References on the Administration of BrdU Using ALZET^® Osmotic Pumps

P8569 Dedkov,E.I., Zheng,W., Christensen,L.P., Weiss,R.M., Mahlberg-Gaudin,F., Tomanek,R.J. Preservation of coronary reserve by ivabradine-induced reduction in heart rate in infarcted rats is associated with decrease in perivascular collagen. Am.J.Physiol Heart Circ.Physiol 2007/7; 293(-1-):H590-H598. >>> Ivabradine; uridine, bromodeoxy 5-; Dextrose; IP; Rat; 4 weeks; 2,6,13 days; 72 hours; Controls received mp w/ vehicle; multiple pumps per animal (2); animal info (male, Sprague-Dawley, 12 months old, MI); ischemia (cardiac).

P8566 Virag,J.A.I., Rolle,M.L., Reece,J., Hardouin,S., Feigl,E.O., Murry,C.E. Fibroblast growth factor-2 regulates myocardial infarct repair - Effects on cell proliferation, scar contraction, and ventricular function. American Journal of Pathology 2007; 171(-5-):1431-1440. >>> Uridine, bromodeoxy-; DMSO; water; SC; Mice (knockout); 1007D; 4 days; Cardiovascular; animal info (FGF2 knockout mice, 6-8 weeks old, 20-30 grams); 50% DMSO 50% water; labeling of endothelial cells.

P8535 Gordon,S.E., Westerkamp,C.M., Savage,K.J., Hickner,R.C., George,S.C., Fick,C.A., McCormick,K.M. Basal, but not overload-induced, myonuclear addition is attenuated by NG-initro-L-arginine methyl ester (L-NAME) administration. Canadian Journal of Physiology and Pharmacology 2007; 85(-6-):646-651. >>> Uridine, bromodeoxy; SC; Rat; 2ML1; 7 days; Animal info (female, Sprague-Dawley, 220 g).

P8522 Kim,I., Morimura,K., Shah,Y., Yang,Q., Ward,J.M., Gonzalez,F.J. Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis 2007; 28(-5-):940-946. >>> Uridine, bromodeoxy-; SC; Mice; 2001; 1 week; Animal info (C57NL/6N, wt, Fxr-null; 3,12 months old).

P8502 Yang,Q., Ito,S., Gonzalez,F.J. Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis. Carcinogenesis 2007/6; 28(-6-):1171-1177. >>> Uridine, bromodeoxy-; SC; Mice (transgenic); 2001; 1 week; labeling of hepatocytes; animal info (transgenic).

P8308 Price,R.J., Walters,D.G., Finch,J.M., Gabriel,K.L., Capen,C.C., Osimitz,T.G., Lake,B.G. A mode of action for induction of liver tumors by Pyrethrins in the rat. TOXICOLOGY AND APPLIED PHARMACOLOGY 2007; 218(-2-):186-195. >>> Uridine, bromodeoxy; Rat; 2ML1; 7 days; Cancer (liver); toxicology; animal info (male, female, Sprague-Dawley CD, 10-11 wks old); labeling of hepatocytes.

P8203 Masunaga,S., Nagasawa,H., Nagata,K., Suzuki,M., Uto,Y., Hori,H., Kinashi,Y., Ono,K. Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray irradiation upon the timing of its administration and tumor size, with reference to the effect on intratumor quiescent cells. Journal of Cancer Research and Clinical Oncology 2007; 133(-1-):47-55. >>> Uridine, bromodeoxy; Saline, physiological; SC; Mice; 5, 8 days; Cancer (carcinoma); animal info (female, 8-11 wks old).

P8068 Cafaro,J., Lee,G.S., Stone,J.S. Atoh1 expression defines activated progenitors and differentiating hair cells during avian hair cell regeneration. Developmental Dynamics 2007; 236(-1-):156-170. >>> Uridine, bromodeoxy, 5-; PBS; Ear (perilymphatic fluid); Bird (chicken); 2002; 8 days; No stress (see p.167); Alzet brain infusion kit used; animal info (White Legorn, 5-10 days old).

P7991 Vogetseder,A., Palan,T., Bacic,D., Kaissling,B., Le Hir,M. Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2007; 292(-2-):C807-C813. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; 1, 2 weeks; Pumps replaced every 7 days for two week studies; animal info (male, Wistar, 4-5 weeks old, 110-140 grams); labeling of kidney.

P8348 Rudnick,D.A., Shikapwashya,O., Blomenkamp,K., Teckman,J.H. Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency. Hepatology 2006; 44(-4-):976-982. >>> Uridine, bromodeoxy-; IP; Mice; 72 hours; Animal info (male, C57BL/6J-piz, 6-12 months old).

P8209 Masunaga,S.I., Kasaoka,S., Maruyama,K., Nigg,D., Sakurai,Y., Nagata,K., Suzuki,M., Kinashi,Y., Maruhashi,A., Ono,K. The potential of transferrin-pendant-type polyethyleneglycol liposomes encapsulating decahydrodecaborate-10B (GB-10) as 10B-carriers for boron neutron capture therapy. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2006; 66(-5-):1515-1522. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice; 5 days; Cancer (squamous cell carcinoma); animal info (female, C3H/He, 8-11 wks old, 20-25g.).

P8169 Masunaga,S.I., Uto,Y., Nagasawa,H., Hori,H., Nagata,K., Suzuki,M., Kinashi,Y., Ono,K. Evaluation of hypoxic cell radio-sensitizers in terms of radio-sensitizing and repair-inhibiting potential. dependency on p53 status of tumor cells and the effects on intratumor quiescent cells. Anticancer Research 2006; 26(-2A-):1261-1270. >>> Uridine, bromodeoxy, 5-; Saline, physiological; SC; Mice (nude); 5, 7 days; Cancer (squamous cell carcinoma); animal info (BALB/cA, C3H/He, 6-7 weeks old, 22 grams); labeling of tumor 'P' cells.

P8135 Finch,J.M., Osimitz,T.G., Gabriel,K.L., Martin,T., Henderson,W.J., Capen,C.C., Butler,W.H., Lake,B.G. A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat. TOXICOLOGY AND APPLIED PHARMACOLOGY 2006; 214(-3-):253-262. >>> Uridine, bromodeoxy, 5-; 2ML1; 7, 14 days; Pumps replaced after 7 days; animal info (male, female, Sprague-Dawley CD, 10-11 wks old, 450-500g., 250-300g.).

P8099 Bernstein,D.M., Rogers,R., Smith,P., Chevalier,J. The toxicological response of Brazilian chrysotile asbestos: A multidose subchronic 90-day inhalation toxicology study with 92-day recovery to assess cellular and pathological response. INHALATION TOXICOLOGY 2006; 18(-5-):313-332. >>> Uridine, bromodeoxy, 5-; SC; Rat; 2001; 3 days; Toxicology; animal info (male, Wistar Han-Ibm, 9 wk old).

