References on Immunology Research Using ALZET^® Osmotic Pumps

P8610 Dietrich,T., Onderka,J., Bock,F., Kruse,F.E., Vossmeyer,D., Stragies,R., Zahn,G., Cursiefen,C. Inhibition of Inflammatory Lymphangiogenesis by Integrin alpha 5 Blockade. American Journal of Pathology 2007; 171(-1-):361-372. >>> JSM6427; JSM6424; SC; Mice; 2 weeks; Controls received mp w/ vehicle; functionality of mp verified by mp and plasma levels analysis; dose-response (p. 368); pumps replaced after one week; half-life (p. 363) "rapid;" cardiovascular; immunology; animal info (BALB/C, 6 weeks old, suture-induced inflammatory corneal neovascularization); integrin a5B1 and avB3 antagonists; angiogenesis; lymphangiogenesis.

P8557 Oh,K., Shen,T., Le Gros,G., Min,B. Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils. Blood 2007; 109(-7-):2921-2927. >>> Interleukin-3; SC; Mice; mice (transgenic); 7 days; Controls received mp w/ PBS or no treatment; immunology; peptides; animal info (C57BL/6, BIO.A Rag -/-); "Sought an alternative strategy to generate basophils in vivo by administering IL-3 into mice via a miniosmotic pump." (p. 2923).

P8509 Bhasin,M., Wu,M.Z., Tsirka,S.E. Modulation of microglial/macrophage activation by macrophage inhibitory factor (TKP) or tuftsin (TKPR) attenuates the disease course of experimental autoimmune encephalomyelitis. BMC IMMUNOLOGY 2007; 8(--):U1-U16. >>> Tuftsin; macrophage inhibitory factor; SC; Mice; 2002; 30 days; Controls received mp w/ PBS; pumps replaced after 14 days; enzyme inhibitor (ACE); immunology; peptides; animal info (female, tPA -/- or wt, 6-10 weeks old); neurodegenerative (Multiple Sclerosis).

P8463 Shen,X.Z., Li,P., Weiss,D., Fuchs,S., Xiao,H.D., Adams,J.A., Williams,I.R., Capecchi,M.R., Taylor,W.R., Bernstein,K.E. Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma. American Journal of Pathology 2007; 170(-6-):2122-2134. >>> Captopril; losartan; SC; Mice; 2 weeks; Functionality of mp verified by systolic blood pressure; enzyme inhibitor (ACE); cancer (melanoma); immunology; animal info (C56BL/6, wt, ACE 10/10, 8wks old).

P8446 Coenen,J.J.A., Koenen,H.J.P.M., van Rijssen,E., Kasran,A., Boon,L., Hilbrands,L.B., Joosten,I. Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+ CD25+ FoxP3+ T cells. Bone Marrow Transplantation 2007; 39(-9-):537-545. >>> Cyclosporin A; SC; Mice; 2004; 7,14,28 days; Controls received mp w/PBS; dose-response (fig. 1); cardiovascular; immunology; animal info (C3H (H-2K), BALB/C (H-2d), 8-12 wks old).

P8441 Kabashima,K., Shiraishi,N., Sugita,K., Mori,T., Onoue,A., Kobayashi,M., Sakabe,J.I., Yoshiki,R., Tamamura,H., Fujii,N., Inaba,K., Tokura,Y. CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. American Journal of Pathology 2007; 171(-4-):1249-1257. >>> TN14003, 4F-benzoyl; Saline; SC; Mice; 1007D; 2,4,5,7 days; Controls received mp w/ vehicle; immunology; animal info (female, C57BL/6, 8 wks old).

P8416 Khalaf,W.F., Yang,F.C., Chen,S., White,H., Bessler,W., Ingram,D.A., Clapp,D.W. K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells. Journal of Immunology 2007; 178(-4-):2527-2534. >>> Kit-ligand; SC; Mice; 7 days; Controls received mp w/ PBS; replacement therapy (irradiation, fetal liver cell transfer); immunology; animal info (W/Wv).

P8367 Wranning,C.A., El-Akouri,R.R., Groth,K., Moelne,J., Parra,A.K., Braennstroem,M. Rejection of the transplanted uterus is suppressed by cyclosporine A in a semi-allogeneic mouse model. Human Reproduction 2007; 22(-2-):372-379. >>> Cyclosporin A; Propylene glycol; SC; Mice; 1007D; 7-10 days; Controls received mp w/ vehicle, or no treatment; functionality of mp verified by serum CyA levels; dose-response (Table 1); immunology; post op.care (buprenorphin, carprofen, cefuroxine); animal info (female, C57BL/6, B6CBAF1, 6-8 wks old, uterine transplant).

P8310 Singh,A.K., Gudehithlu,K.P., Litbarg,N.O., Sethupathi,P., Arruda,J.A.L., Dunea,G. Transplanting fragments of diabetic pancreas into activated omentum gives rise to new insulin producing cells. Biochemical and Biophysical Research Communications 2007; 355(-1-):258-262. >>> Insulin; SC; Rat; 28 days; Replacement therapy (STZ-induced diabetes, pancreatectomy and autotransplanted into omentum; immunology; animal info (male, Sprague-Dawley, 150-200g.); nephrology.

P8394 Earle,S.A., El-Haddad,A., Patel,M.B., Ruiz,P., Pham,S.M., Majetschak,M. Prolongation of skin graft survival by exogenous ubiquitin. Transplantation 2006; 82(-11-):1544-1546. >>> Ubiquitin; albumin; Saline, normal; IP; Mice; 2002; 5,14 days; Controls received mp w/ vehicle, or albumin or no treatment; functionality of mp verified by serum ubiquitin levles; dose-response (fig. 1); no stress (see pg. 1546); immunology; peptides; animal info ( C3H/HEJ, DBA2, 22g., skin grafts); "Ubiquitin administration was well tolerated and body weight was similar in both groups" (pg. 1546).

P8261 Si,Y., Ciccone,S., Yang,F.C., Yuan,J., Zeng,D., Chen,S., van de Vrugt,H.J., Critser,J., Arwert,F., Haneline,L.S., Clapp,D.W. Continuous in vivo infusion of interferon-gamma (IFN-gamma) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg-/- mice. Blood 2006; 108(-13-):4283-4287. >>> Interferon-gamma, mouse; PBS; SC; Mice; 1007D; 7 days; Controls received mp w/ vehicle; no stress (see pg. 4286); immunology; peptides; animal info (C57BL/6).

P8205 McCandless,E.E., Wang,Q., Woerner,B.M., Harper,J.M., Klein,R.S. CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis. Journal of Immunology 2006; 177(-11-):8053-8064. >>> AMD3100; PBS; SC; Mice; 1002; 14 days; Controls received mp w/ vehicle; dose-response (fig.3); immunology; animal info (C57BL/6, 8-12 wk old, female).

P8143 Griffiths,G.D., Hornby,R.J., Jagger,C.P., Brown,A.P., Stoten,A., Pearce,P.C., Scott,L., Pritchard,D.I. Development of methods to measure humoral immune responses against selected antigens in the common marmoset (Callithrix jacchus) and the effect of pyridostigmine bromide administration. INTERNATIONAL IMMUNOPHARMACOLOGY 2006; 6(-12-):1755-1764. >>> Pyridostigmine bromide; Saline, sterile isotonic; SC; Marmoset; 28 days; Controls received mp w/ vehicle; no stress (see p.1759,1762); immunology; animal info (male, female, 300-500g.); mp primed 40 hours; "delivery by pump ensured the animals would receive an appropriate dose of the drug over the desired time period.", oral delivery "would introduce unacceptable stress into the experiment and presentation in food was discounted because of difficulties in estimating the dose administered." (p.1757).

P8084 Hirayama,S., Shiraishi,T., Shirakusa,T., Higuchi,T., Miller,E.J. Prevention of neutrophil migration ameliorates rat lung allograft rejection. MOLECULAR MEDICINE 2006; 12(-9-10-):208-213. >>> Antileukinate; PBS; IP; Rat; 2001; 7 days; Controls received mp w/ vehicle; comparison of bolus IM injection vs. mp; immunology; peptides; ischemia (lung); animal info (male, Fischer 344, 250-300g, left lung transplantation); mp primed 4 hrs in 37 celcius saline.

P8082 Hornby,R.J., Pearce,P.C., Bowditch,A.P., Scott,L., Griffiths,G.D. Multiple vaccine and pyridostigmine bromide interactions in the common marmoset Callithrix jacchus: Immunological and endocrinological effects. INTERNATIONAL IMMUNOPHARMACOLOGY 2006; 6(-12-):1765-1779. >>> Pyridostigmine bromide; Saline, sterile isotonic; SC; Marmoset; 2004; 28 days; Controls received mp w/ vehicle; no stress (see p.1776); immunology; animal info (female, vasectomized male, 331-565g. 2-5.5 yrs. old); mp primed 40 hours.

P7881 Hu,J.S., Freeman,C.M., Stolberg,V.R., Chiu,B.C., Bridger,G.J., Fricker,S.P., Lukacs,N.W., Chensue,S.W. AMD3465, a novel CXCR4 receptor antagonist, abrogates schistosomal antigen-elicited (type-2) pulmonary granuloma formation. American Journal of Pathology 2006; 169(-2-):424-432. >>> AMD 3465; PBS; IP; Mice; 5 days; Controls received mp w/ vehicle; dose-response (fig. 1); no stress (see pg. 426); immunology; animal info (female, CBA/J, 6-8 wk old).

