. Nerve growth factor inhibition prevents traumatic neuroma formation in the rat.. JOURNAL OF HAND SURGERY-AMERICAN VOLUME 2001; 26A(-4-):635-644. >>> Immunoglobulin G, trkA; PBS;; CSF/CNS (sciatic nerve);; rat;; 2004;; 30 days;; Controls received mp w/ vehicle; tissue perfusion (sciatic nerve); stress/adverse reaction: (see p. 643) foreign body reaction observed, but did not interfere with pump delivery; peptides; silicone tube used; trkA-IgG is a nerve growth factor inhibitor; trkA-IgG consists of the high affinity NGF receptor (trkA) fused to an IgG heavy chain;.

P6332 Costanzo,E.M., Barry,J.A., Ribchester,R.R. Competition at silent synapses in reinnervated skeletal muscle. Neuroscience 2000; 3(-7-):694-700. >>> Tetrodotoxin; Saline; CSF/CNS (sciatic nerve); Rat; 14 days; Controls received mp w/ agent and resectioned SN axons; no stress (see pg. 697, 699); "the advantage of this technique is that it does not cause nerve damage...while restricting the rapid diffusion of TTX from its site of administration and thereby ensuring patent, reliable and long-lasting nerve conduction block." (p. 699).

P4731 Everill,B, Kocsis,J.D. Nerve growth factor maintains potassium conductance after nerve injury in adult cutaneous afferent dorsal root ganglion neurons.. Neuroscience 2000; 100(-2-):417-422. >>> Nerve growth factor;; Saline;; CSF/CNS (sciatic nerve);; rat;; 2002;; 14 days;; Controls received mp w/ vehicle; peptides; tissue perfusion (sciatic nerve); mouse NGF used;.

P4396 Cormery,B., Pons,F., Marini,J.-F., Gardiner,P.F. Myosin heavy chains in fibers of TTX-paralyzed rat soleus and medial gastrocnemius muscles;. J.Appl.Physiol. 2000; 88(--):66-76. >>> Tetrodotoxin;; Penicillin; Streptomycin;; CSF/CNS (sciatic nerve);; rat;; 2004; 2002;; 2, 4 weeks;; controls received mp with sterile saline; tissue perfusion (nerve cuff);.

P4364 Leong,J., Hayes,A., Austin,L., Morrison,W. Muscle protection following motor nerve repair in combination with leukemia inhibitory factor. J.Hand Surg.[Am] 1999; 24A(--):37-45. >>> Leukemia inhibitory factor;; Serum, rat; Saline; Radio-isotopes; 125I tracer;; CSF/CNS (gastrocnemius nerve);; rat;; 2004;; 28 days;; controls received mp with vehicle; tissue perfusion (nerve repair site); functionality of mp verified by cross-section; peptides; recomb. mouse LIF used; rat serum reduced binding to pump reservoir; bioavailabilitiy of LIF was 50%; diagram of experimental model (p. 40).

P4355 Mohiuddin,L., Delcroix,J.D., Fernyhough,P., Tomlinson,D.R. Focally administered nerve growth factor suppresses molecular regenerative responses of axotomized peripheral afferents in rats. Neuroscience 1999; 91(-1-):265-271. >>> Nerve growth factor;; CSF/CNS (sciatic nerve);; rat;; 2002;; 12 days;; controls received mp with normal saline; peptides; recomb. human NGF used; pain;.

P4351 Cioffi,G.A., Sullivan,P. The effect of chronic ischemia on the primate optic nerve. European Journal of Ophthalmology 1999; 9(-Supp. 1-):S34-S36. >>> Endothelin-I; CSF/CNS (optic nerve);; monkey; 2-6 months;; long-term study, pumps replaced after 4 weeks; peptides; abstract states pump implanted in rabbits also but no mention of rabbits throughout paper; ischemia.

