References on the Administration of Dopaminergic Agonists and Antagonists Using ALZET® Osmotic Pumps
1. Apomorphine
P6896 Fornai,F., Schlueter,O.M., Lenzi,P., Gesi,M., Ruffoli,R., Ferrucci,M., Lazzeri,G., Busceti,C.L., Pontarelli,F., Battaglia,G., Pellegrini,A., Nicoletti,F., Ruggieri,S., Paparelli,A., Suedhof,T.C. Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and alpha-synuclein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2005; 102(-9-):3413-3418. >>> MPTP; L-dopa; apomorphine; IP; SC; Mice; 2004; 1-28 days; Controls received mp w/ saline; comparison of IP injections vs. mp; neurodegenerative (Parkinson's disease); L-dopa and apomorphine group had SC implanted pumps; route is unclear for the MPTP group; "Continuous MPTP infusions thus recreate a disease state that mimics human PD better than acute MPTP bolus injections." (p. 3417); MPTP group received IP pumps (2004 model), verified by e-mailing author.
P5291 Battaglia,G., Busceti,C.L., Cuomo,L., Giorgi,F.S., Orzi,F., De Blasi,A., Nicoletti,F., Ruggieri,S., Fornai,F. Continuous subcutaneous infusion of apomorphine rescues nigro-striatal dopaminergic terminals following MPTP injection in mice. Neuropharmacology 2002; 42(-3-):367-373. >>> Apomorphine; Saline; SC; Mice; 28 days; Controls received mp w/ vehicle; comparison of sc bolus injections vs. mp; 20-day stability verified by HPLC (p.368); neurodegenerative (Parkinson's disease); "The neurorescue effect of continuous subcutaneous infusion of apomorphine is particularly promising from a clinical standpoint." (p.372).
P3178 Vander Borght,T., Kilbourn,M., Desmond,T., Kuhl,D., Frey,K. The vesicular monoamine transporter is not regulated by dopaminergic drug treatments. Eur.J.Pharmacol. 1995; 294(--):577-583. >>> Apomorphine; L-DOPA methyl ester; Benserazide; Tetrabenazine; Ascorbic acid; Propylene glycol; SC; rat; 2ML2; 2 weeks; controls received mp with propylene glycol; 2 mps used to deliver apomorphine.
P1345 Tanaka,M., Morimasa,T., Kaneyuki,T., Shohmori,T. Dopaminergic activity and met-enkephaline levels in the rat striatum after continuous treatment with various dopaminergic agents. Neuroscience 1988; 14(--):114-116. >>> Apomorphine; Haloperidol; Methamphetamine; SC; rat; 2 weeks; japanese with english abstract.
P1339 Lyerly,M.A., Rossitch,E., Ovelmen-Levitt,J., Nashold,B.S. The deafferentation syndrome in the rat: effects of intraventricular apomorphine. Exp.Neurol. 1988; 100(--):188-202. >>> Apomorphine; Ascorbic acid; Water; CSF/CNS; rat; 2002; 2 weeks; mp connected to cannula; stress/adverse reaction (pg 198).
P1291 Altar,C.A., Berner,B., Beall,P., Carlsen,S.F., Boyar,W.C. Dopamine release and metabolism after chronic delivery of selective or nonselective dopamine autoreceptor agonists. Mol.Pharmacol. 1988; 33(--):690-695. >>> CGS-15855A; Apomorphine; Dopamine, antagonists; Ascorbic acid; Saline; SC; rat; 2ML2; 2, 14 days; comparison of ip injections vs. mp infusion; functionality of mp verified by serum, brain levels; stability verified at 14 days by HPLC.
S0741 Lyerly,M.A., Rossitch,E., Ovelmen-Levitt,J., Nashold,B.S. The deafferentation syndrome in the rat: effects of intraventricular apomorphine. Society for Neuroscience Abstracts, 17th Annual Meeting, Nov.16-21, New Orleans, LA 1987; 13(--):112-. >>> Apomorphine; Ascorbate; Ringer's solution; CSF/CNS; rat; 2 weeks; Pump model not stated; controls received mp w/ lactated ringers; rats underwent dorsal root ganglionectomies.
P0595 George,S., Kertesz,M. Met-enkephalin concentrations in straitum respond reciprocally to alterations in dopamine neurotransmission. Peptides 1987; 8(-3-):487-492. >>> Apomorphine; FK-33824; Haloperidol; Naloxone; Ethanol; Tartaric acid; Water; SC; rat; 5, 9 days; mp model not stated; controls received mp w/unspecified vehicle or were sham-operated; agents infused separately w/appropriate vehicle; comparison of sc inject. vs. mp infusion.
S0607 Winkler,J.D., Weiss,B. Effect of continuous exposure to apomorphine in dopaminergically supersensitive mice on the binding of [3H]spiroperidol and on the rotational behavior induced by dopaminergic agonists. Society for Neuroscience Abstracts, 16th Annual Meeting, Nov.9-14, Washington, DC 1986; 12(--):25-. >>> Apomorphine; mice; 8 days; controls received mp w/vehicle; mice w/ 6-OHDA lesions of nigrostriatal neurons.
S0555 Winkler,J.D., Weiss,B. Continuous exposure of mice to apomorphine reverses the supersensitive rotational behavior induced by dopaminergic agonists. Fed.Proc. 1986; 45(-3-):322-. >>> Apomorphine; SC; mice; 4 days; mice w/unilateral 6-OHDA lesions of nigrostriatal dopaminergic neurons.
P0860 Winkler,J.D., Weiss,B. Reversal of supersensitive apomorphine-induced rotational behavior in mice by continuous exposure to apomorphine. J.Pharmacol.Exp.Ther. 1986; 238(-1-):242-247. >>> Apomorphine; Ascorbic acid; DMSO; SC; mice; 2002; 8-10 days; controls rec'd mp w/ vehicle; 6-OHDA unilateral lesions of the nigrostriatal dopaminergic neurons; no stress (see p. 243).
S0532 Costall,B., Domeney,A.M., Hui,S.C.G., Naylor,R.J., Ogle,C.W. Acute and long-term changes in locomotor activity related to the continuity of dopamine receptor stimulation. Br.J.Pharmacol. 1985; 86(--):690P-. >>> Apomorphine, (-)n-n-propylnor; Apomorphine; SC; mice; 13 days; comparison of injections vs. mp infusion; controls received mp w/ vehicle.
P0704 Robin,M., Forler,C., Palfreyman,M.G. Effect of chronic apomorphine on the development of denervation supersensitivity. Pharmacol.Biochem.Behav. 1985; 22(--):547-551. >>> Apomorphine HCl; Ascorbic acid; Water; SC; rat; 2ML1; 5 and 15 days; pump replaced on 8th day; pumps replaced w/ pumps previously incubated in saline.
P0197 Porreca,F., Cowan,A., Tallarida,R.J. Differentiation of apomorphine from bromocriptine, piribidel and TRH by chronic administration in rats. Psychopharmacology 1982; 76(--):70-74. >>> Apomorphine HCl; Saline; SC; rat; 2001; no duration posted; comparison of agents effects.
2. Bromocriptine
P7450 Leonard,S.T., izadeh-Naderi,R., Stokes,K., Ferkin,M.H. The role of prolactin and testosterone in mediating seasonal differences in the self-grooming behavior of male meadow voles, Microtus pennsylvanicus. PHYSIOLOGY&BEHAVIOR 2005; 85(-4-):461-468. >>> Bromocriptine; prolactin, ovine; Saline, sterile; SC; Prairie vole; 2004; ; Controls received mp w/ vehicle; replacement therapy (gonadectomy); animal info (male, meadow); animals also received testosterone via silastic implant at same time.
P7133 Brooks,P.L., Vella,E.T., Wynne-Edwards,K.E. Dopamine agonist treatment before and after the birth reduces prolactin concentration but does not impair paternal responsiveness in Djungarian hamsters Phodopus campbelli. Hormones and Behavior 2005; 47(-3-):358-366. >>> Bromocriptine; Saline, isotonic; ethanol; tartaric acid; SC; Hamster; 1003D; 3 days; Controls received mp w/ vehicle; comparison of SC injections vs. mp; 10% ethanol; mp primed in 37 degrees celsius saline for >4 hours.
P7705 Combs,T.P., Berg,A.H., Rajala,M.W., Klebanov,S., Iyengar,P., Jimenez-Chillaron,J.C., Patti,M.E., Klein,S.L., Weinstein,R.S., Scherer,P.E. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 2003/2; 52(-2-):268-276. >>> Prolactin; bromocriptine; SC; Mice; 1007D; 3 days; Animal info (female, C57BL/6J).
P5563 Douglas,D.A., Houde,A., Song,J.H., Farookhi,R., Concannon,P.W., Murphy,B.D. Luteotropic hormone receptors in the ovary of the mink (Mustela vison) during delayed implantation and early-postimplantation gestation. Biol.Reprod. 1998/9; 59(-3-):571-578. >>> Bromocriptine; Saline; Mink; 13 days; Controls received mp w/ vehicle.
P4191 Azaryan,A.V., Clock,B.J., Rosenberger,J.G., Cox,B.M. Transient upregulation of m opioid receptor mRNA levels in nucleus accumbens during chronic cocaine administration. Can.J.Physiol.Pharmacol. 1998; 76(--):278-283. >>> Cocaine HCl; SKF-82958; Bromocriptine; Hydrobromide, R(+)-6-bromo-APB; PD 128907; Saline; SC; rat; 2ML1; 24,48,66,72,90,96,168,336 hours; controls received mp w/vehicle; dopamine agonists.
P6301 Payne,A.P., Shah,S.W., Marr,F.A., McGadey,J., Thompson,G.G., Moore,M.R. Hormones and the Control of Porphyrin Biosynthesis and Structure in the Hamster Harderian Gland. Microscopy Res.and Tech. 1996; 34(--):123-132. >>> Bromocriptine; prolactin; Hamster; ; Replacement therpay (castration, ovariectomy); multiple pumps per animal (2).
P3596 Martinelli,G.P., Liu,H., Clarke,W.P., Heisenleder,D.J., Knight,R.J. Prolactin suppression enhances the effects of perioperative donor-specific blood transfusions on graft survival. J.Surg.Res. 1996; 64(--):190-197. >>> Bromocriptine; Domperidone; PEG 400; SC; rat; 2ML2; no duration posted; controls received mp w/ PEG; immunology.
P3446 Azaryan,A.V., Clock,B.J., Cox,B.M. Mu opioid receptor mRNA in nucleus accumbens is elevated following dopamine receptor activation. Neurochem.Res. 1996; 21(-11-):1411-1415. >>> Hydrobromide, R(+)-6-bromo-APB-SKF-38393; Nafadotride, (5)-bromocriptine; Cocaine HCl; Saline; rat; 2ML1; 3 days; controls received mp w/ saline.