P7930 Voss,K.A., Riley,R., Dunn,C., Corton,J.C. The role of tumor necrosis factor alpha and the peroxisome proliferator-activated receptor alpha in modulating the effects of fumonisin in mouse liver. Toxicology 2006; 222(-3-):165-174. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 7 days; Toxicology; animal info (male, 1.5 weeks old); labeling of hepatocytes.

P7887 Dedkov,E.I., Zheng,W., Tomanek,R.J. Compensatory growth of coronary arterioles in postinfarcted heart: regional differences in DNA synthesis and growth factor/receptor expression patterns. American Journal of Physiology-Heart and Circulatory Physiology 2006; 291(-4-):H1686-H1693. >>> Uridine, bromodeoxy-; Rat; 72 hours; Cardiovascular; animal info (male, Sprague-Dawley, 12 month old); left coronary artery ligation to induce MI; labeling of coronary arterioles (endothelial cells of the coronary arterioles).

P7801 Overstreet-Wadiche,L.S., Bromberg,D.A., Bensen,A.L., Westbrook,G.L. Seizures accelerate functional integration of adult-generated granule cells. Journal of Neuroscience 2006; 26(-15-):4095-4103. >>> Uridine, bromodeoxy; Saline; NaOH; SC; Mice (transgenic); 2001D; 1 day; Animal info (adult, -13/+8POMC-EGFP Tg.); labeling of granule cells.

P7796 Martins,K.J.B., Gordon,T., Pette,D., Dixon,W.T., Foxcroft,G.R., MacLean,I.M., Putman,C.T. Effect of satellite cell ablation on low-frequency-stimulated fast-to-slow fibre-type transitions in rat skeletal muscle. JOURNAL OF PHYSIOLOGY-LONDON 2006; 572(-1-):281-294. >>> Uridine, bromodeoxy-; SC; Rat; 2004; 21 days; Animal info (male, Wistar, 296g.); labeling of satellite cells.

P7794 Schrier,L., Ferns,S.P., Barnes,K.M., Emons,J.A.M., Newman,E.I., Nilsson,O., Baron,J. Depletion of resting zone chondrocytes during growth plate senescence. Journal of Endocrinology 2006; 189(-1-):27-36. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Rabbit; rabbit (pregnant); 2ML1; 1 week; Controls did not receive BrdU; animal info (New Zealand White, male; 5, 9&17 wk. old, female, pregnant); endocrinology; labeling of chondocytes.

P7786 Pauluhn,J., Mohr,U. Mosquito coil smoke inhalation toxicity. Part II: Subchronic nose-only inhalation study in rats. Journal of Applied Toxicology 2006; 26(-3-):279-292. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; 7 days; Animal info (male, Wistar, 5 months old); labeling of lung cells (alveolar, epithelial).

P7738 Hyatt,J.P.K., Roy,R.R., Baldwin,K.M., Wernig,A., Edgerton,V.R. Activity-unrelated neural control of myogenic factors in a slow muscle. Muscle&Nerve 2006; 33(-1-):49-60. >>> Uridine, bromodeoxy-; SC; Rat; 2ML2; 14 days; Animal info (female, Sprague-Dawley, 200-235g.; denervation or spinal cord isolation); labeling of satellite cells.

P7671 Campbell,J.S., Riehle,K.J., Brooling,J.T., Bauer,R.L., Mitchell,C., Fausto,N. Proinflammatory cytokine production in. liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4. Journal of Immunology 2006; 176(-4-):2522-2528. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 48 hours; Comparison of IP injection vs. mp; animal info (C57BL/6, KO, heterozygous, male, 11 wk old); labeling of hepatocytes.

P7623 Ohyama,M., Terunuma,A., Tock,C.L., Radonovich,M.F., Pise-Masison,C.A., Hopping,S.B., Brady,J.N., Udey,M.C., Vogel,J.C. Characterization and isolation of stem cell-enriched human hair follicle bulge cells. Journal of Clinical Investigation 2006; 116(-1-):249-260. >>> Uridine, bromodeoxy-; SC; Mice (nude); 1002; 4-6 weeks; Pumps replaced every 2 weeks; multiple pumps per animal (2).

P7510 Voss,K.A., Liu,J., Anderson,S.P., Dunn,C., Miller,J.D., Owen,J.R., Riley,R.T., Bacon,C.W., Corton,J.C. Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha. TOXICOLOGICAL SCIENCES 2006; 89(-1-):108-119. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 7 days; No stress (see pg. 111); animal info (female, SV129, 20-22 g); labeling of hepatocytes.

P8234 Keenan,K.P., Hoe,C.M., Mixson,L., McCoy,C.L., Coleman,J.B., Mattson,B.A., Ballam,G.A., Gumprecht,L.A., Soper,K.A. Diabesity: A polygenic model of dietary-induced obesity from ad libitum overfeeding of Sprague-Dawley rats and its modulation by moderate and marked dietary restriction. Toxicologic Pathology 2005; 33(-6-):650-674. >>> Uridine, bromodeoxy; Sodium bicarbonate; SC; Rat; 2ML1; 7 days; Toxicology; animal info (male, female, Sprague-Dawley, 12, 25, or 52 weeks old).

P8095 Ohashi,K., Kay,M.A., Yokoyama,T., Kuge,H., Kanehiro,H., Hisanaga,M., Ko,S., Nakajima,Y. Stability and repeat regeneration potential of the engineered liver tissues under the kidney capsule in mice. CELL TRANSPLANTATION 2005; 14(-9-):621-627. >>> Uridine, bromodeoxy, 5-; Mice; 2001; 2 weeks; Animal info (FVB/N, partial hepatectomy, hepatocyte transplantation); labeling of hepatocytes.

P8093 Kai,K., Yoshida,M., Sugawara,T., Kato,M., Uchida,K., Yamaguchi,R., Tateyama,S., Furuhuma,K. Investigation of initial changes in the mouse olfactory epithelium following a single intravenous injection of vincristine sulphate. Toxicologic Pathology 2005; 33(-7-):750-759. >>> Uridine, bromodeoxy-; SC; Mice; 2001D; 6, 24 hours; Animal Info (male, BALB/c, 8 wks. old); vincristine or unilateral bubectomy.

P8065 Kronenberg,G., Wang,L.P., Synowitz,M., Gertz,K., Katchanov,J., Glass,R., Harms,C., Kempermann,G., Kettenmann,H., Endres,M. Nestin-expressing cells divide and adopt a complex electrophysiologic phenotype after transient brain ischemia. Journal of Cerebral Blood Flow and Metabolism 2005; 25(-12-):1613-1624. >>> Uridine, bromodeoxy, 5-; SC; Mice; mice (transgenic); 4 days; Ischemia (cerebral); animal info (C57BL/6 nestin-GFP tg, 10-12 wk old, 20-25g, MCAO); "this dose is nontoxic and labels approximately 4 times more cells after cerebral ischemia than twice daily intraperitoneal injections" (p.1614).

