References on the Intracerebroventricular Administration of Agents to Rats Using ALZET^® Osmotic Pumps

P8541 Muramatsu,Y., Furuichi,Y., Tojo,N., Moriguchi,A., Maemoto,T., Nakada,H., Hino,M., Matsuoka,N. Neuroprotective efficacy of FR901459, a novel derivative of cyclosporin A, in in vitro mitochondrial damage and in vivo transient cerebral ischemia models. Brain Research 2007; 1149(--):181-190. >>> Cyclosporin A; FR901459; Cremophor EL; saline;; CSF/CNS; Rat; 1003D; 48 hours; Dose-response (fig. 7); comparison of IV injections vs. mp; ischemia (cerebral); animal info (male, Wistar, 9-10 weeks old, 274-280 grams, MCAO).

P8532 Moenkkoenen,K.S., Hakumaeki,J.M., Hirst,R.A., Miettinen,R.A., O'Callaghan,C., Maennistoe,P.T., Laitinen,J.T. Intracerebroventricular antisense knockdown of G alpha i2 results in ciliary stasis and ventricular dilatation in the rat. BMC NEUROSCIENCE 2007; 8(--):U12-U26. >>> Oligodeoxynucleotide, antisense; oligodeoxynucleotide, missense; Saline, sterile; CSF/CNS; Rat; 1007D; 2002; 7,11 days; Controls received mp w/ vehicle or nonsense or mismatched oligos; no stress (see pg. 2); antisense (G alpha i2); brain tissue distribution; animal info (male, Harlan Wistar, 3 weeks old, 50-100 grams, adult, 250 grams).

P8526 Randolph,C.L., Bierl,M.A., Isaacson,L.G. Regulation of NGF and NT-3 protein expression in peripheral targets by sympathetic input. Brain Research 2007; 1144(--):59-69. >>> Nerve growth factor, mouse; Bisbenzimide; CSF/CNS; Rat; 2002; 2 weeks; Controls received no treatment; peptides; animal info (female, Sprague-Dawley, 3 months old); bisbenzimide (fluorescent marker) added to infusate to monitor cannula placement.

P8497 Strbian,D., Karjalainen-Lindsberg,M.L., Kovanen,P.T., Tatlisumak,T., Lindsberg,P.J. Mast cell stabilization reduces hemorrhage formation and mortality after administration of thrombolytics in experimental ischemic stroke. Circulation 2007; 116(-4-):411-418. >>> Cromoglycate; CSF/CNS; Rat; 2001; ; ALZET brain infusion kit 2 used; ischemia (cerebral); animal info (13-14 weeks old).

P8488 Smith,J.M., Lunga,P., Story,D., Harris,N., Le Belle,J., James,M.F., Pickard,J.D., Fawcett,J.W. Inosine promotes recovery of skilled motor function in a model of focal brain injury. Brain 2007; 130(--):915-925. >>> Inosine; CSF, artificial; CSF/CNS; Rat; 2004; 4 weeks; ALZET Brain Infusion Kit 2 used; multiple pumps per animal (2); post op. care (carprofen, IP); traumatic brain inujury; behavioral study; dental cement used; animal info (male, lister, hooded, 200-300 g).

P8431 Pan,Y.X., Gao,L., Wang,W.Z., Zheng,H., Liu,D.M., Patel,K.P., Zucker,I.H., Wang,W. Exercise training prevents arterial baroreflex dysfunction in rats treated with central angiotensin II. Hypertension 2007; 49(-3-):519-527. >>> Angiotensin II; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ aCSF; cardiovascular; ALZET brain infusion kit II used; peptides; animal info (male, Sprague-Dawley, 300-310g.); cannula placement confirmed with chicago blue dye.

P8428 Iwashita,A., Muramatsu,Y., Yamazaki,T., Muramoto,M., Kita,Y., Yamazaki,S., Mihara,K., Moriguchi,A., Matsuoka,N. Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective Agonists in vitro and in vivo. Journal of Pharmacology and Experimental Therapeutics 2007; 320(-3-):1087-1096. >>> L-165041; GW501516; PEG 300; saline; DMSO; CSF/CNS; Rat; mice; 1003D; 1007D; 2, 6 days; Controls received mp w/ vehicle; dose-response (fig. 6); cardiovascular; ischemia (cerebral); animal info (male, Wistar, 9-10 wks old, 250-280 g.; male, C57/BL6, 9-10 wks old, 19-22g.); neurodegenerative (Parkinson's disease); Right middle cerebral artery occlusion; 30% DMSO.

P8422 Lavoie,N., Peralta,MR III, Chiasson,M., Lafortune,K., Pellegrini,L., Seress,L., Toth,K. Extracellular chelation of zinc does not affect hippocampal excitability and seizure-induced cell death in rats. JOURNAL OF PHYSIOLOGY-LONDON 2007; 578(-1-):275-289. >>> Tricine; EDTA, copper; EDTA, zinc; EDPA; EDTA, calcium; Saline; cresyl violet; CSF/CNS; Rat; 2001D; 12 hours; Controls received mp w/ vehicle; functionality of mp verified by residual volume; brain tissue distribution; animal info (male, Sprague-Dawley, >35 days old); cresyl violet used to verify injection site.