P2999 De Krey,G.K., Hollingshead,N.C., Kerkvliet,N.I., Smith,B.B. Suppression of prolactin and cytotoxic T-lymphocyte activity in PCB-treated mice. Int.J.Immunopharmac. 1994; 16(-3-):251-257. >>> Bromocriptine; Ethanol; Water, distilled; Tartaric acid; SC; mice; 2002; no duration posted; controls received mp w/ vehicle or no treatment; 70% ethanol used but diluted 10-fold by adding water.
P2027 Tan,B.K.H. Effects of bromocriptine on systolic blood pressure, prolactin, saline and water intakes in second-generation offspring of a cross between New Zealand genetically hypertensive and normotensive rats. Asia Pac.J.Pharmacol. 1992; 7(--):111-114. >>> Bromocriptine; Tartaric acid; IP; rat; 2ML2; 13 days; functionality of mp verified (p. 111); SC pump connected to IP catheter.
P3134 Tan,B.K.H., Hutchinson,J.S. Effects of bromocriptine on pituitary arginine vasopressin content in the segregating generation of the hybrid of spontaneously hypertensive and Wistar Kyoto rats. Asia Pac.J.Pharmacol. 1991; 6(--):63-66. >>> Bromocriptine; Tartaric acid; IP; rat; 13 days; pumps implanted sub-q, interscapularly, SC pump connected to IP catheter.
S1145 Tan,B.K.H., Hutchinson,J.S. Pituitary arginine vasopressin content in bromocriptine-treated hybrid rats of spontaneously hypertensive and normotensive rats. Eur.J.Pharmacol. 1990; 183(--):1818-. >>> Bromocriptine; Tartaric acid; IP; rat; 13 days; no comment posted.
P3700 Tan,B.K.H., Hutchinson,J.S. Plasma and pituitary thyroid-stimulating hormone levels in bromocriptine-treated new zealand genetically hypertensive and normotensive rats. Clin.Exp.Pharmacol.Physiol. 1990; 17(--):439-443. >>> Bromocriptine; Tartaric acid; IP; rat; 13 days; controls received mp w/ vehicle; pumps implanted sc but PE-50 cannula directed IP.
P1766 Tan,B.K.H., Hutchinson,J.S. Changes in saline and water intakes in bromocriptine-treated genetically hypertensive and normotensive rats. Clin.Exp.Pharmacol.Physiol. 1990; 17(-2-):129-133. >>> Bromocriptine; IP; rat; 2ML2; 13 days; no comment posted.
P1754 Tan,B.K.H., Hutchinson,J.S. Saline and water intake in the bromocriptine-treated hybrid of spontaneously hypertensive and normotensive rats. Asia Pac.J.Pharmacol. 1990; 5(--):91-94. >>> Bromocriptine; Tartaric acid; IP; rat; 2ML2; 13 days; no comment posted.
P1634 Tan,B.K.H., Hutchinson,J.S. Changes in saline and water intakes in bromocriptine-treated spontaneously hypertensive and Wistar-Kyoto rats. Asia Pac.J.Pharmacol. 1989; 4(--):121-124. >>> Bromocriptine; IP; rat; 2ML2; 13 days; no comment posted.
P1506 Tan,B.K.H., Hutchinson,J.S. Blood pressure, plasma and pituitary prolactin responses to bromocriptine in new zealand genetically hypertensive and normotensive rats. Clin.Exp.Pharmacol.Physiol. 1988; 15(--):13-18. >>> Bromocriptine; Ethanol; Saline; Tartaric acid; Water; IP; rat; 2ML2; 13 days; no comment posted.
P1285 Tan,B.K.H., Hutchinson,J.S. Plasma and pituitary prolactin and blood pressure in bromocriptine-treated spontaneously hypertensive and Wistar-Kyoto rats. Clin.Exp.Pharmacol.Physiol. 1987; 14(--):797-803. >>> Bromocriptine; Ethanol; Saline; Tartaric acid; IP; rat; 2ML2; 13 days; SC pump connected to IP catheter.
3. Dinapsoline
P4791 Gulwadi,A.G., Korpinen,C.D., Mailman,R.B., Nichols,D.E., Sit,S.Y., Taber,M.T. Dinapsoline: Characterization of a D1 dopamine receptor agonist in a rat model of Parkinson's disease.. Journal of Pharmacology and Experimental Therapeutics 2001; 296(-2-):338-344. >>> Dinapsoline;; DMSO; Ascorbic acid;; CSF/CNS;; rat;; 2ML2;; 14 days;; Controls received mp w/ vehicle; neurodegenerative (Parkinson's disease); vehicle used was 50% DMSO, 12.5% ascorbic acid; dinapsoline is a potent D1 dopamine receptor agonist..
4. Domperidone
P8230 Craven,A.J., Nixon,A.J., Ashby,M.G., Ormandy,C.J., Blazek,K., Wilkins,R.J., Pearson,A.J. Prolactin delays hair regrowth in mice. Journal of Endocrinology 2006; 191(-2-):415-425. >>> Prolactin, ovine; domperidone; Sodium bicarbonate buffer; PEG 400; SC; Mice; 1003D; 1007D; 1002; 3, 12, 14, days; Controls received no treatment; functionality of mp verified by plasma prolactin levels; animal info (Balb/c, 18-30 days old).
P7254 Kippin,T.E., Kapur,S., van der Kooy,D. Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs. Journal of Neuroscience 2005; 25(-24-):5815-5823. >>> Haloperidol; domperidone; water, distilled; saline; SC; Rat; mice; 1002; 2ML2; 2ML4; 14, 30 days; Controls received mp w/ vehicle; functionality of mp verified by plasma drug levels; dose-response (fig. 1); comparison of ip injections vs. mp; dopamine D2 receptor antagonist.
P3596 Martinelli,G.P., Liu,H., Clarke,W.P., Heisenleder,D.J., Knight,R.J. Prolactin suppression enhances the effects of perioperative donor-specific blood transfusions on graft survival. J.Surg.Res. 1996; 64(--):190-197. >>> Bromocriptine; Domperidone; PEG 400; SC; rat; 2ML2; no duration posted; controls received mp w/ PEG; immunology.
5. Dopamine
P8290 Brinkkoetter,P.T., Beck,G.C., Gottmann,U., Loesel,R., Schnetzke,U., Rudic,B., Hanusch,C., Rafat,N., Liu,Z.Z., Weiss,C., Leuvinik,H.G.D., Ploeg,R., Braun,C., Schnuelle,P., van der Woude,F.J., Yard,B.A. Hypothermia-induced loss of endothelial barrier function is restored after dopamine pretreatment: Role of p42/p44 activation. Transplantation 2006; 82(-4-):534-542. >>> Dopamine; IV (femoral); Rat; 2ML1; 24 hours; Controls received mp w/ isotonic saline; ischemia; reperfusion injury; animal info (male, Lewis, 220-250 g).
P7802 Oberbeck,R., Schmitz,D., Wilsenack,K., Schueler,M., Husain,B., Schedlowski,M., Exton,M.S. Dopamine affects cellular immune functions during polymicrobial sepsis. Intensive Care Medicine 2006; 32(-5-):731-739. >>> Dopamine; IP; Mice; 48 hours; Controls received mp w/ saline; functionality of mp verified by dopamine plasma concentration; animal info (male, NMRI, 8-9 wk old, 30-34-g.); laparotomy or polymicrobial sepsis induced by cecal ligation and puncture.
P7469 Gottmann,U., Notheisen,A., Brinkkoetter,P.T., Yard,B.A., Waldherr,R., Schnuelle,P., van der Woude,F.J., Braun,C. Influence of donor pretreatment with dopamine on allogeneic kidney transplantation after prolonged cold storage in rats. Transplantation 2005; 79(-10-):1344-1350. >>> Dopamine; Saline; IV (femoral); Rat; 2ML1; 24 hours; Controls received mp w/ vehicle; animal info (male, Lewis Fisher).
P6552 Oberbeck,R., Schmitz,D., Schueler,M., Wilsenack,K., Schedlowski,M., Exton,M. Dopexamine and cellular immune functions during systemic inflammation. Immunobiology 2004; 208(-5-):429-438. >>> Dopexamine; dopamine; IP; Mice; 48 hours; Controls received saline&sham operation; immunology; polymicrobial sepsis induced cecal ligation&puncture (CLP).
P6447 Ozono,R., Ueda,A., Oishi,Y., Yano,A., Kambe,M., Katsuki,M., Oshima,T. Dopamine D2 receptor modulates sodium handling via local production of dopamine in the kidney. Journal of Cardiovascular Pharmacology 2003; 42(--):S75-S79. >>> Dopamine; Saline; SC; Mice (knockout); 2002; 3 days; cardiovascular.
P6218 Blanchet,P.J. The fluctuating parkinsonian patient - Clinical and pathophysiological aspects. Canadian Journal of Neurological Sciences 2003; 30(--):S19-S26. >>> Dopamine, agonists; SC; Monkey; ; Pump model and duration not listed; neurodegenerative (Parkinson's disease).
P5642 Carr,L., Tucker,A., Fernandez-Botran,R. In vivo administration of L-dopa or dopamine decreases the number of splenic IFN-gamma-producing cells. Journal of Neuroimmunology 2003; 137(-1-2-):87-93. >>> Dopamine; HCL; saline; ascorbic acid; SC; Mice; 1007D; 5 days; Controls received mp w/ vehicle (without HCL); Incorrectly states the pump's release rate was 0.25 ul/hr, (correct rate is 0.5 ul/hr)..
P4754 Maeda,H, Sasaguri,M, Sakai,T, Kinoshita,A, Koga,M, Noda,K, Tsuji,E, Ideishi,M., Arakawa,K. Roles of renal dopamine and Kallikrein-Kinin systems in antihypertensive mechanisms of exercise in rats.. Hypertens Res 2000; 23(--):511-519. >>> Dopamine;; Water, distilled; Sodium metabisulfate;; SC;; rat;; 2ML4;; 2 weeks;; Antihypertensive; vehicle was water w/ 0.1% sodium metabisulfate;.
R0223 During,M.J, Leone,P. Targets for Gene Therapy of Parkinson's Disease: Growth Factors, Signal Transduction, and Promoters. Experimental Neurology 1997; 144(--):74-81. >>> Dopamine, hydroxy-6; CSF/CNS (striatum); 4 days; ALZET pumps mentioned on pg. 76; neurodegenerative (Parkinson's disease).