P7856 Liu,Y.R., Liu,J., Tetzlaff,W., Paty,D.W., Cynader,M.S. Biliverdin reductase, a major physiologic cytoprotectant, suppresses experimental autoimmune encephalomyelitis. Free Radical Biology and Medicine 2006; 40(-6-):960-967. >>> CSF, artificial; CSF, artificial; gentamicin; CSF/CNS (intrathecal, subarachnoid space); Rat; 2004; ; Immunology; animal info (male, Lewis, 200g., EAE (experimental autoimmune encephalomyelitis)); freshly prepared antioxidant enzymes were delivered intrathecally once daily through the PE tubing via Hamilton syringe on days 13-17, mp then reconnected to keep tube clear; multiple sclerosis model; pump used to maintain catheter patency.

P7791 Ulusal,B.G., Ulusal,A.E., Hung,L.M., Wei,F.C. The effect of A2A adenosine receptor agonist on composite tissue allotransplant survival: An in vivo preliminary study. Journal of Surgical Research 2006; 131(-2-):261-266. >>> CGS 21680; SC; Rat; 7 days; Controls received no treatment; no stress (see pg. 263); immunology; animal info (Brown Norway, Lewis, Hindlimb transplantation); A-2a adenosine receptor agonist; "The animals tolerated the minipumps well." (pg.263).

P7782 Glezer,I., Lapointe,A., Rivest,S. Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries. FASEB Journal 2006; 20(-2-):U405-U430. >>> Endotoxin, LPS; MK-801; Saline, sterile; CSF/CNS; Rat; 2004; 3, 7 days; Controls received mp w/ vehicle; immunology; animal info (male, Sprague-Dawley, 250g.).

P7610 Feng,P., Rahim,R.T., Cowan,A., Liu-Chen,L.Y., Peng,X.H., Gaughan,J., Meissler,JJ Jr, Adler,M.W., Eisenstein,T.K. Effects of mu, kappa or delta opioids administered by pellet or pump on oral Salmonella infection and gastrointestinal transit. European Journal of Pharmacology 2006; 534(-1-3-):250-257. >>> Morphine sulfate; enkephalin analog DPDPE; U50,488H; deltorphin II, D-ala2-; Saline, pyrogen free; SC; Mice; 1003D; 48 hours; Controls received mp w/ vehicle; dose-response (fig 1); comparison of pellets vs. mp; immunology; animal info (female, 6 wk old); mp primed 4 hours in 37 C saline; "morphine pellet potently exacerbated oral salmonella infection, but morphine given by pump, at doses which were immunosuppresive had a substantially lesser effect (of infection)." (p. 251).

P7468 Kim,J.H., Bronson,C.L., Hayton,W.L., Radmacher,M.D., Roopenian,D.C., Robinson,J.M., Anderson,C.L. Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces. American Journal of Physiology-Gastrointestinal and Liver Physiology 2006; 290(-2-):G352-G360. >>> Leucine, 3H-; SC; Mice; 1002; 2 weeks; Controls received mp w/ agent and were WT mice; functionality of mp verified by residual volume and steady state plasma concentrations of labeled proteins; comparison of IV bolus injections vs. mp; half-life (p. G353)<15 minutes; immunology; animal info (C57BL/6J, FcRn a-chain, knockout, male 28 g); mp primed 4 hours in 37C isotonic saline.

P7715 Fukada,K., Koyanagi,M., Arimura,Y., Ogiuchi,H., Uchiyama,T., Yagi,J. CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4+ T cells in vivo. Cellular Immunology 2005; 238(-2-):103-112. >>> Staphylococcal enterotoxin A; SC; Mice; 2001; 7 days; Immunology; post op. care (penicillin G); animal info (C57BL/6, female, B-12 wk. old, CD28 -/- or B6 wt).

P7665 Guzman,E.A., Chen,Y.H., Langowski,J.L., De Guzman,A., Lo,H.L., Walter,B., Muller,H.K., Walker,A.M., Owen,L.B. Abrogation of delayed type hypersensitivity response to Candida albicans produced by a molecular mimic of phosphorylated prolactin. Journal of Neuroimmunology 2005; 170(-1-2-):31-40. >>> Prolactin, recomb.; prolactin, S179D; Saline; SC; Mice; 2004; 21 days; Controls received mp w/ vehicle; immunology; animal info (male, C3H/HeJ or C3H/HeJ-TnFsF6gld, 10-12 wk. old).

P7663 Kaplin,A.I., Deshpande,D.M., Scott,E., Krishnan,C., Carmen,J.S., Shats,I., Martinez,T., Drummond,J., Dike,S., Pletnikov,M., Keswani,S.C., Moran,T.H., Pardo,C.A., Calabresi,P.A., Kerr,D.A. IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis. Journal of Clinical Investigation 2005; 115(-10-):2731-2741. >>> Interleukin 6, recomb. rat; PBS; BSA; CSF/CNS (intrathecal, subarachnoid space); Rat; 1007D; 7 days; Controls received mp w/ vehicle; immunology; neurodegenerative (transverse myelitis, spinal cord injury); animal info (Sprague-Dawley, adult); SCI.

P7589 Gemma,C., Fister,M., Hudson,C., Bickford,P.C. Improvement of memory for context by inhibition of caspase-1 in aged rats. European Journal of Neuroscience 2005; 22(-7-):1751-1756. >>> YVAD-CMK, Ac-; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ 0.6% DMSO in saline; functionality of mp verified by mp weight (not suggested by manufacturer); enzyme inhibitor (caspase -1); immunology; animal info (young, aged, make, Fischer 344 g); mp primed 48 hr in 37 C sterile saline.

P7574 Yamashita,N., Tashimo,H., Ishida,H., Matsuo,Y., Arai,H., Nagase,H., Adachi,T., Ohta,K. Role of insulin-like growth factor-I in allergen-induced airway inflammation and remodeling. Cellular Immunology 2005; 235(-2-):85-91. >>> Antibody, anti-IGF-I, murine; immunoglobulin G, goat; Saline, physiological; SC; Mice; 2 weeks; Controls received mp w/ goat IgG; dose-response (fig 2); immunology; animal info (male, 10-12 wk old).

P7537 Morishima,Y., Ishii,Y., Kimura,T., Shibuya,A., Shibuya,K., Hegab,A.E., Iizuka,T., Kiwamoto,T., Matsuno,Y., Sakamoto,T., Nomura,A., Taniguchi,M., Sekizawa,K. Suppression of eosinophilic airway inflammation by treatment with alpha-galactosylceramide. European Journal of Immunology 2005; 35(-10-):2803-2814. >>> Galactosylceramide, a-; Saline; SC; Mice; 29 days; Controls received mp w/ vehicle; comparison of SC injection vs. mp; immunology; animal info (BALB/c, 7-12 wk. old).

P7507 Wieland,C.W., Florquin,S., Chan,E.D., Leemans,J.C., Weijer,S., Verbon,A., Fantuzzi,G., van der Poll,T. Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice. International Immunology 2005; 17(-11-):1399-1408. >>> Leptin; SC; Mice; 2004; 18 days; Controls received mp w/ saline; immunology; peptides; animal info (female, C57BL/6, ob/ob or WT, 6-8 wk old).

P7498 De Klerck,B., Geboes,L., Hatse,S., Kelchtermans,H., Meyvis,Y., Vermeire,K., Bridger,G., Billiau,A., Schols,D., Matthys,P. Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis. ARTHRITIS RESEARCH&THERAPY 2005; 7(-6-):R1208-R1220. >>> AMD 3100; SC; Mice; 2002; 14 days; Controls received mp w/ PBS; immunology; animal info (male, 8-12 weeks).

P7493 Cao,H., Jung,M., Stamatoyannopoulos,G. Hydroxamide derivatives of short-chain fatty acid have erythropoietic activity and induce gamma gene expression in vivo. Experimental Hematology 2005; 33(-12-):1443-1449. >>> Hydroxamate, butyryl; hydroxamate, propionyl; hydroxamic acid, suberoylanilide; hydroxamic acid, subericbis; SC; Mice (transgenic); 2001; 7 days; Controls received mp w/ PBS; dose-response; enzyme inhibitor (histone deacetylase); cardiovascular; immunology.

P7460 Roychowdhury,S., Blaser,B.W., Freud,A.G., Katz,K., Bhatt,D., Ferketich,A.K., Bergdall,V., Kusewitt,D., Baiocchi,R.A., Caligiuri,M.A. IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease. Blood 2005; 106(-7-):2433-2435. >>> Interleukin-15, recomb. human; interleukin-2, recomb. human; PBS; albumin, human; SC; Mice (SCID); 1007D; 10 days; Controls received mp w/ vehicle; immunology; animal info (female, CB17, hu-PBL-SCID, 8-12 weeks old).

P7432 Ellis,S., Mouihate,A., Pittman,Q.J. Early life immune challenge alters innate immune responses to lipopolysaccharide: implications for host defense as adults. FASEB Journal 2005; 19(-8-):U826-U842. >>> Corticosterone; PEG; IP; Rat; 2001; 1 week; Replacement therapy (adrenalectomy); no stress (see pg. 4); immunology; post op. care (derapen); "the survival rate of this procedure (ADX + mp) was 100% with animals having normal body temperature within 24 hours after the surgery.".