P8420 Jang,S., Lee,J.H., Choi,K.R., Kim,D., Yoo,H.S., Oh,S. Cytochemical alterations in the rat retina by LPS administration. Neurochemical Research 2007; 32(-1-):1-10. >>> Endotoxin, LPS; sphingosine-1-phosphate; CSF/CNS; Rat; 2ML1; 7 days; Controls received mp w/ saline; cyanoacrylate adhesive; animal info (male, Sprague-Dawley, 260-280g).

P8413 Ochedalski,T., Subburaju,S., Wynn,P.C., Aguilera,G. Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity. Journal of Neuroendocrinology 2007; 19(-3-):189-197. >>> Oxytocin; Saline, sterile; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; replacement therapy (ovariectomy); ALZET brain infusion kit used; animal info (female, Sprague-Dawley, 250-300g.).

P8406 Zeevalk,G.D., Manzino,L., Sonsalla,P.K., Bernard,L.P. Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: Relevance to Parkinson's disease. Experimental Neurology 2007; 203(-2-):512-520. >>> Glutathione, monoethyl ester; MPP+; Saline; SC; CSF/CNS; Rat; 2ML4; 28 days; Controls received mp w/ vehicle; dose-response (fig. 6); stability verified by incubation for 0-28 days at 37 celsius, assessed by HPLC; half-life (pg. 515) 10-14 hours in culture; brain tissue distribution; toxicology; animal info (Sprague-Dawley, 300g.); neurodegenerative (Parkinson's disease).

P8403 Marchalant,Y., Rosi,S., Wenk,G.L. Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation. Neuroscience 2007; 144(-4-):1516-1522. >>> Endotoxin, LPS; CSF, artificial; CSF/CNS (fourth ventricle); Rat; 2004; 21 days; Controls received mp w/ vehicle; no stress (see pg. 1518); animal info (male, F-344, 3 months old); neurodegenerative (Alzheimer's disease, Parkinson's disease, MS); Neuroinflammation; "Chronic infusion of LPS and WIN-55212-2 injections was well tolerated by all rats: they gained weight normally for the duration of the study." (pg. 1518); plastics one cannula used.

P8319 Burgos-Ramos,E., Hervas-Aguilar,A., Puebla-Jimenez,L., Boyano-Adanez,M.C., rilla-Ferreiro,E. Chronic but not acute intracerebroventricular administration of amyloid beta-peptide(25-35) decreases somatostatin content, adenylate cyclase activity, somatostatin-induced inhibition of adenylate cyclase activity, and adenylate cyclase I levels in the rat hippocampus. Journal of Neuroscience Research 2007; 85(-2-):433-442. >>> Amyloid protein, beta (25-35); amyloid protein, beta (35-25); Acetic acid; CSF/CNS; Rat; 14 days; Controls received mp w/ vehicle; comparison of ICV injections vs. mp peptides; animal info (male, Wistar, 200-250 grams); neurodegenerative (Alzheimer's disease).

P8300 Messina,M.M., Overton,J.M. Cardiovascular effects of melanin-concentrating hormone. REGULATORY PEPTIDES 2007; 139(-1-3-):23-30. >>> Melanin-concentrating hormone; PBS; BSA; CSF/CNS; Rat; 1002; 10 days; Controls received mp w/ vehicle; dose-response (fig. 1); comparison of acute icv infusion vs. mp; peptides; post op. care (Bupivacaine); animal info (male, Long-Evans, 330g.).

P8267 Warner-Schmidt,J.L., Duman,R.S. VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007; 104(-11-):4647-4652. >>> Vascular endothelial growth Factor 164, recomb. rat; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; peptides; animal info (male, Sprague-Dawley, 175-200g.).

P8263 Nishimura,M., Takahashi,H., Yoshimura,M. Upregulation of the brain renin-angiotensin system in rats with chronic renal failure. ACTA PHYSIOLOGICA 2007; 189(-4-):369-377. >>> Candesartan; CSF, artificial; IV (jugular); CSF/CNS; Rat; 2001; 6 days; Controls received mp w/ vehicle; replacement therapy (subtotal nephrectomy, dorsal rhizotomy); antihypertensive; cyanoacrylate adhesive; animal info (male, SHR/Izumo, 8 wks old, 300-350g.); ATI receptor antagonist.

P8253 Leker,R.R., Soldner,F., Velasco,I., Gavin,D.K., ndroutsellis-Theotokis,A., McKay,R.D.G. Long-lasting regeneration after ischemia in the cerebral cortex. Stroke 2007; 38(-1-):153-161. >>> AraC; Saline; CSF/CNS; Rat; 1007D; 7 days; Controls received mp w/ vehicle; ischemia (cerebral); animal info (SHR, permanent distal middle cerebral artery occlusion).