P4216 Yang,Z.-J., Meguid,M.M., Chai,J.-K., Chen,C., Oler,A. Bilateral hypothalamic dopamine infusion in male Zucker rat suppresses feeding due to reduced meal size. Pharmacol.Biochem.Behav. 1997; 58(-3-):631-635. >>> Dopamine HCl; Sodium metabisulfite; CSF/CNS (hypothalamus); rat; 2002; 13 days; controls received mp w/vehicle; stability verified by HPLC after 13 days; two pumps implanted per animal; bilateral cannula used.
P3932 Kasamatsu,T., Schmidt,E.K. Continuous and direct infusion of drug solutions in the brain of awake animals: implementation, strengths and pitfalls. Brain Res.Protocols 1997; 1(--):57-69. >>> Forskolin; Dopamine, 6-hydroxy-; Ascorbate; Saline; DMSO; CSF/CNS (visual cortex); cat; 2001; 7 days; no stress (see pg. 64); stability verified by HPLC assays; good methods (extremely detailed for all CSF/CNS aspects and protocols).
P3514 Jones,B.E., Boylan,C.B., Fritsche,M., Juhasz,M., Jackson,C., Wiegand,S.J., Hyman,C., Lindsay,R.M., Alter,C.A. A continuous striatal infusion of 6-hydroxydopamine produces a terminal axotomy and delayed behavioral effects. Brain Research 1996; 709(--):275-284. >>> Dopamine, 6-hydroxy-; Ascorbate; Saline; CSF/CNS (striatum); rat; 2001; 7 days; controls received vehicle infusion; dose-response (figure z); comparison of acute infusion vs. mp; stability verified by bioassay of pump effluent.
P3277 McCorkle,F.M., Taylor Jr,R.L. Continuous adminstration of dopamine alters cellular immunity in chickens. Comp.Biochem.Physiol. 1994; 109C(-3-):289-293. >>> Dopamine; Saline, acidified; SC; bird (chicken); 2001; 24,48,72 hours; controls received mp w/saline; immunology.
P2562 Altar,C.A., Boylan,C.B., Fritsche,M., Jones,B.E., Jackson,C., Wiegand,S.J., Lindsay,R.M., Hyman,C. Efficacy of brain-derived neurotrophic factor and neurotrophin-3 on neurochemical and behavioral deficits associated with partial nigrostriatal dopamine lesions. J.Neurochem. 1994; 63(--):1021-1032. >>> Brain-derived neurotrophic factor; NT-3; Dopamine, 6-hydroxy-; PBS; CSF/CNS (substantia nigra); CSF/CNS (central caudate putamen); rat; 2002; 2 weeks; controls received mp w/ vehicle; stability verified by DRG bioassay; 77-85% biological activity of BDNF&NT-3 remained after 14 days; 6-hydroxydopamine stable for 8 days; peptides; after 6 days, concomitant infusion of BDNF, NT-3 or vehicle with 6-OHDA; recomb. human BDNF used.
P2366 Takeshi,M., Ogura,T., Otz,Z., Ogawa,N. Effects of dopamine on renal receptors for arginine vasopressin. Res.Commun.Chem.Pathol.Pharmacol. 1992; 76(-2-):131-141. >>> Dopamine HCl; SC; rat; 2 weeks; controls received mp with saline.
P2584 Mataga,N., Imamura,K., Watanabe,Y. 6R-tetrahydrobiopterin perfusion enhances dopamine, serotonin, and glutamate outputs in dialysate from rat striatum and frontal cortex. Brain Research 1991; 551(--):64-71. >>> Dopamine, 6-hydroxy-; Saline; Ascorbate; CSF/CNS (striatum); rat; 2001; 1 week; microdialysis probes implanted after pumps taken out.
P1733 Kroin,J.S., Kao,L.C., Zhang,T.J., Penn,R.D., Klawans,H.L., Carvey,P.M. Dopamine distribution and behavioral alterations resulting from dopamine infusion into the brain of the lesioned rat. J.Neurosurg. 1991; 74(--):105-111. >>> Dopamine HCl; Sodium metabisulfite; CSF/CNS; CSF/CNS (striatum); rat; 2002; no duration posted; stability verified in vehicle for 10 days at 37 degrees celsius by HPLC.
P1782 Katayama,E., Ogura,T., Ota,Z. Characteristics of rat kidney dopamine receptors and the effects of renal denervation and dopamine infusion on these receptors. Nephron 1989; 53(--):358-363. >>> Dopamine; SC; rat; 1, 2 weeks; controls received pumps with saline only.
P1446 Garcia de Yebenes,J., Fahn,S., Mena,M.A., Pardo,B., Casarejos,M.J. Intracerebroventricular infusion of dopamine and its agonists in rodents and primates. ASAIO Transactions 1988; 34(--):951-957. >>> Dopamine; Lisuride; Pergolide; Hydroxynaphthoxacine, 4-propyl-9-; HCl; Water; CSF/CNS; rat; 1, 2 weeks; PHNO is dopamine D-2 receptor agonist;.
P1444 Ueda,H. Time course study of changes in the activity of rats during intraventricular infusion of 6-hydroxydopamine, haloperidol and sulpiride: a study of the relationship between an origin of the negative symptoms in schizophrenia and catecholamines. J.Iwate Med.Assoc. 1988; 40(-3-):385-398. >>> Dopamine, 6-hydroxy-; Haloperidol; Sulpiride; CSF/CNS; rat; 8 days; Japanese, English abstract.
P1313 de Yebenes,J.G., Fahn,S., Jackson-Lewis,V., Jorge,P., Mena,M.A., Reiriz,J. Continuous intracerebroventricular infusion of dopamine and dopamine agonists through a totally implanted drug delivery system in animal models of Parkinson's disease. J.Neural Transm. 1988; 27(--):141-160. >>> Deprenyl; Dopamine; Lisuride; Pargyline; Pergolide; HCl; Sodium metabisulfite; Water; CSF/CNS; rat; 2001; 6, 7 days; mp connected to cannula; stability of DA verified in several vehicles, p 146; concomitant DA infusion with pargyline; DA infusion with deprenyl; replacement therapy (dopamine deficiency); stability verified in vitro; antihypertensive; neurodegenerative (Parkinson's disease).
P1291 Altar,C.A., Berner,B., Beall,P., Carlsen,S.F., Boyar,W.C. Dopamine release and metabolism after chronic delivery of selective or nonselective dopamine autoreceptor agonists. Mol.Pharmacol. 1988; 33(--):690-695. >>> CGS-15855A; Apomorphine; Dopamine, antagonists; Ascorbic acid; Saline; SC; rat; 2ML2; 2, 14 days; comparison of ip injections vs. mp infusion; functionality of mp verified by serum, brain levels; stability verified at 14 days by HPLC.
R0077 Ray,N., Theeuwes,F. Implantable osmotically powered drug delivery systems. In 'Drug Delivery Systems: Fundamentals and Techniques,' P.Johnson and J.G.Lloyd-Jones (eds.), Ellis Horwood Ltd., Chichester, England and VCH Verlasgesellschaft mbH, Weinheim, Federal Republic of Germany 1987; (-Ch. 7-):120-138. >>> Antipyrine; bleomycin; dopamine HCl; melatonin; methotrexate, sodium; nicotine; prednisolone; radio-isotopes; valproic acid; 14C tracer; 3H tracer; IA; IP; SC; Mice, rabbit, rat; no duration posted; ALZA-authored; synoptic review of mp; post op. care (antibiotic); comparison of sc injections vs. mp infusion; pulsed delivery.
P2709 de Yebenes,J.G., Fahn,S., Lovelle,S., Jackson-Lewis,V., Jorge,P., Mena,M.A., Reiriz,J., Bustos,J.C., Magarinos,C., Martinez,A. Continuous intracerebroventricular infusion of dopamine and dopamine agonists through a totally implanted drug delivery system in animal models of Parkinson's disease. Movement Disorders 1987; 2(-3-):143-158. >>> Dopamine; Pargyline; Deprenyl; Lisuride; Pergolide; HCl; Sodium metabisulfate; CSF/CNS; rat; 2001; 6,7 days; controls received mp with vehicles; replacement therapy (lesion in dopamine pathway); stability verified for 1 week by measuring dopamine concentrations and its metabolites at varying time intervals with HPLC; concomitant dopamine infusion w/ pargyline and w/ deprenyl; antihypertensive; neurodegenerative (Parkinson's disease).
P1135 Barnes,N.J.G., Costall,B., Domeney,A.M., Naylor,R.J. Behavioural consequences of the infusion of dopamine into the nucleus accumbens of the common marmoset (callithrix-jacchus). Neuropharmacology 1987; 26(-9-):1327-1335. >>> Dopamine; Sodium metabisulfate; CSF/CNS (nucleus accumbens); monkey; 13 days; Pump model not stated; controls received mp w/ vehicle; mp connected to cannulae in nucleus accumbens; mp primed overnight; multiple pumps per animal (2).
P1033 Hargraves,R., Freed,W.J. Chronic intrastriatal dopamine infusions in rats with unilateral lesions of the substantia nigra. Life Sci. 1987; 40(--):959-966. >>> Dopamine; 3H tracer; Ascorbate; Saline; Sodium metabisulfite; Water; CSF/CNS (corpus striatum); rat; 2002; 13 days; controls rec'd mp w/veh.; mp connected to cann. in corpus striatum; some groups rec'd unilat. lesions of substantia nigra; mp inf. diff. amounts of agents to diff. groups; pumps primed o'night with saline.
P0905 Costall,B., Domeney,A.M., Naylor,R.J., Tyers,M.B. Effects of the 5-HT3 receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain. Br.J.Pharmacol. 1987; 92(--):881-894. >>> Dopamine; CSF/CNS (amygdala); CSF/CNS (nucleus accumbens); monkey; rat; 13 days; Pump model not stated; controls rec'd mp w/ unspecif. vehicle; mp conn. to cannulae in amygdala/rat; mp conn. to cath. in nucleus accumbens/monkey; mp primed overnight; concomit. haloperidol admin.; tissue perf. (amygdala, nucleus accumbens).
P0959 Barnes,J.C., Costall,B., Naylor,R.J. Modulation of dopamine function by glycine in the nucleus accumbens of the brain of the rat. Neuropharmacology 1986; 25(-12-):1347-1351. >>> Dopamine; Glycine; Strychnine; Water; CSF/CNS (nucleus accumbens); rat; 2001; 13 days; controls received mp w/vehicle; mp connected to cannula in nucleus accum.; mps primed overnight at 37C; agents infused sep.&simult.; stability.
P0925 Ek,B., Lundgren,B. Increased Beta -adrenoceptor density after 6-hydroxydopamine pretreatment in rat colon and lung. Acta Physiol.Scand. 1986; 127(--):455-460. >>> Dopamine, 6-hydroxy-; Ascorbic acid; Saline; SC; rat; 2001; 3 days; comparison of iv injection vs. mp infusion.