P7375 Bao,L.H., Osawe,I., Puri,T., Lambris,J.D., Haas,M., Quigg,R.J. C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist. European Journal of Immunology 2005; 35(-8-):2496-2506. >>> C5a receptor antagonist; DMSO; saline; SC; Mice (transgenic); 2001; 6 weeks; Controls received mp w/ vehicle; pumps replaced every week; immunology; peptides; 50% DMSO; C5a anaphylatoxin; "subcutaneous mini-osmotic pumps were used to deliver C5aRa or vehicle continuously, thereby achieving steady-state concentrations and avoiding the need for frequent injections." (p. 2498).

P7329 Kim,S.J., Winter,K., Nian,C., Tsuneoka,M., Koda,Y., McIntosh,C.H.S. Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. Journal of Biological Chemistry 2005; 280(-23-):22297-22307. >>> Glucose-dependent insulinotropic polypeptide (1-42), synthetic porcine; IP; Rat; 2 weeks; Replacement therapy (diabetic); immunology; peptides.

P7316 Dokur,M., Chen,C.P., Advis,J.P., Sarkar,D.K. Beta-endorphin modulation of interferon-gamma, perforin and granzyme B levels in splenic NK cells: Effects of ethanol. Journal of Neuroimmunology 2005; 166(-1-2-):29-38. >>> Endorphin, B-; CSF/CNS (paraventricular nucleus); Rat; 2002; 18 hours; Controls received mp w/ aCSF; immunology; peptides.

P7302 Singer,H.S., Mink,J.W., Loiselle,C.R., Burke,K.A., Ruchkina,I., Morshed,S., Parveen,S., Leckman,J.F., Hallett,J.J., Lombroso,P.J. Microinfusion of antineuronal antibodies into rodent striatum: Failure to differentiate between elevated and low titers. Journal of Neuroimmunology 2005; 163(-1-2-):8-14. >>> Serum, human; dye trypan blue; PBS; CSF/CNS (ventrolateral striatum); Rat; 1007D; 2002; 96 hours; Controls received mp w/ vehicle, or sham surgery; functionality of mp verified by observing progression of Typan blue in the catheter; immunology; cannula placement confirmed by India ink dye injection; 65 ul serum placed in catheter, Trypan blue solution placed in mp; serum continued high or low levels of antineuronal antibodies.

P7263 Min,B., Yamane,H., Hu-Li,J., Paul,W.E. Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms. Journal of Immunology 2005; 174(-10-):6039-6044. >>> Interleukin-7, recomb. mouse; Mice; mice (transgenic); 7, 28 days; Controls received mp w/ PBS; immunology; peptides.

P7249 Lay,A.J., Liang,Z., Rosen,E.D., Castellino,F.J. Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. Journal of Clinical Investigation 2005; 115(-6-):1552-1561. >>> Hirudin; IP; Mice (transgenic); 3 days; Controls received mp w/ saline; no stress (see pg. 1555); enzyme inhibitor (thrombin); cardiovascular; immunology.

P7217 Griffiths,G.D., Telford,G., Hooi,D.S.W., Cook,D.L., Wilkinson,L.J., Green,C.A., Pritchard,D.I. A T-cell-dependent humoral immune response is preserved during the administration of the nerve agent pre-treatment pyridostigmine bromide in a murine model. INTERNATIONAL IMMUNOPHARMACOLOGY 2005; 5(-3-):525-540. >>> Pyridostigmine bromide; Saline, sterile isotonic; SC; Mice; 2004; 28 days; Controls received mp w/ vehicle; enzyme inhibitor (cholinesterase); immunology; mp primed in saline at 37 degrees celsius for 48 hours; "PB administration was achieved by 28-day mini-osmotic pumps thus removing the requirement for multiple oral dosing and the associated stress this may have caused." (p. 536).

P7203 Rochman,I., Paul,W.E., Ben-Sasson,S.Z. IL-6 increases primed cell expansion and survival. Journal of Immunology 2005; 174(-8-):4761-4767. >>> Cytochrome c, pigeon; intereukin-6, recomb.mouse; PBS; Mice; 7 days; Dose-response (Fig. 1); immunology; peptides.

P7186 Newman,R., Cuan,N., Hampartzoumian,T., Connor,S.J., Lloyd,A.R., Grimm,M.C. Vasoactive intestinal peptide impairs leucocyte migration but fails to modify experimental murine colitis. Clinical and Experimental Immunology 2005; 139(-3-):411-420. >>> Vasoactive intestinal peptide; SC; Mice; 3, 7 days; Controls received mp w/ saline; functionality of mp verified by VIP plasma levels; comparison of IP injections vs. mp; immunology; peptides; TNBS-induced colitis.

P7184 Mathian,A., Weinberg,A., Gallegos,M., Banchereau,J., Koutouzov,S. IFN-alpha induces early lethal lupus in preautoimmune (New Zealand black x New Zealand White)F1 but not in BALB/c mice1. Journal of Immunology 2005; 174(-5-):2499-2506. >>> Interferon, mouse; PBS; BSA; SC; Mice; 1002; 8-10 weeks; Controls received mp w/ vehicle; long-term study; pumps replaced every 2 weeks; immunology.

P7163 Inokuchi,Y., Morohashi,T., Kawana,I., Nagashima,Y., Kihara,M., Umemura,S. Amelioration of 2,4,6-trinitrobenzene sulphonic acid induced colitis in angiotensinogen gene knockout mice. Gut 2005; 54(-3-):349-356. >>> Losartan; SC; Mice (knockout); 21 days; Controls received mp w/ normal saline, comparison of oral delivery vs. mp, immunology.

P7124 Day,Y.J., Li,Y.S., Rieger,J.M., Ramos,S.I., Okusa,M.D., Linden,J. A2A adenosine receptors on bone marrow-derived cells protect liver from ischemia-reperfusion injury1. Journal of Immunology 2005; 174(-8-):5040-5046. >>> ATL146e; SC; Mice; 1003D; 24 hours; Controls received mp w/ vehicle; immunology; ischemia (hepatic); Chimeric mice of rA24 receptor created by irradiaton and bone marrow transplant.

P6950 Chen,W.H., Langer,R.M., Janczewska,S., Furian,L., Geary,R., Qu,X.M., Wang,M., Verani,R., Condon,T., Stecker,K., Bennett,C.F., Stepkowski,S.M. Methoxyethyl-modified intercellular adhesion molecule-1 antisense phosphorothiateoligonucleotides inhibit allograft rejection, ischemic-reperfusion injury, and cyclosporine-induced nephrotoxicity. Transplantation 2005; 79(-4-):401-408. >>> Oligonucleotide, antisense; Saline; IV; Rat; 7 days; Comparison of gavage and IV injections vs. mp; antisense (phosphorothioate/phosphodiester); transplantation; 14 d pump used; immunology.

P6865 Goodridge,H.S., Marshall,F.A., Else,K.J., Houston,K.M., Egan,C., Al-Riyami,L., Liew,F.Y., Harnett,W., Harnett,M.M. Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. Journal of Immunology 2005; 174(-1-):284-293. >>> ES-62; PBS; SC; Mice; 2002; 14 days; Controls received mp w/ vehicle; dose-response (fig. 1); immunology.

P7044 Auchtung,T.L., Dahl,G.E. Prolactin mediates photoperiodic immune enhancement: Effects of administration of exogenous prolactin on circulating concentrations, receptor expression, and immune function in steers. Biology of Reproduction 2004; 71(-6-):1913-1918. >>> Prolactin, recomb. bovine; Saline; SC; Cattle; 2ML2; 10 days; Comparison of IV injections vs mp; no stress ( see pg. 1914); immunology; peptides; post op. care (prodine, excenel); each animal received 4 rounds of 10 day prolactin treatment (2 w/ mp, 2 IV injection) with 11 days of non treatment between each round.

P7009 Dillon,S.R., Sprecher,C., Hammond,A., Bilsborough,J., Rosenfeld-Franklin,M., Presnell,S.R., Haugen,H.S., Maurer,M., Harder,B., Johnston,J., Bort,S., Mudri,S., Kuijper,J.L., Bukowski,T., Shea,P., Dong,D.L., Dasovich,M., Grant,F.J., Lockwood,L., Levin,S.D., LeCiel,C., Waggie,K., Day,H., Topouzis,S., Kramer,J., Kuestner,R., Chen,Z., Foster,D., Parrish-Novak,J., Gross,J.A. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. NATURE IMMUNOLOGY 2004; 5(-7-):752-760. >>> Interleukin-31, mouse; PBS; BSA; SC; Mice; 7-14 days; Controls received mp w/ vehicle; immunology.

P6978 Chu,Y.W., Memon,S.A., Sharrow,S.O., Hakim,F.T., Eckhaus,M., Lucas,P.J., Gress,R.E. Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function. Blood 2004; 104(-4-):1110-1119. >>> Interleukin-7, recomb. mouse; PBS; sucrose; serum, normal mouse; SC; Mice; 1007D; 1002; 7,14 days; Controls received mp w/ vehicle; replacement therapy (thymectomy); immunology.