P8246 Sud,R., Ignatowski,T.A., Lo,C.P.K., Spengler,R.N. Uncovering molecular elements of brain-body communication during development and treatment of neuropathic pain. BRAIN BEHAVIOR AND IMMUNITY 2007; 21(-1-):112-124. >>> Tumor necrosis Factor-a, recomb. rat: tumor necrosis factor-a, recomb. rat, heat-inactivated; amitriptyline; CSF, artificial; CSF/CNS; Rat; 8 days; Controls received mp w/ vehicle, or heat-inactivated rr-TNFa; comparison of ip injections vs. mp; peptides; animal info (male, Sprague-Dawley, 300-350g); chronic constriction injury to the right sciatic nerve.

P8233 D'Addario,C., Di Benedetto,M., Izenwasser,S., Candeletti,S., Romualdi,P. Role of serotonin in the regulation of the dynorphinergic system by a kappa-opoid agonist and cocaine treatment in rat CNS. Neuroscience 2007; 144(-1-):157-164. >>> Cocaine; Water, sterile; CSF/CNS; Rat; 7 days; Controls received mp w/ vehicle; animal info (male, Sprague-Dawley, 200-250 grams).

P8166 Di Benedetto,M., D'Addario,C., Candeletti,S., Romualdi,P. Alterations of CREB and DARPP-32 phosphorylation following cocaine and monoaminergic uptake inhibitors. Brain Research 2007; 1128(-1-):33-39. >>> Cocaine; fluoxetine; GBR12909; nisoxetine; Water, sterile; SC; CSF/CNS; Rat; 2001; 2ML1; 7 days; Controls received mp w/ vehicle; no stress (see pg. 37); animal info (male, Sprague-Dawley, 200-250 grams).

P8149 Kovacs,P., Morales,J.C., Karkanias,G.B. The effect of diabetes and centrally administered insulin on anterior hypothalamic estrogen receptor alpha immunoreactivity. ACTA DIABETOLOGICA 2007; 44(-1-):38-44. >>> Insulin, human; Saline; CSF/CNS (third ventricle); Rat; 2002; 14 days; Controls received mp w/ vehicle; replacement therapy (STZ-induced Diabetes, ovariectomy); peptides; animal info (female, Sprague-Dawley, 175-200g.); tissue perfusion (ventricle).

P8035 Nogueiras,R., Pfluger,P., Tovar,S., Arnold,M., Mitchell,S., Morris,A., Perez-Tilve,D., Vazquez,M.J., Wiedmer,P., Castaneda,T.R., DiMarchi,R., Tschoep,M., Schurmann,A., Joost,H.G., Williams,L.M., Langhans,W., Dieguez,C. Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology 2007; 148(-1-):21-26. >>> Obestatin; Saline; CSF/CNS; Rat; 2ML2; 2001D; 7 days; Controls received mp w/ vehicle; animal info (adult, male, 10-12 weeks old, 350-360 grams); obesity.

R0233 Monnet,F.P., Maurice,T. The sigma1 protein as a target for the non-genomic effects of neuro (active) steroids: Molecular, physiological, and behavioral aspects. JOURNAL OF PHARMACOLOGICAL SCIENCES 2006; 100(-2-):93-118. >>> Amyloid protein, beta (1-40); CSF/CNS; Rat; 14 days; Neurodegenerative (alzheimer's disease); see pg. 111, ref. 29.

P8386 Serralta,A., Barcia,J.A., Ortiz,P., Duran,C., Hernandez,M.E., Alos,M. Effect of intracerebroventricular continuous infusion of valproic acid versus single i.p. and i.c.v. injections in the amygdala kindling epilepsy model. Epilepsy Research 2006; 70(-1-):15-26. >>> Valproic acid; Saline; CSF/CNS; Rat; 2001; 2002; 7 days; Controls received no treatment; dose-response (fig. 1); comparison of icv, IP injections vs. mp; no stress (see pg. 22); toxicology; multiple pumps per animal (2); animal info (male, Wistar, amygdala-kindled epilepsy, 380-420g.); mp primed 1 hr. in 37.5 celsius saline; evans blue dye used to confirm cannula placement, "chronic i.c.v. VPA infusion affords protection against kindled seizures accompanied by less ataxia and sedation" (pg. 24).

P8327 Schwenke,D.O., Pearson,J.T., Mori,H., Shirai,M. Does central nitric oxide elicit pulmonary hypertension in conscious rats?. RESPIRATORY PHYSIOLOGY&NEUROBIOLOGY 2006; 153(-3-):250-260. >>> L-NAME; SIN-1; CSF, artificial; CSF/CNS; Rat; 2004; 3 weeks; Controls received mp w/ vehicle; enzyme inhibitor (NO synthase); cardiovascular; animal info (male, Sprague-Dawley, 200-320 grams, 8 weeks old); Evans blue dye used to confirm correct cannula placement; SIN-1 is 2-[4-morpholinyl]-sydnonimine-hydrochloride.

P8291 Won,S.J., Xie,L., Kim,S.H., Tang,H.D., Wang,Y.M., Mao,X.O., Banwait,S., Jin,K.L. Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke. Brain Research 2006; 1123(--):237-244. >>> Fibroblast growth factor-2; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; animal info (24 month old/3 month old, male, Fisher); ischemia (cerebral).