P7630 Bauer,S., Patterson,P.H. The cell cycle-apoptosis connection revisited in the adult brain. Journal of Cell Biology 2005; 171(-4-):641-650. >>> Uridine, bromodeoxy-; Saline; CSF/CNS; Mice; 1003D; 24 hours; ALZET Brain Infusion Kit 2 used; animal info (2-4 month old, C57BL/6).

P7593 Kaufmann,W., Mellert,W., van Ravenzwaay,B., Landsiedel,R., Poole,A. Effects of styrene and its metabolites on different lung compartments of the mouse - cell proliferation and histomorphology. Regulatory Toxicology and Pharmacology 2005; 42(-1-):24-36. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 2001; ; Cancer; toxicology; animal info (female, CD1, 49 days old); labeling of lung cells.

P7580 Poluektova,L., Meyer,V., Walters,L., Paez,X., Gendelman,H.E. Macrophage-induced inflammation affects hippocampal plasticity and neuronal development in a murine model of HIV-1 encephalitis. Glia 2005; 52(-4-):344-353. >>> Uridine, bromodeoxy; Saline, physiological; CSF/CNS; Mice (SCID); 2004; 7, 28 days; Animal info (SCID, 4 wk old, male).

P7459 Sales,V.L., Sukhova,G.K., Lopez-Ilasaca,Ma, Libby,P., Dzau,V.J., Pratt,R.E. Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. Circulation 2005; 112(-21-):3328-3336. >>> Uridine, bromodeoxy-; SC; IP; Mice; 2001; 7 days; Cardiovascular; animal info (male, C57 BL/6J, high cholesterol diet).

P7452 Elder,A., Gelein,R., Finkelstein,J.N., Driscoll,K.E., Harkema,J., Oberdoerster,G. Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. TOXICOLOGICAL SCIENCES 2005; 88(-2-):614-629. >>> Uridine, bromodeoxy-; SC; Rat; mice; hamster; 2001; 5 days; Animal info (female f-344 rat; female b6c3f1 mice; female 276f1b syrian golden hamster); labeling of lung cells.

P7444 Green,T., Toghill,A., Lee,R., Waechter,F., Weber,E., Noakes,J. Thiamethoxam induced mouse liver tumors and their relevance to humans - Part 1: Mode of action studies in the mouse. TOXICOLOGICAL SCIENCES 2005; 86(-1-):36-47. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Mice; 1003D; 3 days; Cancer (hepatic); toxicology; animal info (male, 30-43 g); labeling of hepatocytes.

P7441 Green,T., Toghill,A., Lee,R., Waechter,F., Weber,E., Peffer,R., Noakes,J., Robinson,M. Thiamethoxam induced mouse liver tumors and their relevance to humans - Part 2: Species differences in response. TOXICOLOGICAL SCIENCES 2005; 86(-1-):48-55. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Rat; 2ML1; 3 days; Cancer (hepatic); toxicology; animal info (female, 140-160 g).

P7409 Roy,S.K., Thilagar,A.K., Eastmond,D.A. Chromosome breakage is primarily responsible for the micronuclei induced by 1,4-dioxane in the bone marrow and liver of young CD-1 mice. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 2005; 586(-1-):28-37. >>> Uridine, bromodeoxy-; SC; Mice; 5 days; Labeling of hepatocytes; animal info (21 days old, CD-1, male).

P7408 Rissler,P., Soederdahl,G., Nordman,T., Xia,L., Torndal,U.B., Bjoernstedt,M., Ericzon,B.G., Olsson,J.M., Eriksson,L.C. Adriamycin cytotoxicity may stimulate growth of hepatocellular tumours in an experimental model for adjuvant systemic chemotherapy in liver transplantation. TRANSPLANT INTERNATIONAL 2005; 18(-8-):992-1000. >>> Uridine, bromodeoxy-; NaOH; SC; Rat; ; Labeling of hepatocytes; animal info (male, wistar-kyoto, 4-5 weeks old, 110 g).

P7384 Currie,R.A., Bombail,V., Oliver,J.D., Moore,D.J., Lim,F.L., Gwilliam,V., Kimber,I., Chipman,K., Moggs,J.G., Orphanides,G. Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: Application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate. TOXICOLOGICAL SCIENCES 2005; 86(-2-):453-469. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 48,72 hours; Animal info (B6C3F1, male, 7-10 wks); labeling of hepatocytes.

P7368 Mohapel,P., Frielingsdorf,H., Haeggblad,J., Zachrisson,O., Brundin,P. Platelet-derived growth factor (PDGF-BB) and brainderived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions. Neuroscience 2005; 132(-3-):767-776. >>> Platelet-derived growth factor-BB; brain-derived neurotrophic factor; uridine, bromodeoxy-; PBS; CSF/CNS; Rat; 2002; 10 days; Controls received mp w/ vehicle; functionality of mp verified by residual volume; ALZET brain infusion kit used; neurodegenerative (parkinson's disease); labeling of striatum.

P7355 Smith,G.H. Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands. Development 2005; 132(-4-):681-687. >>> Uridine, bromodeoxy - 5; Mice; 14 days; Labeling of mammary cells.

P7337 Yoon,Y.S., Wecker,A., Heyd,L., Park,J.S., Tkebuchava,T., Kusano,K., Hanley,A., Scadova,H., Qin,G.J., Cha,D.H., Johnson,K.L., Aikawa,R., Asahara,T., Losordo,D.W. Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. Journal of Clinical Investigation 2005; 115(-2-):326-338. >>> Uridine, bromodeoxy-; DMSO; NaCl; SC; Rat (nude); 2ML4; 4 weeks; Ischemia (cardiac); Labeling of myocardial cells; 50% DMSO used.

P7326 Kishore,R., Qin,G.J., Luedemann,C., Bord,E., Hanley,A., Silver,M., Gavin,M., Goukassain,D., Losordo,D.W. The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A. Journal of Clinical Investigation 2005; 115(-7-):1785-1796. >>> Uridine, bromodeoxy-; Mice (nude); 7 days; Cardiovascular; ischemia (hindlimb); labeling of ischemic hind limb muscle.

P7311 Yang,P., Baker,K.A., Hagg,T. A disintegrin and metalloprotease 21 (ADAM21) is associated with neurogenesis and axonal growth in developing and adult rodent CNS. Journal of Comparative Neurology 2005; 490(-2-):163-179. >>> Uridine, bromodeoxy-; IP; Rat; 2ML2; 14 days; Labeling of subventricular zone (SVZ).