P4340 Costanzo,E.M., Barry,J.A., Ribchester,R.R. Co-regulation of synaptic efficacy at stable polyneuronally innervated neuromuscular junctions in reinnervated rat muscle. Journal of Physiology 1999; 521.2(--):365-374. >>> Tetrodotoxin;; CSF/CNS (sciatic nerve);; rat;; 2002;; ; tissue perfusion (nerve cuff); no stress (see pg. 366); pumps implanted IP;.

P4326 Tyml,K., Mathieu-Costello,O., Cheng,L., Noble,E.G. Differential microvascular response to disuse in rat hindlimb skeletal muscles. J.Appl.Physiol. 1999; 87(-4-):1496-1505. >>> Tetrodotoxin;; Saline;; CSF/CNS (sciatic nerve);; rat;; 2002;; 2, 8 weeks;; controls received no treatment; tissue perfusion (nerve cuff); long-term study, pumps replaced every 2 weeks;.

P4264 Mendell,L.M., Johnson,R.D., Munson,J.B. Neurotrophin modulation of the monosynaptic reflex after peripheral nerve transection. Journal of Neuroscience 1999/4/15; 19(-8-):3162-3170. >>> NT-3; NT-4/5; Mannitol; Sucrose; Histidine;; CSF/CNS (gastocnemius nerve); cat; 2ML2; 2ML4;; 8-35 days; axotomized nerve controls received mp w/ vehicle or SC NT-3; tissue perfusion (medial gastrocnemius nerve); good methods (p. 3163); peptides; schematic of delivery model (p. 3163); 10 mm Gore-tex sleeve on nerve was connected via silastic tubing to pump.

P4385 Fernandes,K.J.L., Kobayashi,N.R., Jasmin,B.J., Tetzlaff,W. Acetylcholinesterase gene expression in axotomized rat facial motoneurons is differentially regulated by neurotrophins: Correlation with trkB and trkC mRNA levels and isoforms. Journal of Neuroscience 1998/12/1; 18(-23-):9936-9947. >>> Nerve growth factor; NT-3; NT-4/5; Brain-derived neurotrophic factor;; Saline; Buffer, sodium phosphate; Albumin, rat serum; Penicillin; Streptomycin;; CSF/CNS (facial nerve);; rat;; 2001;; 7 days;; controls received mp with vehicle; tissue perfusion (nerve stump); dose-response for BDNF (p. 9939); peptides; some animals underwent bilateral axotomy, with one pump infusing each side; silastic tubing was sutured in place over nerve stump, and adhesive prevented leakage from tubing;.

P4337 Matute,C. Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve. Proc.Natl.Acad.Sci.USA 1998/8; 95(--):10229-10234. >>> Kainate; CNQX; GYKI53655; glutamate; cyclothiazide; Saline, sterile; CSF/CNS (optic nerve); Rabbit; 2-6 days; Tissue perfusion (nerve); comparison of injections to optic nerve vs. mp.

P4134 Dib-Hajj,S.D., Black,J.A., Cummins,T.R., Kenney,A.M., Kocsis,J.D., Waxman,S.G. Rescue of a-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo. J.Neurophysiol. 1998; 79(--):2668-2676. >>> Nerve growth factor; Ringer's solution; CSF/CNS (sciatic nerve); rat; 10-12 days; controls received mp w/vehicle; peptides; mouse NGF used.

P4336 Matute,C., Sanchez-Gomez,M.V., Martinez-Millan,L., Miledi,R. Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes. Proc.Natl.Acad.Sci.USA 1997/8; 94(--):8830-8835. >>> Kainate; CNQX;; Saline;; CSF/CNS (optic nerve);; rabbit;; 7 days; controls received mp with vehicle; tissue perfusion (nerve); a 24G catheter was implanted under the dura mater, and enwrapped the optic nerve; kainate infused alone or with CNQX;.