P8284 Yazdani,U., German,D.C., Liang,C.L., Manzino,L., Sonsalla,P.K., Zeevalk,G.D. Rat model of Parkinson's disease: Chronic central delivery of 1-methyl-4-phenylpyridinium (MPP+). Experimental Neurology 2006; 200(-1-):172-183. >>> MPP+; Saline-iodine; CSF/CNS; Rat; 2ML4; 14 days; Stability verified by HPLC, 28 days; animal info (male, Sprague-Dawley, 300-350 grams); neurodegenerative (Parkinson's Disease); "This study presents a chronic model of PD in rats that encompasses the desirable components of current chronic models while reducing their less desirable aspects." P. 181.

P8283 Yau,J.L.W., Noble,J., Graham,M., Seckl,J.R. Central administration of a cytochrome P450- 7 alpha product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats. Journal of Neuroscience 2006; 26(-43-):11034-11040. >>> Pregnenolone; dehydroepiandrosteone; CSF, artificial; cyclodextrin, hydroxypropyl, beta; CSF/CNS; Rat; 2002; 2 weeks; Controls received mp w/ vehicle; ALZET brain infusion kit used; animal info (male, Lister hooded, 29 months, 500-600 grams); dental cement used to secure cannula; behavioral study; 10% cyclodextrin used; aging.

P8262 Nogueiras,R., Tovar,S., Mitchell,S.E., Barrett,P., Rayner,D.V., Dieguez,C., Williams,L.M. Negative energy balance and leptin regulate neuromedin-U expression in the rat pars tuberalis. Journal of Endocrinology 2006; 190(-2-):545-553. >>> Leptin, recomb. human; Saline; CSF/CNS; Rat; 2ML2; 7 days; 24, 48 hours; Controls received mp w/ vehicle; dose-response (fig. 6); peptides; animal info (male, Sprague-Dawley, 8-10 wks old, 300g.); cannula placement confirmed by methylene blue staining; endocrinology.

P8258 Rosi,S., Vazdarjanova,A., Ramirez-Amaya,V., Worley,P.F., Barnes,C.A., Wenk,G.L. Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat. Neuroscience 2006; 142(-4-):1303-1315. >>> Endotoxin, LPS; memantine; CSF, artificial; SC; CSF/CNS (fourth ventricle); Rat; 2004; 2ML4; 28 days; Controls received mp w/ vehicle; no stress (see pg. 1308); multiple pumps per animal (2); animal info (male, F-344, 3 months old); neurodegenerative (Alzheimer's disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, etc.).

P8236 Lecanu,L., Greeson,J., Papadopoulos,V. Beta-amyloid and oxidative stress jointly induce neuronal death, amyloid deposits, gliosis, and memory impairment in the rat brain. Pharmacology 2006; 76(-1-):19-33. >>> Amyloid protein, beta 42; ferrous sulfate; buthionine sulfoximine; CSF, artificial; water, distilled; CSF/CNS; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; stability verified by 14 days in mp at 37 C; animal info (male, Long-Evans, 3-4 month old, 300-325 grams); neurodegenerative (Alzheimer's disease).

P8217 Castellano,J.M., Navarro,V.M., Fernandez-Fernandez,R., Roa,J., Vigo,E., Pineda,R., Dieguez,C., Aguilar,E., Pinilla,L., Tena-Sempere,M. Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes 2006; 55(-9-):2602-2610. >>> Insulin; leptin; Saline; HCI; CSF/CNS; Rat; 2001; 6 days; Controls received mp w/ vehicle, or nondiabetic; replacement therapy (STZ-induced Diabetes); peptides; animal info (male, Wistar, adult).

P8183 Hill-Pryor,C., Dunbar,J.C. The effect of high fat-induced obesity on cardiovascular and physical activity and opioid responsiveness in conscious rats. Clinical and Experimental Hypertension 2006; 28(-2-):133-145. >>> Funaltrexamine, B-; DAMGO; CSF/CNS; Rat; 2ML4; 2 weeks; Controls received mp w/ aCSF; cardiovascular; peptides; animal info (male, Wistar, 275-300 grams); mu opioid agonist, antagonist.

P8178 Robichaud,M., Debonnel,G. Allopregnanolone and ganaxolone increase the firing activity of dorsal raphe nucleus serotonergic neurons in female rats. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 2006; 9(-2-):191-200. >>> Allopregnanolone; citalopram; RU-486; ganaxolone; Water, distilled; ethanol; SC; CSF/CNS; Rat; 3, 7 days; Controls received mp w/ vehicle; animal info (female, Sprague-Dawley, 250-325 grams); 3% ethanol used.

P8142 Iores-Marcal,L.M., Viel,T.A., Buck,H.S., Nunes,V.A., Gozzo,A.J., Cruz-Silva,I., Miranda,A., Shimamoto,K., Ura,N., Araujo,M.S. Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease. Peptides 2006; 27(-12-):3363-3369. >>> Amyloid protein, beta (1-40), human; E-64; HEPES; E-64; CSF/CNS; Rat; 2004; 28 days; Controls received mp w/ vehicle; brain tissue distribution; peptides; animal info (male, Wistar, 3 mo. old); neurodegenerative (Alzheimer's disease); cathepsin B inhibitor.