P7296 Budak,M.T., Alpdogan,O.S., Zhou,M.Y., Lavker,R.M., Akinci,M.A.M., Wolosin,J.M. Ocular surface epithelia contain ABCG2-dependent side population cells exhibiting features associated with stem cells. Journal of Cell Science 2005; 118(-8-):1715-1724. >>> Uridine, bromodeoxy-; SC; Rabbit; 2ML2; 14-16 days; Labeling of the ocular surface.

P7269 Huss,W.J., Gray,D.R., Greenberg,N.M., Mohler,J.L., Smith,G.J. Breast cancer resistance protein-mediated efflux of androgen in putative benign and malignant prostate stem cells. Cancer Research 2005; 65(-15-):6640-6650. >>> Uridine, bromodeoxy-; Mice (transgenic); 2002; 2 weeks; Cancer (prostate); labeling of the prostate.

P7240 Hayashi,S., Asahara,T., Masuda,H., Isner,J.M., Losordo,D.W. Functional ephrin-B2 expression for promotive interaction between arterial and venous vessels in postnatal neovascularization. Circulation 2005; 111(-17-):2210-2218. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2002; 14 days; Controls received mp w/ vehicle; cardiovascular; ischemia (hindlimb).

P7239 Farah,M.H., Easter,SS Jr  Journal of Comparative Neurology 2005; 489(-1-):120-134. >>> Uridine, bromodeoxy-; SC; Mice (pregnant); 2001; 1-7 days; Teratology.

P7232 Karam,S.M., John,R., Alpers,D.H., Ponery,A.S. Retinoic acid stimulates the dynamics of mouse gastric epithelial progenitors. Stem Cells 2005; 23(-3-):433-441. >>> Retinoic acid; uridine, bromodeoxy-; SC; Mice; 1, 3, 6 days; Controls received mp w/ vehicle; comparison of SC injections vs. mp; cancer (gastric); multiple pumps per animal (2).

P7126 Bursch,W., Wastl,U., Hufnagl,K., Schulte-Hermann,R. No increase of apoptosis in regressing mouse liver after withdrawal of growth stimuli or food restriction. TOXICOLOGICAL SCIENCES 2005; 85(-1-):507-514. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 1003D; 2001; ; Labeling of hepatocytes.

P6968 Matsusaka,T., Xin,J., Niwa,S., Kobayashi,K., Akatsuka,A., Hashizume,H., Wang,Q.C., Pastan,I., Fogo,A.B., Ichikawa,I. Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury. Journal of the American Society of Nephrology 2005; 16(-4-):1013-1023. >>> Uridine, bromodeoxy-; SC; Mice (transgenic); 2002; 14 days; Labeling of interstitial cells.

P8568 Ma,J., Matsusaka,T., Yang,H., Kawachi,H., Shimizu,F., Isaka,Y., Imai,E., Kon,V., Ichikawa,I. Local actions of endogenous angiotensin II in injured glomeruli. J.Am.Soc.Nephrol. 2004/5; 15(-5-):1268-1276. >>> Uridine, bromodeoxy-; SC; Rat; 1007D; 3 days; Animal info (male, Wistar, 140-160 grams); ischemia (renal artery); nephrology.

P7210 Bermudez,E., Mangum,J.B., Wong,B.A., Asgharian,B., Hext,P.M., Warheit,D.B., Everitt,J.I. Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. TOXICOLOGICAL SCIENCES 2004; 77(-2-):347-357. >>> Uridine, bromodeoxy-; SC; Rat; mice; hamster; 2001; 2ML1; 5 days; Toxicology; labeling of the lung.

P7105 Roberson,D.W., Alosi,J.A., Cotanche,D.A. Direct transdifferentiation gives rise to the earliest new hair cells in regenerating avian auditory epithelium. Journal of Neuroscience Research 2004; 78(-4-):461-471. >>> Uridine, bromodeoxy-; Ear (cochlea); Bird (chicken); 2002; 3-11 days; Controls received untreated contralateral ear; functionality of mp verified by (epithelial immunohistochemistry); stability verified by epithelial immunohistochemistry; tissue perfusion (cochlea).

P7065 Masunaga,S.I., Takahashi,A., Ohnishi,K., Ohnishi,T., Nagata,K., Suzuki,M., Kinashi,Y., Ono,K. Effects of mild temperature hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, with reference to the effect in intratumor quiescent cell populations. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2004; 60(-2-):570-577. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice (nude); 2001; 7 days; Controls received no treatment; cancer (squamous cell carcinoma).

P7041 Lock,T., Cottrell,L., Soames,T., Jacobsen,M., Williams,R. Formic acid excretion in rats and mice exposed to bromodichloromethane: a possible link to renal tubule cell proliferation in long-term studies. Archives of Toxicology 2004; 78(-7-):410-417. >>> Uridine, bromodeoxy-; Saline, isotonic; SC; Rat; mice; 2001; 2ML1; 5 days; Functionality of mp verified by BrdU staining of duodenum; toxicology.

P7016 van den Hoff,M.J.B., Deprez,R.H.L., Ruijter,J.M., de Boer,P.A.J., Tesink-Taekema,S., Buffing,A.A., Lamers,W.H., Moorman,A.F.M. Increased cardiac workload by closure of the ductus arteriosus leads to hypertrophy and apoptosis rather thian to hyperplasia in the late fetal period. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 2004; 370(-3-):193-202. >>> Uridine, bromodeoxy-; IP; Rat (pregnant); 2001D; 24 hours; Cardiovascular.

P7014 Wozniak,D.F., Hartman,R.E., Boyle,M.P., Vogt,S.K., Brooks,A.R., Tenkova,T., Young,C.L., Olney,J.W., Muglia,L.J. Apoptotic neuro degeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults. NEUROBIOLOGY OF DISEASE 2004; 17(-3-):403-414. >>> Uridine, bromodeoxy-; SC; Mice; 1007D; 7 days; Brain tissue distribution; behavioral study.

P6939 Anderson,S.P., Dunn,C., Laughter,A., Yoon,L., Swanson,C., Stulnig,T.M., Steffensen,K.R., Chandraratna,R.A.S., Gustafsson,J.A., Corton,J.C. Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha retinoid X receptor, and liver X receptor in mouse liver. MOLECULAR PHARMACOLOGY 2004; 66(-6-):1440-1452. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 7 days; Labeling of hepatocytes.

P6868 Shteyer,E., Liao,Y.J., Muglia,L.J., Hruz,P.W., Rudnick,D.A. Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice. Hepatology 2004; 40(-6-):1322-1332. >>> Uridine, bromodeoxy-; IP; Mice; 48 hours.

P6856 Frielingsdorf,H., Schwarz,K., Brundin,P., Mohapel,P. No evidence for new dopaminergic neurons in the adult mammalian substantia nigra. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004; 101(-27-):10177-10182. >>> Uridine, bromodeoxy-; brain-derived neurotrophic factor; CSF/CNS; Rat; mice; 2002; 2004; 10,21 days; Brain tissue distribution.