P0857 Barnes,J.C., Costall,B., Domeney,A.M., Naylor,R.J. Lithium and bupropion antagonise the phasic changes in locomotor activity caused by dopamine infused into the rat nucleus accumbens. Psychopharmacology 1986; 89(--):311-316. >>> Dopamine HCl; Lithium; Sodium metabisulfite; CSF/CNS (nucleus accumbens); IP; rat; 2002; 13 days; controls rec'd mps w/vehicle; mp connected to cannula in NC; mps&injection units primed overnight; lithium admin. ip; agents admin. simult. in 1 group; comparison of ip inject. vs mp infusion.
P0856 Bradbury,A.J., Costall,B., Domeney,A.M., Jenner,P.J., Marsden,C.D., Naylor,R.J. The neurotoxic actions of 6-hydroxydopamine infused into the rat substantia nigra. Neuroscience 1986; 67(--):208-212. >>> Dopamine, 6-hydroxy-; CSF/CNS (substantia nigra); rat; 2002; 4 or 10 days; controls rec'd mp w/vehicle; mp connected to steel guide cannula in SN; multiple pumps per animal (2); mps primed overnight.
P0753 Bradbury,A.J., Costall,B., Domeney,A.M., Naylor,R.J. Laterality of dopamine function and neuroleptic action in the amygdala in the rat. Neuropharmacology 1985; 24(-12-):1163-1170. >>> Dopamine HCl; Sodium metabisulfite; CSF/CNS (amygdala); rat; 2002; 9 days; mp connected to steel cannula in amygdala; no stress (see pg. 1164).
P0740 Stromberg,I., Herrera-Marschitz,M., Ungerstedt,U., Ebendal,T., Olson,L. Chronic implants of chromaffin tissue into the dopamine-denervated striatum. Effects of NGF on graft survival, fiber growth and rotational behavior. Exp.Brain Research 1985; 60(-2-):335-349. >>> Dopamine; L-DOPA; Nerve growth factor; Saline; CSF/CNS (corpus striatum); rat; 2002; 28 days; comparison of injections vs. mp infusion; mp replaced after 14 days; mp connected to cannula in striatum mounted w/dialysis fiber; l-dopa&dopamine used only to test fiber; 6-OHDA lesions.
P0630 Costall,B., Domeney,A.M., Naylor,R.J. The continuity of dopamine receptor antagonism can dictate the long-term behavioural consequences of a mesolimibic infusion of dopamine. Neuropharmacology 1985; 2(-3-):193-197. >>> Dopamine HCl; Sulpiride; Nitrogen; Sodium metabisulfite; CSF/CNS (nucleus accumbens); IP; rat; 13 days; mp model not stated; comparison of SULP ip injec vs. mp infusion; 2 mp/rat - bilateral infusion; mp primed overnight; vehicles listed used w/DOP; concomitant SULP admin. ip.
P0592 Sendelbeck,S.L., Urquhart,J. Spatial distribution of dopamine, methotrexate and antipyrine during continuous intracerebral microperfusion. Brain Research 1985; 328(--):251-258. >>> Antipyrine; Dopamine HCl; Methotrexate, sodium; Radio-isotopes; 14C tracer; 3H tracer; CSF, artificial; Sodium fluorescein; CSF/CNS (diencephalon); rabbit; 2001; 6 days; comparison of agents effects; mp primed in saline 16 hr. prior to implant; stability of labelled&unlabelled Dop.&MTX tested by paper chromat. after 7 days at 37C; brain tissue distribution;.
P0606 Kojima,H., Gorio,A., Janigro,D., Jonsson,G. GM1 ganglioside enhances regrowth of noradrenaline nerve terminals in rat cerebral cortex lesioned by the neurotoxin 6-hydroxydopamine. Neuroscience 1984; 13(-4-):1011-1022. >>> Dopamine HCl, 6-hydroxy-; Ascorbic acid; Saline; CSF/CNS (cortex); rat; 2001; 3 or 7 days; cited previous mp paper for 6-OHDA stability.
P0554 Nakai,K., Kasamatsu,T. Accelerated regeneration of central catecholamine fibers in cat occipital cortex: effects of substance P. Brain Research 1984; 323(--):374-379. >>> Dopamine HBr, 6-hydroxy-; Substance P; CSF/CNS (occipital cortex); cat (kitten); 1 week; comparison of agents effects; ALZET not mentioned but author cites previous mp papers as methods reference; cannot be positive substance P deliv. by mp; peptides.
P0495 Haycock,D.A., Bear,M.F. The stability of 6-hydroxydopamine under minipump conditions. Exp.Brain Research 1984; 56(--):183-186. >>> Dopamine HBr, 6-hydroxy-; Ascorbic acid; Saline; pump not used; ; Stability of 6-OHDA in 0.4% ascorbic acid at room temp, 20-38C for at least 1 week verified by HPLC-ECD&biologic activity; minipump itself not used in exp.
P0444 Costall,B., Domeney,A.M., Naylor,R.J. Long-term consequences of antagonism by neuroleptics of behavioural events occurring during mesolimbic dopamine infusion. Neuropharmacology 1984; 23(-3-):287-293. >>> Dopamine HCl; Nitrogen; Sodium metabisulfite; CSF/CNS (nucleus accumbens); rat; 2002; 13 days; no stress p. 288; pumps primed overnight, bilateral pump implantation.
P0439 Costall,B., Domeney,A.M., Naylor,R.J. Locomotor hyperactivity caused by dopamine infusion into the nucleus accumbens of rat brain: specificity of action. Psychopharmacology 1984; 82(--):174-180. >>> Acetylcholine HCl; Aminobutyric acid, Y-; Serotonin bimaleinate; Dopamine HCl; Norepinephrine bitartrate; Nitrogen; Sodium metabisulfite; CSF/CNS (nucleus accumbens); rat; 2002; 13 days; Cholinergic agent; comparison of agents effects; no stress p. 175; stability of substances remaining in pump after 13 days was verified.
P0391 Aguilera,G., Catt,K.J. Dopaminergic modulation of aldosterone secretion in the rat. Endocrinology 1984; 114(-1-):176-181. >>> Angiotensin II; Dopamine; Metoclopramide; IP; IV; rat; 2 days; simultaneous administration of MCP (iv) w/ AII (ip), and MCP (iv) w/ DOP (iv); MCP and AII also infused alone, all by mp; peptides.
P1255 Paradiso,M.A., Bear,M.F., Daniels,J.D. Effects of intracortical infusion of 6-Hydroxydopamine on the response of kitten visual cortex to monocular deprivation. Exp.Brain Research 1983; 51(-3-):413-422. >>> Dopamine HBr, 6-hydroxy-; Ascorbate; Saline; CSF/CNS (visual cortex); cat (kitten); 2001; 1 week; Multiple pumps per animal (2); 1st pump contained agent and infused into one hemisphere, 2nd pump contained the vehicle only and infused the other hemisphere.
P0378 Costall,B., Domeney,A.M., Naylor,R.J. A comparison of the behavioural consequences of chronic stimulation of dopamine receptors in the nucleus accumbens of rat brain effected by a continuous infusion or by single daily injections. Naunyn-Schmiedeberg's Arch.Pharmacol. 1983; 324(--):27-33. >>> Dopamine HCl; Nitrogen; Sodium metabisulfite; CSF/CNS (nucleus accumbens); rat; 13 days; mp model not stated; comparison of injection vs. mp infusion; no stress - p. 28; multiple pumps per animal (2); pumps primed overnight before implantation.
P0321 Daw,N.W., Rader,R.K., Robertson,T.W., Ariel,M. Effects of 6-hydroxydopamine on visual deprivation in the kitten striate cortex. J.Neurosci. 1983; 3(-5-):907-914. >>> Dopamine, 6-hydroxy-; Ascorbate; Saline; CSF/CNS (occipital cortex); cat (kitten); 2001; 1 week; no comment posted.
P0305 Bear,M.F., Paradiso,M.A., Schwartz,M., Nelson,S.B., Carnes,K.M., Daniels,J.D. Two methods of catecholamine depletion in kitten visual cortex yield different effects on plasticity. Nature 1983; 302(--):245-247. >>> Dopamine, 6-hydroxy-; Ascorbate; Saline; CSF/CNS (visual cortex); cat (kitten); 1 week; comparison of injection vs. infusion; multiple pumps per animal (2).
P0440 Costall,B., Domeney,A.M., Naylor,R.J. Behavioral and biochemical consequences of persistent overstimulation of mesolimbic dopamine systems in the rat. Neuropharmacology 1982; 21(--):327-335. >>> Dopamine HCl; Nitrogen; Sodium metabisulfite; CSF/CNS (nucleus accumbens); rat; 2002; 13 days; no stress p. 328, 333; 2 pumps implanted simultaneously, bilaterally; pumps primed overnight; post-infusion N-propylnorapomorphine challenge.
P0156 Kasamatsu,T., Pettigrew,J.D., Ary,M. Cortical recovery from effects of monocular deprivation: acceleration with norepinephrine and suppression with 6-hydroxydopamine. J.Neurophysiol. 1981; 45(-2-):254-266. >>> Dopamine HBr, 6-hydroxy-; Norepinephrine HCl, l-; Saline; CSF/CNS (visual cortex); cat (kitten); no duration posted; no comment posted.
P0138 Kasamatsu,T., Itakura,T., Jonsson,G. Intracortical spread of exogenous catecholamines: effective concentration for modifying cortical plasticity. J.Pharmacol.Exp.Ther. 1981; 217(-3-):841-850. >>> Dopamine HBr, 6-hydroxy-; Norepinephrine HCl; Radio-isotopes; 3H tracer; Ascorbate; Saline; CSF/CNS (visual cortex); cat; cat (kitten); 1701; 1, 3,&7 days; no comment posted.
P0033 Kasamatsu,T., Pettigrew,J.D., Ary,M. Restoration of visual cortical plasticity by local microperfusion of norepinephrine. J.Comp.Neurol. 1979; 185(-1-):163-181. >>> Dopamine, 6-hydroxy-; Norepinephrine; Radio-isotopes; 3H tracer; Ascorbate; Saline; CSF/CNS (visual cortex); cat (kitten); no duration posted; pumps replaced after 1 week.
P0007 Pettigrew,J.D., Kasamatsu,T. Local perfusion of noradrenaline maintains visual cortical plasticity. Nature 1978; 271(-5647-):761-763. >>> Norepinephrine; dopamine, 6-hydroxy-; saline; ascorbate; CSF/CNS (visual cortex); cat (kitten); 1701; 7 days; controls received mp with vehicle in other visual cortex; multiple pumps per animal (2); pump/cannula schematic P. 762, Fig. 1.