P8141 Huang,Q.L., Timofeeva,E., Richard,D. Regulation of corticotropin-releasing factor and its types 1 and 2 receptors by leptin in rats subjected to treadmill running-induced stress. Journal of Endocrinology 2006; 191(-1-):179-188. >>> Leptin, recomb. murine; CSF/CNS (third ventricle); Rat; 2001; 5 days; Controls received mp w/ PBS; peptides; animal info (male, Wistar, 270-290g.); tissue perfusion (ventricle).

P8123 Lensman,M., Korzhevskii,D.E., Mourovets,V.O., Kostkin,V.B., Izvarina,N., Perasso,L., Gandolfo,C., Otellin,V.A., Polenov,S.A., Balestrino,M. Intracerebroventricular administration of creatine protects against damage by global cerebral ischemia in rat. Brain Research 2006; 1114(--):187-194. >>> Creatine; glycerol; Saline; CSF/CNS; Rat; 1002; 7, 13 days; Controls received mp w/ vehicle, or glycerol in saline; no stress (see pg.193); ischemia (cerebral); animal info (male, Sprague-Dawley, 270-320g, carotid artery occlusion); mp use overcomes the "poor brain bioavailability of systemically administered creatine. " (p.188).

P8113 Kanehisa,M., Akiyoshi,J., Kitaichi,T., Matsushita,H., Tanaka,E., Kodama,K., Hanada,H., Isogawa,K. Administration of antisense DNA for ghrelin causes an antidepressant and anxiolytic response in rats. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY&BIOLOGICAL PSYCHIATRY 2006; 30(-8-):1403-1407. >>> Oligodeoxynucleotide, antisense; oligodeoxynucleotide, missense; Saline; CSF/CNS; Rat; 1003D; 1007D; 3 days; Controls received mp w/ vehicle, or missense oligo; antisense (ghrelin); post op. care (ceftriaxone sodium); animal info (male, Wistar, 7-9 wks old, 300-330g.).

P8085 Date,I., Takagi,N., Takagi,K., Tanonaka,K., Funakoshi,H., Matsumoto,K., Nakamura,T., Takeo,S. Hepatocyte growth factor attenuates cerebral ischemia-induced increase in permeability of the blood-brain barrier and decreases in expression of tight junctional proteins in cerebral vessels. Neuroscience Letters 2006; 407(-2-):141-145. >>> Hepatocyte growth factor, recomb. human; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ physiological saline; peptides; ischemia (cerebral); animal info (male, Wistar, 180-220g, microsphere-induced cerebral embolism).

P8064 Zhang,B., Hata,R., Zhu,P.X., Sato,K., Wen,T.C., Yang,L.H., Fujita,H., Mitsuda,N., Tanaka,J., Samukawa,K., Maeda,N., Sakanaka,M. Prevention of ischemic neuronal death by intravenous infusion of a ginseng saponin, ginsenoside Rb(1), that upregulates Bcl-x(L) expression. Journal of Cerebral Blood Flow and Metabolism 2006; 26(-5-):708-721. >>> Ginsenoside Rb1; Saline, isotonic; IV (femoral); CSF/CNS; Rat; gerbil; 2001; 2004; 4 weeks; 1, 7 days; Controls received mp w/ vehicle; dose-response (fig. 2); cardiovascular; ischemia (cerebral); animal info (SHR-SP, 16-18 wk old, 250-300g. MCAO; male, Mongolian Gerbil, 70-80g., 12 wk old, MCAO).

P8062 Gelling,R.W., Morton,G.J., Morrison,C.D., Niswender,K.D., Myers,MG Jr, Rhodes,C.J., Schwartz,M.W. Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metabolism 2006; 3(-1-):67-73. >>> LY294002; CSF/CNS (third ventricle); Rat; 2002; 9 days; Controls received mp w/ vehicle; comparison of icv injections vs. mp; enzyme inhibitor (phosphatidylinositol 3-kinase); animal info (male, Sprague-Dawley, 250-350g); cannula placement confirmed; tissue perfusion (ventricle).

P8054 Cifani,C., Guerrini,R., Massi,M., Polidori,C. Chronic intracerebroventricular infusion of nociceptin/orphanin FQ increases food and ethanol intake in alcohol-preferring rats. Peptides 2006; 27(-11-):2803-2810. >>> Nociceptin/orphanin FQ; Saline; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; dose-response (fig.1); peptides; post op.care (benzyl penicillin, dihydrostreptomycin); animal info(Marchigian-Sardinian alcohol-preferring (msp), male, 250-300g.); cannula placement verified with india ink injection at experiment end.

P8023 Niewiadomska,G., Baksalerska-Pazera,M., Gasiorowska,A., Mietelska,A. Nerve growth factor differentially affects spatial and recognition memory in aged rats. Neurochemical Research 2006; 31(-12-):1481-1490. >>> Nerve growth factor, beta; CSF, artificial; CSF/CNS; Rat; 2004; 1 month; ALZET brain infusion kit used; post op. care (antibiotic and analgesic to scalp + fluid therapy); silastic tubing used; 28 G cannula.