P6841 Khmelewski,E., Becker,A., Meinertz,T., Ito,W.D. Tissue resident cells play a dominant role in arteriogenesis and concomitant macrophage accumulation. Circulation Research 2004; 95(-6-):e56-e64. >>> Monocyte chemotactic protein-1; uridine, bromodeoxy-; PBS; sodium citrate buffer; SC; Rat; 2ML1; 7 days; cardiovascular; peptides.

P6734 Hong,K.U., Reynolds,S.D., Watkins,S., Fuchs,E., Stripp,B.R. Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. American Journal of Pathology 2004; 164(-2-):577-588. >>> Ganciclovir; uridine, bromodeoxy-; Saline; SC; Mice (transgenic); 2002; 8 days, 24 hours; Controls received mp w/ BrdU; 2002 pump used for 8 days of BrdU infusion; GCV infused for 24 hours.

P6685 Crunkhorn,S.E., Plant,K.E., Gibson,G.G., Kramer,K., Lyon,J., Lord,P.G., Plant,N.J. Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth. Biochemical Pharmacology 2004; 67(-1-):107-118. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; 48,72 hours; Labeling of hepatocytes; toxicology.

P6668 Zhao,S.P., Sherwood,O.D. Induction of labor with RU 486 (mifepristone) in relaxin-deficient rats: Antepartum administration of relaxin facilitates delivery and increases pup survival. American Journal of Obstetrics and Gynecology 2004; 190(-1-):229-238. >>> Relaxin, porcine; uridine, bromodeoxy-; Saline; SC; Rat (pregnant); 2001; 2ML1; 3 days; Controls received mp w/ vehicle; peptides.

P6622 Cheung,C., Akiyama,T.E., Ward,J.M., Nicol,C.J., Feigenbaum,L., Vinson,C., Gonzalez,F.J. Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha. Cancer Research 2004; 64(-11-):3849-3854. >>> Uridine, bromodeoxy-; SC; Mice; 2001; 1 week; Labeling of hepatocytes; toxicology.

P6615 Sakata,T., Wang,Y.M., Halloran,B.P., Elalieh,H.Z., Cao,J., Bikle,D.D. Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways. Journal of Bone and Mineral Research 2004; 19(-3-):436-446. >>> Insulin-like growth factor; uridine, bromodeoxy-; Sodium succinate; DMSO; propylene glycol; SC; Rat (dwarf); 14 days; BrdU was dissolved in 50% DMSO/50% propylene glycol for labeling of osteocytes; pump model not listed.

P6571 Weglarz,T.C., Sandgren,E.P. Cell cross-talk mediates PPARalpha; null hepatocyte proliferation after peroxisome proliferator exposure. Carcinogenesis 2004; 25(-1-):107-112. >>> Uridine, bromodeoxy-; Mice (transgenic); 2001; 7 days; hepatocyte labeling; toxicology.

P6439 Reynolds,R., Witherspoon,S., Fox,T. The infant mouse as a in vivo model for the detection and study of DNA damage-induced changes in the liver. MOLECULAR CARCINOGENESIS 2004; 40(-1-):62-72. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 3 days; Labeling of hepatocytes.

P6418 Mercer,A., Roennholm,H., Holmberg,J., Lundh,H., Heidrich,J., Zachrisson,O., Ossoinak,A., Frisen,J., Patrone,C. PACAP promotes neural stem cell proliferation in adult mouse brain. Journal of Neuroscience Research 2004; 76(-2-):205-215. >>> PACAP38; uridine, bromodeoxy-; Saline; serum albumin, mouse; CSF/CNS; Mice; 1007D; 3.5,7 days.

P6381 Dilley,R.J., Rizkalla,B., Bertram,J.F. Cardiovascular hypertrophy in one-kidney, one-clip renal hypertension is resistant to heparin. Journal of Hypertension 2004; 22(-4-):767-774. >>> Heparin; uridine, bromodeoxy-; Saline; IV; Rat; 2 weeks; Controls received mp w/ vehicle; blood pressure taken; cardiovascular; pump model not listed.

P6366 Apostolou,I., von Boehmer,H. In vivo instruction of suppressor commitment in naive T cells. Journal of Experimental Medicine 2004; 199(-10-):1401-1408. >>> Influenza HA (107-119); uridine, bromodeoxy-; PBS; SC; Mice; 1002; 2001; 7,14 days; Controls received mp w/ BrdU; 2001 pumps replaced at 7 days for BrdU group; immunology; peptides; labeling of splenocytes.

P6350 Burkhardt,S., Bahnemann,R., Failing,K., Reinacher,M. Zonal distribution of cell proliferation in the liver of untreated B6C3F1 and C57BL mice. Toxicologic Pathology 2004; 32(-1-):100-105. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 3, 7 days; Comparison of IP injections vs. mp; labeling of hepatocytes; toxicology.

P8464 Zhao,M., Momma,S., Delfani,K., Carlen,M., Cassidy,R.M., Johansson,C.B., Brismar,H., Shupliakov,O., Frisen,J., Janson,A.M. Evidence for neurogenesis in the adult mammalian substantia nigra. Proc.Natl.Acad.Sci.U.S.A 2003/6/24; 100(-13-):7925-7930. >>> Uridine, bromodeoxy-; thymidine, 3H; Ara-C; Saline, radio-isotopes; CSF/CNS; IP; Mice; 1003D; 1002; 2004; 2,3,10,14,21 days; Comparison of oral administration vs. IP injections; animal info (male, C57BL/6, 2-20 months old); neurodegenerative (Parkinson's disease); "the blood brain barrier and or peripheral metabolism limit the availability of BrdUrd in the brain." (p. 7929).

P7703 Van Miller,J.P., Garman,R.H., Hermansky,S.J., Mirsalis,J.C., Frederick,C.B. Skin irritation, basal epithelial cell proliferation, and carcinogenicity evaluations of a representative specialty acrylate and methacrylate. Regul.Toxicol.Pharmacol. 2003/2; 37(-1-):54-65. >>> Uridine, bromodeoxy; thymidine, 3H methyl-; PBS, dulbecco's; IP; Mice; 1003D; 2001D; 24 hours; Animal info (male wistar).

P6231 Masunaga,S., Ono,K., Takahashi,A., Ohnishi,K., Ohnishi,T., Suzuki,M., Nagata,K., Kinashi,Y., Nagasawa,H., Uto,Y., Hori,H. Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors: its independence of p53 status. CANCER SCIENCE 2003; 94(-1-):125-133. >>> Uridine, bromodeoxy-; Saline, physiological; SC; Mice (nude); 2001; 7 days; Controls received no treatment; cancer (squamous cell carcinoma).