6. Dopexamine
P6552 Oberbeck,R., Schmitz,D., Schueler,M., Wilsenack,K., Schedlowski,M., Exton,M. Dopexamine and cellular immune functions during systemic inflammation. Immunobiology 2004; 208(-5-):429-438. >>> Dopexamine; dopamine; IP; Mice; 48 hours; Controls received saline&sham operation; immunology; polymicrobial sepsis induced cecal ligation&puncture (CLP).
P2831 Martin,S.W., Broadley,K.J. Effects of chronic intraveneous infusions of dopexamine and isoprenaline to rats on D1-, B1- and B2-receptor-mediated responses. Br.J.Pharmacol. 1994; 112(--):595-603. >>> Dopexamine; Isoprenaline; Saline; EDTA; HCl; IV (jugular); rat; 2ML1; 7 days; controls received mp with saline.
7. Fenoldopam
P3071 Nichols,A.J., Koster,P.F., Brooks,D.P., Ruffolo Jr,R.R. Effect of fenoldopam on the acute and subacute nephrotoxicity produced by amphotericin B in the dog. J.Pharmacol.Exp.Ther. 1992; 260(-1-):269-274. >>> Fenoldopam mesylate; Water, distilled; Citric acid; Propylene glycol; Sodium metabisulfate; IV (jugular); dog; 2ML2; no duration posted; controls received mp with vehicle; multiple pumps per animal (2).
P1466 Winkler,J., Weiss,B. Effect of continuous exposure to selective D1 and D2 dopaminergic agonists on rotational behavior in supersensitive mice. J.Pharmacol.Exp.Ther. 1989; 249(-2-):507-516. >>> CY-208-243; Fenoldopam; N-0437; SKF-75670; Quinpirole; SKF-38393; Ascorbic acid; DMSO; Water; SC; mice; 2001; 7 days; Dopamine agonists; comparison of sc injections vs. mp infusion; stability verified in vitro at 37 degrees for 7 days.
8. Haloperidol
P8279 Lin,E.J.D., Lee,N.J., Slack,K., Karl,T., Duffy,L., O'Brien,E., Matsumoto,I., Dedova,I., Herzog,H., Sainsbury,A. Distinct endocrine effects of chronic haloperidol or risperidone administration in male rats. Neuropharmacology 2006; 51(-7-8-):1129-1136. >>> Haloperidol; risperidone; Acetic acid; SC; Rat; 2ML4; 28 days; Controls received mp w/ vehicle; no stress (see pg. 1131); half-life (p. 1131) 4-6 times shorter in rodents than in humans; post op. care (bupivicaine); animal info (male, Sprague-Dawley, 9-10 weeks old, 280-430 grams); "This dosing regimen also takes into consideration the reported 4-6 times shorter half-life of antipsychotic drugs in rodents than humans and highlights the advantage of using minipumps in the present study for continuous drug administration to achieve receptor occupancies comparable to clinical use in humans." (p. 1131).
P7448 Li,M., Budin,R., Fleming,A.S., Kapur,S. Effects of chronic typical and atypical antipsychotic drug treatment on maternal behavior in rats. SCHIZOPHRENIA RESEARCH 2005; 75(-2-3-):325-336. >>> Haloperidol; olanzapine; Water, double distilled; acetic acid, glacial; SC; Rat; 2ML4; 3 weeks; Controls received mp w/ vehicle; functionality of mp verified by plasma drug levels; comparison of daily SC injections vs. mp; tolerance; animal info (female, Sprague-Dawley, 60-100 day old, postpartum, 250-380 g).
P7421 Siegel,S.J., Maxwell,C.R., Majumdar,S., Trief,D.F., Lerman,C., Gur,R.E., Kanes,S.J., Liang,Y. Monoamine reuptake inhibition and nicotine receptor antagonism reduce amplitude and gating of auditory evoked potentials. Neuroscience 2005; 133(-3-):729-738. >>> Bupropion, HCL; haloperidol; Water; SC; Mice; 1002; 12 days; Controls received mp w/ vehicle; animal info (C57BL/6J, 10-16 weeks old).
P7334 Turrone,P., Remington,G., Kapur,S., Nobrega,J.N. Continuous but not intermittent olanzapine infusion induces vacuous chewing movements in rats. Biological Psychiatry 2005; 57(-4-):406-411. >>> Haloperidol; olanzapine; SC; Rat; 2ML4; 8 weeks; Controls received mp w/ vehicle; comparison of injections vs. mp; long-term study; pumps replaced every four weeks in a new incision; post op. care (placed in heated plexiglass cage); wound clips and vetbond were used to close incision.
P7312 Zhou,R., Gray,N.A., Yuan,P.X., Li,X.X., Chen,J.S., Chen,G., mschroder-Williams,P., Du,J., Zhang,L., Manji,H.K. The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers. Journal of Neuroscience 2005; 25(-18-):4493-4502. >>> Amphetamine; fluvoxamine; haloperidol; Water; ethanol; SC; Rat; 2ML4; 3 weeks; Functionality of mp verified by residual volume; 50% ethanol used [not suggested by ALZET].
P7254 Kippin,T.E., Kapur,S., van der Kooy,D. Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs. Journal of Neuroscience 2005; 25(-24-):5815-5823. >>> Haloperidol; domperidone; water, distilled; saline; SC; Rat; mice; 1002; 2ML2; 2ML4; 14, 30 days; Controls received mp w/ vehicle; functionality of mp verified by plasma drug levels; dose-response (fig. 1); comparison of ip injections vs. mp; dopamine D2 receptor antagonist.
P6365 Turrone,P., Remington,G., Kapur,S., Nobrega,J.N. Differential effects of within-day continuous vs transient dopamine D2 receptor occupancy in the development of vacuous chewing movements (VCMs) in rats. Neuropsychopharmacology 2003; 28(-8-):1433-1439. >>> Haloperidol; SC; Rat; 2ML4; 8 weeks; Haloperidol plasma levels taken; comparison of SC injections vs. SC mp; long-term study; pumps replaced every 4 weeks; Vetbond glue and wound clips used to close wounds; "...minipump treated animals had stable haloperidol plasma levels throughout the day...subcutaneously [injection] treated rats experienced a dramatic decline over the same period." p. 1437.
P6201 Cochran,S.M., Kennedy,M., McKerchar,C.E., Steward,L.J., Pratt,J.A., Morris,B.J. Induction of metabolic hypofunction and neurochemical deficits after chronic intermittent exposure to phencyclidine: Differential modulation by antipsychotic drugs. Neuropsychopharmacology 2003; 28(-2-):265-275. >>> Clozapine; haloperidol; Acetic acid, glacial; water; SC; Rat; 2ML4; 21 days; Controls received mp w/ vehicle.
P6169 Kapur,S, Susan C. Antipsychotic Dosing in Preclinical Models is Often Unrepresentative of the Clinical Condition: A Suggested Solution Based on in Vivo Occupancy. Journal of Pharmacology and Experimental Therapeutics 2003; 305(-2-):625-631. >>> Haloperidol; olanzapine; risperidone; quetiapine; clozapine; Water; acetic acid, glacial; SC; Rat; 2ML2; 7 days; Plasma levels taken; dose-response (p. 629); comparison of daily injections vs. chronic mp; half-life (p. 626) 2-4 hours; haloperidol and risperidone were dissolved in distilled water; olanzapine, quetiapine and clozapine were dissolved in 1% to 2% acetic acid; great dose information; "we propose that only administration by pump (or administration more than four times a day[injections]) can provide clinical-like occupancies for haloperidol, olanzapine, and risperidone." p. 630.
P6604 Marino,M.J., Awad-Granko,H., Ciombor,K.J., Conn,P.J. Haloperidol-induced alteration in the physiological actions of group I mGlus in the subthalamic nucleus and the substantia nigra pars reticulata. Neuropharmacology 2002; 43(-2-):147-159. >>> Haloperidol; Lactic acid; NaOH; saline; SC; Rat (neonate); 2001; 16 hours; Cyanoacrylate adhesive applied over sutures; animal info (15-18 days old, 20-37 grams).
P4958 Powell,K.R., Iuvone,P.M., Holtzman,S.G. The role of dopamine in the locomotor stimulant effects and tolerance to these effects of caffeine. Pharmacology Biochemistry and Behavior 2001; 69(--):59-70. >>> Haloperidol; SC; rat; 2ML2; 14 days; controls received sham pumps; tolerance; caffeine tolerance.
P4835 Andersen,M.P., Pouzet,B. Effects of acute versus chronic treatment with typical or atypical antipsychotics on d-amphetamine-induced sensorimotor gating deficits in rats.. Psychopharmacology 2001; 156(--):291-304. >>> Haloperidol; Olanzapine; Sertindole;; Saline; HCl; Tartaric acid;; SC;; rat;; 2ML4;; 21 days;; Controls received mp w/ vehicle; functionality of mp verified by drug plasma levels (" ... the continuous infusion via mini-pumps is certainly the most relevant way to mimic conditions of treatment in clinic." p. 302); dose response (p. 302); comparison of SC injections vs. mp; half-life (p. 293); compared acute, subchronic (3 day) vs chronic (21 day) treatment; oral administration also examined; antipsychotics; schizophrenia; neurodegenerative (Huntington's disease); Olanzapine and sertindole were dissolved in a minimum amount of dilute HCl before dilution in saline; Haloperidol dissolved in minimal amount of dilute tartaric acid before final dilution in 0.9% saline;.
P4765 Martinez,Z.A., Oostwegel,J, Geyer,M.A., Ellison,G.D., Swerdlow,N.R. "Early" and "Late" effects of sustained haloperidol on apomorphine- and phencyclidine-induced sensorimotor gating deficits.. Neuropsychopharmacology 2000; 23(-5-):517-527. >>> Haloperidol;; Saline;; SC;; rat;; 28-day pump;; 28, 49 days;; Controls received mp w/ vehicle or sham pump; pumps replaced after 28 days; Schizophrenia; Haloperidol is a high-potency dopamine antagonist (D2 receptor); antipsychotic drugs; rats were housed singly to prevent excessive perturbation of the pumps; sham pumps consisted of silastic polymer pellets of approx. the same size and shape as minipumps..
P5292 Kaplan,G.B., Leite-Morris,K.A., Keith,D.J. Differential effects of treatment with typical and atypical antipsychotic drugs on adenylyl cyclase and G proteins. Neurosci.Lett. 1999/10/8; 273(-3-):147-150. >>> Haloperidol; Olanzapine; PEG; SC; Mice; 2002; 14 days; Controls received mp w/ vehicle; atypical antipsychotics; 2001 pump model listed, but release rate given as 0.5 ul/hr.