P4274 Howell,S., Zhan,W.-Z., Sieck,G.C. Diaphragm disuse reduces Ca2+ uptake capacity of sarcoplasmic reticulum. Journal of Applied Physiology 1997; 82(-1-):164-171. >>> Tetrodotoxin;; Saline;; CSF/CNS (phrenic nerve);; hamster; 2002;; 2 weeks; controls received mp w/ vehicle; tissue perfusion (nerve cuff); no stress (see pg. 166) -weights carefully monitored, with no difference between experimental groups; silastic cuff placed around nerve and connected via PE tubing to pump; surgical wounds treated with topical 0.2% nitrofurazone solution; animals received ampicillin injections for 2 days post-surgery.

P4271 Zhan,W.-Z., Miyata,H., Prakash,Y.S., Sieck,G.C. Metabolic and phenotypic adaptations of diaphragm muscle fibers with inactivation. Journal of Applied Physiology 1997; 82(-4-):1145-1153. >>> Tetrodotoxin; Saline; CSF/CNS (phrenic nerve);; rat;; 2002;; 2 weeks;; controls received no treatment or sham surgery; tissue perfusion (silastic nerve cuff); after phrenic nerve transection, ~20 mm of distal nerve removed to avoid reinnervation.

P3912 Seburn,K.L., Cope,T.C. Low-frequency depression of the monosynaptic reflex is not altered by tetrodotoxin-induced nerve conduction blockade. J.Neurophysiol. 1997; 78(--):19-23. >>> Tetrodotoxin; Penicillin; Gentamicin; CSF/CNS (sciatic nerve); rat; 2002; 3, 10 days; controls received mp w/vehicle; tissue perfusion (nerve cuff); functionality of mp verified by physical symptoms 12-24 h after mp implantation.

P3906 Lewin,S.L., Utley,D.S., Cheng,E.T., Verity,A.N., Terris,D.J. Simultaneous treatment with BDNF and CNTF after peripheral nerve transection and repair enhances rate of functional recovery compared with BDNF treatment alone. Laryngoscope 1997; 107(--):992-999. >>> Brain-derived neurotrophic factor; Ciliary neurotrophic factor; Ringer's solution, lactated; CSF/CNS (sciatic nerve); rat; 2ML4; 30 days; tissue perfusion (sciatic nerve): functionality of mp verified by residual volume; stress/adverse reaction: cannula extrusion, problems in denervated hindpaws; peptides; agents given singly and concomitantly in same pump.

P3868 Oyelese,A.A., Rizzo,M.A., Waxman,S.G., Kocsis,J.D. Differential effects of NGF and BDNF on axotomy-induced changes in GABAA-receptor-mediated conductance and sodium currents in cutaneous afferent neurons. J.Neurophysiol. 1997; 78(--):31-42. >>> Nerve growth factor; Brain-derived neurotrophic factor; Ringer's solution; CSF/CNS (sciatic nerve); rat; 2002; 2 weeks; controls received mp w/vehicle; tissue perfusion (nerve cuff); functionality of mp verified by florescent labelling; peptides; mouse NGF used; recomb. human BDNF used.

P3841 Munson,J.B., Johnson,R.D., Mendell,L.M. NT-3 increases amplitude of EPSPs produced by axotomized group Ia afferents. J.Neurophysiol. 1997; 77(--):2209-2212. >>> NT-3; nerve; cat; 4, 5 weeks; controls received mp w/saline, or no treatment; peptides; tissue perfusion (medial gastrocnemius muscle nerve cuff).

P3829 Widerberg,A., Bergman,S., Danielsen,N., Lundborg,G., Dahlin,L.B. Nerve injury induced by vibration: prevention of the effect of a conditioning lesion by D600, a Ca2+ channel blocker. Occup Environ Med 1997; 54(--):312-315. >>> Verapamil, methoxy-; Ringer's solution; CSF/CNS (sciatic nerve); rat; 2002; no duration posted; controls received mp w/vehicle; no stress (see pg. 314); good methods (pg. 312); diagram of nerve perfusion (pg. 313).