P6866 Goodridge,H.S., Marshall,F.A., Wilson,E.H., Houston,K.M., Liew,F.Y., Harnett,M.M., Harnett,W. In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype. Immunology 2004; 113(-4-):491-498. >>> ES-62; ovalbumin, phosphorylcholine-; BSA, phosphorylcholine-; PBS; SC; Mice; 2002; 14 days; Controls received mp w/ vehicle, or sham conjugated OVA or BSA; dose-response (fig 2); immunology.

P6767 Tamamura,H., Fujisawa,M., Hiramatsu,K., Mizumoto,M., Nakashima,H., Yamamoto,N., Otaka,A., Fujii,N. Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent. FEBS Letters 2004; 569(-1-3-):99-104. >>> TN14003, 4F-benzoyl-; PBS; SC; Mice; 1007D; 2002; 7,14 days; Controls received mp w/ vehicle; dose-response (Fig.2); immunology; peptides.

P6552 Oberbeck,R., Schmitz,D., Schueler,M., Wilsenack,K., Schedlowski,M., Exton,M. Dopexamine and cellular immune functions during systemic inflammation. Immunobiology 2004; 208(-5-):429-438. >>> Dopexamine; dopamine; IP; Mice; 48 hours; Controls received saline&sham operation; immunology; polymicrobial sepsis induced cecal ligation&puncture (CLP).

P6539 Locher,C.P., Witt,S.A., Ashlock,B.M., Levy,J.A. Evaluation of genetic immunization adjuvants to improve the effectiveness of a human immunodeficiency virus type 2 (HIV-2) envelope DNA vaccine. DNA and Cell Biology 2004; 23(-2-):107-110. >>> DNA, plasmid; Gene, HIV-2 gpl40; SC; Mice; 2004; 28 days; 28 day stability verified by agarose gel electrophoresis; immunology; different methods of immunization used; genetic immunization; DNA did not adhere to the osmotic minipump after 1 month since DNA concentration remained stable and intact.

P6525 Bai,S., Stepkowski,S.M., Kahan,B.D., Brunner,L.J. Metabolic interaction between cyclosporine and sirolimus. Transplantation 2004; 77(-10-):1507-1512. >>> Cyclosporin; sirolimus; Sandimmune IV solution; dimethylacetamide, N-N-; tween 80; PEG 400; IV (femoral); Rat; 2002; 14 days; Controls received mp w/ vehicle; multiple pumps per animal (2); CSA was purchased as sandimmune IV solution (cremophor or castor oil and 33% ethanol); SRL was dissolved in Tween 80 (10%), PEG 400 (70%), and dimethyl acetamide, N-N- (20%); Immunology.

P6417 Langley,R.J., Kalra,R., Mishra,N.C., Sopori,M.L. Central but not the peripheral action of cholinergic compounds suppresses the immune system. Journal of Neuroimmunology 2004; 148(-1-2-):140-145. >>> Physostigmine; pyridostigmine bromide; edrophonium; Saline; CSF, artificial; SC; CSF/CNS; Rat; 2ML4; 3 weeks; Controls received mp w/ vehicle; enzyme inhibitor (acetylcholinesterase); immunology; ALZET brain infusion kit.

P6379 Mendel,I., Natarajan,K., Ben-Nun,A., Shevach,E.M. A novel protective model against experimental allergic encephalomyelitis in mice expressing a transgenic TCR-specific for myelin oligodendrocyte glycoprotein. Journal of Neuroimmunology 2004; 149(-1-2-):10-21. >>> Interleukin-12; PBS; SC; Mice; 2001; 7 days; Immunology.

P6366 Apostolou,I., von Boehmer,H. In vivo instruction of suppressor commitment in naive T cells. Journal of Experimental Medicine 2004; 199(-10-):1401-1408. >>> Influenza HA (107-119); uridine, bromodeoxy-; PBS; SC; Mice; 1002; 2001; 7,14 days; Controls received mp w/ BrdU; 2001 pumps replaced at 7 days for BrdU group; immunology; peptides; labeling of splenocytes.

R0202 Yang,G.X., Hagmann,W.K. VLA-4 antagonists: Potent inhibitors of lymphocyte migration. Medicinal Research Reviews 2003; 23(-3-):369-392. >>> Peptides, synthetic; SC; Mice; ; Immunology; peptides; VLA-4 antagonists.

P6598 Roonprapunt,C., Huang,W.C., Grill,R., Friedlander,D., Grumet,M., Chen,S.H., Schachner,M., Young,W. Soluble cell adhesion molecule L1-Fc promotes locomotor recovery in rats after spinal cord injury. Journal of Neurotrauma 2003; 20(-9-):871-882. >>> Immunoglobin, L1-Fc chimera; antibody, monoclonal, mouse IgM; PBS; CSF/CNS (intrathecal); Rat; 2002; 2 weeks; Controls received mp w/ vehicle, or mouse IgM Ab; no stress (see pg.876); stress/adverse reaction: (see pg.876) "One rat died in each group during the planned 12 week observation period."; immunology; brain tissue distribution; the chimera construct includes the extracellular domain of mouse L1 fused to the human Fc (hinge, CH2-CH3 region) and inserted into a PEE-14 vector (p. 872).

P6442 Xu,B., Li,S., Brown,A., Gerlai,R., Fahnestock,M., Racine,R.J. EphA/ephrin-A interactions regulate epileptogenesis and activity-dependent axonal sprouting in adult rats. MOLECULAR AND CELLULAR NEUROSCIENCE 2003; 24(-4-):984-999. >>> EphB2; EphA5; ephrin-A5; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; immunology; peptides; 7 day post surgical recovery; fusion proteins consisted of an IgG domain; immunoadhesins.

P6244 Furukawa,T., Kimura,O., Go,S., Iwai,N. Small bowel allografts maintained by administration of bombesin while under immunosuppression. Journal of Pediatric Surgery 2003; 38(-1-):83-86. >>> Bombesin; IP; Rat; 2002; 2 weeks; Controls received mp w/ saline; no stress (see pg. 84); immunology; peptides.

P6136 Goodman,S., Trindade,M., Ma,T., Lee,M., Wang,N., Ikenou,T., Matsuura,I., Miyanishi,K., Fox,N., Regula,D., Genovese,M., Klein,J., Bloch,D., Smith,R.L. Modulation of bone ingrowth and tissue differentiation by local infusi on of interleukin-10 in the presence of ultra-high molecular weight po lyethylene (UHMWPE) wear particles. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 2003; 65A(-1-):43-50. >>> Interleukin-10; PBS; BSA; Bone; Rabbit; 2004; 3 or 6 weeks; Controls received mp w/ vehicle; immunology; peptides; diagram of pump and bone chamber (p. 44).

P6135 Schito,M.L., Goel,A., Song,Y., Inman,J.K., Fattah,R.J., Rice,W.G., Turpin,J.A., Sher,A., Appella,E. In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model. Aids Research and Human Retroviruses 2003; 19(-2-):91-101. >>> YS1332D; AG2006; PBS; SC; Mice (transgenic); 2001; 7 days; Immunology; antivirals; nucleocaspid protein (Ncp7) inhibitors.

P5911 Grimm,M.C., Newman,R., Hassim,Z., Cuan,N., Connor,S.J., Le,Y.Y., Wang,J.M., Oppenheim,J.J., Lloyd,A.R. Cutting edge: Vasoactive intestinal peptide acts as a potent suppressor of inflammation in vivo by trans-deactivating chemokine receptors. Journal of Immunology 2003; 171(-10-):4990-4994. >>> Vasoactive intestinal peptide; Saline; SC; Mice; 48 hours; Controls received mp w/ saline; immunology; peptides.

P5910 Weinstock,J.V., Blum,A., Metwali,A., Elliott,D., Bunnett,N., Arsenescu,R. Substance P regulates Th1-type colitis in IL-10 knockout mice. Journal of Immunology 2003; 171(-7-):3762-3767. >>> SR140333; SC; Mice; 2 weeks; Controls received mp w/ control buffer; immunology; SR140333 is an NKJR antagonist.

P5887 Matsumoto,Y., Hof,A., Baumlin,Y., Hof,R.P. Differential effect of cyclosporine A and SDZ RAD on neointima formation of carotid allografts in apolipoprotein E-deficient mice. Transplantation 2003; 76(-8-):1166-1170. >>> SDZ RAD; cyclosporin A; Propylene glycol; SC; Mice (knockout); 2002; 8 weeks; Dose-response (survival dose response) p. 1168; pumps replaced every 2 weeks; immunology; (RAD) is a novel rapamycin derivative and is an immunosuppresant, aka everolimus or certican; sandimmun IV solution used; "CSA&RAD were administered by ALZET minipumps, which we prefer because of the well-defined drug exposure." p. 1168.

P5683 Saito,J.M., Bostick,M.K., Campe,C.B., Xu,J.Q., Maher,J.J. Infiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis. HEPATOLOGY RESEARCH 2003; 25(-2-):180-191. >>> Antiserum, rabbit anti-rat neutrophil; serum, rabbit; SC; Rat; 2ML1; 7 days; immunology; peptides..

P5662 Dixit,V.D., Yang,H.W., Udhayakumar,V., Sridaran,R. Gonadotropin-releasing hormone alters the T helper cytokine balance in the pregnant rat. Biology of Reproduction 2003; 68(-6-):2215-2221. >>> Gonadotrophin-releasing hormone agonist; Saline; SC; Rat (pregnant); 1003D; 24 hours; Controls received mp w/ vehicle; immunology; the GnRH agonist used was wyeth-40972..