P3459 Bergeron,R., de Montigny,C., Debonnel,G. Effect of short-term and long-term treatments with sigma ligands on the N-methyl-D-aspartate response in the CA(3) region of the rat dorsal hippocampus. Br.J.Pharmacol. 1997; 120(--):1351-1359. >>> Haloperidol; JO-1784; Pentazocine; DTG; SC; rat; 2-21 days; controls received mp w/saline; DTG is di(2-tolyl)guanidin.
P2833 Merchant,K.M., Dobie,D.J., Filloux,F.M., Totzke,M., Aravagiri,M., Dorsa,D.M. Effects of chronic haloperidol and clozapine treatment on neurotensin and c-fos mRNA in rat neostriatal subregions. J.Pharmacol.Exp.Ther. 1994; 271(-1-):460-471. >>> Haloperidol; Clozapine; SC; rat; 2ML2; 28 days; controls received mp with saline; pumps replaced at 14 days.
P2611 Alberch,J., Arenas,E., Perez-Navarro,E., Marsal,J. Control of tachykinin-evoked acetylcholine release from rat striatal slices by dopaminergic neurons. Naunyn-Schmiedeberg's Arch.Pharmacol. 1993; 348(--):445-449. >>> Haloperidol; SCH-23390; SC; rat; 14 days; controls received mp w/ saline.
P2204 Ericson,H., Ross,S.B. Subchronic treatment of rats with remoxipride fails to modify sigma binding sites in the brain. Eur.J.Pharmacol.- Mol.Pharmacol.Sect. 1992; 226(--):157-161. >>> Remoxipride HCl; Haloperidol; Water; Acetic acid; SC; rat; 3,14 days; controls received sham operations.
P3085 Yamada,T., Hirayama,K., Kimura,H. Differential responses of noradrenaline and dopamine neurons in the mouse forebrain induced by continuous parenteral infusion of haloperidol. Eur.Neurol. 1991; 31(-Supl1-):28-33. >>> Haloperidol; Lactic acid; IP; mice; 2001; 1 week; controls received mp with vehicle; multiple pumps per animal (2).
P2717 Konings,P.N.M., Culling-Berglund,A., Davis,T.P. Chronic haloperidol and chlorpromazine treatment alters in vitro B-endorphin metabolism in rat brain. Eur.J.Pharmacol. 1990; 191(--):115-128. >>> Haloperidol; Chlorpromazine; Saline, sterile; SC; rat; 2001; 2ML1; 8 days; controls received mp w/ vehicle.
P1802 See,R.E., Ellison,G. Intermittent and continuous haloperidol regimens produce different types of oral dyskinesias in rats. Psychopharmacology 1990; 100(--):404-412. >>> Haloperidol; Acetic acid; Sodium hydroxide; Water; SC; rat; 2ML4; 28 days; controls received an empty plastic pellet of identical size.
P1706 See,R.E., Ellison,G. Comparison of chronic administration of haloperidol and the atypical neuroleptics, clozapine and raclopride, in an animal model of tardive dyskinesia. Eur.J.Pharmacol. 1990; 181(--):175-186. >>> Clozapine; Haloperidol; Raclopride; Acetic acid, glacial; HCl; Sodium hydroxide; Water; SC; rat; 2ML4; 28 days; controls received an empty plastic pellet of identical size.
P1444 Ueda,H. Time course study of changes in the activity of rats during intraventricular infusion of 6-hydroxydopamine, haloperidol and sulpiride: a study of the relationship between an origin of the negative symptoms in schizophrenia and catecholamines. J.Iwate Med.Assoc. 1988; 40(-3-):385-398. >>> Dopamine, 6-hydroxy-; Haloperidol; Sulpiride; CSF/CNS; rat; 8 days; Japanese, English abstract.
P1345 Tanaka,M., Morimasa,T., Kaneyuki,T., Shohmori,T. Dopaminergic activity and met-enkephaline levels in the rat striatum after continuous treatment with various dopaminergic agents. Neuroscience 1988; 14(--):114-116. >>> Apomorphine; Haloperidol; Methamphetamine; SC; rat; 2 weeks; japanese with english abstract.
P1137 Davis,T.P., Culling-Berglund,A. Neuroleptic drug treatment alters in vitro central neurotensin metabolism. Psychoneuroendocrinology 1987; 12(-4-):253-260. >>> Chlorpromazine; Haloperidol; SC; rat; 2001; 2ML1; 8 days; controls received sham op; concomitant infusion of agents; comparison of agents effects; functionality of mp verified by gravimetric analyses.
P0595 George,S., Kertesz,M. Met-enkephalin concentrations in straitum respond reciprocally to alterations in dopamine neurotransmission. Peptides 1987; 8(-3-):487-492. >>> Apomorphine; FK-33824; Haloperidol; Naloxone; Ethanol; Tartaric acid; Water; SC; rat; 5, 9 days; mp model not stated; controls received mp w/unspecified vehicle or were sham-operated; agents infused separately w/appropriate vehicle; comparison of sc inject. vs. mp infusion.
P0838 Matsuda,L.A., Schmidt,C.J., Hanson,G.R., Gibb,J.W. Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal tyrosine hydroxylase and tryptophan hydroxylase in rat. Neuropharmacology 1986; 25(-3-):249-255. >>> Haloperidol; MPTP; Water; SC; rat; 2ML1; 24 hours; same mp used in many animals; sc space around mp filled w/saline to facilitate pump action; controls received mp w/vehicle; see also P568.
P0908 Frey,P. Changes in cholecystokinin content in rat brain after subchronic treatment with neuroleptics. Ann.N.Y.Acad.Sci. 1985; 448(--):601-603. >>> Flupenthixol, cis-; Flupenthixol, trans-; Amitriptyline; Amphetamine; Atropine; Chlorpromazine; Clozapine; Fluphenazine; Haloperidol; Morphine; Prazosin; SC; rat; 2 weeks; mp model not stated; comparison of sc injections vs. mp infusion; antihypertensive.
P0813 McMillen,B.A. Comparative chronic effects of buspirone or neuroleptics on rat brain dopaminergic neurotransmission. J.Neural Transm. 1985; 64(-1-):1-12. >>> Buspirone-HCl; Haloperidol; SC; rat; 2 weeks; mp model not stated; comparison of chronic administration in drinking water vs. mp infusion; stability of agent; toxicology.
P0623 McMillen,B.A. Acute and subchronic effects of MJ-13859, a potential antipsychotic drug, on rat brain dopaminergic function. J.Pharmacol.Exp.Ther. 1985; 233(-2-):369-375. >>> Haloperidol; MJ-13859; SC; rat; 2 weeks; mp model not stated; comparison of agents effects; comparison of ip or sc injection vs. mp infusion; controls had an incision only; 2 doses MJ-13859 infused; MJ-13859 is an antipsychotic.
P0556 Gysling,K., Beinfeld,M.C. Failure of chronic haloperidol treatment to alter levels of cholecystokinin in the rat brain striatum and olfactory tubercle-nucleus accumbens area. Neuropeptides 1984; 4(-5-):421-423. >>> Haloperidol; Saline; SC; rat; 2ML4; 2 weeks; comparison of daily sc injec vs. mp infusion; stability of residual Hal. verified by HPLC; peptides.
P0465 Le Douarin,C., Fage,D., Scatton,B. Effects of cyclo (Leu-Gly) on neurochemical indices of striatal dopaminergic supersensitivity induced by prolonged haloperidol treatment. Life Sci. 1984; 34(-4-):393-399. >>> Haloperidol; SC; rat; 2002; 2 weeks; concomitant deliv. cyclo (Leu-Gly).
P0447 Davis,T.P., Schoemaker,H., Culling,A.J. Centrally acting drugs alter in vitro B-endorphin processing in the rat. Eur.J.Pharmacol. 1984; 100(--):249-251. >>> Chlorpromazine; haloperidol; phenobarbital; promethazine; SC; Rat; 2001; 8 days; Comparison of agents effects.
P0420 Scatton,B., Fage,D. Hypophysectomy fails to affect the supersensitivity of striatal dopamine target cells induced by prolonged haloperidol treatment. Eur.J.Pharmacol. 1984; 98(--):1-7. >>> Haloperidol; SC; rat; 2002; 2 weeks; no comment posted.
P0472 Joseph,J.A., Bartus,R.T., Clody,D., Morgan,D., Finch,C., Beer,B., Sesack,S. Psychomotor performance in the senescent rodent: reduction of deficits via striatal dopamine receptor up-regulation. Neurobiol.Aging 1983; 4(-4-):313-319. >>> Haloperidol; HCl; Water; SC; rat; 2 weeks; 2 pumps/animal.
P0385 Frey,P. Cholecystokinin octapeptide levels in rat brain are changed after subchronic neuroleptic treatment. Eur.J.Pharmacol. 1983; 95(--):87-92. >>> Chlorpromazine; Clozapine; Haloperidol; HCl; Saline; SC; rat; 2ML2; 2ML4; 2 and 4 weeks; comparison of single injec vs. infusion; comparison of agents effects; Hal. given for 2&4 weeks, Chlor.&Cloz. for 2 weeks; saline&HCl vehicle used w/Cloz., others used saline only; stability of Hal., Chlor.&Cloz. by TLC.
P0371 Le Douarin,C., Oblin,A., Fage,D., Scatton,B. Influence of lithium on biochemical manifestations of striatal dopamine target cell supersensitivity induced by prolonged haloperidol treatment. Eur.J.Pharmacol. 1983; 93(--):55-62. >>> Haloperidol; SC; rat; 2002; 2 weeks; no comment posted.
P0301 Chang,R.S.L., Lotti,V.J., Martin,G.E., Chen,T.B. Increase in brain 125I-cholecystokinin (CCK) receptor binding following chronic haloperidol treatment, intracisternal 6-hydroxydopamine or ventral tegmental lesions. Life Sci. 1983; 32(--):871-878. >>> Haloperidol; SC; guinea-pig; mice; 2002; 2ML2; 8-21 days; 2002 in mice, 2ML2 in GP.
P0208 Kapetanovic,I.M., Sweeney,D.J., Rapoport,S.I. Age effects on haloperidol pharmacokinetics in male, Fischer-344 rats. J.Pharmacol.Exp.Ther. 1982; 221(-2-):434-438. >>> Haloperidol; Acetic acid; IP; rat; 4 days; comparison of bolus ip injection vs. infusion.
P0166 Login,I.S., Nagy,I., MacLeod,R.M. Restoration of pituitary prolactin synthesis and release by the administration of morphine to rats bearing a transplanted prolactin-secreting tumor. Neuroendocrinology 1981; 33(-2-):101-104. >>> Haloperidol; Morphine sulfate; Lactic acid; Saline; Water; SC; rat; 1701; 4 days; cancer.