P3789 Rassier,D.E., Tubman,L.A., MacIntosh,B.R. Inhibition of Ca++ release in rat atrophied gastrocnemius muscle. Exp.Physiology 1997; 82(--):665-676. >>> Tetrodotoxin; Saline, sterile physiological; Penicillin; Streptomycin; CSF/CNS (sciatic nerve); rat; 2002; 14 days; controls received mp w/vehicle; tissue perfusion (nerve cuff).

P3667 Munson,J.B., Shelton,D.L., McMahon,S.B. Adult mammalian sensory and motor neurons: roles of endogenous neurotrophins and rescue by exogenous neurotrophins after axotomy. Journal of Neuroscience 1997/1/1; 17(-1-):470-476. >>> Fusion protein; NT-3; NT-4/5;; Acetate; Saline;; CSF/CNS (gastrochemius nerve); CSF/CNS (fibial nerve);; rat;; 2002;; 2 weeks;; controls received mp with vehicle; tissue perfusion (nerve stump;) tissue perfusion (intact nerve); peptides; schematic of delivery model (p. 471);.

P4008 Michel,R.N., Campbell,R.J., Jasmin,B.J. Regulation of succinate dehydrogenase within muscle fiber compartments by nerve-mediated activity and CNTF. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.39) 1996; 270(--):R80-R85. >>> Tetrodotoxin; Saline; CSF/CNS (sciatic nerve); rat; no duration posted; controls received vehicle via sham cuff; tissue perfusion (nerve cuff); osmotic pump attached to a silastic nerve cuff.

P3788 Tubman,L.A., Rassier,D.E., MacIntosh,B.R. Absence of myosin light chain phosphorylation and twitch potentiation in atrophied skeletal muscle. Can.J.Physiol.Pharmacol. 1996; 74(--):723-728. >>> Tetrodotoxin; Penicillin; Saline, sterile physiological; CSF/CNS (sciatic nerve); Rat; 2002; 14 days; controls received mp w/vehicle; tissue perfusion (nerve cuff).

P3482 Hodges-Savola,C., Rogers,S.D., Ghilardi,J.R., Timm,D.R., Mantyh,P.W. B-adrenergic receptors regulate astrogliosis and cell proliferation in the central nervous system in vivo. Glia 1996; 17(--):52-62. >>> Isoproterenol; propranolol; CSF, artificial; CSF/CNS (optic nerve); rabbit; 2ML2; 14 days; tissue perfusion (optic nerve); good methods.

P3477 Orgul,S., Cioffi,G.A., Bacon,D.R., Van Buskirk,E.M. An endothelin-1-induced model of chronic optic nerve ischemia in rhesus monkeys. J.Glaucoma 1996; 5(--):135-138. >>> Endothelin-1; CSF/CNS (optic nerve); monkey; 2002; 7 days; controls received saline infusion; good methods; peptides; ischemia (optic nerve).

P3475 Orgul,S., Cioffi,G.A., Wilson,D.J., Bacon,D.R., Van Buskirk,E.M. An endothelin-1 induced model of optic nerve ischemia in the rabbit. Invest.Ophthalmol.Vis.Sci. 1996; 37(-9-):1860-1869. >>> Endothelin-1; CSF/CNS (optic nerve); rabbit; 2, 8 weeks; controls received mp w/ balanced salt solution; tissue perfusion (perineural region of optic nerve); long-term study, pumps replaced every 2 weeks; peptides; pump implanted above the eye; ischemia (optic nerve).

P3430 Utley,D.S., Lewin,S.L., Cheng,E.T., Verity,E.T., Sierra,D., Terris,D.J. Brain-derived neurotrophic factor and collagen tubulization enhance functional recovery after peripheral nerve transection and repair. Arch Otolaryngol.Head Neck Surg. 1996; 122(--):407-413. >>> Brain-derived neurotrophic factor; Ringer's solution, lactated; CSF/CNS (sciatic nerve); rat; 2ML4; 30 days; functionality of mp verified by measuring residual volume from explanted pumps; comparison of collagen tubule matrix containing BDNF vs. mp; stability verified by bioassay of residual solution; peptides.