R0171 Lofthouse,S. Immunological aspects of controlled antigen delivery. Advanced Drug Delivery Reviews 2002; 54(-6-):863-870. >>> Antigens; Mice; sheep; ; Immunology; ALZET pumps mentioned on pgs. 865, 866.

P6167 Matsumoto,Y., Hof,A., Baumlin,Y., Hof,R.P. Efficacy of mycophenolate sodium as monotherapy and in combination wit h FTY720 in a DA-to-Lewis-rat heart-transplantation model. Transplantation 2002; 74(-10-):1372-1376. >>> Mycophenolate sodium; Propylene glycol; water, pyrogen free; SC; Rat; 2ML2; 4 weeks; Controls received mp w/ vehicle; dose-response (p. 1374); pumps replaced once; enzyme inhibitor (inosine monophosphate dehydrogenase); immunology; 90% propylene glycol used; transplantation.

P6142 Koyanagi,S., Ohdo,S. Alteration of intrinsic biological rhythms during interferon treatment and its possible mechanism. MOLECULAR PHARMACOLOGY 2002; 62(-6-):1393-1399. >>> Interferon-alpha; Saline, sterile; SC; Mice; 2001; 7 days; Controls received mp w/ vehicle; immunology; peptides.

P5838 Katsume,A., Saito,H., Yamada,Y., Yorozu,K., Ueda,O., Akamatsu,K., Nishimoto,N., Kishimoto,T., Yoshizaki,K., Ohsugi,Y. Anti-interleukin-6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice. Cytokine 2002; 20(-6-):304-311. >>> Interleukin-6; SC; Mice (transgenic); 1007D; 7 days; Functionality of mp verified by IL-6 serum levels; immunology; peptides; IL-6 is human recomb.

P5542 Fernandez-Botran,R., Gorantla,V., Sun,X.C., Ren,X.P., Perez-Abadia,G., Crespo,F.A., Oliver,R., Orhun,H.I., Quan,E.E., Maldonado,C., Ray,M., Barker,J.H. Targeting of glycosaminoglycan-cytokine interactions as a novel therapeutic approach in allotransplantation. Transplantation 2002; 74(-5-):623-629. >>> MC-2; Saline; IA (profunda femoris artery); Rat; 2ML2; ; Controls received mp w/ vehicle; tissue perfusion (skin flap allograft); immunology; peptides; MC-2 is derived from mouse interferon gamma; transplant.

P5533 Exton,M.S., Gierse,C., Meier,B., Mosen,M., Xie,Y.F., Frede,S., Goebel,M.U., Limmroth,V., Schedlowski,M. Behaviorally conditioned immunosuppression in the rat is regulated via noradrenaline and beta-adrenoceptors. Journal of Neuroimmunology 2002; 131(-1-2-):21-30. >>> Propranolol; SC; Rat; ; Controls received mp w/ saline; dose-response (graph, p. 27); immunology.

P5531 Chen,Y., Lin,S.M., Lai,H.S., Tseng,S.H., Chen,W.J. Effects of irradiated tumor vaccine and continuous localized infusion of granulocyte-macrophage colony-stimulating factor on neuroblastomas in mice. Journal of Pediatric Surgery 2002; 37(-9-):1298-1304. >>> Colony-stimulating factor, GM; PBS; BSA; SC (tumor vaccine injection site); Mice; 1002; 14 days; Controls received mp w/ PBS; immunology; GM-CSF is recombinant murine; tissue perfusion.

P5525 Bickerstaff,A., Orosz,C. Evidence for a limited contribution of immune regulation to cardiac allograft acceptance. Human Immunology 2002; 63(-10-):935-947. >>> Gallium nitrate; Mice; 2002; 28 days; Immunology.

P5524 Bickerstaff,A.A., Wang,J.J., Xia,D.Y., Orosz,C.G. Allograft acceptance despite differential strain-specific induction of TGF-beta/IL-10-mediated immunoregulation. AMERICAN JOURNAL OF TRANSPLANTATION 2002; 2(-9-):819-827. >>> Gallium nitrate; Mice; 2002; 28 days; Immunology.

P5522 Bumgardner,G.L., Gao,D.H., Li,J.S., Bickerstaff,A., Orosz,C.G. MHC-identical heart and hepatocyte allografts evoke opposite immune responses within the same host. Transplantation 2002; 74(-6-):855-864. >>> Gallium nitrate; SC; Mice; 2002; 28 days; Immunology; transplantation.

P5518 Bickerstaff,A.A., Wang,J.J., Pelletier,R.P., Orosz,C.G. The graft helps to define the character of the alloimmune response. TRANSPLANT IMMUNOLOGY 2002; 9(-2-4-):137-141. >>> Gallium nitrate; Mice; 2002; 28 days; Immunology.

P5503 Zhu,B., Luo,L.Q., Chen,Y.L., Paty,D.W., Cynader,M.S. Intrathecal Fas ligand infusion strengthens immunoprivilege of central nervous system and suppresses experimental autoimmune encephalomyelitis. Journal of Immunology 2002; 169(-3-):1561-1569. >>> Fas Ligand, recomb; CSF, artificial; gentamicin; albumin, rat; aprotinin; CSF/CNS (intrathecal); Rat; 1003D; 2002; ; 2002 pumps replaced w/ 1003D pumps after 7 days; immunology; 2002 pumps used to infuse vehicle for the first 7 days; then 1003D used to infuse rFasL for 3 days; aprotonin (trypsin inhibitory unit) infused to inhibit rFasL degradation.

P5468 Ohara,K., Kusano,M. Anti-transforming growth factor-beta 1 antibody improves survival rate following partial hepatectomy in cirrhotic rats. HEPATOLOGY RESEARCH 2002; 24(-2-):174-183. >>> Antibody, anti-TGF-B1; PBS; SC; Rat; 1003D; 3 days; Controls received mp w/ vehicle; immunology; hepatic cirrhosis model.

P5463 O'Connor,T.P., Liesen,D.A., Mann,P.C., Rolando,L., Banz,W.J. A high isoflavone soy protein diet and intravenous genistein delay rejection of rat cardiac allografts. Journal of Nutrition 2002; 132(-8-):2283-2287. >>> Antileukinate; PBS; SC; Mice; 1003D; 14 days; Immunology; peptides; antileukinate is a hexapeptide (anti-chemotaxic agent).

P5385 Li,Z., Lin,H., Yang,S., Diehl,A.M. Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system. Gastroenterology 2002/10; 123(-4-):1304-1310. >>> Leptin; SC; Mice; 2 weeks; Controls received mp w/ saline; peptides; immunology.

P5382 Margotti,E., Covaceuszach,S., Tongiorgi,E., Cattaneo,A., Domenici,L. TRKB signalling controls the expression of N-methyl-D-aspartate receptors in the visual cortex. European Journal of Neuroscience 2002; 16(-6-):1067-1074. >>> Immunoglobulin G, TrkB; Saline; CSF/CNS (occipital cortex); Rat (neonate); 16 days; Controls received mp w/ vehicle; functionality of mp verified by TrkB-IgG immunohistochemistry in visual cortex; immunology; TrkB-IgG consists of the soluble form of the tirosine Kinase receptor engineered as an immunoadhesin by fusing it to the Fc portion of an IgG; 20-21 day old rats used; Fig. 2A (graphic of infusion site).

P5355 Marasco,CJ Jr, Kramer,D.L., Miller,J., Porter,C.W., Bacchi,C.J., Rattendi,D., Kucera,L., Iyer,N., Bernacki,R., Pera,P., Sufrin,J.R. Synthesis and evaluation of analogues of 5 '-([(Z)-4-amino-2-butenyl]m ethylamino)-5 '-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. Journal of Medicinal Chemistry 2002; 45(-23-):5112-5122. >>> MDL73811; MDL73811 analogue; Water; Mice; 3, 7 days; Dose-response; immunology.

P5317 Renkonen,R., Fukuda,M.N., Petrov,L., Paavonen,T., Renkonen,J., Hayry,P., Fukuda,M. A peptide mimic of selectin ligands abolishes in vivo inflammation but has no effect on the rat heart allograft survival. Transplantation 2002; 74(-1-):2-6. >>> Selectin binding peptide; BSA; IP; Rat; ; Controls received mp w/ vehicle; comparison of 2x daily IV injections vs. mp; immunology; peptides; transplantation; IELLPAR peptide inhibits E-, P-, and L-selectin adhesion.

P5310 Chen,L., Koyanagi,M., Fukada,K., Imanishi,K., Yagi,J., Kato,H., Miyoshi-Akiyama,T., Zhang,R., Miwa,K., Uchiyama,T. Continuous exposure of mice to superantigenic toxins induces a high- level protracted expansion and an immunological memory in the toxin- reactive CD4+ T cells. J Immunol. 2002/4/15; 168(-8-):3817-3824. >>> Antigen, Staphylococcal enterotoxin A; Antigen, Yersinia pseudotuberculosis-derived mitogen; SC; Mice; 2001; 10 days; dose-response (p.3819); comparison of ip injections vs. mp; immunology; superantigen toxins.