P7987 Wang,Y.M., Galvan,V., Gorostiza,O., Ataie,M., Jin,K.L., Greenberg,D.A. Vascular endothelial growth factor improves recovery of sensorimotor and cognitive deficits after focal cerebral ischemia in the rat. Brain Research 2006; 1115(--):186-193. >>> Vascular endothelial growth factor; CSF, artificial; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; ischemia (cerebral); behavioral study.

P7966 Oh,I., Shimizu,H., Satoh,T., Okada,S., Adachi,S., Inoue,K., Eguchi,H., Yamamoto,M., Imaki,T., Hashimoto,K., Tsuchiya,T., Monden,T., Horiguchi,K., Yamada,M., Mori,M. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006; 443(-7112-):709-712. >>> NUCB2; CSF/CNS; Rat; 10 days; Animal info (male, Wistar, 200-250 grams).

P7932 Zeinoaldini,S., Swarts,H.J.M., Van de Heijning,B.J.M. Effects of central infusion and immunoneutralization of growth hormone on the timing of puberty and plasma leptin levels in the female rat. REGULATORY PEPTIDES 2006; 134(-2-3-):158-163. >>> Growth hormone, recomb. human; immunoglobulin G, goat; growth hormone, anti-rat; Saline, sterile; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle; peptides; post op. care (analgesia, ibuprofen); animal info (female, Wistar, 45 grams).

P7918 Saavedra,J.M., Armando,I., Bregonzio,C., Juorio,A., Macova,M., Pavel,J., Sanchez-Lemus,E. A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding. Neuropsychopharmacology 2006; 31(-6-):1123-1134. >>> Candesartan; Saline; sodium carbonate; SC; CSF/CNS; Rat; 14 days; Controls received mp w/ vehicle; animal info (Wistar, 8 weeks old).

P7914 Chen,L., Yamada,K., Nabeshima,T., Sokabe,M. Alpha 7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal UP induction in beta-amyloid infused rats. Neuropharmacology 2006; 50(-2-):254-268. >>> Amyloid protein, beta (1-40); amyloid protein, beta (40-1); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2002; 11,14 days; Controls received mp w/ vehicle or reverse AB (40-1); no stress (see pg. 255); peptides; neurodegenerative (Alzheimer's disease); animal info (male, KBL Wistar, 280-300 g., 7 weeks old); 35% acetonitrile used.

P7912 Beraud,E., Viola,A., Regaya,I., Confort-Gouny,S., Siaud,P., Ibarrola,D., Le Fur,Y., Barbaria,J., Pellissier,J.F., Sabatier,J.M., Medina,I., Cozzone,P.J. Block of neural Kv1.1 potassium channels for neuroinflammatory disease therapy. Annals of Neurology 2006; 60(-5-):586-596. >>> BgK-F6A; CSF/CNS; Rat; 2001; 2002; 3-5 days; 14-18 days; Controls received mp w/ saline; rats with highest doses of drug had jumping seizures (2 rats), pg. 588; ALZET brain infusion kit 2 used; peptides; animal info (female, Lewis, 6 and 12 wk old).

P7888 da Silva,A.A., Tallam,L.S., Liu,J.K., Hall,J.E. Chronic antidiabetic and cardiovascular actions of leptin: role of CNS and increased adrenergic activity. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2006; 291(-5-):R1275-R1282. >>> Leptin; Saline; CSF/CNS; Rat; 2002; 10 days; Controls received IV saline; functionality of mp verified by plasma leptin concentrations; comparison of IV infusion vs. mp; cardiovascular; peptides; animal info (male, Sprague-Dawley, 275-325g.).

P7874 Naert,G., Ixart,G., Tapia-Arancibia,L., Givalois,L. Continuous i.c.v. infusion of brain-derived neurotrophic factor modifies hypothalamic-pituitary-adrenal axis activity, locomotor activity and body temperature rhythms in adult male rats. Neuroscience 2006; 139(-2-):779-789. >>> Brain-derived neurotrophic factor; Saline; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle, or no treatment; comparison of acute icv injections vs. mp; no stress (see pg. 782); peptides; animal info (male, Sprague-Dawley, 375g.); mp + tubing primed overnight in 37 celsius saline; telemetric transmitter IP.

P7843 Yamaguchi,Y., Miyashita,H., Tsunekawa,H., Mouri,A., Kim,H.C., Saito,K., Matsuno,T., Kawashima,S., Nabeshima,T. Effects of a novel cognitive enhancer, spiro[imidazo[1,2-a]pyridine-3,2- indan]-2(3H)-one (ZSET1446), on learning impairments induced by amyloid-beta (1-40) in the rat. Journal of Pharmacology and Experimental Therapeutics 2006; 317(-3-):1079-1087. >>> Amyloid protein, beta (1-40); amyloid protein, beta (40-1); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 2002; 15 days; Controls received mp w/ vehicle, or AB (40-1); stability verified by testing in solution at 37 celsius (pg. 1080); neurodegenerative (alzheimer's disease); animal info (male, Wistar, 7 wk. old); "An animal model induced by chronic intracerebroventricular (i.c.v.) infusion of AB is particularly attractive for evaluation of drugs for AD because change is similar to those known for AD patients" (pg. 1080); 35% acetonitrile used.