P3425 Newman,J.P., Verity,A.N., Hawatmeh,S., Fee Jr,W.E., Terris,D.J. Ciliary neurotrophic factor enhances peripheral nerve regeneration. Arch Otolaryngol.Head Neck Surg. 1996; 122(--):399-403. >>> Ciliary neurotrophic factor; Nerve growth factor; Water, sterile; CSF/CNS (sciatic nerve); rat; 2ML4; 4 weeks; controls received Ringer's solution, lactated; tissue perfusion (nerve); peptides.

P3333 Thomas,D.A., Ren,K., Besse,D., Ruda,M.A., Dubner,R. Application of nitric oxide synthase inhibitor, Nw-nitro-L-arginine methyl ester, on injured nerve attentuates neuropathy-induced thermal hyperalgesia in rats. Neurosci.Lett. 1996; 210(--):124-126. >>> L-NAME; D-NAME; SC; CSF/CNS (sciatic nerve); rat; 2001; 2 weeks; controls received mp w/saline; tissue perfusion (nerve cuff); comparison of systemic vs. targeted infusion; pumps replaced on day 8.

P4213 Ruigt,G.S.F., den Brok,M.H.C. Retardation of rat sciatic nerve regeneration after local application of minute doses of vincristine. Cancer Chemother.Pharmacol. 1995; 36(--):530-535. >>> Vincristine sulfate; Saline; CSF/CNS (sciatic nerve); rat; 2002; 1007D; 1 week; controls received mp w/vehicle; comparison of i.p. injections vs local infusion via mp; stress/adverse reaction: scar tissue; cytostatic agent; cancer.

P4103 Ren,K., Thomas,D.A., Dubner,R. Nerve growth factor alleviates a painful peripheral neuropathy in rats. Brain Research 1995; 699(--):286-292. >>> Nerve growth factor; Antiserum, anti-nerve growth factor; Saline; CSF/CNS (sciatic nerve); rat; 2001; 7 days; controls received mp w/saline; tissue perfusion (nerve cuff); perforated catheter attached to nerve cuff; delayed infusion; peptides.

P4007 Megeney,L.A., Michel,R.N., Boudreau,C.S., Fernando,P.K., Prasad,M., Tan,M.H., Bonen,A. Regulation of muscle glucose transport and GLUT-4 by nerve-derived factors and activity-related processes. Am.J.Physiol.(Regulatory Integrative Comp.Physiol.38) 1995; 269(--):R1148-R1153. >>> Tetrodotoxin; Saline; CSF/CNS (sciatic nerve); rat; 2002; 3 days; tissue perfusion (nerve cuff); comparison of denervation vs. tetrodotoxin infusion with mp; no stress (see p. R1148); pump attached to silicone rubber cuff via silicone rubber tubing.

P3469 Cioffi,G.A., Orgul,S., Onda,E., Bacon,D.R., Van Buskirk,E.M. An in vivo model of chronic optic nerve ischemia: the dose-dependent effects of endothelin-1 on the optic nerve microvasculature. Curr.Eye Res. 1995; 14(--):1147-1153. >>> Endothelin-1; Balanced salt solution; CSF/CNS (optic nerve); rabbit; 4 weeks, 3 days; controls received mp w/ vehicle; peptides; pumps implanted above the eye; ischemia (optic nerve).

P3315 Jasmin,B.J., Campbell,R.J., Michel,R.N. Nerve-dependent regulation of succinate dehydrogenase in junctional and extrajunctional compartments of rat muscle fibres. J.Physiol. 1995; 484.1(--):155-164. >>> Tetrodotoxin; CSF/CNS (sciatic nerve); rat; 7 days; controls received mp w/saline; tissue perfusion (nerve cuff); functionality of mp verified by muscle inactivation.