P5309 Huang,C.C., Shah,S., Nguyen,P., Altman,J.D., Blackman,M.A. Bacterial superantigen exposure after resolution of influenza virus infection perturbs the virus-specific memory CD8(+)-T-cell repertoire. J Virol. 2002/7; 76(-13-):6852-6856. >>> Antigen, Staphylococcal enterotoxin A; Antigen, Staphylococcal enterotoxin B; PBS; Mice; 7 days; Controls received mp w/ vehicle; immunology; bacterial superantigens.

P5279 Mishra,A., Hogan,S.P., Brandt,E.B., Rothenberg,M.E. IL-5 promotes eosinophil trafficking to the esophagus. J Immunol. 2002/3/1; 168(-5-):2464-2469. >>> Interleukin-5; PBS; BSA; IP; Mice (transgenic); 2001; 8 days; Controls received mp w/ vehicle; Immunology; peptides; human IL-5 used.

P5226 Wang,J., Charboneau,R., Balasubramanian,S., Barke,R.A., Loh,H.H., Roy,S. The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptor. J Leukoc.Biol 2002/5; 71(-5-):782-790. >>> Corticosterone; PEG 400; SC; Mice; 48 hours; Controls received mp w/ vehicle; functionality of mp verified by corticosterone plasma levels; dose-response (p. 784); immunology;.

P5209 Newnham,J.P., Moss,T.J., Kramer,B.W., Nitsos,I., Ikegami,M., Jobe,A.H. The fetal maturational and inflammatory responses to different routes of endotoxin infusion in sheep. Am.J Obstet.Gynecol. 2002/5; 186(-5-):1062-1068. >>> Endotoxin, E. coli; Saline; IP; Intratracheal; intragastric, intra-amniotic; Sheep (lamb); Sheep (fetus);; 2001D; 24 hours; Controls received mp w/ vehicle; comparison of intra-amniotic injections vs. mp; immunology; teratology; description of fetal surgery (p.1063); correct pump placement confirmed by examining newborn lambs.

P5129 Pfaff,A.W., Schulz-Key,H., Soboslay,P.T., Taylor,D.W., MacLennan,K., Hoffmann,W.H. Litomosoides sigmodontis cystatin acts as an immunomodulator during experimental filariasis. International Journal for Parasitology 2002; 32(--):171-178. >>> Antigen, cystatin; IP; mice; 1002; 14 days; controls received mp w/ PBS; immunology; immune response to litomosoides sigmodontis cystatin; cystatins are cysteine protease inhibitors.

P5123 Lukacs,N.W., Berlin,A., Schols,D., Skerlj,R.T., Bridger,G.J. AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity. American Journal of Pathology 2002; 160(-4-):1353-1360. >>> AMD 3100; Saline; IP; mice; 1003D; 3 days; controls received mp w/ vehicle; immunology; asthma.

P5102 Skovseth,D.K., Yamanaka,T., Brandtzaeg,P., Butcher,E.C., Haraldsen,G. Vascular morphogenesis and differentiation after adoptive transfer of human endothelial cells to immunodeficient mice. American Journal of Pathology 2002; 160(-5-):1629-1637. >>> Interferon-gamma; Abdominal wall; mice; 2004; ; tissue perfusion (abdominal wall); immunology; peptides; pump implanted SC, catheter tube perfused matrigel plug in abdominal wall..

P5101 Simonson,M.S., Robinson,A.V., Schulak,J.A., Hricik,D.E. Inhibition of endothelin-1 improves survival and vasculopathy in rat cardiac transplants treated with cyclosporine. Transplantation 2002; 73(-7-):1054-1059. >>> Phosphoramidon; Water; SC; rat; 2ML4; up to 52 days; controls received mp w/ vehicle; pumps replaced after 28 days; immunology; transplantation research; phosphoramidon is an endothelin-converting enzyme inhibitor; animals with allografts surviving longer than 28 days received a fresh pump.

P5094 Matsuno,H., Yudoh,K., Katayama,R., Nakazawa,F., Uzuki,M., Sawai,T., Yonezawa,T., Saeki,Y., Panayi,G.S., Pitzalis,C., Kimura,T. The role of TNF-alpha in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA/SCID mouse chimera. Rheumatology 2002; 41(--):329-337. >>> Tumor Necrosis Factor-a; Interleukin-6; Serum, fetal bovine; Culture medium, RPMI 1640; SC; mice; 1007D; 7 days; controls received mp w/ vehicle; functionality of mp verified by serum cytokine levels; immunology; peptides; cytokines were recombinant; pump incorrectly called an osmium pump (p. 331); agents administered singly..

P5093 Basak,Saroj K., Dubinett,Steven M., Harui,Airi, Mitani,Kohnosuke, Roth,Michael D., Sharma,Sherven, Stolina,Marina  Blood 2002; 99(-8-):2869-2879. >>> Interleukin-4; Colony-stimulating factor, GM; Saline; SC; mice; 1007D; 7 days; controls received mp w/ vehicle; functionality of mp verified by serum levels via ELISA; immunology; peptides; recombinant cytokines; agents administered singly or concomitantly.

P5077 Tezuka,H., Imai,S., Muto,R., Furuhashi,Y., Fujita,K. Recombinant Dirofilaria immitis polyprotein that stimulates murine B cells to produce nonspecific polyclonal immunoglobulin E antibody. Infection and Immunity 2002; 70(-3-):1235-1244. >>> Antigen, recombinant dirofilaria immitis-derived-; Antigen, Excretory-Secretory (whole); Antigen, Excretory-Secretory (rDiAg-depleted); Antigen, Ovalbumin;; PBS; peptide, control;; SC; mice; 1002; 28 days; controls received mp w/ vehicle; functionality of mp verified by plasma levels; pumps replaced after 2 weeks; immunology; peptides; Immune response to antigens infused via mp; ES peptides are nematode polyprotein allergens from parasitic helminths.

P5074 Kown,M.H., van der Steenhoven,T.J., Jahncke,C.L., Mari,C., Lijkwan,M.A., Koransky,M.L., Blankenberg,F.G., Strauss,H.W., Robbins,R.C. Zinc chloride-mediated reduction of apoptosis as an adjunct immunosuppressive modality in cardiac transplantation. J Heart Lung Transplant 2002/3; 21(-3-):360-365. >>> Zinc chloride; SC; rat; 14 days; immunology; 14-day pump used, model not specified; transplantation research.

P5073 Corsini,E, Lucchi,L, Meroni,M, Racchi,M, Solerte,B, Fioravanti,M, Viviani,B, Marinovich,M, Govoni,S, Galli,C.L. In vivo dehydroepiandrosterone restores age-associated defects in the protein kinase C signal transduction pathway and related functional responses. Journal of Immunology 2002; 168(-4-):1753-1758. >>> Dehydroepiandrosterone; Propylene glycol; SC; rat; 2ML2; 2 weeks; controls received mp w/ vehicle; functionality of mp verified by plasma levels; replacement therapy (castration p. 1754); immunology; dehydroepiandrosterone is also known as DHEA..

P5061 Moss,T.J.M., Newnham,J.P., Willett,K.E., Kramer,B.W., Jobe,A.H., Ikegami,M. Early gestational intra-amniotic endotoxin - Lung function, surfactant, and morphometry. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2002; 165(--):805-811. >>> Endotoxin, E. coli; Saline; Amniotic sac; sheep (lamb, fetus); 2ML4; 4 weeks; controls received mp w/ vehicle; tissue perfusion (amniotic sac); comparison of intra-amniotic injections vs. mp; immunology; teratology; pre-natal lung development.

P5049 Elepfandt,P., Rupprecht,S., Schoning-Burkhardt,B., Volk,H.D., Woiciechowsky,C. Oligodeoxynucleotides induce brain inflammation in rats when infused intracerebroventricularly. Neurosci.Lett. 2002/4/5; 322(--):107-110. >>> Oligodeoxynucleotide, antisense; Saline; Albumin, human serum; CSF/CNS; rat; 1003D; 48 hours; controls received mp w/ vehicle; immunology; brain inflammation due to ICV nucleotide.

P5304 Fujiwara,K., Karasuyama,M., Murata,I., Tanabe,T., Yabuuchi,M., Inoue,Y., Tsuru,D. Immunoelectron-microscopic demonstration of histamine depletion in the gastric enterochromaffin-like cells of rats treated with alpha- fluoromethylhistidine. Cell Tissue Res 2001/11; 306(-2-):295-300. >>> Fluoromethylhistidine, a-; Saline; SC; Rat; 2ML1; 12 or 24 hours; Controls received mp w/ vehicle; immunology.

P5022 Teeling,J.L., Jansen-Hendriks,T., Kuijpers,T.W., de Haas,M., van de Winkel,J.G.J., Hack,C.E., Bleeker,W.K. Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia. Blood 2001; 98(-4-):1095-1099. >>> IFN-inducible protein-10; Saline; IP; mice; 2001; ; controls received mp w/ vehicle; immunology; peptides; IP-10 is a CXC chemokine that targets T and NK cells..

P5011 Imai,S., Tezuka,H., Fujita,K. A factor of inducing IgE from a filarial parasite prevents insulin-dependent diabetes mellitus in nonobese diabetic mice. Biochemical and Biophysical Research Communications 2001; 286(--):1051-1058. >>> Antigen, recombinant Dirofilaria immitis-derived; PBS; SC; mice; ; controls received mp w/ vehicle; dose-response (fig. 3); IgE plasma levels; immunology; autoimmune diabetes; DiAg is a factor from Dirofilaria immitis that induces antigen non-specific IgE, suppresses anaphylaxis; IgE immune response to DiAg (p. 1054)..