P7831 Windle,R.J., Gamble,L.E., Kershaw,Y.M., Wood,S.A., Lightman,S.L., Ingram,C.D. Gonadal steroid modulation of stress-induced hypothalamo-pituitary-adrenal activity and anxiety behavior: Role of central oxytocin. Endocrinology 2006; 147(-5-):2423-2431. >>> Oxytocin antagonist; oxytocin antagonist, desGly-; CSF/CNS; Rat; 1007D; 5 days; Controls received mp w/ saline; replacement therapy (ovariectomy); ALZET brain infusion kit used; peptides; animal info (female, Sprague-Dawley, 225-250g.); mp primed overnight in isotonic saline.

P7816 Givalois,L., Naert,G., Tapia-Arancibia,L., Arancibia,S. Involvement of brain-derived neurotrophic factor in the regulation of hypothalamic somatostatin in vivo. Journal of Endocrinology 2006; 188(-3-):425-433. >>> Brain-derived neurotrophic factor, recomb. human; Saline; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle, or no treatment; comparison of icv injections vs. mp; peptides; animal info (male, Sprague-Dawley, 260-280g.); mp primed overnight in 37 celsius saline.

P7793 Seto,S., Nagao,S., Ozeki,S., Tetsuo,H., Akahoshi,M., Yano,K. Contribution of central nitric oxide to the regulation of blood pressure and sodium balance in DOCA-salt hypertension. Journal of Cardiovascular Pharmacology 2006; 47(-5-):680-685. >>> L-NMMA; IP; CSF/CNS; Rat; 2ML4; 4 weeks; Controls received mp w/ saline; replacement therapy (nephrectomy); dose-response (fig. 1); enzyme inhibitor (no synthase); cardiovascular; animal info (male, Wistar, 7 wk. old, 240g.); cannula location confirmed by methylene blue staining.

P7782 Glezer,I., Lapointe,A., Rivest,S. Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries. FASEB Journal 2006; 20(-2-):U405-U430. >>> Endotoxin, LPS; MK-801; Saline, sterile; CSF/CNS; Rat; 2004; 3, 7 days; Controls received mp w/ vehicle; immunology; animal info (male, Sprague-Dawley, 250g.).

P7781 Grimaldi,P., Rossi,F. Lack of neurogenesis in the adult rat cerebellum after Purkinje cell degeneration and growth factor infusion. European Journal of Neuroscience 2006; 23(-10-):2657-2668. >>> Epidermal growth factor, recomb. human; fibroblast growth factor, basic; fibroblast growth factor 8b, recomb. mouse; Phosphate buffer; CSF/CNS; Rat; 2002; 1, 7, 14 days; Controls received mp w/ vehicle; peptides; animal info (Wistar albino, 200-250g, 2-3 months old).

P7762 Jung,K.H., Chu,K., Lee,S.T., Kim,S.J., Sinn,D.I., Kim,S.U., Kim,M., Roh,J.K. Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation. Brain Research 2006; 1073(--):190-201. >>> Granulocyte colony-stimulating factor, recomb.; Saline; CSF/CNS; Rat; 2002; 7 days; Controls received mp w/ vehicle; no stress (see pg. 199); peptides; animal info (male, Sprague-Dawley, 220-240g).

P7747 Schwenke,D.O., Pearson,J.T., Kangawa,K., Shirai,M. Does central nitric oxide chronically modulate the acute hypoxic ventilatory response in conscious rats?. ACTA PHYSIOLOGICA 2006; 186(-4-):309-318. >>> L-NAME; sydnonimine-hydrochloride, 3-[4-morpholinyl]-; CSF, artificial; CSF/CNS; Rat; 2004; 3 weeks; Controls received mp w/ vehicle; no stress (see pg. 312); enzyme inhibitor (no synthase); post op. care (viccillin); animal info (male, Sprague-Dawley, 8 wk. old, 200-320g.); correct catheter positioning confirmed post mortem w/ Evans blue dye.

P7728 Frielingsdorf,H., Thal,L.J., Pizzo,D.P. The septohippocampal cholinergic system and spatial working memory in the Morris water maze. Behavioural Brain Research 2006; 168(-1-):37-46. >>> Nerve growth factor, recomb. human; CSF, artificial; gentamicin; albumin, rat serum; CSF/CNS; Rat; 2004; 4 weeks; Controls received mp w/ vehicle; functionality of mp verified by residual volume; cannula placement confirmed by cresyl violet staining; peptides; animal info (male, Fisher 344, 13-14 wk. old, medial septum lesion, 400g); mp primed 2 days in 37 Celsius saline.

P7719 Mouri,A., Zou,L.B., Iwata,N., Saido,T.C., Wang,D.Y., Wang,M.W., Noda,Y., Nabeshima,T. Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory. Behavioural Brain Research 2006; 168(-1-):83-91. >>> Thiorphan; Saline; NaOH; ascorbic acid; CSF/CNS; Rat; 2ML4; 4 weeks; Controls received mp w/ vehicle; enzyme inhibitor (neprilysin (aka enkephalinase)); neurodegenerative (Alzheimer's disease); animal info (male, wistar, 8 wk. old, 260-300g.); memory; learning.