P6212 Fujitani,Y., Trifilieff,A. In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2003; 167(-2-):193-198. >>> Uridine, bromodeoxy-; SC; Mice; 8 days; Asthma model.

P6203 Christov,K.T., Shilkaitis,A.L., Kim,E.S., Steele,V.E., Lubet,R.A. Chemopreventive agents induce a senescence-like phenotype in rat mammary tumours. European Journal of Cancer 2003; 39(-2-):230-239. >>> Uridine, bromodeoxy-; SC; Rat; 7 days; Cancer (mammary).

P6092 Zimmers,T.A., McKillop,I.H., Pierce,R.H., Yoo,J.Y., Koniaris,L.G. Massive liver growth in mice induced by systemic interleukin 6 administration. Hepatology 2003; 38(-2-):326-334. >>> Uridine, bromodeoxy; Saline; IP; 1003D; 48 hours; Labeling of hepatocytes.

P6042 Terunuma,A., Jackson,K.L., Kapoor,V., Telford,W.G., Vogel,J.C. Side population keratinocytes resembling bone marrow side population stem cells are distinct from label-retaining keratinocyte stem cells. Journal of Investigative Dermatology 2003; 121(-5-):1095-1103. >>> Uridine, bromodeoxy-; SC; Mice (nude); 1002; 6 weeks; Pumps replaced every 2 weeks; multiple pumps per animal (2); labeling of skin grafts.

P6018 Fisson,S., Darrasse-Jeze,G., Litvinova,E., Septier,F., Klatzmann,D., Liblau,R., Salomon,B.L. Continuous activation of autoreactive CD4(+) CD25(+) regulatory T cells in the steady state. Journal of Experimental Medicine 2003; 198(-5-):737-746. >>> Uridine, bromodeoxy-; SC; Mice; 2001; 7 days; Labeling of splenocytes.

P6014 Hyatt,J.P.K., Roy,R.R., Baldwin,K.M., Edgerton,V.R. Nerve activity-independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonuclei. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 2003; 285(-5-):C1161-C1173. >>> Uridine, bromodeoxy-; SC; Rat; 2ML2; 3,14 days; Cell proliferation.

P5989 Park,F., Ohashi,K., Kay,M.A. The effect of age on hepatic gene transfer with self-inactivating lentiviral vectors in vivo. MOLECULAR THERAPY 2003; 8(-2-):314-323. >>> Uridine, bromodeoxy-; SC; Mice; 2001; 7 days; Cell proliferation; labeling of hepatocytes.

P5960 Valles,E.G., Laughter,A.R., Dunn,C.S., Cannelle,S., Swanson,C.L., Cattley,R.C., Corton,J.C. Role of the peroxisome proliferator-activated receptorα in responses to dilsononyl phthalate. Toxicology 2003; 191(-2-3-):211-225. >>> Uridine, bromodeoxy-; PBS; SC; Mice; 2001; 7 days; Toxicology; labeling of hepatocytes.

P5959 Rios-Blanco,M.N., Yamaguchi,S., Dhawan-Robl,M., Kessler,W., Schoonhoven,R., Filser,J.G., Swenberg,J.A. Effects of propylene oxide exposure on rat nasal respiratory cell proliferation. TOXICOLOGICAL SCIENCES 2003; 75(-2-):279-288. >>> Uridine, bromodeoxy-; PBS; SC; Rat; 2ML1; 3 days; Toxicology; labeling of the hepatocytes and anterior face.

P5957 Molon-Noblot,S., Laroque,P., Coleman,J.B., Hoe,C.M., Keenan,K.P. The effects of ad libitum overfeeding and moderate and marked dietary restriction on age-related spontaneous pituitary gland pathology in Sprague-Dawley rats. Toxicologic Pathology 2003; 31(-3-):310-320. >>> Uridine, bromodeoxy-; Sodium bicarbonate; SC; Rat; 2ML1; 1 week; Labeling of pituitary sections.

P5956 Lu,Z.J., Tharappel,J.C., Lee,E.Y., Robertson,L.W., Spear,B.T., Glauert,H.P. Effect of a single dose of polychlorinated biphenyls on hepatic cell proliferation and the DNA binding activity of NF-κB and AP-1 in rats. MOLECULAR CARCINOGENESIS 2003; 37(-4-):171-180. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 48 hours; Hepatocyte labeling.

P5955 Tharappel,J.C., Nalca,A., Owens,A.B., Ghabrial,L., Konz,E.C., Glauert,H.P., Spear,B.T. Cell proliferation and apoptosis are altered in mice deficient in the NF-κB p50 subunit after treatment with the peroxisome proliferator ciprofibrate. TOXICOLOGICAL SCIENCES 2003; 75(-2-):300-308. >>> Uridine, bromodeoxy-; SC; Mice (knockout); 1003D; 3 days; Toxicology; labeling of hepatocytes.

P5785 Ou,Y.C., Conolly,R.B., Thomas,R.S., Gustafson,D.L., Long,M.E., Dobrev,I.D., Chubb,L.S., Xu,Y.H., Lapidot,S.A., Andersen,M.E., Yang,R.S.H. Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. TOXICOLOGICAL SCIENCES 2003; 73(-2-):301-314. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 3 days; Labeling of hepatocytes; toxicology.

P5722 Arras,M., Ito,W.D., Scholz,D., Winkler,B., Schaper,J., Schaper,W. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J Clin.Invest 2003; 101(-1-):40-50. >>> Uridine, bromodeoxy-; IA (carotid); Rabbit; 2ML2; 3,7 days; Study proliferation of collateral arteries and capillaries.

P5689 Masunaga,S., Ono,K., Kirihata,M., Takagaki,M., Sakurai,Y., Kinashi,Y., Kobayashi,T., Suzuki,M., Nagata,K., Nagasawa,H., Uto,Y., Hori,H. Potential of alpha-amino alcohol p-boronophenylalaninol as a boron carrier in boron neutron capture therapy, regarding its enantiomers. Journal of Cancer Research and Clinical Oncology 2003; 129(-1-):21-28. >>> Uridine, bromodeoxy-; Saline; SC; Mice; 2001; 5 Days; Cancer (lymphoma).

P5684 Chouaf-Lakhdar,L., Fevre-Montange,M., Brisson,C., Strazielle,N., Gamrani,H., Didier-Bazes,M. Proliferative activity and nestin expression in periventricular cells of the adult rat brain. NeuroReport 2003; 14(-4-):633-636. >>> Uridine, bromodeoxy-; thymidine; Saline; NaOH (sodium hydroxide); Radio-Isotopes; 3H tracer; CSF/CNS; Rat; 1003D; 3 days; Brain tissue distribution.