P5010 Furuhashi,Y., Imai,S., Tezuka,H., Fujita,K. Recombinant Dirofilaria immitis-derived antigen can suppress passive cutaneous anaphylaxis reactions. International Archives of Allergy and Immunology 2001; 125(--):144-151. >>> Antigen, recombinant Dirofilaria immitis-derived; PBS; SC; rat; 2002; 14 days; controls received mp w/ vehicle; dose-response (fig. 1 p. 147); immunology; rDiAg promotes IgE production, prevents passive cutaneous anaphylaxis reactions; immune response to DiAg shown by plasma IgE levels.

P4996 Umemura,M., Nishimura,H., Hirose,K., Matsuguchi,T., Yoshikai,Y. Overexpression of IL-15 in vivo enhances protection against Mycobacterium bovis Bacillus Calmette-Guerin infection via augmentation of NK and T cytotoxic 1 responses. Journal of Immunology 2001; 167(--):946-956. >>> Antibody, monoclonal anti-IFN-Y; Immunoglobulin G, rat; SC; mice; 2004; 28 days; controls received mp w/ vehicle; functionality of mp verified by serum IFN-Y levels; immunology; peptides.

P4944 Layton,G.T., Harris,S.J., Bland,F.A., Lee,S.R., Fearn,S., Kaleta,J., Wood,M.L., Bond,A., Ward,G. Therapeutic effects of cysteine protease inhibition in allergic lung inflammation: Inhibition of allergen-specific T lymphocyte migration. INFLAMMATION RESEARCH 2001; 50(--):400-408. >>> E-64; DMSO; Water; SC; mice; 2001; 7 days; functionality of mp verified by lung tissue protease levels; immunology; enzyme inhibitor; E64 is a cysteine protease inhibitor; vehicle was 50% DMSO, 50% water..

P4942 Sakamoto,H., Aikawa,M., Hill,C.C., Weiss,D., Taylor,W.R., Libby,P., Lee,R.T. Biomechanical strain induces class a scavenger receptor expression in human monocyte/macrophages and THP-1 cells - A potential mechanism of increased atherosclerosis in hypertension. Circulation 2001; 104(--):109-114. >>> Angiotensin II; Saline; Acetic acid; SC; mice; 1002; 8 weeks; Functionality of mp verified by systolic blood pressure measurements; pumps replaced every 2 weeks for 8 week study; cardiovascular; immunology; peptides; atherosclerosis; vehicle was .01M/L acetic acid in saline..

P4880 Drevets,D., Jelinek,T.A., Freitag,N.E. Listeria Monocytogenes-infected phagocytes can initiate central nervous system infection in mice. Infection and Immunity 2001; March 2001(--):1344-1350. >>> Gentamicin sulfate; PBS; SC; mice; 1007D; 4-6 days; controls received no gentamicin treatment; dose response (graph p. 1346); immunology.

P4874 Masuda,Y., Shimizu,A., Mori,T., Ishiwata,T., Kitamura,H., Ohashi,R., Ishizaki,M., Asano,G., Sugisaki,Y., Yamanaka,N. Vascular endothelial growth factor enhances glomerular capillary repair and accelerates resolution of experimentally induced glomerulonephritis. American Journal of Pathology 2001; 159(--):599-608. >>> Vascular endothelial growth factor; Saline; IP; rat; 2ML1; 7 days; controls received mp w/ vehicle; immunology; peptides;.

P4872 Margenthaler,J.A., Tu,F., Otomo,N., Shimizu,Y., Yu,S., Flye,M.W. Immunogenicity of Ld+ transgenic mouse hearts. Surgery 2001; 130(--):217-224. >>> Interleukin-2; mice; 1007D; 7 days; controls received no IL-2 treatment; immunology; peptides.

P4864 Xia,D.Y., Sanders,A., Shah,M., Bickerstaff,A., Orosz,C. Real-time polymerase chain reaction analysis reveals an evolution of cytokine mRNA production in allograft acceptor mice. Transplantation 2001; 72(-5-):907-914. >>> Gallium nitrate; SC; mice; 2002; 28 days; functionality of mp verified by plasma gallium nitrate levels; pumps replaced after 14 days; immunology; gallium nitrate is an immunosuppressant..

P4862 Goodridge,H.S., Wilson,E.H., Harnett,W., Campbell,C.C., Harnett,M.M., Liew,F.Y. Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae. Journal of Immunology 2001; 167(--):940-945. >>> ES-62; PBS; SC; mice; 2 weeks; controls received mp w/ vehicle; immunology; peptides; ES-62 (excretory-secretory) is a protein secreted by the rodent filarial nematode, a parasite. ES-62 impacts various immune responses. "..the novel approach of using osmotic pumps to delivery parasite molecules such as ES-62 to mice offers an alternative to repeated dosing or serial injection. Importantly, it mimics natural, constant release of the parasite product during infection, as well as minimizing animal handling and stress, which can influence the immune response". p. 945.; no stress.

P4854 Zhang,J.L., Yamaguchi,Y., Mori,K., Okabe,K., Hidaka,H., Ohshiro,H., Uchino,S., Ishihara,K., Furuhashi,T., Yamada,S., Ogawa,M. A serine protease inhibitor, N-alpha-tosyl-L-lysine chloromethyl ketone, prolongs rat hepatic allograft survival. Journal of Surgical Research 2001; 96(--):296-303. >>> Lysine chloromethyl ketone, N-a-tosyl-L-; Saline; SC; rat; up to 7 days; controls received mp w/ vehicle; immunology; enzyme inhibitor; TLCK is a serine protease inhibitor; immunosuppression..

P4849 Tsai,Y.C., Won,S.J. Effects of tramadol on T lymphocyte proliferation and natural killer cell activity in rats with sciatic constriction injury. Pain 2001; 92(--):63-69. >>> Tramadol; Saline; SC; rat; 2ML1; 7 days; Controls received mp w/ vehicle; comparison of sc injections vs. mp; immunology; multiple pumps per animal (2) used in high-dose groups; nociception; tramadol is a centrally acting analgesic..

P4848 Tuncok,Y., Hieda,Y., Keyler,D.E., Brown,S., Ennifar,S., Fattom,A., Pentel,P.R. Inhibition of nicotine-induced seizures in rats by combining vaccination against nicotine with chronic nicotine infusion. EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY 2001; 9(-2-):228-234. >>> Nicotine; Saline; SC; rat; 2ML2; 7 days; functionality of mp verified by serum nicotine levels; dose response (graph p. 231); immunology.

P4817 Griffiths,G.D., Hornby,R.J., Stevens,D.J., Scott,L.A.M., Upshall,D.G. Biological consequences of multiple vaccine and pyridostigmine pretreatment in the guinea pig.. Journal of Applied Toxicology 2001; 21(--):59-68. >>> Pyridostigmine bromide;; Saline;; SC;; guinea-pig;; 28 days;; Controls received mp w/ vehicle; functionality of mp verified by AChE levels via assay p. 60; immunology; enzyme inhibitor; PB is an acetylcholinesterase inhibitor; toxicology.

P4799 Chapital,A.D., Hendrick,S.R., Lloyd,L., Pieper,D. The effects of triiodothyronine augmentation on antithrombin III levels in sepsis.. American Surgeon 2001; 67(--):253-256. >>> Triiodothyronine;; Saline;; SC;; rat;; 24 hours;; Controls received sham surgery; functionality of mp verified by T3 plasma levels by direct chemoluinescence assay; dose-response (graph p. 254); immunology;.

P4780 Dillard,D.G., Gal,A.A., Roman-Rodriguez,J., White,S., Jacobs,I.N. Transforming growth factor and neutralizing antibodies in subglottic stenosis.. Annals of Otology Rhinology and Laryngology 2001; 110(--):393-400. >>> Transforming growth factor-B1; Antibody, anti-human TGF-B1;; PBS; BSA;; Larynx;; rat;; 1, 7, 21 days;; Controls received mp w/ vehicle; immunology; peptides; special delivery device attached to pump, p. 394; wound healing study;.

P4772 Fedele,M.J., Lang,C.H., Farrell,P.A. Immunization against IGF-I prevents increases in protein synthesis in diabetic rats after resistance exercise. Am.J.Physiol.Endocrinol Metab. 2001; 280(--):E877-E885. >>> Antibody, anti-IGF-I polyclonal;; Saline;; SC;; rat;; 2ML1;; 7 days;; Controls received mp w/ non-specific Immunoglobulin G; functionality of mp verified by plasma levels; immunology; peptides; rats underwent partial pancreatetomy to create diabetic state; antibody delivered wan as anti-insulin-like growth factor I antibody; diabetes; pumps used for passive immunization against IGF-I; anti IGF-I antibody used is called SC-7144;.

P4700 Kamachi,A, Munakata,M, Nasuhara,Y, Nishimura,M., Ohtsuka,Y, Amishima,M, Takahashi,T, Homma,Y, Kawakami,Y  Thorax 2001; 56(--):19-24. >>> Salbutamol; Methylprednisolone;; Saline;; SC;; rat;; 2ML4;; 4 weeks;; Controls received mp w/ vehicle; functionality of mp verified by salbutamol plasma levels by HPLC; immunology; asthma research; agents infused separate or concomitantly in same pump;.