9. L-dopa
P7751 Bilbao,G., Ruiz-Ortega,J.A., Miguens,N., Ulibarri,I., Linazasoro,G., Gomez-Urquijo,S., Garibi,J., Ugedo,L. Electrophysiological characterization of substantia nigra dopaminergic neurons in partially lesioned rats: Effects of subthalamotomy and levodopa treatment. Brain Research 2006; 1084(--):175-184. >>> L-DOPA; benserazide; Water, distilled; SC; Rat; 2ML2; 14 days; Enzyme inhibitor (dopadecarboxylase); neurodegenerative (Parkinson's disease); animal info (male, albino Sprague-Dawley, 150-175g); nigrostriatal pathway lesions.
P6896 Fornai,F., Schlueter,O.M., Lenzi,P., Gesi,M., Ruffoli,R., Ferrucci,M., Lazzeri,G., Busceti,C.L., Pontarelli,F., Battaglia,G., Pellegrini,A., Nicoletti,F., Ruggieri,S., Paparelli,A., Suedhof,T.C. Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and alpha-synuclein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2005; 102(-9-):3413-3418. >>> MPTP; L-dopa; apomorphine; IP; SC; Mice; 2004; 1-28 days; Controls received mp w/ saline; comparison of IP injections vs. mp; neurodegenerative (Parkinson's disease); L-dopa and apomorphine group had SC implanted pumps; route is unclear for the MPTP group; "Continuous MPTP infusions thus recreate a disease state that mimics human PD better than acute MPTP bolus injections." (p. 3417); MPTP group received IP pumps (2004 model), verified by e-mailing author.
P6820 Hoglinger,G.U., Rizk,P., Muriel,M.P., Duyckaerts,C., Oertel,W.H., Caille,I., Hirsch,E.C. Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nature Neuroscience 2004; 7(-7-):726-735. >>> L-dopa, methyl ester; Benserazide; ascorbic acid; SC; Rat; 2ML4; 3 weeks; Neurodegenerative (Parkinson's disease).
P5969 Kemmerer,E.S., Desmond,T.J., Albin,R.L., Kilbourn,M.R., Frey,K.A. Treatment effects on nigrostriatal projection integrity in partial 6-OHDA lesions: comparison of L-DOPA and pramipexole. Experimental Neurology 2003; 183(-1-):81-86. >>> L-dopa; benserazide; prazosin; IP; Rat; 2ML4; 4 weeks; Neurodegenerative (Parkinson's disease).
P5834 Caprile,T., Hein,S., Rodriguez,S., Montecinos,H., Rodriguez,E. Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid. MOLECULAR BRAIN RESEARCH 2003; 110(-2-):177-192. >>> Serotonin, binoxaiate; Norepinephrine; serotonin trifluoroacetate; Serotonin creatinin sulfate; L-DOPA; CSF, artificial; radio-isotopes; 3H tracer; CSF/CNS; Rat; 2001; 7 days.
P3515 Trugman,J.M., Hubbard,C.A., Bennett Jr,J.P. Dose-related effects of continuous levodopa infusion in rats with unilateral lesions of the substantia nigra. Brain Research 1996; 725(--):177-183. >>> L-DOPA methyl ester; Benserazide; Water; SC; rat; 2001D; 22 hours; dose response; comparison of injections vs. mp made based upon published studies administering L-dopa by injection.
P3178 Vander Borght,T., Kilbourn,M., Desmond,T., Kuhl,D., Frey,K. The vesicular monoamine transporter is not regulated by dopaminergic drug treatments. Eur.J.Pharmacol. 1995; 294(--):577-583. >>> Apomorphine; L-DOPA methyl ester; Benserazide; Tetrabenazine; Ascorbic acid; Propylene glycol; SC; rat; 2ML2; 2 weeks; controls received mp with propylene glycol; 2 mps used to deliver apomorphine.
P2582 Inglis,G.C., Kenyon,C.J. Effects of long-term infusions of dopa and carbidopa on renin and steroid secretion in the rat. Endocrinology 1992; 131(-6-):2941-2945. >>> L-DOPA; Carbidopa; HCl; SC; rat; 2002; 2 weeks; controls received mp w/ vehicle; agents given separately and together.
P2252 Engber,T.M., Susel,Z., Kuo,S., Gerfen,C.R., Chase,T.N. Levodopa replacement therapy alters enzyme activities in striatum and neuropeptide content in striatal output regions of 6-hydroxydopamine lesioned rats. Brain Research 1991; 552(-1-):113-118. >>> L-dopa; Benserazide; Saline; IP; rat; 2ML2; 21 days; controls received mp w/saline; functionality of mp verified upon removal; comparison of intermittent IP injections vs mp.
P1800 Engber,T.M., Susel,Z., Kuo,S., Chase,T.N. Chronic levodopa treatment alters basal and dopamine agonist-stimulated cerebral glucose utilization. J.Neurosci. 1990; 10(-2-):3889-3895. >>> L-DOPA; IP; rat; 2ML2; 19 days; dose-response (table, p. 3892); comparison of bid injections vs. mp; 'levodopa replacement by continuous infusion may be more physiological than oral intermittent therapy.' (p. 3895).
P1648 Engber,T.M., Susel,Z., Juncos,J.L., Chase,T.N. Continuous and intermittent levodopa differentially affect rotation induced by D-1 and D-2 dopamine agonists. Eur.J.Pharmacol. 1989; 168(--):291-298. >>> L-DOPA; IP; rat; 19 days; functionality of mp verified by blood levels; comparison of IP injections b.i.d. vs. mp.
P0740 Stromberg,I., Herrera-Marschitz,M., Ungerstedt,U., Ebendal,T., Olson,L. Chronic implants of chromaffin tissue into the dopamine-denervated striatum. Effects of NGF on graft survival, fiber growth and rotational behavior. Exp.Brain Research 1985; 60(-2-):335-349. >>> Dopamine; L-DOPA; Nerve growth factor; Saline; CSF/CNS (corpus striatum); rat; 2002; 28 days; comparison of injections vs. mp infusion; mp replaced after 14 days; mp connected to cannula in striatum mounted w/dialysis fiber; l-dopa&dopamine used only to test fiber; 6-OHDA lesions.
10. Lisuride
P1446 Garcia de Yebenes,J., Fahn,S., Mena,M.A., Pardo,B., Casarejos,M.J. Intracerebroventricular infusion of dopamine and its agonists in rodents and primates. ASAIO Transactions 1988; 34(--):951-957. >>> Dopamine; Lisuride; Pergolide; Hydroxynaphthoxacine, 4-propyl-9-; HCl; Water; CSF/CNS; rat; 1, 2 weeks; PHNO is dopamine D-2 receptor agonist;.
P1320 Wachtel,H., Rettig,K.-J., Loschmann,P.-A. Effect of chronic subcutaneous minipump infusion of lisuride upon locomotor activity of rats. J.Neural Transm. 1988; 27(--):177-183. >>> Lisuride; Saline; Tartaric acid; SC; rat; 2002; 14 days; stability.
P1313 de Yebenes,J.G., Fahn,S., Jackson-Lewis,V., Jorge,P., Mena,M.A., Reiriz,J. Continuous intracerebroventricular infusion of dopamine and dopamine agonists through a totally implanted drug delivery system in animal models of Parkinson's disease. J.Neural Transm. 1988; 27(--):141-160. >>> Deprenyl; Dopamine; Lisuride; Pargyline; Pergolide; HCl; Sodium metabisulfite; Water; CSF/CNS; rat; 2001; 6, 7 days; mp connected to cannula; stability of DA verified in several vehicles, p 146; concomitant DA infusion with pargyline; DA infusion with deprenyl; replacement therapy (dopamine deficiency); stability verified in vitro; antihypertensive; neurodegenerative (Parkinson's disease).
P2709 de Yebenes,J.G., Fahn,S., Lovelle,S., Jackson-Lewis,V., Jorge,P., Mena,M.A., Reiriz,J., Bustos,J.C., Magarinos,C., Martinez,A. Continuous intracerebroventricular infusion of dopamine and dopamine agonists through a totally implanted drug delivery system in animal models of Parkinson's disease. Movement Disorders 1987; 2(-3-):143-158. >>> Dopamine; Pargyline; Deprenyl; Lisuride; Pergolide; HCl; Sodium metabisulfate; CSF/CNS; rat; 2001; 6,7 days; controls received mp with vehicles; replacement therapy (lesion in dopamine pathway); stability verified for 1 week by measuring dopamine concentrations and its metabolites at varying time intervals with HPLC; concomitant dopamine infusion w/ pargyline and w/ deprenyl; antihypertensive; neurodegenerative (Parkinson's disease).
11. Metoclopramide
P0391 Aguilera,G., Catt,K.J. Dopaminergic modulation of aldosterone secretion in the rat. Endocrinology 1984; 114(-1-):176-181. >>> Angiotensin II; Dopamine; Metoclopramide; IP; IV; rat; 2 days; simultaneous administration of MCP (iv) w/ AII (ip), and MCP (iv) w/ DOP (iv); MCP and AII also infused alone, all by mp; peptides.
P0124 Chan,V., Katikineni,M., Davies,T.F., Catt,K.J. Hormonal regulation of testicular luteinizing hormone and prolactin receptors. Endocrinology 1981; 108(-5-):1607-1612. >>> Metoclopramide; IP; rat; 7 days; no comment posted.
12. Nafadotride, (5)-bromocriptine-
P3446 Azaryan,A.V., Clock,B.J., Cox,B.M. Mu opioid receptor mRNA in nucleus accumbens is elevated following dopamine receptor activation. Neurochem.Res. 1996; 21(-11-):1411-1415. >>> Hydrobromide, R(+)-6-bromo-APB-SKF-38393; Nafadotride, (5)-bromocriptine; Cocaine HCl; Saline; rat; 2ML1; 3 days; controls received mp w/ saline.
13. PHNO
P5258 Ruzich,M., Martin-Iverson,M.T. Pinealectomy blocks stress-induced motor stimulation but not sensitization and tolerance to a dopamine D2 receptor agonist. Psychopharmacology (Berl) 2000/10; 152(-3-):275-282. >>> Hydroxynaphthoxacine, 4-propyl-9-; Water, distilled; SC; Rat; 2002; 12 days; Controls received mp w/ vehicle; good methods (p.276-77); tolerance; PHNO is a selective dopamine D2 receptor antagonist; "The advantages of using a continuous drug regimen are that sensitization and tolerance are produced independently of the confounding influences..." (p.275).
P4536 Munro,J.D, Martin-Iverson,M.T. Circadian rhythm-dependent development of melatonin effects and tolerance to PHNO in rats.. Pharmacology Biochemistry and Behavior 2000; 65(-3-):495-501. >>> Hydroxynaphthoxacine, 4-propyl-9-;; Water, distilled;; SC;; rat;; 2002;; 12 days;; controls received mp w/vehicle; tolerance; PHNO is a selective dopamine D2 receptor agonist.