P7666 Crocker,S.J., Hayley,S.P., Smith,P.D., Mount,M.P., Lamba,W.R., Callaghan,S.M., Slack,R.S., Park,D.S. Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase. Journal of Neurochemistry 2006; 96(-2-):489-499. >>> CEP11004; Kreb's solution; bicarbonate; ringer's solution; CSF/CNS; Rat; 2001; 7 days; Controls received mp w/ vehicle; enzyme inhibitor (mixed lineage kinases [MLK]); Alzet brain infusion kit 2 used; animal info (male, Wistar, 150-175 g, MFB axotomy).

P7659 Joo,Y., Kim,H.S., Woo,R.S., Park,C.H., Shin,K.Y., Lee,J.P., Chang,K.A., Kim,S., Suh,Y.H. Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's disease models. MOLECULAR PHARMACOLOGY 2006; 69(-1-):76-84. >>> Amyloid protein, beta (1-42); Acetonitrile; trifluoroacetic acid; CSF/CNS; Rat; 1007D; 1 week; Alzet brain infusion kit used; neurodegenerative (Alzheimer's disease); animal info (male, Wistar 200-250 g); 35% acetonitrile.

P7614 Malhotra,S., Savitz,S.I., Ocava,L., Rosenbaum,D.M. Ischemic preconditioning is mediated by erythropoietin through PI-3 kinase signaling in an animal model of transient ischemic attack. Journal of Neuroscience Research 2006; 83(-1-):19-27. >>> Erythropoietin receptor, soluble; PBS; BSA; CSF/CNS; Rat; 1007D; 5 days; Controls received mp w/ vehicle; peptides; ischemia (cerebral); animal info (male, Wistar, 200-225 g, MCA occlusion).

P7585 Day,M., Langston,R.F. Post-training N-methyl-D-aspartate receptor blockade offers protection from retrograde interference but does not affect consolidation of weak or strong memory traces in the water maze. Neuroscience 2006; 137(-1-):19-28. >>> Ap5, D-; CSF, artificial; CSF/CNS; Rat; 1007D; 7, 14 days; Controls received mp w/ vehicle; pumps replaced after 7 days; post op. care (carpofen); animal info (male, Lister-hooded 230-280 g); electrophysiology.

P7584 Darnaudery,M., Perez-Martin,M., Belizaire,G., Maccari,S., Garcia-Segura,L.M. Insulin-like growth factor 1 reduces age-related disorders induced by prenatal stress in female rats. NEUROBIOLOGY OF AGING 2006; 27(-1-):119-127. >>> Insulin-like growth factor I, recomb. human; Saline; CSF/CNS; Rat; 2004; 21 days; Controls received mp w/ vehicle; ALZET brain infusion kit used; animal info (female, Sprague-Dawley 24 month old, 2 month old).

P7582 Cardoso,A., Paula-Barbosa,M.M., Lukoyanov,N.V. Reduced density of neuropeptide Y neurons in the somatosensory cortex of old male and female rats: Relation to cholinergic depletion and recovery after nerve growth factor treatment. Neuroscience 2006; 137(-3-):937-948. >>> Dye, methylene blue; nerve growth factor; CSF, artificial; BSA; CSF/CNS; Rat; 2002; 14 days; Controls received mp w/ vehicle or sham surgery; functionality of mp verified by pretesting; Alzet brain infusion kit used; post op. care (antiseptic); animal info (male, female, Wistar 6 month old, 24 month old); Lynch coil filled with NGF, air-oil spacer between mp and catheter, mp filled with dye.

P7561 Sun,Y.J., Jin,K.L., Childs,J.T., Xie,L., Mao,X.O., Greenberg,D.A. Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: Evidence from knockout mice and growth factor administration. Developmental Biology 2006; 289(-2-):329-335. >>> Vascular endothelial growth factor-B; CSF, artificial; CSF/CNS; Rat; mice; 1003D; 3 days; Controls received mp w/ vehicle; ischemia (cerebral); animal info (mice, 10-12 wk old; male, Sprague-Dawley).

P7518 Wilsey,J., Matheny,M.K., Scarpace,P.J. Oral vanadium enhances the catabolic effects of central leptin in young adult rats. Endocrinology 2006; 147(-1-):493-501. >>> Leptin; CSF, artificial; CSF/CNS; Rat; 2004; 21, 28 days; Controls received mp w/ vehicle; dose-response (fig. 7); ALZET brain infusion kit used; peptides; animal info (F344, brown Norway, male, 3 months old, 357-370 g); mp primed 36 hours in 37 C sterile saline.

P7451 Fekete,C., Singru,P.S., Sanchez,E., Sarkar,S., Christoffolete,M.A., Riberio,R.S., Rand,W.M., Emerson,C.H., Bianco,A.C., Lechan,R.M. Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus. Endocrinology 2006; 147(-1-):520-529. >>> Leptin, recomb. mouse; insulin; glucose; CSF, artificial; CSF/CNS; Rat; 1003D; 3 days; Controls received mp w/ vehicle; functionality of mp verified by agent levels in CSF+ serum; peptides; post op. care (bacitracin ointment); animal info (male Sprague-Dawley, 200-250 g); cannula placement confirmed by light microscope.

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