P8576 Villoslada,P., Hauser,S.L., Bartke,I., Unger,J., Heald,N., Rosenberg,D., Cheung,S.W., Mobley,W.C., Fisher,S., Genain,C.P. Human Nerve Growth Factor Protects Common Marmosets against Autoimmune Encephalomyelitis by Switching the Balance of T Helper Cell Type 1 and 2 Cytokines within the Central Nervous System. Journal of Experimental Medicine 2000; 191(-10-):1799-1806. >>> Saline; nerve growth factor, recomb. human; cytochrome C; CSF/CNS; Marmoset; 2004; 35-42 days; Controls received mp w/ cytochrome C; functionality of mp verified by CSF levels of rhNGF; pumps replaced after 7-14 days of saline; immunology; ALZET brain infusion kit used; peptides; animal info (callithrix jacchus); "we chose to use an intracranial route to ensure accurate delivery of the drug into the CNS. This resulted in sustained elevated concentrations of rhNGF in the CSF of all rhNGF-treated animals." (p. 1801).

P5270 Suga,M., Maclean,A.A., Keshavjee,S., Fischer,S., Moreira,J.M., Liu,M. RANTES plays an important role in the evolution of allograft transplant- induced fibrous airway obliteration. Am.J Respir.Crit Care Med. 2000/11; 162(-5-):1940-1948. >>> Antibody, polyclonal anti-rat RANTES; Immunoglobulin G, rabbit; RANTES; Saline; PBS; BSA; Tracheal graft; Rat; 1007D; 2002;; 7, 14, 24 days; Controls received mp w/ vehicle; pumps replaced after 14 days; 14-day stability verified by RANTES ELISA (p.1944); Immunology; peptides; transplantation; RANTES is a chemokine; concentration of RANTES in mp measured before and after delivery (p.1945).

P5028 Koarai,A., Ichinose,M., Sugiura,H., Yamagata,S., Hattori,T., Shirato,K. Allergic airway hyperresponsiveness and eosinophil infiltration is reduced by a selective iNOS inhibitor, 1400W, in mice. Pulmonary Pharmacology&Therapeutics 2000; 13(--):267-275. >>> 1400W; Saline; SC; mice; 1003D; 26 hours; Controls received mp w/ vehicle; immunology; 1400 W is a selective inducible Nitric Oxide Synthase (iNOS) inhibitor; asthma.

P5007 Dutta,A.S., Gormley,J.J., Coath,M., Hassall,L., Hayward,C.F., Gellert,P.R., Kittlety,R.S., Alcock,P.J., Ferguson,R., Halterman,T., Jamieson,A., Moors,J.A., Moores,J.M., Rees,A., Wood,L.J., Reilly,C.F., Haworth,D. Potent cyclic peptide inhibitors of VLA-4 (alpha(4)beta(1) integrin)-mediated cell adhesion. Discovery of compounds like cyclo-(MePhe-Leu-Asp -Val-D-Arg-D-Arg) (ZD7349) compatible with depot formulation. JOURNAL OF PEPTIDE SCIENCE 2000; 6(--):398-412. >>> ZD7349; Saline; SC; mice; 14 days; Arthritis; controls received mp w/ vehicle; dose-response (graphs p. 404); comparison of sc, ip injections vs. mp; immunology; peptides; arthritis; ZD7349 is a peptide, cyclo (D-Arg-D-Arg-MePhe-Leu-Asp-Val-D-Arg-D-Arg)..

P4884 Rodgers,K., Xiong,S., Espinoza,T., Roda,N. Angiotensin II increases host resistance to peritonitis. Clinical and Diagnostic Laboratory Immunology 2000; July 2000(--):635-640. >>> Angiotensin II; IP; rat; 2002; up to 11 days; dose response (graphs p. 637-38); comparison of sc, ip injections vs mp; immunology; peptides; SC pump connected to IP catheter; Pumps used in initial study only, later studies used sc or ip injections..

P4815 Hautmann,S., Huland,E., Wullbrand,A., Friedrich,M., Huland,H. Treatment of metastatic hormone-refractory prostate adenocarcinoma (MatLyLu) in Copenhagen rats with micro-osmotic interleukin-2 pumps.. Anticancer Research 2000; 20(--):4495-4498. >>> Interleukin-2;; Albumin, human;; SC; Peritumoral (orthotopic); rat;; 2002;; ; Controls received mp w/ vehicle; functionality of mp verified by in vitro assay; no stress (see p. 4496); good methods pumps weighed p. 4496; cancer (prostate); immunology; peptides; rats had a prostatic adenocarcinoma tumor implanted; Albumin vehicle was 20% concentration; SC&peritumoral orthotopic implantation; Note: these pumps were left in for 28 days;.

P4814 Van Horssen,P.J., Preijers,F.W.M.B., Van Oosterhout,Y.V.J.M., Eling,W.M.C., De Witte,T. Relationship of the CD22 immunotoxin dose and the tumour establishment in a SCID mice model. Leuk.Lymphoma 2000; 39(-5-6-):591-599. >>> Chloroquine; PBS; IP; Mice (scid); 2001; 7 days; Controls received mp w/ vehicle; dose-response (p. 595 graph); comparison of oral delivery vs. mp (p. 594); cancer; immunology; toxicology.

P4766 Minami,H., Tada,K., Chowdhury,N.R., Chowdhury,J.R., Onji,M. Enhancement of retrovirus-mediated gene transfer to rat liver in vivo by infusion of hepatocyte growth factor and triiodothyronine. Journal of Hepatology 2000; 33(--):183-188. >>> Hepatocyte growth factor; Triiodothyronine;; Saline; Heparin, sodium;; IV (portal vein);; rat;; 24 hours;; Comparison of portal vein injections vs. mp; cancer; immunology; peptides; HGH used was recombinant human..

P4735 Conover,J.C, Doetsch,F., Garcia-Verdugo,J.-M, Gale,N.W, Yancopoulos,G.D., Alvarez-Buylla,A. Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone.. Nature Neuroscience 2000; 3(-11-):1091-1097. >>> EphB2; Ephrin-B1; Ephrin-B2;; PBS;; CSF/CNS;; mice;; 1007D;; 3.5 days or 13 hours;; Functionality of mp verified by brain slice immunohistochemistry; immunology; peptides; EphB1-3 are receptor tyrosine kinases; Ephrins-B/2-3 are transmembrane ligants; Fusion proteins consisting of Fc domain of human IgG (immunoglobulin) infused for all peptide agents above..

P4734 Brosamle,C, Huber,A.B, Fiedler,M, Skerra,A, Schwab,M.E  The Journal of Neuroscience 2000; 20(-21-):8061-8068. >>> Antibody, monoclonal IN-1 - Fab fragment; Antibody, monoclonal mutant IN-1 - Fab fragment;; BSA;; CSF/CNS (intrathecal);; rat;; 2002;; 14 days;; Controls received mp w/ vehicle; immunology; peptides;.

P4680 Hieda,Y, Keyler,D.E, Ennifar,S, Fattom,A, Pentel,P.R  International Journal of Immunopharmacology 2000; 22(--):809-819. >>> Nicotine bitartrate;; Saline;; SC;; rat;; 2ML4;; 11 weeks;; Controls received mp w/ vehicle; comparison of chronic bolus injections vs. mp; long-term study, pumps replaced after 4 and 8 weeks; immunology; dependence;.

P4675 Jander,S, Schroetter,M, Fischer,J, Stoll,G  Glia 2000; 30(--):401-410. >>> Interferon-gamma; Tumor necrosis factor-a;; PBS, sterile;; CSF/CNS;; rat;; 1007D;; 6 days;; Controls received mp w/ vehicle; immunology; peptides; ALZET brain infusion kit used; proinflammatory cytokines;.

P4665 Kalra,R, Singh,S.P, Savage,S.M., Finch,G.L, Sopori,M.L. Effects of cigarette smoke on immune response: Chronic exposure to cigarette smoke impairs antigen-mediated signaling in T cells and depletes IP3-sensitive Ca2+ stores.. The Journal of Pharmacology and Experimental Therapeutics. 2000; 293(-1-):166-171. >>> Nicotine base;; SC;; rat;; 3-4 weeks;; immunology;.

P4512 Thomas-Vaslin,V, Bellier,B, Cohen,J.L, Boyer,O, Raynal-Raschilas,N, Glotz,Denis, Klatzmann,D  Transplantation 2000/5/27; 69(-10-):2154-2161. >>> Ganciclovir;; Water;; SC;; mice (transgenic);; 2001; 2002;; 7, 14 days;; funtionality of mp verified by ganciclovir plasma levels by liquid chromatography; immunology; transplantation;.

P4254 Wilson,H.M., Minto,A.W.M., Brown,P.A.J., Erwig,L.P., Rees,A.J. Transforming growth factor-beta isoforms and glomerular injury in nephrotoxic nephritis. Kidney International 2000; 57(--):2434-2444. >>> Transforming growth factor-B3, recombinant; Saline; SC; rat; 2001; 7 days; controls received mp w/ vehicle; immunology; peptides; nephritis.

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