P5643 Buttyan,R., Chichester,P., Stisser,B., Matsumoto,S., Ghafar,M.A., Levin,R.M. Acute intravesical infusion of a cobalt solution stimulates a hypoxia response, growth and angiogenesis in the rat bladder. Journal of Urology 2003; 169(-6-):2402-2406. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 6 days.

P6177 Ohashi,K., Park,F., Kay,M.A. Role of Hepatocyte Direct Hyperplasia in Lentivirus-Mediated Liver Transduction In Vivo. Human Gene Therapy 2002; 13(--):653-663. >>> Uridine, bromodeoxy-; SC; Mice; 2001; 24 hours; Labeling of hepatocytes.

P6147 Kilgour,J.D., Foster,J., Soames,A., Farrar,D.G., Hext,P.M. Responses in the respiratory tract of rats following exposure to sulph uric acid aerosols for 5 or 28 days. Journal of Applied Toxicology 2002; 22(-6-):387-395. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 7 days; BrdU was used for labelling lung cells.

P6146 Kilgour,J.D., Rattray,N.J., Foster,J., Soames,A., Hext,P.M. Pulmonary responses and recovery following single and repeated inhalat ion exposure of rats to polymeric methylene diphenyl diisocyanate aero sols. Journal of Applied Toxicology 2002; 22(-6-):371-385. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 7 days; Toxicology; BrdU used for labeling lung and small intestine.

P5806 Mozdziak,P.E., Walsh,T.J., McCoy,D.W. The effect of early posthatch nutrition on satellite cell mitotic activity. POULTRY SCIENCE 2002; 81(-11-):1703-1708. >>> Uridine, bromodeoxy-; Mice; 3,7 days; Cancer; 1 ml/hr pumps used; hepatocyte labeling w/ Brdu.

P5742 Balakrishnan,S., Payawal,J., Schuler,M.J., Hasegawa,L., Eastmond,D.A. Enhancing the in vitro and in vivo detection of aneuploidy by fluorescence in situ hybridization with the use of bromodeoxyuridine as a proliferation marker. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 2002; 521(-1-2-):81-89. >>> Uridine, bromodeoxy-; SC; Rat; 2001; 3 days; Toxicology; lymphocytes and hepatocytes were labelled.

P5576 Gamer,A.O., Jaeckh,R., Leibold,E., Kaufmann,W., Gembardt,C., Bahnemann,R., van Ravenzwaay,B. Investigations on cell proliferation and enzyme induction in male rat kidney and female mouse liver caused by tetrahydrofuran. TOXICOLOGICAL SCIENCES 2002; 70(-1-):140-149. >>> Uridine, bromodeoxy-; saline; SC; rat; mice; 2001; 2ML1; 3, 7 days; toxicology.

P5547 Bermudez,E., Mangum,J.B., Asgharian,B., Wong,B.A., Reverdy,E.E., Janszen,D.B., Hext,P.M., Warheit,D.B., Everitt,J.I. Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles. TOXICOLOGICAL SCIENCES 2002; 70(-1-):86-97. >>> Uridine, bromodeoxy-; SC; Rat; mice; hamster; 2001; 2ML1; 5 days; Rats and hamsters received model 2ML1; mice received model 2001; toxicology.

P5532 Chen,C.M., Stott,N.S., Smith,H.K. Effects of botulinum toxin A injection and exercise on the growth of juvenile rat gastrocnemius muscle. Journal of Applied Physiology 2002; 93(-4-):1437-1447. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 7 days; Functionality of mp verified by measurement of residual volume; toxicology.

P5527 Lake,B.G., Rumsby,P.C., Cunninghame,M.E., Price,R.J. Dose-related effects of the peroxisome proliferator methylclofenapate in rat liver. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 2002; 11(-3-4-):233-242. >>> Uridine, bromodeoxy-; SC; Rat; 2ML1; 1 week; Pumps implanted on study weeks 0, 3, and 12; toxicology.

P5500 Herzog,S., Sager,H., Khmelevski,E., Deylig,A., Ito,W.D. Collateral arteries grow from preexisting anastomoses in the rat hindlimb. American Journal of Physiology-Heart and Circulatory Physiology 2002; 283(-5-):H2012-H2020. >>> Uridine, bromodeoxy-; NaHCO(3); SC; Rat; 2ML1; 7, 21 days.

P5424 Wyde,M.E., Cambre,T., Lebetkin,M., Eldridge,S.R., Walker,N.J. Promotion of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-diox in and 17 beta-estradiol in male Sprague-Dawley rats. TOXICOLOGICAL SCIENCES 2002; 68(-2-):295-303. >>> Uridine, bromodeoxy-; Saline; SC; Rat; 2ML1; 7 days; Toxicology; hepatocyte proliferation.

P5343 Spencer,P.J., Crissman,J.W., Stott,W.T., Corley,R.A., Cieszlak,F.S., Schumann,A.M., Hardisty,J.F. Propylene glycol monomethyl ether (PGME): Inhalation toxicity and carcinogenicity in Fischer 344 rats and B6C3F1 mice. Toxicologic Pathology 2002; 30(-5-):570-579. >>> Uridine, bromodeoxy-;; SC; Rat; mice; ; Toxicology; liver, kidney and duodenum cell proliferation labeling.

P5339 VandenDriessche,T., Thorrez,L., Naldini,L., Follenzi,A., Moons,L., Berneman,Z., Collen,D., Chuah,M.K.L. Lentiviral vectors containing the human immunodeficiency virus type-1 central polypurine tract can efficiently transduce nondividing hepatocytes and antigen-presenting cells in vivo. Blood 2002; 100(-3-):813-822. >>> Uridine, bromodeoxy-; SC; Mice; 2002; 7 days; Functionality verified by BrdU immunofluorescence; pumps removed after 14 days, experiment repeated for a total of 4 2-week implantation intervals; mammary epithelial cell staining.

P5206 Goldsworthy,T.L., Fransson-Steen,R. Quantitation of the cancer process in C57BL/6J, B6C3F1 and C3H/HeJ mice. Toxicol.Pathol. 2002/1; 30(-1-):97-105. >>> Uridine, bromodeoxy-; PBS; Mice; 2001; 3,5-7 days; Cancer; toxicology; hepatocyte proliferation.

P5189 Hahn,F.F., Avila,K.J., Hahn,F.F., Kubatko,J.E., Nikula,K.J. A double-label immunohistochemical method for assessment of epithelial cell replication in paraffin sections of toxicant-damaged lungs. JOURNAL OF HISTOTECHNOLOGY 2002; 25(-1-):15-20. >>> Uridine, bromodeoxy-; Saline; Rat; 2ML1; 7 days; Toxicology.