P3150 Hekimian,K.J., Seckel,B.R., Bryan,D.J., Wang,K.K., Chakalis,D.P., Bailey,A. Continuous alteration of the internal milieu of a nerve-guide chamber using an osmotic pump and internal exhaust system. J.Reconst.Microsurg. 1995; 11(-2-):93-98. >>> Dye, Methylene blue; Saline; CSF/CNS (sciatic nerve); rat; 2ML4; no duration posted; functionality of mp verified by dye infusion; no stress (see pg. 97); novel nerve guide chamber designed.

P2862 Maves,T.J., Gebhart,G.F., Meller,S.T. Continuous infusion of acidified saline around the rat sciatic nerve produces thermal hyperalgesia. Neurosci.Lett. 1995; 194(--):45-48. >>> Saline; saline, acidified; CSF/CNS (sciatic nerve); rat; 2001; 7 days; pump attached to silastic nerve cuff via silastic tubing; saline was preservative-free and acidified saline was unbuffered; each rat served as its own control -- one sciatic nerve in cuff, the other just exposed; tissue perfusion (sciatic nerve).

P2806 Barry,J.A., Ribchester,R.R. Persistent polyneuronal innervation in partially denervated rat muscle after reinnervation and recovery from prolonged nerve conduction block. J.Neurosci. 1995; 15(-10-):6327-6339. >>> Tetrodotoxin; Citrate buffer; Saline, sterile; Ampicillin; CSF/CNS (sciatic nerve); rat; 2002; 2 weeks; pump connected by catheter to nerve cuff; ampicillin used in drug solution.

P2549 Ishii,D.N., Lupien,S.B. Insulin-like growth factors protect against diabetic neuropathy: effects on sensory nerve regeneration in rats. J.Neurosci.Res. 1995; 40(--):138-144. >>> Insulin-like growth factor I; Insulin-like growth factor II; Acetic acid; SC; CSF/CNS (sciatic nerve); rat; 7 days; controls received mp w/ vehicle; peptides; comparison of targeted vs. systemic infusion; recomb. human IGF-I used.

P2547 Laird,J.M.A., Mason,G.S., Thomas,K.A., Hargreaves,R.J., Hill,R.G. Acidic fibroblast growth factor stimulates motor and sensory axon regeneration after sciatic nerve crush in the rat. Neuroscience 1995; 65(-1-):209-216. >>> Fibroblast growth factor; Heparin; CSF/CNS (sciatic nerve); rat; 1007D; 3 days; controls received mp w/ vehicle; comparison of iv injections vs. mp; peptides; fenestrated catheter sewn to muscle layer underlying nerve; acidic FGF used.

P3340 Michel,R.N., Cowper,G., Chi,M.M.-Y., Manchester,J.K., Falter,H., Lowry,O.H. Effects of tetrodotoxin-induced neural inactivation on single muscle fiber metabolic enzymes. Am.J.Physiol.(Cell Physiol.36) 1994; 267(--):C55-C66. >>> Tetrodotoxin; Saline, sterile; CSF/CNS (sciatic nerve); rat; 2002; no duration posted; controls received mp w/vehicle; tissue perfusion (nerve cuff).

P3314 Michel,R.N., Vu,C.Q., Tetzlaff,W., Jasmin,B.J. Neural regulation of acetylcholinesterase mRNAs at mammalian neuromuscular synapses. J.Cell Biol. 1994; 127(-4-):1061-1069. >>> Tetrodotoxin; Saline; CSF/CNS (sciatic nerve); rat; 10 days; tissue perfusion (nerve cuff); functionality of mp verified by muscle inactivation.

P2661 Cioffi,G.A., Van Buskirk,E.M. Microvasculature of the anterior optic nerve. Survey of Opthalmol. 1994; 38(-Suppl-):S107-S117. >>> Endothelin-1; Balanced salt solution; CSF/CNS (optic nerve); rabbit; no duration posted; controls received mp w/ vehicle; comparison of intravitreal injections vs. mp; peptides; pumps implanted above upper eyelid.