P1884 Alexander,G.M., Brainard,D.L., Gordon,S.W., Hichens,M., Grothusen,J.R., Schwartzman,R.J. Dopamine receptor changes in untreated and (+)-PHNO-treated MPTP parkinsonian primates. Brain Research 1991; 547(--):181-189. >>> Hydroxynaphthoxacine, 4-propyl-9-; SC; monkey; 7, 30, 40 days; Neurodegenerative (Parkinson's disease); PHNO is dopamine D-2 receptor agonist.
P1557 Martin-Iverson,M.T., Stahl,S.M., Iversen,S.D. Chronic administration of a selective dopamine D-2 agonist: factors determining behavioral tolerance and sensitization. Psychopharmacology 1988; 95(--):534-539. >>> Hydroxynaphthoxacine, 4-propyl-9-; SC; rat; 2002; 11-15 days; 12 hours (intermittently); comparison of injections vs. mp infusion; functionality of mp verified in vitro; pulsed delivery using coiled tubing, intermittent inert placebo, 12h 'on' and 12h 'off'; PHNO is dopamine D-2 receptor agonist.
P1446 Garcia de Yebenes,J., Fahn,S., Mena,M.A., Pardo,B., Casarejos,M.J. Intracerebroventricular infusion of dopamine and its agonists in rodents and primates. ASAIO Transactions 1988; 34(--):951-957. >>> Dopamine; Lisuride; Pergolide; Hydroxynaphthoxacine, 4-propyl-9-; HCl; Water; CSF/CNS; rat; 1, 2 weeks; PHNO is dopamine D-2 receptor agonist;.
P1233 Martin-Iverson,M.T., Iverson,S.D., Stahl,S.M. Long-term motor stimulant effects of (+) -4-propyl-9-hydroxynaphthoxazine (PHNO), a dopamine D-2 receptor agonist: interactions with a dopamine D-1 receptor antagonist and agonist. Eur.J.Pharmacol. 1988; 149(--):25-31. >>> Hydroxynaphthoxacine, 4-propyl-9-; SCH-23390; Water; SC; rat; 2002; 11 days; controls received mp w/water; multiple pumps per animal (2); separate and simultaneous infusion of agents; PHNO is a dopamine antagonist.
P1207 de Yebenes,J.G., Fahn,S., Jackson-Lewis,V., Mena ,M.A. The effect of intracerebroventricular infusion of (+)-4-propyl-9-hydroxynapthoxacine (PHNO) through a totally implanted drug delivery system in rats with dopamine deficiency. Movement Disorders 1987; 2(-4-):291-299. >>> Hydroxynaphthoxacine, 4-propyl-9-; HCl; CSF/CNS; rat; 2001; 2002; 2ML4; 7, 14 days; PHNO is a dopamine antagonist; mp connected to cannula; concomitant apomorphine administration in some animals, reserpine in the others.
14. Pergolide
P1446 Garcia de Yebenes,J., Fahn,S., Mena,M.A., Pardo,B., Casarejos,M.J. Intracerebroventricular infusion of dopamine and its agonists in rodents and primates. ASAIO Transactions 1988; 34(--):951-957. >>> Dopamine; Lisuride; Pergolide; Hydroxynaphthoxacine, 4-propyl-9-; HCl; Water; CSF/CNS; rat; 1, 2 weeks; PHNO is dopamine D-2 receptor agonist;.
P1313 de Yebenes,J.G., Fahn,S., Jackson-Lewis,V., Jorge,P., Mena,M.A., Reiriz,J. Continuous intracerebroventricular infusion of dopamine and dopamine agonists through a totally implanted drug delivery system in animal models of Parkinson's disease. J.Neural Transm. 1988; 27(--):141-160. >>> Deprenyl; Dopamine; Lisuride; Pargyline; Pergolide; HCl; Sodium metabisulfite; Water; CSF/CNS; rat; 2001; 6, 7 days; mp connected to cannula; stability of DA verified in several vehicles, p 146; concomitant DA infusion with pargyline; DA infusion with deprenyl; replacement therapy (dopamine deficiency); stability verified in vitro; antihypertensive; neurodegenerative (Parkinson's disease).
P2709 de Yebenes,J.G., Fahn,S., Lovelle,S., Jackson-Lewis,V., Jorge,P., Mena,M.A., Reiriz,J., Bustos,J.C., Magarinos,C., Martinez,A. Continuous intracerebroventricular infusion of dopamine and dopamine agonists through a totally implanted drug delivery system in animal models of Parkinson's disease. Movement Disorders 1987; 2(-3-):143-158. >>> Dopamine; Pargyline; Deprenyl; Lisuride; Pergolide; HCl; Sodium metabisulfate; CSF/CNS; rat; 2001; 6,7 days; controls received mp with vehicles; replacement therapy (lesion in dopamine pathway); stability verified for 1 week by measuring dopamine concentrations and its metabolites at varying time intervals with HPLC; concomitant dopamine infusion w/ pargyline and w/ deprenyl; antihypertensive; neurodegenerative (Parkinson's disease).
15. Pramipexole
P5488 Ellinwood,E.H., Davidson,C., Yu,G.Z., King,G.R., Lee,T.H. Effect of daily dosing duration of direct and indirect dopamine receptor agonists: cocaine cross-tolerance following chronic regimens. European Neuropsychopharmacology 2002; 12(-5-):407-415. >>> Cocaine; pramipexole; Saline; SC; Rat; 2ML2; 14 days; Functionality of mp verified by measuring residual volume; pulsed delivery - drugs administered either continuously or for 16 or 20 hrs per day (p. 409); study included behavioral testing; pramipexole is a direct dopamine agonist; microdialysis fiber attached to pump via catheter to minimize tissue necrosis caused by the cocaine (p. 408); intermittent delivery made possible by disconnecting and reconnecting an externalized catheter.
16. Quinpirole
P2670 Chen,J.F., Aloyo,V.J., Weiss,B. Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum. Neuroscience 1993; 54(-3-):669-680. >>> Quinpirole; SKF-38393; Ascorbic acid; DMSO; mice; 6 days; Quinpirole is a dopamine agonist; controls received mp w/ vehicle.
P2254 Engber,T.M., Marin,C., Susel,Z., Chase,T.N. Differential effects of chronic dopamine D1 and D2 receptor agonists on rotational behavior and dopamine receptor binding. Eur.J.Pharmacol. 1993; 236(--):385-393. >>> Quinpirole; SKF-38393; Ascorbate; DMSO; Water; IP; rat; 2ML2; 19 days; Quinpirole is a dopamine agonist; controls received mp w/vehicle; functionality of mp verified upon removal; comparison of intermittent ip injections vs mp.
P2253 Engber,T.M., Boldry,R.C., Kuo,S., Chase,T.N. Dopaminergic modulation of striatal neuropeptides: differential effects of D1 and D2 receptor stimulation on somatostatin, neuropeptide Y, neurotensin, dynorphin and enkephalin. Brain Research 1992; 581(--):261-268. >>> Quinpirole; SKF-38393; Ascorbate; DMSO; Water; IP; rat; 2ML1; 7 days; Quinpirole is a dopamine agonist; controls received mp w/vehicle; functionality of mp verified upon removal; comparison of IP injections vs mp; prophylactic penicillin G benzathine treatment.
P2115 Zhou,L.-W., Zhang,S.-P., Welsh,S., Connell,T.A., Weiss,B. Triazolam blocks the initial rotational effects of quinpirole but permits the later developing reduction of dopamine D2-mediated rotational behavior and dopamine D2 receptors. Eur.J.Pharmacol. 1992; 218(--):219-227. >>> Quinpirole HCl; Sulpiride; Triazolam; Ascorbic acid; DMSO; SC; mice; 2001; 6 days; Quinpirole is a dopamine agonist; antidepressant; stability verified in vitro for 7 days.
P1836 Zhou,L.-W., Qin,Z.-H., Weiss,B. Downregulation of stereotyped behavior and production of latent locomotor behaviors in mice treated continuously with quinpirole. Neuropsychopharm. 1991; 4(-1-):47-55. >>> Quinpirole; Ascorbic acid; DMSO; SC; mice; 2001; 6 days; Quinpirole is a dopamine agonist; states solvent (50% DMSO with ascorbic acid) produced no unusual effects in the mice (p. 48).
P1972 Gerfen,C., Engber,T., Mahan,L., Susel,Z., Chase,T., Monsma,Jr.F., Sibley,D. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 1990; 250(--):1429-1432. >>> Quinpirole; SKF-38393; IP; 21 days; comparison of injections vs. mp; dopamine agonists (D1 and D2), paper states 'continuous treatment [vs. injection] with a D2 agonist appears necessary to regulate striatopallidal neurons.'.
P1775 Jeziorski,M., White,F.J. Dopamine agonists at repeated 'autoreceptor-selective' doses: effects upon the sensitivity of A10 dopamine autoreceptors. Synapse 1989; 4(--):267-280. >>> Quinpirole; SC; 7 days; Dopamine agonist; stability verified in vitro at 37 degrees celsius for 7 days.
P1466 Winkler,J., Weiss,B. Effect of continuous exposure to selective D1 and D2 dopaminergic agonists on rotational behavior in supersensitive mice. J.Pharmacol.Exp.Ther. 1989; 249(-2-):507-516. >>> CY-208-243; Fenoldopam; N-0437; SKF-75670; Quinpirole; SKF-38393; Ascorbic acid; DMSO; Water; SC; mice; 2001; 7 days; Dopamine agonists; comparison of sc injections vs. mp infusion; stability verified in vitro at 37 degrees for 7 days.
17. Remoxipride HCL
P2736 Georgieva,J., Mohringe,B., Magnusson,O. Neurochemical effects of prolonged treatment with remoxipride as assessed by intracerebral microdialysis in freely moving rats. Prog.Neuro-Psychopharmacol.Biol.Psychiat. 1994; 18(--):1187-1201. >>> Remoxipride HCl; Sodium chloride; SC; rat; 2002; 14 days; controls received sodium chloride; functionality of mp verified by checking blood levels of drug and determining residual drug amount; comparison of sc injections vs mp; remoxipride is an antipsychotic drug.
P2204 Ericson,H., Ross,S.B. Subchronic treatment of rats with remoxipride fails to modify sigma binding sites in the brain. Eur.J.Pharmacol.- Mol.Pharmacol.Sect. 1992; 226(--):157-161. >>> Remoxipride HCl; Haloperidol; Water; Acetic acid; SC; rat; 3,14 days; controls received sham operations.
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Sterile Catheter Tubing for Infusion StudiesPolyethylene and vinyl tubing are now conveniently available in sterile form, individually packaged, and ready to use for infusion studies |
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