P5165 Halloran,B., Uden,P., Duh,Q.Y., Kikuchi,S., Wieder,T., Cao,J., Clark,O. Parathyroid gland volume increases with postmaturational aging in the rat. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2002; 282(--):E557-E563. >>> Meglumine iothalamate; Uridine, bromodeoxy-; DMSO; Propylene glycol; SC; rat; 2001; 2ML1; 4 days; iothalamate used to measure glomerular filtration rate; multiple pumps per animal (2); undiluted iothalamate infused via 2ML1 pumps; BrdU in DMSO/PG (50:50) was infused via 2001 pumps; parathyroid cell proliferation labelling.

P5152 Constan,A.A., Wong,B.A., Everitt,J.I., Butterworth,B.E. Chloroform inhalation exposure conditions necessary to initiate liver toxicity in female B6C3F1 mice. TOXICOLOGICAL SCIENCES 2002; 66(--):201-208. >>> Uridine, bromodeoxy-; PBS; SC; mice; 2001; 3.5 days; toxicology; liver&duodenum cell proliferation.

P5150 Nicholes,K., Guillet,S., Tomlinson,E., Hillan,K., Wright,B., Frantz,G.D., Pham,T.A., Dillard-Telm,L., Tsai,S.P., Stephan,J.P., Stinson,J., Stewart,T., French,D.M. A mouse model of hepatocellular carcinoma - Ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. American Journal of Pathology 2002; 160(-6-):2295-2307. >>> Uridine, bromodeoxy-; PBS; SC; mice (transgenic); 1002; 6 days; cancer; BrdU 100 mg/ml was dissolved in PBS by heating; pumps filled while solution was still warm.

P5139 Rosen,J.M., Welm,B.E., Tepera,S.B., Venezia,T., Graubert,T.A., Rosen,J.M., Goodell,M.A. Sca-1(pos) cells in the mouse mammary gland represent an enriched prog enitor cell population. Developmental Biology 2002; 245(--):42-56. >>> Uridine, bromodeoxy-; SC; mice; 2002; 14 days; mammary gland proliferation.

P5099 Tharappel,J.C., Lee,E.Y., Robertson,L.W., Spear,B.T., Glauert,H.P. Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by polychlorinated biphenyls. Toxicol.Appl.Pharmacol 2002/3/15; 179(--):172-184. >>> Uridine, bromodeoxy-; SC; rat; 2ML1; 3 days; toxicology; hepatocyte proliferation.

P5075 Elcombe,C.R., Elcombe,C.R., Odum,J., Foster,J.R., Stone,S., Hasmall,S., Soames,A.R., Kimber,I., Ashby,J. Prediction of rodent nongenotoxic carcinogenesis: Evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens. Environmental Health Perspectives 2002; 110(-4-):363-375. >>> Uridine, bromodeoxy-; PBS; SC; rat; mice; 2001; 2ML1; 7 days; toxicology; rats received 2ML1 pumps, mice received 2001 pumps..

P5060 Pierce,R.H., Vail,M.E., Ralph,L., Campbell,J.S., Fausto,N. Bcl-2 expression inhibits liver carcinogenesis and delays the development of proliferating foci. American Journal of Pathology 2002; 160(-5-):1555-1560. >>> Uridine, bromodeoxy-; mice (transgenic); 1003D; 3 days; cancer.

P5033 Masunaga,S., Ono,K., Takahashi,A., Ohnishi,T., Kinashi,Y., Takagaki,M. Radiobiological characteristics of solid tumours depending on the p53 status of the tumour cells, with emphasis on the response of intratumour quiescent cells. European Journal of Cancer 2002; 38(--):718-727. >>> Uridine, bromodeoxy-; Saline; SC; mice (nude); 2001; 7 days; cancer; tumor cell proliferation labelling.

P5756 Karas,R.H., van Eickels,M., Lydon,J.P., Roddy,S., Kwoun,M., Aronovitz,M., Baur,W.E., Conneely,O., O'Malley,B.W., Mendelsohn,M.E. A complex role for the progesterone receptor in the response to vascular injury. J Clin Invest 2001; 108(-4-):611-618. >>> Uridine, bromodeoxy-; SC; Mice (transgenic); 14 days; Cardiovascular; cell proliferation measured in carotid artery sections.

P5536 Katchanov,J., Harms,C., Gertz,K., Hauck,L., Waeber,C., Hirt,L., Priller,J., von Harsdorf,R., Bruck,W., Hortnagl,H., Dirnagl,U., Bhide,P.G., Endres,M. Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death. J Neurosci. 2001; 21(-14-):5045-5053. >>> Uridine, bromodeoxy-; SC; Mice; 1003D; 72 hours; "The administratioin of BrdU via osmotic minipumps was at least as effective as a more established method of daily intraperitoneal injections as determined by comparing the number of BrdU-positive cells using the two protocols." (p. 5046); ischemia (cerebral); comparison of SC pump vs. IP injection.

P5205 Molon-Noblot,S., Keenan,K.P., Coleman,J.B., Hoe,C.M., Laroque,P. The effects of ad libitum overfeeding and moderate and marked dietary restriction on age-related spontaneous pancreatic islet pathology in Sprague-Dawley rats. Toxicol.Pathol. 2001/5; 29(-3-):353-362. >>> Uridine, bromodeoxy; Sodium bicarbonate; SC; Rat; 2ML1; 7 days; Toxicology; islet cell proliferation labeling.

P4961 Lewis,C.D., Olson,N.E., Raines,E.W., Reidy,M.A., Jackson,C.L. Modulation of smooth muscle proliferation in rat carotid artery by platelet-derived mediators and fibroblast growth factor-2. PLATELETS 2001; 12(--):352-358. >>> Uridine, bromodeoxy-; SC; rat; 2ML1; 2-4 days; comparison of sc injections vs. mp; peptides; smooth muscle cell proliferation; cardiovascular.

P4951 Park,F., Kay,M.A. Modified HIV-1 based lentiviral vectors have an effect on viral transduction efficiency and gene expression in vitro and in vivo. MOLECULAR THERAPY 2001; 4(--):164-173. >>> Uridine, bromodeoxy-; SC; mice; 2001; 7 days; liver injury; BrdU used for labelling hepatocyte injury..

P4926 Pencea,V., Bingaman,K.D., Wiegand,S.J., Luskin,M.B. Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. Journal of Neuroscience 2001; 21(-17-):6706-6717. >>> Brain-derived neurotrophic factor; Uridine, bromodeoxy-; PBS; CSF/CNS; rat; 2002; 12 days; controls received mp w/ vehicle; comparison of IP BrdU injections vs mp; peptides; brain tissue distribution; BrdU used for labelling in both control and experimental pumps; measured cell proliferation with CNS-infused BrdU vs. IP-injected BrdU..

P4651 Bahnemann,R  Toxicology Methods 2001; 10(--):81-97. >>> Uridine, bromodeoxy-;; Saline;; SC;; rat;; 2ML1;; 3, 7 days;; Comparison of IP injections vs. mp; cancer; toxicology; liver cell proliferation;.

top of page