P2554 Svenningsen,A.F., Kanje,M., Sjoberg,J. Insulin-like growth factor II (IGF-II) stimulates regeneration and proliferation in the rat sciatic nerve. Neurosci.Res.Comm. 1994; 15(-2-):111-118. >>> Insulin-like growth factor II; Ringer's solution; CSF/CNS (sciatic nerve); rat; 2001; 6 days; peptides; perforated catheter sutured alongside nerve; recomb. IGF-II used.

P2863 Near,S.L., Whalen,L.R., Miller,J.A., Ishii,D.N. Insulin-like growth factor II stimulates motor nerve regeneration. Proc.Natl.Acad.Sci.USA 1992; 89(--):11716-11720. >>> Insulin-like growth factor II; Antiserum, human IGF II, rabbit; Insulin; Culture medium, RPMI; CSF/CNS (sciatic nerve); rat; 1007D; 1 week; controls received mp with RPMI vehicle, insulin or were untreated; tissue perfusion (sciatic nerve); fenestrated catheter was used; good diagram of pump placement (pg. 11717); peptides; recomb. human IGF-II used.

P2544 Inaishi,Y., Kashihara,Y., Sakaguchi,M., Nawa,H., Kuno,M. Cooperative regulation of calcitonin gene-related peptide levels in rat sensory neurons via their central and peripheral processes. J.Neurosci. 1992; 12(-2-):518-524. >>> Nerve growth factor; Kreb's solution; SC; CSF/CNS (sciatic nerve); rat; 12 days; peptides; B-NGF used.

P2161 Rusovan,A., Kanje,M. D600, a Ca2+ antagonist, prevents stimulation of nerve regeneration by magnetic fields. NeuroReport 1992; 3(--):813-814. >>> Verapamil, methoxy-; Ringer's solution; CSF/CNS (sciatic nerve); rat; 2001; 4, 6 days; controls received mp with vehicle; tissue perfusion (sciatic nerve); agent also called D600.

P2113 Zhan,W.-Z., Sieck,G.C. Adaptations of diaphragm and medial gastrocnemius muscles to inactivity. J.Appl.Physiol. 1992; 72(-4-):1445-1453. >>> Tetrodotoxin; Saline; CSF/CNS (phrenic nerve); CSF/CNS (sciatic nerve); hamster; 2002; 2 weeks; controls received mp with saline; tissue perfusion (peripheral nerve); pump attached to catheter and silastic nerve cuff.

P2018 Webb,C.B., Cope,T.C. Modulation of Ia EPSP amplitude: the effects of chronic synaptic inactivity. J.Neurosci. 1992; 12(-1-):338-344. >>> Tetrodotoxin; Saline; CSF/CNS (motor nerves); cat; 2002; 2 weeks; silastic nerve cuff.

P1875 Gold,B.G., Mobley,W.C., Matheson,S.F. Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor. J.Neurosci. 1991; 11(-4-):943-955. >>> Cytochrome C; Nerve growth factor; PBS; CSF/CNS (sciatic nerve); rat; no duration posted; tissue perfusion (sciatic nerve); peptides.

P1830 Wong,J., Oblinger,M.M. NGF rescues substance P expression but not neurofilament or tubulin gene expression in axotomized sensory neurons. J.Neurosci. 1991; 11(-2-):543-552. >>> Nerve growth factor; CSF/CNS (sciatic nerve); rat; 1-12 days; controls received pumps with saline only; tissue perfusion (sciatic nerve); peptides; pump connected by catheter to nerve cuff.

P3317 Michel,R.N., Gardiner,P.F. To what extent is hindlimb suspension a model of disuse?. Muscle&Nerve 1990; 13(--):646-653. >>> Tetrodotoxin; Saline; CSF/CNS (sciatic nerve); rat; 2 weeks; tissue perfusion (nerve cuff); functionality of TTX delivery verified by muscle inactivation; antibiotic given prophylactically.

P2026 Nachemson,A.K., Lundborg,G., Hansson,H.A. Insulin-like growth factor I promotes nerve regeneration: an experimental study on rat sciatic nerve. Growth Factors 1990; 3(--):309-314. >>> Insulin-like growth factor I; Albumin, bovine serum; Saline; CSF/CNS (sciatic nerve); rat; 2002; 18 days; tissue perfusion (sciatic nerve); peptides; silicone chamber designed for nerve perfusion.

P1565 Sjoberg,J., Kanje,M. Insulin-like growth factor (IGF-1) as a stimulator of regeneration in the freeze-injured rat sciatic nerve. Brain Research 1989; 485(--):102-108. >>> Insulin-like growth factor I; Ringer's solution; CSF/CNS (sciatic nerve); rat; 2001; 6 days; tissue perfusion; peptides.

P1404 MacIntosh,B.R., Roberge,M.-C. Absence of staircase following disuse in rat gastrocnemius muscle. Can.J.Physiol.Pharmacol. 1988; 66(--):707-713. >>> Tetrodotoxin; Saline; CSF/CNS (sciatic nerve); rat; 2002; 2 weeks; mp connected to silastic cuff; tissue perfusion.

P1379 Kanje,M., Lundborg,G., Edstrom,A. A new method for studies of the effects of locally applied drugs on peripheral nerve regeneration in vivo. Brain Research 1988; 439(--):116-121. >>> Actinomycin D; Cycloheximide; Mitomycin C; Vinblastine; Ringer's solution; CSF/CNS (sciatic nerve); rat; 2001; 2002; 3, 4, 6 days; mp connected to silicone cuff; functionality of mp verified in vivo with dye; tissue perfusion.

P1284 Van der Zee,C.E.E.M., Brakkee,J.H., Gispen,W.H. Alpha-MSH and ORG-2766 in peripheral nerve regeneration: different routes of delivery. Eur.J.Pharmacol. 1988; 147(--):351-357. >>> ACTH analog; ORG-2766; Melanocyte-stimulating hormone, a-; Saline; CSF/CNS (sciatic nerve); SC; rat; 2002; 2 weeks; comparison of oral admin. and admin. by s.c. microspheres; comparison of s.c. injections vs. mp infusion; tissue perfusion (sciatic nerve).

P0680 Spector,S.A. Effects of elimination of activity on contractile and histochemical properties of rat soleus muscle. J.Neurosci. 1985; 5(-8-):2177-2188. >>> Tetrodotoxin; Bicarbonate; Ringer's solution; CSF/CNS (sciatic nerve); rat; 2002; 2 or 4 weeks; tissue perfusion (sciatic nerve); pump replaced after 2 weeks.

P0662 Fitzgerald,M., Wall,P.D., Goedert,M., Emson,P.C. Nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section. Brain Research 1985; 332(-1-):131-141. >>> Nerve growth factor; Ringer-Locke solution; CSF/CNS (sciatic nerve); rat; 2002; 10-12 days; tissue perfusion (sciatic nerve); peptides.

P0097 Betz,W.J., Caldwell,J.H., Ribchester,R.R. Sprouting of active nerve terminals in partially inactive muscles of the rat. J.Physiol. 1980; 303(--):281-297. >>> Tetrodotoxin; Saline; CSF/CNS (plantar muscle motor nerves); rat; 1701; 1702; 5-7 days and 12-13 days; tissue perfusion; comparison of surgical denervation vs. infusion; implanted ip w/tubing opening in vicinity of motor nerves of plantar muscle in mid-calf area.

P0034 Lorkovic,H. Effects of motor nerve anesthesia and tenotomy on muscle membrane properties. Pflugers Arch. 1979; 379(-1-):89-93. >>> Lidocaine HCl; Marcaine HCl; Ethylene glycol; CSF/CNS (soleus muscle motor nerves); rat; 7 days; tissue perfusion (soleus muscle motor nerves); comparison of surgical denervation vs. infusion.

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